The present invention discloses a sterilization composition adopting 
fluxapyroxad and difenoconazole as main 
active components, and an application thereof, and belongs to the technical field of compounded pesticides. According to the present invention, the sterilization composition adopts 
fluxapyroxad and difenoconazole as main 
active components, wherein a weight ratio of the 
fluxapyroxad to the difenoconazole is 1-90:1-90, and the total amount of the fluxapyroxad and the difenoconazole is 2-90% of the 
mass of the sterilization composition; and the sterilization composition provides significant effects for preparation of drugs for prevention and control of 
crop resistance 
plant fungous diseases of cereals, 
fruits and vegetables, and specifically for preparation of sterilization drugs for prevention and control of 
powdery mildew, 
botrytis cinerea, 
sclerotinia rot, rot 
disease, 
rust disease, 
glume spot of rice, web blotch, 
downy mildew, rice blast, 
seedling blight and scab of cucurbits, especially sterilization drugs for prevention and control of 
pear scab of cucurbits and cucumber 
powdery mildew. In addition, compared with the single-agent substance, the composition has characteristics of prevention and control spectrum expanding, production and use cost reducing, and 
drug resistance overcome and delaying.