The invention belongs to a water-soluble fertilizer suitable for topdressing of apples in a coloring period and an application thereof. The fertilizer is prepared from the following raw materials: urea, industrial monoammonium, monopotassium phosphate, potassium nitrate, urea phosphate, phenylalanine, tyrosine, urine black acid, abscisic acid, gibberellin, jasmonate, ethylene, cane sugar, sodium nitroprusside and genistein. As a water-soluble topdressing fertilizer, the water-soluble fertilizer disclosed by the invention can realize topdressing in the coloring period of apples so as to realize rapid coloring of the apples, also considers the solubility of each component in the fertilizer, and can avoid the influence on the effect of the water-soluble fertilizer due to precipitation generated by interaction of the raw materials; the product has the advantages that after the bags outside the apples are picked off, leaf picking, fruit turning, flower thinning and film laying are not needed, the apples can be rapidly colored, and the fruits have both the appearance and the quality.