13results about How to "Prevent invasion" patented technology

The application belongs to the technical field of biological medicine, and provides application of combined use of tocopherol and mulberroside C in preparation of a drug for treating liver cancer, which is combined use of tocopherol and mulberroside C in preparation of a drug for treating liver cancer. Through in-vitro cell experiments, the growth inhibition effect of tocopherol and mulberroside C on liver cancer cells is evaluated; the results show that tocopherol and mulberroside C can inhibit the growth activity of liver cancer cells to achieve the purpose of treating liver cancer.

The invention discloses a tumor detection marker and application thereof in medicine preparation, and belongs to the technical field of biomedicine. Clinical sample qRT-PCR (quantitative real-time polymerase chain reaction) shows that ENST00000412203.1 is obviously up-regulated in breast cancer tissues, the area (AUC) under the ROC curve reaches 0.9822, and the diagnosis efficiency is excellent. In addition, the invention further finds that the expression of the polypeptide in lymph node metastasis tissues is obviously improved, and metastasis specificity is displayed. Meanwhile, the expression of ENST00000412203.1 is knocked down through siRNA, it is found that proliferation, migration and invasion of breast cancer cells are remarkably inhibited, and therefore the siRNA can be used for preparing targeted therapy drugs for breast cancer and has important clinical application value.

The application discloses a kind of high flame-retardant temperature-resistant corrosion-resistant optical fiber composite cable and preparation method thereof, belong to cable manufacturing technical field, from inside to outside include optical fiber unit, conductor layer, insulating layer, shielding layer, anticorrosive layer and sheath layer in sequence.Optical fiber unit uses ceramicized silicone rubber buffer layer;Conductor layer is nickel-plated copper alloy stranded wire, and oxidation resistance is enhanced by nano titanium dioxide sol treatment;Insulating layer is three-layer co-extrusion structure;Shielding layer uses aluminum-plastic composite tape and plated tin copper wire braided composite structure;Anticorrosive layer is polytetrafluoroethylene film treated by plasma;Sheath layer uses two-component ceramicized silicone rubber, and it is flexible at room temperature vulcanization, and it is converted into ceramic body at high temperature.The application realizes excellent continuous use stability, strong corrosion resistance in salt spray environment and other performances through the synergistic design of multilayer structure, is suitable for high temperature, corrosion, fire and other harsh environments, significantly improves the safety and durability of composite cable.

This invention relates to the field of biomedical technology, and in particular to a method for preparing and applying a nanomedicine for treating deep endometriosis. The method involves mixing ferrous ammonium sulfate, trisodium citrate, and polyethyleneimine, then adding thioacetamide and triethanolamine via a solvothermal reaction to obtain two-dimensional iron sulfide nanosheets. Dopamine hydrochloride is then added and stirred at room temperature in anhydrous ethanol to obtain polydopamine-coated iron sulfide (FP). FP is then mixed with larotrectinib and anhydrous ethanol to obtain the nanomedicine FPL for treating deep endometriosis. The synthesis method of this invention is simple and highly operable; the product is stable and reproducible; FPL exhibits good biocompatibility and biodegradability. After entering the microenvironment of deep endometriosis lesions, it can responsively release larotrectinib, effectively inhibiting the Trk signaling pathway and significantly reducing the degree of nerve infiltration; simultaneously, the anti-inflammatory effect of the FP carrier alleviates the local inflammatory response, jointly inhibiting lesion progression.

This invention discloses the pharmaceutical applications of a P2Y11-specific inhibitor and compositions containing it, belonging to the field of biomedical technology. This invention discloses for the first time the use of NF157 in the preparation of drugs related to the treatment of HD5-induced pathogen infection. In combating pathogen infection, NF157 can specifically inhibit the binding of P2Y11 to HD5, thereby eliminating the role of HD5 in regulating cytoskeleton rearrangement and promoting filopodia formation, thus becoming a key link in interrupting pathogen infection. By preventing the formation of filopodia, NF157 effectively blocks the bacterial capture pathway, showing significant intervention effects on some pathogens that lack adhesion devices and flagella and rely on cellular pseudopodia capture for invasion.

The application discloses application of a PI3K-gamma-delta signal path inhibitor in preparation of a product for treating central nervous system leukemia and the product, and solves the technical problem that the prior art lacks a molecular targeting product for acute lymphoblastic leukemia with CNSL which has better effect. The application comprises: application of the PI3K-gamma-delta signal path inhibitor in preparation of a product for treating acute lymphoblastic leukemia with central nervous system leukemia, and application of the PI3K-gamma-delta signal path inhibitor in preparation of a product for inhibiting proliferation, invasion and migration of acute lymphoblastic leukemia with central nervous system leukemia. The application also comprises a product of the PI3K-gamma-delta signal path inhibitor. The application discloses that central nervous system leukemia is closely related to an expression level of MSLN, and the PI3K-gamma-delta signal path inhibitor can inhibit the infiltration degree of acute lymphoblastic leukemia with central nervous system leukemia by reducing the expression level of MSLN, and prolong the survival time.

The invention discloses a preparation method and application of a probiotic-entrapped collagen composite nano-carrier. The preparation method is characterized by comprising the following steps: mixing a fish gelatin protein solution and a polysaccharide solution, adjusting the pH value to be alkaline, heating to carry out glycosylation reaction, and purifying to obtain glycosylated fish gelatin protein. Mixing and emulsifying the glycosylated fish gelatin protein solution serving as a water phase and the oil phase by adopting a reversed-phase emulsification method to form a W / O type emulsion; adding a probiotic bacterial suspension, uniformly stirring, adding a cross-linking agent, carrying out a cross-linking reaction, carrying out solid-liquid separation, washing, and drying, so as to obtain the probiotic-entrapped collagen composite nano-carrier; the preparation method has the advantages that precise and slow-release release in intestinal tracts is realized, and the survival rate and bioavailability of probiotics are remarkably improved.

This application discloses a laser scanner dust cover, relating to the field of dust covers. It includes a push rod base disposed above a mounting base on the outside of a laser scanner. An electric push rod is provided on one side of the push rod base, and the output end of the electric push rod is connected to the dust cover. A first dustproof cotton is provided on the bottom surface of the dust cover, a second dustproof cotton is provided on the surface of the dust cover, and a third dustproof cotton is provided inside the push rod base. When the laser scanner needs to be used, the electric push rod will activate, causing the dust cover to rise and expose the laser scanner for laser scanning. After use, the electric push rod will activate again, causing the dust cover to descend and cover the laser scanner, providing protection for the scanner head and preventing external wind and sand from damaging it. The first and second dustproof cotton fill the gaps at the connection between the dust cover and the push rod base, and the third dustproof cotton fills the gaps at the connection between the push rod base and the laser scanner, preventing wind and sand from seeping in.

This invention discloses a heparin trisaccharide compound, its preparation method, and its applications, belonging to the field of compound preparation technology. The heparin trisaccharide compound is mainly prepared by the following method: linking a monosaccharide donor and a disaccharide acceptor through glycosylation, then reacting in a methanol / sodium methoxide system or a tetrahydrofuran / sodium hydroxide / water system, followed by sequential O-sulfonation, catalytic hydrogenation, and N-sulfonation post-treatment steps to obtain the heparin trisaccharide compound. This compound has a well-defined structure, a single component, and exhibits anti-angiogenic activity and anti-tumor potential.

This invention discloses a ZIF-8 nanomedicine delivery system co-loaded with doxorubicin and siTDRKH, its preparation method, and its applications, belonging to the fields of biomedicine and nanomaterials technology. The nanomedicine delivery system uses the zeolite imidazole ester framework material ZIF-8 as a carrier. Its porous structure encapsulates the chemotherapeutic drug doxorubicin within the framework, and small interfering RNA targeting the TDRKH gene is loaded onto the surface through electrostatic adsorption. This structure exhibits high pH responsiveness: it remains stable under normal physiological conditions (pH 7.4), preventing premature drug leakage; upon entering the slightly acidic environment of a tumor (pH 6.5) or a lysosomal environment (pH 5.0), the ZIF-8 framework immediately disintegrates, achieving targeted and synergistic release of the loaded drug.

The application provides a use of an NR2F2 agonist levomilnacipran in preparation of a drug for treating female renal clear cell carcinoma (ccRCC). In an estrogen environment, the levomilnacipran can significantly promote expression of NR2F2, and significantly inhibit proliferation, invasion and migration of ccRCC cells. The levomilnacipran can be used as a novel therapeutic drug for female ccRCC, and can specifically inhibit progression of the female ccRCC, and has important significance for disease prognosis.

This invention relates to the application of (E)-2-(4-(dimethylamino)styryl)-6-methoxy-3-methylbenzo[d]thiazol-3-onthium in the preparation of anticancer drugs, belonging to the field of pharmaceutical technology. The structure of (E)-2-(4-(dimethylamino)styryl)-6-methoxy-3-methylbenzo[d]thiazol-3-onthium is shown in Formula I below. The (E)-2-(4-(dimethylamino)styryl)-6-methoxy-3-methylbenzo[d]thiazol-3-onthium of this invention can inhibit the growth of gastric cancer cells. By promoting autophagy and mitochondrial fragmentation in gastric cancer cells AGS and HGC-27, it inhibits the proliferation, invasion, and migration of gastric cancer cells and arrests them in the G1 phase. Furthermore, in vivo experiments in mice have confirmed that ZWK-3 can inhibit tumor growth in mice in a significant dose-dependent manner, without affecting mouse body weight or visceral indices. Formula I.

This invention belongs to the field of microbial technology, and relates to a probiotic agent containing *Lactobacillus rhamnosus* CL-03 for relieving eczema, its preparation method, and its application. The strain in the agent is *Bifidobacterium longum* subsp. *infantile* with accession number GDMCC No:64541. Bifidobacterium longum subsp.infantis Strain C-3 and Lactobacillus rhamnosus with accession number GDMCC No. 65725 Lactobacillus rhamnosus Composition of CL-03 strain. The probiotic agent prepared by this invention can relieve eczema, repair the skin barrier, and inhibit the proliferation of harmful bacteria on the skin. Moreover, the Bifidobacterium longum subsp. infantis C-3 strain and Lactobacillus rhamnosus CL-03 strain have a certain synergistic effect on the above-mentioned effects.