117 results about "Diarrheal disease" patented technology

The invention relates to the technical field of veterinary medicines, and in particular relates to a traditional Chinese medicinal composition for pigs. The traditional Chinese medicinal composition consists of 6-14 parts of smoked plum, 6-14 parts of myrobalan, 4-8 parts of rhizoma picrorhizae, 2-6 parts of sanguisorba carbon, 2-6 parts of astragalus membranaceus, 8-12 parts of halloysitum rubrum, 6-10 parts of anemone chinensis, 2-6 parts of rhizoma atractylodis and 2-6 parts of liquorice. The traditional Chinese medicinal composition can be powder, granules or oral administration liquid. The traditional Chinese medicinal composition for the pigs, which is disclosed by the invention, is a pure traditional Chinese medicinal composition, does not contain any chemical medicaments, has no residue and no toxic or side effect, is high in safety and difficultly generates drug resistance; an application test in a pig farm shows that the traditional Chinese medicinal composition has good treating effects of bacterial diarrhea, viral diarrhea, nutritional diarrhea and diarrhea caused by other various reasons of piglets; the pharmaceutical effect is quick to take, a quick respond is realized; the using amount of medicines is small; the cost is reduced; the survival rate of piglets is obviously improved; the treatment rate can be over 95 percent; the price is low; the medication safety is realized; the drug resistance can be avoided; the traditional Chinese medicinal composition can be popularized and applied.

With the goal of creating a combination vaccine against Shigella and other diarrheal pathogens we have constructed a prototype vaccine strain of Shigella flexneri 2a (SC608) that can serve as a vector for the expression and delivery of heterologous antigens to the mucosal immune system. SC608 is an asd derivative of SC602, a well-characterized vaccine strain, which has recently undergone several phase 1 and 2 trials for safety and immunogenicity. Using non-antibiotic asd-based plasmids, we have created novel constructs for the expression of antigens from enterotoxigenic E. coli (ETEC), including CFA / I (CfaB and CfaE) and the B-subunit from heat-labile enterotoxin (LTB) in Shigella vaccine strain SC608. Heterologous protein expression levels and cellular localization are critical to immune recognition and have been verified by immunoblot analysis. Following intranasal immunization (SC608(CFAI) and SC608(CFAI / LTB) of guinea pigs, serum IgG and IgA immune responses to both the Shigella LPS and ETEC antigens can be detected by ELISA. In addition, ELISPOT analysis for ASCs from cervical lymph nodes and spleen showed similar responses. All vaccine strains conferred high levels of protection against challenge with wild-type S. flexneri 2a using the Sereny test. Furthermore, serum from guinea pigs immunized with SC608 expressing CfaB and LTB contained antibodies capable of neutralizing the cytological affects of heat-labile toxin (HLT) on Chinese Hamster Ovary (CHO) cells. These initial experiments demonstrate the validity of a multivalent invasive Shigella strain that can serve as a vector for the delivery of pathogen-derived antigens.