94 results about "Fungal pathogen" patented technology

The present invention is in the field of agricultural pathogen control. Methods and compositions are described for controlling plant diseases caused by pathogens, including fungi and oomycete phytopathogens. Chemicals were screened for activity as autophagy inhibitors. The screening method used a bioluminescence resonance energy transfer (BRET)-based high-throughput screening strategy to identify compounds that inhibit fungal ATG4 cysteine protease-mediated cleavage of ATG8 for autophagosome formation. Ebselen and ebselen analogs were identified as inhibitors of fungal pathogens ATG4-mediated ATG8 processing. Identified chemicals inhibit spore germination, hyphal development, and appressorium formation. The autophagy inhibitors significantly reduced the virulence of pathogens in their corresponding plant hosts. The invention also provides for compositions comprising the same, methods of making the same, and methods of controlling plant disease.

Described are immunogenic compositions comprising a non-naturally occurring pan-fungal Kex peptide, and methods of using such compositions for the treatment or prevention of infection and / or diseases associated with fungal pathogens (e.g., Pneumocystis, Aspergillus, Candida, or Cryptococcus) in the subject. Also provided are compositions and kits for detecting or quantifying the presence of antibodies directed against a non-naturally occurring pan-fungal Kex peptide in a subject.

The present invention relates to transfer DNAs which can be used to produce a genetically modified plant that only has DNA from that species of plant. The present invention also relates to genetically modified plants with a transfer DNA of the invention which has been processed during integration and methods of making such plants. Also provided is a DNA construct and methods of making a multigene construct comprising five genes which confer upon a plant enhanced resistance to a wide variety of fungal pathogens.

The invention belongs to the technical field of biological agriculture, and relates to bacillus licheniformis and application thereof. The strain disclosed by the invention has a good broad-spectrum antibacterial effect, has a good inhibition effect on various plant fungal pathogenic bacteria and bacterial pathogenic bacteria causing plant diseases, and particularly has a relatively good prevention and treatment effect on pumpkin anthracnose, and the prevention and treatment effect on the pumpkin anthracnose reaches 95% or above by using 10,000,000 cfu / mL of a microbial agent diluent; the prevention effect is obvious. The bacterial strain and the biological agent containing the bacterial strain can effectively overcome the defect that an existing product is single in control effect, and crop plant growth can be further promoted. And the bacillus licheniformis is collected from the natural environment, is safe, environment-friendly and pollution-free, and has a wide application prospect.

The disclosure relates to methods and compositions for altering the production of one or more secondary plant metabolites comprising applying an effective amount of at least one elicitor, wherein the elicitor is a jasmonate or a salicylate, and combinations thereof. The disclosure further teaches compositions comprising effective amounts of the elicitors disclosed here. The disclosure further relates to methods and compositions for controlling plant pathogens, such as fungal pathogens.

The present disclosure relates to a method for controlling phytopathogens including fungal pathogens. Particularly, the disclosure provides method of controlling fungal infestation in Soybean crop by application of fungicides. The disclosure also relates to corresponding use thereof.

The present invention is directed to stable flumetylsulforim compositions, combinations of fluxapyroxad and rapeseed oil, and to a method for the control and / or prevention of (i) fungal pathogen attack on a plant or (ii) plant and / or soil fungal disease, wherein the method comprises applying the composition or the combination described herein.

This invention provides compounds and methods of application that possess both broad-spectrum antifungal activity and plant-induced resistance, belonging to the field of agricultural technology. It addresses the problem that "traditional pure immune inducers must be applied before disease onset, making it difficult to meet the full-cycle control needs of disease prevention and treatment in the field." Compared to the previously developed PC1 and PC20, the two compounds of this invention, 2,4-dibromo-6-nitrophenol and 7-deazon-2'-deoxy-7-iodoadenosine, can both inhibit the growth of rice blast fungus and significantly improve rice resistance to rice blast through foliar spraying, meeting the full-cycle control needs of disease prevention and treatment in the field. Furthermore, these two compounds can directly inhibit the growth of various fungal pathogens such as peanut white mold, tomato gray mold, wheat scab, rice bakanae disease, rice false smut, mango malformation, and banana wilt.

The present invention provides for an engineered, genetically modified, and / or synthetic plant receptor comprising a binding sequence that is capable of binding a fungal pathogen Avr ligand; wherein the non-engineered, genetically unmodified, and / or naturally occurring plant receptor does not bind the fungal pathogen Avr ligand, or bind with a lower binding affinity.

The present disclosure is directed to an approach using dsRNA to reduce or eliminate the production of DON by the fungal pathogen, F. graminearum or other fungal pathogens of the genus Fusarium and / or to control F. graminearum or other fungal pathogens of the genus Fusarium. In particular embodiments, methods and compositions are described to provide control of DON production and / or to control the fungal pathogen by causing mortality, suppression of growth, decrease in virulence or pathogenicity, or decrease in propagation / reproduction capacity (sporulation), by using exogenous dsRNA application administered to plants that are infected by or may become infected by F. graminearum or another member of the genus Fusarium that produces DON or otherwise is involved in Fusarium species complex that caused head blight.

The present invention provides a drug target protein MoFrd1 and its application in agricultural disease control. The amino acid sequence of MoFrd1 is shown in SEQ ID No.1, and the nucleotide sequence of its encoding gene is shown in SEQ ID No.4. Studies have shown that knocking out the MoFrd1 encoding gene significantly reduces the pathogenicity of rice blast fungus. Homologous proteins of MoFrd1 are widely present in plant pathogenic fungi and show high conservation in pathogenic mechanisms, but homologous proteins have not been found in plants and mammals, indicating its potential as a pathogen-specific drug target. Based on the key domains and functional sites of the MoFrd1 protein, it is expected to develop specific agents for controlling plant fungal pathogens through design or screening. The present invention provides new drug targets and control strategies for controlling fungal diseases of crops, and has important application value and market potential.

This invention relates to the fields of microbiology and biotechnology, and discloses Bacillus coagulans PPX-13 and its applications. Strain PPX-13 is a thermotolerant, multifunctional phosphate-solubilizing biocontrol bacterium that can reduce rhizosphere soil acidification in tea trees, improve fertility, enhance the microbial ecological environment, improve the functional microbial community and structure, inhibit mold communities and structure, and increase the yield of spring tea. It has been identified as Bacillus coagulans. This bacterium exhibits mesophilic and thermotolerant phosphate-solubilizing activity; phytase activity; multiple enzyme activities; and mesophilic antagonistic activity against isolates of anthracnose fungal pathogens. This strain holds promise for development into a novel agricultural microbial agent, which is of great significance for mitigating soil acidification, reducing fertilizer use, activating soil nutrients, improving soil quality, and increasing plant (especially tea) yield and quality.

The application discloses a method for synthesizing an antifungal pathogen reagent N-methyl-3-[(4-methylphenyl)thio]quinolinium iodide by realizing quinoline C3-H heteroatomization under nickel catalysis and mild conditions. The method comprises two steps, first, 3-(p-tolylthio)quinoline is synthesized under room temperature conditions, and then quinoline is N-methylated, so as to prepare the antifungal pathogen reagent N-methyl-3-[(4-methylphenyl)thio]quinolinium iodide. Compared with the past reports, the starting material is more cheap and easy to obtain, the steps are more simple, the atom utilization rate is higher, and the conditions are more mild, so the method is more suitable for kilogram scale amplification production.

A multifunctional agricultural composition is disclosed. The multifunctional agricultural composition combines organic insecticides, organic fertilizers, and organic fungicides for providing a cost-effective and environmentally sustainable solution for improving crop yield and health. The multifunctional agricultural composition is a versatile composition designed for universal crop applications that provides broad-spectrum pest control while delivering consistent performance across diverse crop varieties and environmental conditions. The multifunctional agricultural composition effectively targets a wide range of agricultural pests, fungal pathogens, and nutrient deficiencies, thereby making it suitable for use in varied farming systems, including horticulture, field crops, and orchard management.

The present invention relates to a method of conferring or increasing resistance to a plant and / or plant material against a fungal pathogen. To this end, the invention focuses on promoting or increasing the production and / or accumulation of Membrane Steroid Binding Protein 1 (MSBP1), fragments or homologues thereof in a plant or plant material as compared to the corresponding wild type plant or plant material. The invention also relates to plants and plant materials having increased resistance to fungal pathogens, as well as materials and methods of producing or using such plants, plant parts or products therefrom.

Described herein are fungicidal compositions and methods of controlling and / or suppressing phytopathogenic fungi and fungus-like pathogens and maintaining crop health. Particularly described are fungicidal compositions and methods of controlling the phytopathogenic fungi and the Aphanomyces fungus-like pathogen and maintaining crop health in crops susceptible to infection.

A system and methods for gas infusion tailored for manufacturing, prevention, and the application of fungicides in agriculture and aquaculture includes a microporous hollow fiber gas infusion module, engineered to efficiently dissolve gases such as oxygen or ozone into aqueous streams, thereby revolutionizing disease prevention and treatment strategies. Complementing the gas infusion module is a suite of manufacturing equipment and methodologies tailored for the production of oxygen-infused or other nutrient gas-infused products, catering to the diverse needs of agricultural and aquacultural industries. The system and method addresses the pervasive challenges posed by fungal pathogens in agriculture, such as Botrytis cinerea, Sclerotinia sclerotiorum, Pythium spp., and in aquaculture, particularly Saprolegnia, by offering comprehensive solutions encompassing precise gas infusion techniques, innovative disease prevention strategies, and sustainable manufacturing processes to enhance crop yields, promote environmental sustainability, and ensure the long-term viability of agricultural and aquacultural sectors.

In one aspect, the present application discloses compositions of extracellular vesicles (EVs) comprising heterologous effector RNAs, such as antifungal RNAs. In certain embodiments, the effector RNAs comprise dsRNA, while in other embodiments the effector RNAs comprise mRNA In certain embodiments, the EVs are plant EVs, microbial EVs (e.g., bacterial EVs or fungal EVs), or artificial EVs. In particular embodiments, the EVs are plant EVs and the effector RNA is mRNA. In other particular embodiments, the EVs are microbial EVs and the effector RNA is dsRNA. In other aspects, the application discloses microbes that produce RNA-loaded EVs; methods of treating and / or preventing fungal diseases by applying such microbes and / or RNA-loaded EVs to plants, plant parts, and / or soil; and methods of producing such RNA-loaded EVs. In certain examples, the antifungal RNAs may target DCL1 / 2 genes the VDS genes, and / or the tetraspanin (PLS1) genes of a fungal pathogen such as B. cinerea, Verticillium dahliae, Sclerotinia sclerotiorum, Fusarium oxysporum, Fusarium graminearum, Aspergillus niger or even oomycete pathogens, such as Phytophthora infestans.

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, tautomers, N oxides, and salts thereof, wherein R1, R2, R3, R4, R5, R6, m and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

A Capsicum plant resistant to powdery mildew caused by the fungal pathogen Leveillula taurica, a cell, plant part or seed of the Capsicum plant and to methods for identifying it, and the use of the plants for improving the yield of pepper production in an environment infected by Leveillula taurica and / or for limiting or controlling an infection by Leveillula taurica; wherein, the Capsicum plant includes introgressed in its genome a quantitative trait locus (QTL) conferring resistance to powdery mildew, wherein the QTL is located on chromosome 6 within the genomic interval delimited by the marker PE-0014628 (SEQ ID NO: 1) and the marker PE-0021476 (SEQ ID NO: 37).

The present invention relates to an emulsion concentrate (EC) formulation of succinate dehydrogenase inhibitor fungicides, the manufacture of such a formulation, and the use of its diluted form for the control of fungal pathogens, in particular in crops of useful plants. More specifically, the present invention relates to an emulsion concentrate of-difluoromethyl-1-methyl-1H-pyrazol-4-methoxyl-[1-methyl-2-(2, 4, 6-trichlorophenyl)-ethyl]-amide comprising a blend of at least three surfactants and an aromatic ester solvent.

TITLE: USE OF A BACILLUS SIAMENSIS STRAIN AS A BIOSOLUTION IN MUSHROOM CULTIVATION The present invention relates to the use of a particular bacterial species as a biosolution in the production and cultivation of mushrooms. More specifically, the invention relates to the use of a Bacillus siamensis strain, registered with the CNCM under CNCM order number I-5921, in stimulating the development and growth of a mycelium or fungus, improving the yields of edible mushroom crops, and controlling the main fungal pathogens of edible mushroom crops. [Fig. 1]

The object of the present invention is to provide a strain of Streptomyces with biocontrol effect and a disease-resistant and growth-promoting bacterial agent and their applications. The strain of the present invention can effectively control plant diseases and promote plant growth. The Streptomyces SF1 of the present invention has antagonistic effects on a variety of fungal pathogens, and can effectively control a variety of plant diseases including plant root rot, plant leaf spot, plant anthracnose and plant phyllosticta; at the same time, the Streptomyces SF1 can metabolize and produce a variety of growth-promoting substances such as indole acetic acid, NH3, ACC deaminase, nitrogen fixation, siderophore production, inorganic phosphorus solubilization, organic phosphorus solubilization, protease production, potassium solubilization and cellulase, and has the effect of promoting plant growth.

The present invention relates to a method of conferring or increasing resistance against fungal pathogens in plants, plant parts, and / or plant cells. To this end the invention focuses on facilitating or increasing the production and / or accumulation of a Myb41-type transcription factor (Myb41), fragment or homolog thereof in a plant, plant part and / or plant cell compared to corresponding wild type plants, wild type plant parts and / or wild type plant cells. The invention also relates to plants, plant parts, and / or plant cells having an increased resistance against fungal pathogens and to material and methods to create or use such plants plant parts or to produce products therefrom.

Disclosed are compounds of Formula 1, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof,whereinR1, L and J are as defined in the disclosure.Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

The present invention relates to methods for conferring or increasing resistance to fungal pathogens in plants, plant parts and / or plant cells. To this end, the present invention focuses on promoting or increasing the production and / or accumulation of Myb41-type transcription factors (Myb41), fragments thereof or homologs thereof in plants, plant parts and / or plant cells compared to corresponding wild-type plants, wild-type plant parts and / or wild-type plant cells. The present invention also relates to plants, plant parts and / or plant cells having increased resistance to fungal pathogens, as well as materials and methods for producing or using such plants, plant parts or products produced therefrom.

An antifungal compound / conjugate is derived from quercetin, a naturally occurring flavonoid, through a strategic conjugation approach. The resulting quercetin conjugate exhibits enhanced antifungal activity and improved pharmacological properties compared to its parent molecule. The conjugate demonstrates potent efficacy against a range of drug-resistant fungal pathogens, including Candida auris, a critical threat in clinical settings due to its multidrug resistance. The invention also encompasses methods for synthesizing the conjugate, formulating the conjugate in a pharmaceutical preparation, and methods of use for treatment and prevention of superficial and systemic fungal infections.

The present disclosure provides compositions and methods for making transgenic plants expressing a resistant Lr34 protein that exhibit increased resistance to fungal diseases, and transgenic plants produced by these methods, and plant parts thereof. The present disclosure provides transgenic plants, and plant parts thereof, that are resistant or immune, or have reduced susceptibility, to Asian Soybean Rust (ASR) and other fungal pathogens, while demonstrating minimized or reduced undesirable off-types. The present disclosure provides effective transgenic expression of Lr34 in soybean varieties to reduce the need for one or more fungicide applications, and / or protecting against fungal pathogens developing resistance to both the chemical control agents and other native or engineered disease resistance genes.

The present application provides a new technology to confer or enhance insect resistance and, optionally also resistance to fungal pathogens in plants. In particular, the present invention provides a method for conferring or increasing resistance or tolerance to insect and optionally also to fungal pathogens in maize and oil seed rape (OSR) by targeting the endogenous Lox3 gene. Further provided are resistant or tolerant maize or oil seed rape plants, cells, tissues, organs or seeds, which are obtained or obtainable by the method according to the present invention. Expression constructs and vectors for the different approaches described herein are also provided as well as the use of such constructs and methods to confer or increase insect and optionally fungal resistance in plants.