38 results about "Mitochondrial respiratory chain" patented technology

Methods of treating mitochondrial respiratory chain disorders using compounds having erythropoietin activity or thrombopoietin activity are disclosed. Indicators for assessing the efficacy of treatment are discussed.

This invention discloses methods of using krill oil and compositions comprising krill oil to treat risk factors for metabolic, cardiovascular, and inflammatory disorders. The present invention also relates to methods of using compositions comprising krill oil to modulate biological processes selected from the group consisting of glucose metabolism, lipid biosynthesis, fatty acid metabolism, cholesterol biosynthesis, and the mitochondrial respiratory chain. The present invention further includes pharmaceutical and/or nutraceutical formulations made from krill oil, methods of making such formulations, and methods of administering them to treat risk factors for metabolic, cardiovascular, and inflammatory disorders.

Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidine nucleotide precursors in amounts sufficient to treat symptoms resulting from mitochondrial respiratory chain deficiencies.

The invention relates to novel use of a mitochondrial respiratory chain inhibitor rotenone in reversing the tolerance of non-small cell lung cancer cells to targeted antineoplastic agents. The rotenone serves as a non-small cell lung cancer cell sensitizer and can reverse the tolerance of the non-small cell lung cancer cells to the targeted antineoplastic agents. The invention shows the combination of rotenone compounds and TRAIL has no obvious toxic or side effect on normal cells and is a novel medicinal composition used for treating the non-small cell lung cancer.

The invention relates to a feed additive for improving the sea bass liver mitochondria function under high fat stress, a preparation method and application thereof, and a sea bass feed, and belongs tothe field of feeds. Each 100 parts by weight of the feed additive comprises 10-20 parts by weight of Chinese tallow bark extract, 10-20 parts by weight of ampelopsis grossedentata extract, 5-15 partsby weight of silymarin, 8-16 parts by weight of bamboo fungus polysaccharide chelated zinc, 6-12 parts by weight of methionine chelated iron, 4-8 parts by weight of biotin and the balance of carrier.The feed additive not only can improve the generation of sea bass mitochondria, promote the regeneration of mitochondria and enhance the respiratory chain activity of mitochondria, but also can improve the antioxidant capacity of liver mitochondria and reduce the oxidative damage of mitochondria, and has the effect of reducing blood fat. The preparation method is simple. The feed has good stability and good application prospect. When applied to the preparation of the sea bass feed, the feed additive can improve the sea bass liver mitochondria function under high fat stress.

The invention provides a feedstuff for killing fish and protecting crayfishes. The feedstuff consists of croton, tea bran, wheat bran, fish flour, rotenone and quicklime, wherein croton can kill most fish; the tea bran contains 12-18% of tea saponin that can dissolve the red blood cells of fish, thereby killing miscellaneous fishes, loach, fresh-water snails, fresh-water mussels, tadpoles and some aquatic insects; when taken by fish, rotenone can inhibit the mitochondrial respiratory chain, and cause disorders of the respiratory system, such as dyspnea and convulsion, slackness, paralysis, and death; fish flour contains much protein and wheat bran, and can induce miscellaneous fishes, loach, and fresh-water snails who will take croton, tea bran, and rotenone, thereby killing the miscellaneous fishes, loach, fresh-water snails and other wild aquatic lives. The feedstuff for killing fish and protecting crayfishes provided in the invention is highly sensitive and can kill rough fish, fresh-water snails, etc. in the aquaculture water area of crayfishes, thereby protecting the growth environment of crayfishes.

The invention relates to a composite feed additive capable of improving liver mitochondria function of jewfish as well as a preparation method and application of the composite feed additive, and belongs to the field of feeds. Each 100 parts by weight of the composite feed additive comprises the following components in parts by weight of 6-10 parts of manganese chelate methionine, 2-6 parts of copper chelate methionine, 30-50 parts of berberine, 20-30 parts of creatine, 0.5-2 parts of red Fife yeast and the balance of a carrier. The raw materials of the composite feed additive are safe, harmless, and free from residues, and create condition for production of green feeds and aquatic products. According to the preparation method of the composite feed additive, the raw materials are mixed in compounding ratio. The preparation method is simple, good in condition controllability, and good in stability, and has favorable application prospects. The composite feed additive is applied to preparation of the feed for jewfish, so that the liver mitochondria antioxidant ability and the mitochondrial respiratory chain function of the jewfish can be improved, and the mitochondria oxidative damagecan be reduced.

The invention provides a micro-nano hydrogel microsphere for targeted adjustment of a mitochondrial respiratory chain as well as preparation and application of the micro-nano hydrogel microsphere. According to the invention, hyaluronic acid microspheres are prepared through a microfluidic technology, and SS-31 peptide and Wyrgrl peptide modified resveratrol-loaded long-circulating liposome are connected in a microsphere nano network through a non-covalent bond, so that a micro-nano hydrogel microsphere system with a targeted cell MRC adjustment function is constructed. The system has efficient cellular uptake efficiency and mitochondrial targeting, and can significantly improve the MRC function, reduce proton leakage, protect mitochondria, down-regulate ROS expression, and promote generation of cartilage extracellular matrix. Meanwhile, the system can effectively slow down the progress of osteoarthritis in a rat osteoarthritis model. The micro-nano hydrogel microsphere system for the targeted adjustment and control of the cell MRC function, provided by the invention, has great potential in treating various degenerative diseases related to MRC dysfunction.

The present invention relates to regulation of adult lifespan in eukaryotes. More particularly, the present invention is directed to methods of assaying for genes, gene products, and genes in pathways controlled by such genes and gene products, using RNAi and microarray analysis, that regulate lifespan (e.g., extend or truncate adult lifespan) in eukaryotes such as invertebrates (e.g., C. elegans), plants, and mammals, e.g., humans. For example, the present invention is directed to genes encoding components of the mitochondrial respiratory chain and genes encoding glycolysis enzymes, which are involved in lifespan regulation, and genes and gene products in pathways controlled by such genes. Other genes and gene products identified as regulating aging and aging pathways include a gene encoding a GTPase; a transcriptional activator; novel genes: llw-1, llw-2, llw-3, and llw-4; genes encoding cytochrome P450 proteins (involved in steroid biosynthesis); a melatonin synthesis gene; genes encoding insulin and insulin-like peptides; genes encoding heat shock factors; genes encoding catalases; stress-response genes; and metabolic genes. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, antisense nucleic acids, and ribozymes, that regulate, e.g., enhance, adult lifespan via modulation of aging associated proteins; as well as to the use of expression profiles, markers, and compositions in diagnosis and therapy related to lifespan extension, life expectancy, and aging. The present invention also relates to gene therapy involving lifespan associated genes.

The invention discloses application of MV in preparation of a medicine with protection effect on neuronal injury caused by PD. The protection effect of the MV on neurotoxicity induced by Rotenone (Rot) is researched; in-vivo and in-vitro models of PD are established; then behavioristics and nerve injury, cell viability, ROS (reactive oxygen species) level, mitochondrial membrane potential (MMP), mitochondrial respiratory chain function, early apoptosis and ATP (adenosine triphosphate) level of model mice are detected; and finally, by up-regulating Sirtuin 3 (SIRT3), the action mechanism of the MV in the neuroprotection of PD is discussed.