The invention provides a flexible and foldable biomembrane and a preparation method thereof. The flexible and foldable biomembrane is composed of an inner layer and an outer layer, wherein the outer layer is a medical polyurethane membrane which can be fragmented after absorbing liquid, the inner layer is a wounded surface covering layer and is composed of, for example, chitosan and derivatives thereof or alginate or the mixture dressings of both the chitosan and the alginate, the inner layer can be separately applied to wounded surface repairing and can be used for bonding treatment medicinesto a medicine carrier absorbing layer before the inner layer is used to achieve a treating effect, wounded surfaces comprises skin, mucous membranes or in vivo tissues, and the biomembrane is particularly suitable for cervical repairing. The flexible and foldable biomembrane is produced to be a mushroom-shaped, a protrusion is arranged in the middle, before the flexible and foldable biomembrane is used, the treating medicines are bonded to the chitosan and the derivatives thereof or the alginate dressings, when the biomembrane is used, a special vaginal clamp or a special pushing tool is usedfor pushing the biomembrane and covering the surface of os uteri, the protrusion is fixed to orificium vaginae, sustained local application of a cervical part is achieved, and the treating effect onchronic cervical diseases of cervical erosion and HPV is improved.