216results about How to "Prevent invasion" patented technology

The invention discloses a sand source resistance and control dynamic configuration method for a hole-to-wind sand area, and relates to the technical field of wind and sand protection, and the method comprises the following steps: collecting meteorological data, wind and sand data and historical sand source change data of the hole-to-wind sand area, and obtaining geographic information and vegetation coverage conditions of the sand source area through a remote sensing technology and ground monitoring equipment; by monitoring key parameters such as wind speed, wind direction and dust concentration in real time and combining high-resolution ground image data acquired by an unmanned aerial vehicle and a satellite remote sensing technology, real-time sensing and accurate analysis of sand source changes are realized, the efficiency and accuracy of data collection are improved, and the detection accuracy is improved. In addition, the prevention and control measures can be dynamically and accurately arranged according to the specific sand source, and by dynamically adjusting the arrangement and density of prevention and control facilities and optimizing the type and area of vegetation coverage, sand storm invasion can be more effectively prevented, the occurrence frequency and intensity of sand storm are reduced, and the efficiency and accuracy of sand source prevention and control are remarkably improved.

The invention discloses a warm-keeping fabric containing hollow polyester fibers as well as a preparation method and application thereof, and relates to the field of fabrics. When the thermal fabric containing the hollow polyester fibers is prepared, hollow mesoporous nano cerium oxide is selectively protected by molten paraffin and then reacts with chloromethyl trimethoxy silane and isocyanuric acid in sequence, paraffin is dissolved by chloroform, and then N-(3-trimethoxysilylpropyl) pyrrole is grafted to obtain modified hollow mesoporous nano cerium oxide; reacting terephthalic acid, a multifunctional monomer and ethylene glycol to obtain modified polyester particles; the preparation method comprises the following steps: granulating modified polyester, uniformly mixing modified hollow mesoporous nano cerium oxide and polyethylene glycol 10000, performing melt spinning, treating with a pyrrole solution, twisting, spinning and weaving, and treating with a sodium hypochlorite mixed solution to obtain the thermal fabric containing the hollow polyester fibers. The warm-keeping fabric containing the hollow polyester fibers prepared by the invention has excellent warm-keeping, antibacterial, anti-aging, flame-retardant, antistatic and mechanical properties.

According to the method, bacillus licheniformis bacterial liquid and calcium ion liquid are sequentially, slowly and evenly sprayed on the surface of a soil body, soil particles on the surface of a slope are cemented, a layer of calcium carbonate protection film is formed on the surface of the soil body, the anti-scouring capacity of the soil body can be effectively improved, flowing of the soil particles is reduced, and plant growth is protected; the adopted bacillus licheniformis can also increase the number of effective microbial communities in soil, improve the root system environment, promote plant growth, inhibit reproduction of harmful microorganisms, improve the granular structure of the soil, improve the soil, regulate the pH value of the soil, improve the water storage, energy storage and heat preservation of the soil, improve the disease resistance of crops and promote the maturity of plants; after vegetation grows, the effect of water and soil conservation can be improved, generated calcium carbonate can also bond soil particles, water and soil loss is reduced, bacillus licheniformis plays a dual role, multiple utilization of resources is achieved, and wide application prospects are achieved.

The invention provides Motixazotide-camptothecin conjugates as well as a preparation method and application of the Motixazotide-camptothecin conjugates, and belongs to the fields of polypeptide preparation and biological medicines. According to the invention, a series of novel Motixafortide-camptothecin conjugates are synthesized, and the Motixafortide-camptothecin conjugates are formed by connecting Motixafortide with different quantities of camptothecin through a linking group. An anti-tumor proliferation and migration experiment, cellular uptake and an aging curve show that the Motixazotide-camptothecin conjugate can improve the membrane penetrability and the anti-tumor activity of the camptothecin, improve the selectivity of the camptothecin to tumor cells and reduce the toxicity of the camptothecin to normal cells. Meanwhile, the solubility of the Motixazotide-camptothecin conjugate is more than 1000 times of that of the camptothecin. In addition, according to the intramolecular self-quenching Motixazotide-camptothecin conjugate prepared by the preparation method disclosed by the invention, the real-time monitoring on the release condition of the camptothecin anti-tumor drugs is realized. Therefore, the method has good practical application value.

The invention discloses a lightweight sound-insulation aerated concrete block and a preparation method thereof, and relates to the technical field of aerated concrete blocks. The polypropylene fibers are blended into the aerated concrete at a low mixing amount, so that the overall performance of the concrete is remarkably improved, the concrete is endowed with a new acoustic characteristic, and the polypropylene fibers have a unique physical property and a distribution mode; a structure similar to a natural or artificial fabric is formed in a pore network of the aerated concrete, when sound waves pass, tiny vibration of fibers can be induced, then the sound waves interact with surrounding pore walls, friction and energy conversion are generated, mechanical energy of the sound waves is effectively converted into heat energy in the process, and the sound waves can be effectively absorbed by the aerated concrete. The absorption and weakening of sound waves are realized, so that a remarkable sound absorption effect is shown.

The invention discloses markers for diagnosing and treating tumors. It is found for the first time that overexpressed circRNABP9 can inhibit proliferation, migration and invasion of gastric cancer cells and promote aging of the gastric cancer cells; the circTMEM45A can inhibit proliferation, migration and invasion of esophageal cancer cells, and further through mouse transplantation tumor experiment verification, a new thought and direction are provided for diagnosis and treatment of gastric cancer and esophageal cancer, and the circTMEM45A has a wide application prospect.

An acupuncture needle with a needle handle and a needle body capable of being separated comprises the needle handle and the needle body. The needle handle is of a two-section chuck structure, the needle body head of the needle body is slightly larger in the upper portion and slightly smaller in the lower portion, and protruding strips are arranged on the two sides. The size and the shape of the needle body head are matched with those of the inner cavities of the two chucks, the needle body head is clamped by the two chucks of the needle handle, the needle handle and the needle body form a whole, and normal acupuncture operation can be carried out; when a needle needs to be reserved, the two clamping heads are loosened, the needle handle is taken down, the needle body is reserved in the body, only a short needle body head is reserved outside the body, and if the weather is cold, a quilt can be directly covered for keeping warm, so that invasion of wind-cold damp evil can be avoided, and the comfort of a patient in the acupuncture process can be improved.

The fire-extinguishing flame-retardant explosion-proof battery storage bag composite structure comprises a heat transfer layer, a cooling explosion-proof layer, a fire-extinguishing barrier layer and a waterproof and fireproof layer which are sequentially arranged from inside to outside, a heat transfer layer, a cooling explosion-proof layer, a fire-extinguishing barrier layer and a waterproof and fireproof layer which are sequentially arranged from inside to outside form a fire-extinguishing flame-retardant explosion-proof battery storage bag composite structure; the heat transfer layer is used for conducting heat generated by batteries in the battery storage bag to the cooling explosion-proof layer; the cooling explosion-proof layer is used for cooling and extinguishing the fire of the batteries in the battery storage bag; the fire extinguishing barrier layer is used for extinguishing and blocking fire of batteries in the battery storage bag; the waterproof and fireproof layer is used for preventing external fire sources and water sources from invading the batteries in the battery storage bag. The explosion-proof battery can prevent internal fire sources from leaking out, can also prevent external fire sources, water sources and the like from invading, can be applied to various protection products needing to be used for charging batteries, is good in fire extinguishing, flame-retardant and explosion-proof performance, guarantees personnel safety, and reduces property loss.

The invention provides application of combination of tageteoside and difacitinib or ponatinib to blocking of esophageal squamous cell carcinoma progression. The tageteoside is combined with an FAK inhibitor defacitinib or an Src family kinase inhibitor ponatinib, so that the metastasis of esophageal squamous carcinoma, especially lymphatic metastasis, can be inhibited, the growth of primary focus and metastatic focus esophageal squamous carcinoma cells can be inhibited, and a synergistic anti-cancer effect is achieved.

The invention relates to the technical field of biological medicines, and particularly discloses application of chrysophyceae laminarin in preparation of medicines for promoting tumor cell aggregation and inhibiting tumor cell migration and diffusion. The chrysophyceae laminarin provided by the invention has the effects of promoting tumor cell aggregation and inhibiting tumor cell migration and diffusion, has a potential treatment effect on clinical treatment of tumor metastasis diseases, and can be used for research and development of related drugs.

The invention relates to a pharmaceutical composition for preventing and treating lung cancer, and belongs to the technical field of natural pharmaceutical compositions. In order to solve the problem that the risk of drug resistance exists when a single component of icariin is used for preventing and treating cancers, the invention provides a pharmaceutical composition for preventing and treating lung cancers, which comprises a component icariin derived from herba epimedii and a component daphnetin derived from stellera chamaejasme. The icariin and daphnoretin are compounded for preventing and treating lung cancer, and the pharmaceutical composition has the advantages of multiple components, multiple targets, small adverse reaction and synergistic interaction after compatibility. In-vitro experiments prove that through compatibility of icariin and daphnetin, proliferation, migration and invasion of lung cancer cell lines A549 and Lewis cells can be inhibited, apoptosis of the two cells is promoted, and the effect is better than that of a single icariin component. The possibility is provided for application of the icariin and daphnetin composition in lung cancer treatment, and clinical application of the icariin and daphnetin composition to lung cancer can be further developed on the basis of the anticancer effect of the composition.

The invention discloses an oligopeptide for treating neonatal bacterial meningitis and a preparation method of the oligopeptide, and belongs to the technical field of biological medicines. The invention successfully designs and prepares small molecular mimic peptides capable of effectively blocking escherichia coli from invading into the brain based on a lactam cyclization technology, the small molecular mimic peptides are named as EC-MP-1 and EC-MP-2, and animal level research proves that the mimic peptides disclosed by the invention can inhibit the invasion of E44 escherichia coli to HBMEC; cell and molecular level researches prove that the mimic peptide disclosed by the invention can play an effective therapeutic role. A new thought is provided for prevention and treatment of neonatal meningitis, and reliable scientific data is accumulated for subsequent development and clinical application of micromolecule polypeptide drugs.

The invention discloses a computer-aided breast cancer drug screening method and system, finds that miR-223-3p plays a role in regulating and controlling proliferation and apoptosis of breast cancer cells by regulating and controlling KIF4A for the first time, and provides a computer-aided drug screening method, system and equipment based on miR-223-3p and KIF4A and a computer readable storage medium based on miR-223-3p and KIF4A.

The present invention belongs to the field of medicine, and specifically relates to the use of simvastatin in the preparation of a drug for preventing or treating liver cancer. The results of pharmacological experiments show that simvastatin can inhibit the proliferation, migration and invasion of liver cancer cells HepG2, and promote apoptosis of liver cancer cells. In addition, the drug also contains a second active ingredient, which is an immune checkpoint inhibitor. The results of pharmacological experiments show that the drug containing the second active ingredient significantly inhibits the growth of human liver cancer Hep3B nude mouse transplanted tumors, and the effect is significantly better than the same dose of simvastatin and immune checkpoint inhibitors alone, which shows that the drug has a significant synergistic effect after combined use, and has good prospects for clinical application.

The utility model belongs to the fire safety technical field, concretely relates to a kind of inductive smoke detector, including detector body, the top of the detector body is detachably connected with protective cover, the protective cover is narrow in upper and wide in lower conical structure, its outer wall is evenly spaced apart and is provided with several flow guide grooves in circumferential direction, and the top end opening width of each flow guide groove is greater than the bottom end opening width, the top axial center of the protective cover is fixedly connected with the adapter pipe, the inner side wall edge of the protective cover is fixedly connected with the water cutting ring, the water cutting ring is continuous wave shape and surrounds structure;The utility model is through the height of adapter pipe, and reserve safety interval between protective cover and ceiling, avoid the direct paste of protective cover and ceiling and block up moisture invasion, and cooperate with the isolation effect of protective cover to ceiling water seepage and the drainage structure of flow guide groove, prevent water seepage erosion detector body, guarantee the safe operation of internal electronic device, to eliminate the equipment failure hidden danger caused by water seepage.

The cold protective coat for the motorcycle comprises a coat body, sleeves are fixedly connected to the two sides of the coat body, a coat cap is fixedly connected to the top of the coat body, a face mask is fixedly connected to the inner wall of one side of the coat cap, a plurality of sub-buttons are fixedly connected to one end of the face mask, and the sub-buttons are fixedly connected to the other end of the face mask. The inner wall of one side of the coat cap is fixedly connected with mother buckles corresponding to the son buckles, the inner wall of the bottom of the coat body is fixedly connected with two kneecaps which are symmetrically arranged, the inner side walls of the bottom ends of the kneecaps are fixedly connected with cotton and wool stickers, the inner side wall of the coat body is fixedly connected with hook stickers corresponding to the cotton and wool stickers, and the hook stickers are fixedly connected with the hook stickers. Cold air can be effectively prevented from directly invading the face, and the kneecaps and the clothes body are integrally arranged, so that storage is simple and convenient.

The application belongs to the technical field of biological medicine, and provides application of combined use of tocopherol and mulberroside C in preparation of a drug for treating liver cancer, which is combined use of tocopherol and mulberroside C in preparation of a drug for treating liver cancer. Through in-vitro cell experiments, the growth inhibition effect of tocopherol and mulberroside C on liver cancer cells is evaluated; the results show that tocopherol and mulberroside C can inhibit the growth activity of liver cancer cells to achieve the purpose of treating liver cancer.

This invention discloses an engineered probiotic expressing D-lactate dehydrogenase, its construction method, and its applications, belonging to the field of biomedical technology. The engineered probiotic of this invention is constructed by exogenously introducing the D-lactate dehydrogenase encoding gene into *Escherichia coli* Nissle 1917. This invention utilizes synthetic biology techniques to construct a "living therapeutic factory" capable of in-situ clearing specific metabolites, realizing a paradigm shift from "inhibiting proteins" to "clearing metabolites" in treatment. Through lipid coating technology, oral delivery and intestinal targeted colonization of the engineered bacteria are achieved, improving the precision and efficiency of treatment. Based on the probiotic EcN, it exhibits high biosafety. The treatment process is oral administration, non-invasive, and avoids the systemic toxicity of traditional chemotherapy.

The invention discloses a tumor detection marker and application thereof in medicine preparation, and belongs to the technical field of biomedicine. Clinical sample qRT-PCR (quantitative real-time polymerase chain reaction) shows that ENST00000412203.1 is obviously up-regulated in breast cancer tissues, the area (AUC) under the ROC curve reaches 0.9822, and the diagnosis efficiency is excellent. In addition, the invention further finds that the expression of the polypeptide in lymph node metastasis tissues is obviously improved, and metastasis specificity is displayed. Meanwhile, the expression of ENST00000412203.1 is knocked down through siRNA, it is found that proliferation, migration and invasion of breast cancer cells are remarkably inhibited, and therefore the siRNA can be used for preparing targeted therapy drugs for breast cancer and has important clinical application value.

The invention discloses application of shikonin combined with osimertinib in reversing osimertinib drug-resistant non-small cell lung cancer, and belongs to the technical field of biological medicine. According to the application of the shikonin combined with the osimertinib in reversing the osimertinib drug-resistant non-small cell lung cancer disclosed by the invention, the shikonin combined with the osimertinib promotes ferroptosis by inhibiting an HES1 / ATF3 / SLC7A11 signal axis, so that the drug resistance of the osimertinib drug-resistant non-small cell lung cancer is reversed; the combined scheme is expected to be a promising treatment means for overcoming the drug resistance of osimertinib drug-resistant non-small cell lung cancer.

The invention belongs to the technical field of medical preparations, and particularly relates to a resveratrol-succinyl glycan-tetravalent platinum nano-drug as well as a preparation method and application of the resveratrol-succinyl glycan-tetravalent platinum nano-drug. In the resveratrol-succinyl glycan-tetravalent platinum nano-drug provided by the invention, the succinyl glycan (RIC) can exert the anti-tumor activity by improving the immune function of a body; resveratrol (RES) can be used for directly acting on related targets and the like to exert anti-tumor activity by inhibiting proliferation of tumor cells, inducing apoptosis of the tumor cells, inhibiting invasion and metastasis of the tumor cells and regulating the immune function of a body. According to the invention, the succinylglycan-tetravalent platinum conjugate is used for wrapping an anti-cancer drug micromolecule RES, so that the anti-cancer curative effect of the drug is improved, the problems of toxic and side effects of platinum drugs, drug resistance of tumor cells and the like are solved, and a new idea is provided for construction and application of platinum nano-drugs.

The invention discloses a chimeric antigen receptor targeting human alpha-enolase, a CAR-T cell and application of the chimeric antigen receptor. The invention relates to a chimeric antigen receptor targeting human alpha-enolase, the chimeric antigen receptor comprises an scFv structural domain aiming at the human alpha-enolase, a transmembrane region and an intracellular signal transduction region, and the amino acid sequence of the chimeric antigen receptor is SEQUENCE No.1. The chimeric antigen receptor aiming at the tumor metabolic protein ENO1 is constructed, on one hand, tumor cells are recognized and killed through the highly expressed ENO1, and on the other hand, the chimeric antigen receptor has the effect of inhibiting invasion and metastasis of the tumor cells. Compared with ENO1 monoclonal antibody targeted therapy, the ENO1CAR therapy can directly kill tumor cells, and the effect is stronger; compared with other CAR treatment targets, the ENO1 has more adaptations and can play a role in inhibiting invasion and metastasis of tumors.

The invention provides a bis-substituted phenyl acrylamide / ester compound as well as a preparation method and application thereof. The structural formula of the compound is shown as a formula (I) or a formula (II). The compound provided by the invention can be used as a covalent inhibitor of DHHC family proteins, and inhibits proliferation, migration and invasion of tumor cells and plays an anti-tumor role by inhibiting the activity of DHHC palmitoyltransferase and blocking the palmitoylation modification process of substrate proteins. Experimental results show that the bis-substituted phenylacrylamide / ester compound has remarkable anti-proliferative activity on various tumor cells, the inhibition effect of the compound is superior to that of a positive control drug 2-BP, and the bis-substituted phenylacrylamide / ester compound has the potential of being further developed into a new generation of efficient and low-toxicity anti-tumor drugs.

The utility model relates to a PE (Poly Ethylene) packaging film with moisture-proof and waterproof performance, which belongs to the technical field of packaging films and comprises a bottom layer used for contacting with a product, a contact bulge fixed at the bottom of the bottom layer, a buffer layer arranged above the bottom layer, an accommodating groove formed on the buffer layer through stamping, and a protective layer arranged above the buffer layer. A protective structure is embedded in the bottom of the protective layer, a top layer is arranged above the protective layer, the containing grooves are filled with expansion filler, the expansion filler is bentonite or a cement-based material, the number of the buffer layers is two, the number of the protective layers is two, the containing grooves in the buffer layers are arranged in a matrix mode, and the containing grooves in different layers are arranged in a staggered mode. According to the packaging film, friction force is increased through the bottom layer contact protrusions, sliding displacement of a product is avoided, and stability is enhanced; the buffer layer containing groove is filled with materials, water can be absorbed, holes can be blocked, impact force can be dispersed, and the damp-proof and waterproof performance is improved; the protective structure of the protective layer enhances the strength and toughness, so that the protection is more uniform, and the protective effect is enhanced.

The invention belongs to the technical field of medicine, and particularly relates to application of Nimbidiol in preparation of medicine for preventing and treating inflammation-induced angiogenesis, Nimbidiol can remarkably inhibit migration, invasion and lumen formation of vascular endothelial cells induced by inflammation conditions, effectively destroy inflammation-condition-induced angiogenesis in an in-vitro simulated body and in an in-vivo model at the same time, and can be used for preparing medicine for preventing and treating inflammation-induced angiogenesis. Therefore, the Nimbidiol can be used for inhibiting angiogenesis induced by inflammation (such as rheumatoid arthritis), and can be used as a novel candidate medicine in developing an anti-angiogenesis strategy for treating rheumatoid arthritis.

The utility model discloses a kind of fireproof light power cable of rat and termite prevention, including conductor, the outside of the conductor is equipped with shielding layer, the outside of the shielding layer is equipped with insulating layer, the outside of the insulating layer is equipped with inner protective layer, the outside of the inner protective layer is equipped with physical protection layer, the outside of the physical protection layer is equipped with protective net layer, in the utility model, the power cable, by inner protective layer inner layer elastic memory resistance layer hardens and releases chlorpyrifos when receiving ≥5N bite pressure, outer layer honeycomb metal-ceramic composite layer improves bite resistance strength;Physical protection layer forms barrier with material hardness;Protective net layer can release medicament, and the defense capability of rat and termite bite is improved compared with traditional cable by multilayer protection;And insulating layer uses high-temperature resistant material to guarantee fireproof basis;Inner protective layer outer layer honeycomb metal-ceramic composite layer can form fireproof barrier when meeting fire.These structures cooperate and improve the fire resistance in fire situation compared with traditional cable.

The invention relates to application of NF2 gene / protein as a target spot in preparation of a medicine for preventing or treating influenza A and B virus infection, and belongs to the technical field of biological genetic engineering. In order to solve the problem that common targets of influenza A and B viruses and drugs capable of effectively inhibiting influenza A and B infection at the same time are lacked in the prior art, the invention provides application of the NF2 gene / protein as a target in preparation of drugs for preventing or treating influenza A and B virus infection. CRISPR (clustered regularly interspaced short palindromic repeats) Screen is used for screening to obtain a common new target NF2 gene / protein for infection and invasion of influenza A virus and influenza B virus in a human host cell, and the new target NF2 gene / protein can be applied to preparation of an expression inhibitor and inhibition of replication of influenza A virus and influenza B virus; the invention also can be applied to preparation of NF2 gene expression synergists, and preparation of replication synergists or vaccine production synergists of influenza A and B viruses.

The utility model belongs to the technical field of hydraulic dampers, and particularly relates to a hydraulic damper which comprises a bottom cylinder, the lower end of the bottom cylinder is fixedly connected with a first installation lug, the inner wall of the bottom cylinder is connected with a telescopic cylinder in a sliding mode, and the upper end of the telescopic cylinder is fixedly connected with a second installation lug. The second fixing ring is pushed to make contact with the bottom cylinder, the first fixing ring makes contact with the telescopic cylinder, the dustproof sleeve covers the gap between the telescopic cylinder and the bottom cylinder, dustproof treatment is conducted on the telescopic gap of the hydraulic damper, and the problem of invasion of impurities such as dust in the bottom cylinder is solved; through arrangement of structures such as an end rod I, a spring I and an insertion block I, insertion treatment can be performed on a telescopic cylinder, and through arrangement of structures such as an end rod II, a spring II and an insertion block II, insertion limiting can be performed on a bottom cylinder, so that a fixing ring I, a fixing ring II and a dustproof sleeve are stably arranged, and rapid installation and use by an operator are facilitated.

This invention provides a monoclonal antibody specifically targeting fungal enolase 1, its preparation, and its application. The monoclonal antibody of this invention comprises the gene and amino acid sequences of the heavy chain variable region (VH) and the light chain variable region (VL). The monoclonal antibody or antibody fragment of this invention specifically targeting fungal enolase 1 can bind with high affinity to the fungal Eno1 protein and also bind to fungal cells, thereby inhibiting fungal adhesion, infection, and invasion of host cells. The monoclonal antibody provided by this invention has the characteristics of high specificity and good efficacy. When used alone, it can significantly treat invasive fungal infections. When used in combination with existing antifungal small molecule compound drugs, it can significantly enhance the efficacy of the small molecule compound drugs, achieving better therapeutic effects.

The utility model provides an air guide device for an air conditioner and an air conditioner indoor unit, the air guide device comprises a first plate body, and the first plate body is provided with a plurality of first air outlet holes. The multiple first air outlet holes are arranged into multiple sets, and the multiple sets of first air outlet holes are formed in the first plate body. And in every two adjacent groups of first air outlet holes, the hole diameter of one group of first air outlet holes is not equal to the hole diameter of the other group of first air outlet holes. According to the air guide device for the air conditioner and the air conditioner indoor unit, the problem that an existing air guide plate cannot meet different air blowing requirements of users can be solved, and the effect that differentiated use experience is brought to different user groups is achieved.