69results about How to "Prevent invasion" patented technology

The invention discloses a warm-keeping fabric containing hollow polyester fibers as well as a preparation method and application thereof, and relates to the field of fabrics. When the thermal fabric containing the hollow polyester fibers is prepared, hollow mesoporous nano cerium oxide is selectively protected by molten paraffin and then reacts with chloromethyl trimethoxy silane and isocyanuric acid in sequence, paraffin is dissolved by chloroform, and then N-(3-trimethoxysilylpropyl) pyrrole is grafted to obtain modified hollow mesoporous nano cerium oxide; reacting terephthalic acid, a multifunctional monomer and ethylene glycol to obtain modified polyester particles; the preparation method comprises the following steps: granulating modified polyester, uniformly mixing modified hollow mesoporous nano cerium oxide and polyethylene glycol 10000, performing melt spinning, treating with a pyrrole solution, twisting, spinning and weaving, and treating with a sodium hypochlorite mixed solution to obtain the thermal fabric containing the hollow polyester fibers. The warm-keeping fabric containing the hollow polyester fibers prepared by the invention has excellent warm-keeping, antibacterial, anti-aging, flame-retardant, antistatic and mechanical properties.

According to the method, bacillus licheniformis bacterial liquid and calcium ion liquid are sequentially, slowly and evenly sprayed on the surface of a soil body, soil particles on the surface of a slope are cemented, a layer of calcium carbonate protection film is formed on the surface of the soil body, the anti-scouring capacity of the soil body can be effectively improved, flowing of the soil particles is reduced, and plant growth is protected; the adopted bacillus licheniformis can also increase the number of effective microbial communities in soil, improve the root system environment, promote plant growth, inhibit reproduction of harmful microorganisms, improve the granular structure of the soil, improve the soil, regulate the pH value of the soil, improve the water storage, energy storage and heat preservation of the soil, improve the disease resistance of crops and promote the maturity of plants; after vegetation grows, the effect of water and soil conservation can be improved, generated calcium carbonate can also bond soil particles, water and soil loss is reduced, bacillus licheniformis plays a dual role, multiple utilization of resources is achieved, and wide application prospects are achieved.

The invention discloses markers for diagnosing and treating tumors. It is found for the first time that overexpressed circRNABP9 can inhibit proliferation, migration and invasion of gastric cancer cells and promote aging of the gastric cancer cells; the circTMEM45A can inhibit proliferation, migration and invasion of esophageal cancer cells, and further through mouse transplantation tumor experiment verification, a new thought and direction are provided for diagnosis and treatment of gastric cancer and esophageal cancer, and the circTMEM45A has a wide application prospect.

An acupuncture needle with a needle handle and a needle body capable of being separated comprises the needle handle and the needle body. The needle handle is of a two-section chuck structure, the needle body head of the needle body is slightly larger in the upper portion and slightly smaller in the lower portion, and protruding strips are arranged on the two sides. The size and the shape of the needle body head are matched with those of the inner cavities of the two chucks, the needle body head is clamped by the two chucks of the needle handle, the needle handle and the needle body form a whole, and normal acupuncture operation can be carried out; when a needle needs to be reserved, the two clamping heads are loosened, the needle handle is taken down, the needle body is reserved in the body, only a short needle body head is reserved outside the body, and if the weather is cold, a quilt can be directly covered for keeping warm, so that invasion of wind-cold damp evil can be avoided, and the comfort of a patient in the acupuncture process can be improved.

The invention relates to a pharmaceutical composition for preventing and treating lung cancer, and belongs to the technical field of natural pharmaceutical compositions. In order to solve the problem that the risk of drug resistance exists when a single component of icariin is used for preventing and treating cancers, the invention provides a pharmaceutical composition for preventing and treating lung cancers, which comprises a component icariin derived from herba epimedii and a component daphnetin derived from stellera chamaejasme. The icariin and daphnoretin are compounded for preventing and treating lung cancer, and the pharmaceutical composition has the advantages of multiple components, multiple targets, small adverse reaction and synergistic interaction after compatibility. In-vitro experiments prove that through compatibility of icariin and daphnetin, proliferation, migration and invasion of lung cancer cell lines A549 and Lewis cells can be inhibited, apoptosis of the two cells is promoted, and the effect is better than that of a single icariin component. The possibility is provided for application of the icariin and daphnetin composition in lung cancer treatment, and clinical application of the icariin and daphnetin composition to lung cancer can be further developed on the basis of the anticancer effect of the composition.

The invention discloses an oligopeptide for treating neonatal bacterial meningitis and a preparation method of the oligopeptide, and belongs to the technical field of biological medicines. The invention successfully designs and prepares small molecular mimic peptides capable of effectively blocking escherichia coli from invading into the brain based on a lactam cyclization technology, the small molecular mimic peptides are named as EC-MP-1 and EC-MP-2, and animal level research proves that the mimic peptides disclosed by the invention can inhibit the invasion of E44 escherichia coli to HBMEC; cell and molecular level researches prove that the mimic peptide disclosed by the invention can play an effective therapeutic role. A new thought is provided for prevention and treatment of neonatal meningitis, and reliable scientific data is accumulated for subsequent development and clinical application of micromolecule polypeptide drugs.

The invention discloses a computer-aided breast cancer drug screening method and system, finds that miR-223-3p plays a role in regulating and controlling proliferation and apoptosis of breast cancer cells by regulating and controlling KIF4A for the first time, and provides a computer-aided drug screening method, system and equipment based on miR-223-3p and KIF4A and a computer readable storage medium based on miR-223-3p and KIF4A.

The present invention belongs to the field of medicine, and specifically relates to the use of simvastatin in the preparation of a drug for preventing or treating liver cancer. The results of pharmacological experiments show that simvastatin can inhibit the proliferation, migration and invasion of liver cancer cells HepG2, and promote apoptosis of liver cancer cells. In addition, the drug also contains a second active ingredient, which is an immune checkpoint inhibitor. The results of pharmacological experiments show that the drug containing the second active ingredient significantly inhibits the growth of human liver cancer Hep3B nude mouse transplanted tumors, and the effect is significantly better than the same dose of simvastatin and immune checkpoint inhibitors alone, which shows that the drug has a significant synergistic effect after combined use, and has good prospects for clinical application.

The utility model belongs to the fire safety technical field, concretely relates to a kind of inductive smoke detector, including detector body, the top of the detector body is detachably connected with protective cover, the protective cover is narrow in upper and wide in lower conical structure, its outer wall is evenly spaced apart and is provided with several flow guide grooves in circumferential direction, and the top end opening width of each flow guide groove is greater than the bottom end opening width, the top axial center of the protective cover is fixedly connected with the adapter pipe, the inner side wall edge of the protective cover is fixedly connected with the water cutting ring, the water cutting ring is continuous wave shape and surrounds structure;The utility model is through the height of adapter pipe, and reserve safety interval between protective cover and ceiling, avoid the direct paste of protective cover and ceiling and block up moisture invasion, and cooperate with the isolation effect of protective cover to ceiling water seepage and the drainage structure of flow guide groove, prevent water seepage erosion detector body, guarantee the safe operation of internal electronic device, to eliminate the equipment failure hidden danger caused by water seepage.

The application belongs to the technical field of biological medicine, and provides application of combined use of tocopherol and mulberroside C in preparation of a drug for treating liver cancer, which is combined use of tocopherol and mulberroside C in preparation of a drug for treating liver cancer. Through in-vitro cell experiments, the growth inhibition effect of tocopherol and mulberroside C on liver cancer cells is evaluated; the results show that tocopherol and mulberroside C can inhibit the growth activity of liver cancer cells to achieve the purpose of treating liver cancer.

This invention discloses an engineered probiotic expressing D-lactate dehydrogenase, its construction method, and its applications, belonging to the field of biomedical technology. The engineered probiotic of this invention is constructed by exogenously introducing the D-lactate dehydrogenase encoding gene into *Escherichia coli* Nissle 1917. This invention utilizes synthetic biology techniques to construct a "living therapeutic factory" capable of in-situ clearing specific metabolites, realizing a paradigm shift from "inhibiting proteins" to "clearing metabolites" in treatment. Through lipid coating technology, oral delivery and intestinal targeted colonization of the engineered bacteria are achieved, improving the precision and efficiency of treatment. Based on the probiotic EcN, it exhibits high biosafety. The treatment process is oral administration, non-invasive, and avoids the systemic toxicity of traditional chemotherapy.

The invention discloses a tumor detection marker and application thereof in medicine preparation, and belongs to the technical field of biomedicine. Clinical sample qRT-PCR (quantitative real-time polymerase chain reaction) shows that ENST00000412203.1 is obviously up-regulated in breast cancer tissues, the area (AUC) under the ROC curve reaches 0.9822, and the diagnosis efficiency is excellent. In addition, the invention further finds that the expression of the polypeptide in lymph node metastasis tissues is obviously improved, and metastasis specificity is displayed. Meanwhile, the expression of ENST00000412203.1 is knocked down through siRNA, it is found that proliferation, migration and invasion of breast cancer cells are remarkably inhibited, and therefore the siRNA can be used for preparing targeted therapy drugs for breast cancer and has important clinical application value.

The invention belongs to the technical field of medical preparations, and particularly relates to a resveratrol-succinyl glycan-tetravalent platinum nano-drug as well as a preparation method and application of the resveratrol-succinyl glycan-tetravalent platinum nano-drug. In the resveratrol-succinyl glycan-tetravalent platinum nano-drug provided by the invention, the succinyl glycan (RIC) can exert the anti-tumor activity by improving the immune function of a body; resveratrol (RES) can be used for directly acting on related targets and the like to exert anti-tumor activity by inhibiting proliferation of tumor cells, inducing apoptosis of the tumor cells, inhibiting invasion and metastasis of the tumor cells and regulating the immune function of a body. According to the invention, the succinylglycan-tetravalent platinum conjugate is used for wrapping an anti-cancer drug micromolecule RES, so that the anti-cancer curative effect of the drug is improved, the problems of toxic and side effects of platinum drugs, drug resistance of tumor cells and the like are solved, and a new idea is provided for construction and application of platinum nano-drugs.

The invention provides a bis-substituted phenyl acrylamide / ester compound as well as a preparation method and application thereof. The structural formula of the compound is shown as a formula (I) or a formula (II). The compound provided by the invention can be used as a covalent inhibitor of DHHC family proteins, and inhibits proliferation, migration and invasion of tumor cells and plays an anti-tumor role by inhibiting the activity of DHHC palmitoyltransferase and blocking the palmitoylation modification process of substrate proteins. Experimental results show that the bis-substituted phenylacrylamide / ester compound has remarkable anti-proliferative activity on various tumor cells, the inhibition effect of the compound is superior to that of a positive control drug 2-BP, and the bis-substituted phenylacrylamide / ester compound has the potential of being further developed into a new generation of efficient and low-toxicity anti-tumor drugs.

The utility model relates to a PE (Poly Ethylene) packaging film with moisture-proof and waterproof performance, which belongs to the technical field of packaging films and comprises a bottom layer used for contacting with a product, a contact bulge fixed at the bottom of the bottom layer, a buffer layer arranged above the bottom layer, an accommodating groove formed on the buffer layer through stamping, and a protective layer arranged above the buffer layer. A protective structure is embedded in the bottom of the protective layer, a top layer is arranged above the protective layer, the containing grooves are filled with expansion filler, the expansion filler is bentonite or a cement-based material, the number of the buffer layers is two, the number of the protective layers is two, the containing grooves in the buffer layers are arranged in a matrix mode, and the containing grooves in different layers are arranged in a staggered mode. According to the packaging film, friction force is increased through the bottom layer contact protrusions, sliding displacement of a product is avoided, and stability is enhanced; the buffer layer containing groove is filled with materials, water can be absorbed, holes can be blocked, impact force can be dispersed, and the damp-proof and waterproof performance is improved; the protective structure of the protective layer enhances the strength and toughness, so that the protection is more uniform, and the protective effect is enhanced.

The utility model discloses a kind of fireproof light power cable of rat and termite prevention, including conductor, the outside of the conductor is equipped with shielding layer, the outside of the shielding layer is equipped with insulating layer, the outside of the insulating layer is equipped with inner protective layer, the outside of the inner protective layer is equipped with physical protection layer, the outside of the physical protection layer is equipped with protective net layer, in the utility model, the power cable, by inner protective layer inner layer elastic memory resistance layer hardens and releases chlorpyrifos when receiving ≥5N bite pressure, outer layer honeycomb metal-ceramic composite layer improves bite resistance strength;Physical protection layer forms barrier with material hardness;Protective net layer can release medicament, and the defense capability of rat and termite bite is improved compared with traditional cable by multilayer protection;And insulating layer uses high-temperature resistant material to guarantee fireproof basis;Inner protective layer outer layer honeycomb metal-ceramic composite layer can form fireproof barrier when meeting fire.These structures cooperate and improve the fire resistance in fire situation compared with traditional cable.

This invention provides a monoclonal antibody specifically targeting fungal enolase 1, its preparation, and its application. The monoclonal antibody of this invention comprises the gene and amino acid sequences of the heavy chain variable region (VH) and the light chain variable region (VL). The monoclonal antibody or antibody fragment of this invention specifically targeting fungal enolase 1 can bind with high affinity to the fungal Eno1 protein and also bind to fungal cells, thereby inhibiting fungal adhesion, infection, and invasion of host cells. The monoclonal antibody provided by this invention has the characteristics of high specificity and good efficacy. When used alone, it can significantly treat invasive fungal infections. When used in combination with existing antifungal small molecule compound drugs, it can significantly enhance the efficacy of the small molecule compound drugs, achieving better therapeutic effects.

The invention relates to the technical field of crushers, and discloses energy-saving efficient jaw crushing equipment for building solid waste disposal, which comprises a crusher main body, a movable jaw plate and a fixed jaw plate are respectively mounted in the crusher main body, and a stress dispersion assembly is arranged in the crusher main body. The stress dispersion assembly comprises a plurality of waved plates mounted on the outer surfaces of the movable jaw plate and the fixed jaw plate and a plurality of crushing teeth mounted on the outer surfaces of the waved plates, and building solid waste enters from the upper part of the crusher, so that the large fluctuation of the waved plates can enable the movable jaw plate to generate large impact force on the building solid waste which just enters the crusher at the initial stage; when the lower waved plate at the upper part of the fixed jaw plate is matched with the movable jaw plate according to the fluctuating degree and height, a special crushing space can be formed, and building solid wastes can be guided to a proper crushing position when being pushed and extruded by the driven jaw plate; and the situation that the building solid waste cannot enter the crushing process smoothly due to the fact that the upper structure of the movable jaw plate is too complex is avoided.

This invention discloses the application of small molecule compounds in the preparation of drugs for treating breast cancer. MEN 10207 was screened using molecular docking analysis, and its ability to significantly inhibit the proliferation, migration, and invasion of breast cancer cells was verified in MDA-MB-231 cells, indicating its potential as an inhibitor of breast cancer brain metastasis. Further studies found that MEN 10207 did not exhibit significant toxicity in zebrafish and showed good tolerability in mouse intravenous injection experiments. Treatment of zebrafish transplanted with breast cancer cells with MEN 10207 significantly reduced the survival and migration ability of breast cancer cells in zebrafish; treatment of a mouse model of breast cancer brain metastasis with MEN 10207 also significantly reduced the colonization of breast cancer cells in the mouse brain, confirming its in vivo activity against breast cancer brain metastasis.

The application discloses a kind of high flame-retardant temperature-resistant corrosion-resistant optical fiber composite cable and preparation method thereof, belong to cable manufacturing technical field, from inside to outside include optical fiber unit, conductor layer, insulating layer, shielding layer, anticorrosive layer and sheath layer in sequence.Optical fiber unit uses ceramicized silicone rubber buffer layer;Conductor layer is nickel-plated copper alloy stranded wire, and oxidation resistance is enhanced by nano titanium dioxide sol treatment;Insulating layer is three-layer co-extrusion structure;Shielding layer uses aluminum-plastic composite tape and plated tin copper wire braided composite structure;Anticorrosive layer is polytetrafluoroethylene film treated by plasma;Sheath layer uses two-component ceramicized silicone rubber, and it is flexible at room temperature vulcanization, and it is converted into ceramic body at high temperature.The application realizes excellent continuous use stability, strong corrosion resistance in salt spray environment and other performances through the synergistic design of multilayer structure, is suitable for high temperature, corrosion, fire and other harsh environments, significantly improves the safety and durability of composite cable.

This invention relates to the field of biomedical technology, and in particular to a method for preparing and applying a nanomedicine for treating deep endometriosis. The method involves mixing ferrous ammonium sulfate, trisodium citrate, and polyethyleneimine, then adding thioacetamide and triethanolamine via a solvothermal reaction to obtain two-dimensional iron sulfide nanosheets. Dopamine hydrochloride is then added and stirred at room temperature in anhydrous ethanol to obtain polydopamine-coated iron sulfide (FP). FP is then mixed with larotrectinib and anhydrous ethanol to obtain the nanomedicine FPL for treating deep endometriosis. The synthesis method of this invention is simple and highly operable; the product is stable and reproducible; FPL exhibits good biocompatibility and biodegradability. After entering the microenvironment of deep endometriosis lesions, it can responsively release larotrectinib, effectively inhibiting the Trk signaling pathway and significantly reducing the degree of nerve infiltration; simultaneously, the anti-inflammatory effect of the FP carrier alleviates the local inflammatory response, jointly inhibiting lesion progression.

The invention discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis and gastric precancerous lesions, belonging to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 8-15 parts of ginseng, 15-45 parts of quinquefolius, 10-30 parts of acanthopanax senticosus, 5-15 parts of fructus aurantii, 10-30 parts of trigonosciadium japonicum, 10-20 parts of zedoaria, 5-15 parts of parsley, 3-6 parts of scorpion, 3-5 parts of centipede, 10-30 parts of smilax china and 5-15 parts of roasted liquorice. The traditional Chinese medicine composition of the present invention uses ginseng, Acanthopanax senticosus and Tripterygium wilfordii as main medicines, uses Eleutherodactyla quinquefolia, Curcuma zedoaria, Paris polyphylla, Rhizoma scutellariae, Scorpio and Scolopendra subspinipes as assistant medicines, uses Fructus aurantii and Radix Glycyrrhizae Radix et Rhizoma as adjuvant medicines, and can improve the general state, body weight, gastric mucosal lesions, gastric digestive function, and expression of gastric "inflammation-cancer" transformation markers of mice with chronic atrophic gastritis and gastric precancerous lesions models, has significant therapeutic effects on chronic atrophic gastritis and gastric precancerous lesions, and has no liver and kidney toxicity.

The invention discloses pharmaceutical application of a P2Y11 specific inhibitor and a composition containing the P2Y11 specific inhibitor, and belongs to the technical field of biological medicine. The invention discloses application of NF157 in preparation of drugs related to treatment of HD5-promoted pathogenic infection for the first time. In the aspect of pathogen infection treatment, NF157 can specifically inhibit combination of P2Y11 and HD5, so that the effect that HD5 regulates cytoskeleton rearrangement to promote filamentous pseudopod generation is eliminated, and the NF157 becomes a key link for cutting off pathogen infection. By preventing the cells from generating filamentous pseudopod, the NF157 effectively blocks the capturing path of bacteria, and has a remarkable intervention effect on part of pathogens which are lack of adhesion devices and flagellum and are invaded by relying on cell pseudopod capturing.

The invention provides an outdoor power switch cabinet with high safety protection performance, which comprises a base and a cabinet body fixedly connected to the top wall of the base, and further comprises an anti-collision assembly and a power supply assembly, the anti-collision part comprises a supporting shaft rotationally connected to the inner wall of the base, a first gear and a second gear fixedly connected to the outer wall of the supporting shaft, and a buffering part slidably connected to the side wall of the base. The supporting part comprises a third gear, a fourth gear and a telescopic supporting part, the third gear and the fourth gear are fixedly connected to the outer wall of the supporting shaft, the telescopic supporting part is slidably connected to the side wall of the base, the telescopic supporting part is in linkage with the buffering part, and the reinforcing part is slidably connected to the inner wall of the reinforcing groove through a sliding groove; when the cabinet is impacted, the purpose of increasing the supporting range of the base is achieved, the overall stability is improved, meanwhile, when the supporting frame moves, the sliding blocks are pulled to move through the reinforcing rods, then the cabinet body is reinforced, the cabinet body is prevented from toppling over after being impacted, and the overall protection performance is improved.

The invention belongs to the technical field of compound fertilizers, and particularly relates to a compound fertilizer microbial fertilizer as well as a preparation method and application thereof. The preparation method of the compound microbial fertilizer comprises the following steps: respectively fermenting livestock slaughtering wastes, livestock wastes, waste melons and fruits and eggshells to obtain a solution a, a solution b, a solution c and a solution d; mixing the obtained solutions in proportion, adding molasses, bacillus subtilis, EM bacteria and trichoderma harzianum, fully mixing, and carrying out secondary fermentation to obtain a compound microorganism stock solution; and adding the nitrogen-phosphorus-potassium inorganic fertilizer and the compound microorganism stock solution, and fully stirring to obtain the fertilizer. The invention discloses a compound microbial fertilizer prepared by a preparation method, which is used for solving the problems of soil hardening, acidification and plant diseases and insect pests caused by chemical fertilizer application, soil quality improvement, harmful substance reduction and fertility improvement.

This invention discloses the pharmaceutical applications of a P2Y11-specific inhibitor and compositions containing it, belonging to the field of biomedical technology. This invention discloses for the first time the use of NF157 in the preparation of drugs related to the treatment of HD5-induced pathogen infection. In combating pathogen infection, NF157 can specifically inhibit the binding of P2Y11 to HD5, thereby eliminating the role of HD5 in regulating cytoskeleton rearrangement and promoting filopodia formation, thus becoming a key link in interrupting pathogen infection. By preventing the formation of filopodia, NF157 effectively blocks the bacterial capture pathway, showing significant intervention effects on some pathogens that lack adhesion devices and flagella and rely on cellular pseudopodia capture for invasion.

This invention belongs to the field of pharmaceutical technology, specifically relating to a novel use of berberine hydrochloride and a pharmaceutical composition. Berberine hydrochloride has the structure shown below, and it significantly inhibits the expression of HMGB3 in triple-negative breast cancer cells, significantly inhibits the proliferation, colony formation, invasion, and migration of triple-negative breast cancer cells, and promotes apoptosis in triple-negative breast cancer cells. Therefore, berberine hydrochloride can be used to prepare drugs for the prevention and / or treatment of triple-negative breast cancer. Furthermore, berberine hydrochloride can enhance the drug sensitivity of cisplatin; the combined use of berberine hydrochloride and cisplatin has a strong synergistic effect in the treatment of triple-negative breast cancer, providing more treatment options for clinical treatment of triple-negative breast cancer.

The invention relates to the technical field of biological medicines, and particularly discloses application of piceatannol in preparation of a medicine for treating or preventing esophageal squamous cell carcinoma. Experiments prove that piceatannol has good effects of inhibiting proliferation, transfer and invasion of ESCC in both in-vivo and in-vitro experiments, an action target in the ESCC is GMPS, piceatannol can inhibit a GMPS / USP7 axis and inhibit interaction combination of GMPS and USP7, and the piceatannol has remarkable clinical transformation significance for development of targeted therapeutic drugs of ESCC.

The application discloses a pteris multifida exosome-like vesicle and application thereof in treatment of prostate cancer and / or bladder cancer. The pteris multifida exosome-like vesicle is prepared by differential ultracentrifugation combined with filter membrane filtration. Further, the pteris multifida exosome-like vesicle is subjected to anti-cancer effect test in multiple prostate cancer and bladder cancer cell lines. The results show that the pteris multifida exosome-like vesicle can effectively inhibit the proliferation, migration and invasion of prostate cancer cells, and block the cell cycle of prostate cancer cells, thereby inhibiting the growth of cancer cells and playing a role in treating prostate cancer. In addition, the pteris multifida exosome-like vesicle can also inhibit the proliferation of bladder cancer cells. It is shown that the pteris multifida exosome-like vesicle can have the treatment effect on prostate cancer and / or bladder cancer, and provides a new strategy and idea for the treatment of prostate cancer and bladder cancer.

The utility model discloses a kind of shellfish bottom rearing cages, belong to the technical field of aquaculture equipment, including cage, cage is the structure of side opening type, several through holes are set on cage, the opening of cage side is equipped with door plate, several through holes are set on door plate, the upper of cage is equipped with float, the lower of cage is equipped with fixing device. By suspending bottom rearing cage in seabed, provide excellent growth environment for filter-feeding economic shellfish, prevent the escape of cultured organisms, while it can prevent enemy organisms from invading, can effectively improve survival rate and recapture rate. The bottom rearing cage of the application is suitable for mechanized operation, can carry out scallop, oyster and other filter-feeding economic shellfish and sea cucumber and other bottom-dwelling economic animals in nearshore and deep sea area seabed Scale culture, greatly expand shellfish culture space, help to promote China's mariculture industrial structure adjustment, improve marine space and resource utilization rate.