Preparation method of green chitosan/carboxymethyl cellulose/P-type molecular sieve/potassium diformate slow-release antibacterial microspheres

A molecular sieve and slow-release technology, which is applied to medical preparations of non-active ingredients, active ingredients of anhydrides/acids/halides, antibacterial drugs, etc., can solve the problems of inability to reach the end of the intestinal tract, rapid decomposition, etc., and achieve good The effect of exploiting prospects

Pending Publication Date: 2020-02-14
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Potassium diformate, as an efficient and environmentally friendly antibacterial agent, can inhibit the growth of Escherichia coli in the intestinal tract of

Method used

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  • Preparation method of green chitosan/carboxymethyl cellulose/P-type molecular sieve/potassium diformate slow-release antibacterial microspheres
  • Preparation method of green chitosan/carboxymethyl cellulose/P-type molecular sieve/potassium diformate slow-release antibacterial microspheres
  • Preparation method of green chitosan/carboxymethyl cellulose/P-type molecular sieve/potassium diformate slow-release antibacterial microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The stilbene was crushed to 140 meshes, mixed with 12% hydrochloric acid and stilbene at a liquid-solid ratio of 3:1, and stirred at 85° C. for 2 hours. To destroy the structure of stilbite to form some amorphous substances, and remove useless mineral impurities, the acidified zeolite can be used as a precursor for the preparation of molecular sieves; 2g of zeolite precursor is mixed with 50ml NaOH of 1.5 molar concentration, and stirred at a constant temperature of 85°C for 15min , the product was centrifuged for 15min, and the supernatant was taken for subsequent use; 50ml of the supernatant was taken, and the 2 / Al 2 o 3 )=1, n(Na 2 O / SiO 2 )=1.5, n(H 2 O / Na 2 (0)=35 molar ratio proportioning completes the phase proportioning of preparing molecular sieve. The reaction temperature is controlled at 90°C, the reaction time is 6.3 hours, the hydrothermal crystallization temperature and crystallization time are well controlled, and the product is centrifuged, washed...

Embodiment 2

[0028] The stilbene was crushed to 150 meshes, mixed with 13% hydrochloric acid and stilbene at a liquid-solid ratio of 3:1, and stirred at 88° C. for 2.2 hours. To destroy the structure of stilbite to form some amorphous substances, and remove useless mineral impurities, the acidified zeolite can be used as a precursor for the preparation of molecular sieves; 2.1g of zeolite precursor is mixed with 50ml NaOH of 1.7 molar concentration, and the temperature is 83°C Stir for 17min, centrifuge the product for 17min, take the supernatant for later use; take 50ml of the supernatant, 2 / Al 2 o 3 )=3, n(Na 2 O / SiO 2 )=1.5, n(H 2 O / Na 2 (0)=36 molar ratio proportioning completes the phase proportioning of preparing molecular sieve. The reaction temperature was controlled at 91°C, the reaction time was 6.4 hours, the hydrothermal crystallization temperature and crystallization time were well controlled, and the product was centrifuged, washed, and dried to obtain a P-type molecul...

Embodiment 3

[0030]The stilbene was crushed to 160 meshes, mixed with 14% hydrochloric acid and stilbene at a liquid-solid ratio of 3:1, and stirred at 90° C. for 2.5 hours. To destroy the structure of stilbite to form some amorphous substances, and remove useless mineral impurities, the acidified zeolite can be used as a precursor for the preparation of molecular sieves; 2.2g of zeolite precursor is mixed with 50ml NaOH of 2.0 molar concentration, and the temperature is 85°C Stir for 20min, centrifuge the product for 18min, take the supernatant for later use; take 50ml supernatant, 2 / Al 2 o 3 )=5, n(Na 2 O / SiO 2 )=1.6, n(H 2 O / Na 2 (0)=37 molar ratio proportioning completes the phase proportioning of preparing molecular sieve. The reaction temperature is controlled at 92°C, the reaction time is 6.5 hours, the hydrothermal crystallization temperature and crystallization time are well controlled, and the product is centrifuged, washed, and dried to obtain a P-type molecular sieve. P...

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Abstract

The invention discloses a preparation method of chitosan/carboxymethyl cellulose/P-type molecular sieve/potassium diformate slow-release antibacterial microspheres for livestock. The problems of drugresidue and drug resistance caused by antibiotics are increasingly serious, and an acidifier potassium diformate plays role in middle rear section and large intestine section of small intestine are aimed; the novel green livestock slow-release antibacterial microsphere can be prepared by taking a green chitosan/carboxymethyl cellulose/P-type molecular sieve as a drug carrier, carrying out physicalaction on the drug carrier and Ca <2+>, and taking potassium diformate as a target drug. The sustained-release and in-vitro antibacterial tests show that the antibacterial microspheres have sustained-release performance, have an excellent antibacterial effect on escherichia coli, and can prevent and treat diarrhea caused by escherichia coli.

Description

technical field [0001] The invention belongs to the technical field of preparation of antibacterial agents, and in particular relates to a method for preparing slow-release antibacterial agents by compounding chitosan, carboxymethyl cellulose, P-type molecular sieves and potassium diformate. Background technique [0002] Guangxi stilbene is the best ore found in the world so far, the raw material is easy to mine, and it can be used as the precursor of synthetic molecular sieve after acidification. The method uses stilbite as a raw material, and prepares P-type zeolite molecular sieves by controlling reaction time, reaction temperature and other conditions through a hydrothermal synthesis method. Using chitosan / carboxymethyl cellulose / P-type molecular sieve as drug carrier, composite slow-release antibacterial microspheres were prepared by coacervation method. Potassium diformate, as an efficient and environmentally friendly antibacterial agent, can inhibit the growth of Esc...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/19A61K47/02A61K47/36A61K47/38A61P31/04
CPCA61K9/1611A61K9/1652A61K31/19A61P31/04
Inventor 郭小炜陈南春李玉妍解庆林王秀丽
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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