112 results about "Fluopyram" patented technology

The invention discloses a process method for preparing a fluopyram key intermediate. The key intermediate is [3-chloro-5-(trifluoromethyl) pyridine-2-yl] ({[2-(trifluoromethyl) benzoyl] amino} methyl) dimethyl malonate, and the process method comprises the following steps: in the presence of a solvent 1, carrying out a reaction on a compound 2-[3-chloro-5-(trifluoromethyl) pyridyl] dimethyl malonate potassium salt and a compound 1-D in a reaction container, and distilling and recovering the solvent 1 to obtain the intermediate compound. Wherein the solvent 1 is selected from acetic ester solvents with the boiling point range of 40-110 DEG C at normal temperature and normal pressure. The process method is simple and convenient, the total yield is high, the solvent is easy to recover, and the product purity is high; the intermediate does not need purification post-treatment, can be directly used for synthesis of fluopyram, can be amplified, and is beneficial to cost reduction, efficiency improvement and commercial mass production.

The invention relates to a green preparation method of fluopyram intermediate 3-chloro-5-(trifluoromethyl)-2-ethylaminopyridine, which comprises the following steps: step 1, Ullmann reaction: coupling 3-chloro-2-methyl-5-trifluoromethylpyridine (C1) and N-bromomethyl phthalimide (C2) in the presence of a copper catalyst and potassium tert-butoxide to generate an intermediate (C3); and step 2, hydrolysis reaction: hydrolyzing the intermediate (C3) in the presence of hydrazine sulfate and an alkaline condition to generate the fluopyram intermediate 3-chloro-5-(trifluoromethyl)-2-ethylamino pyridine. The method has the advantages of short synthesis steps, easily available raw materials, no use of high-toxicity cyanogen compounds, low catalyst cost, difficult poisoning, recycling, simple post-treatment process, and less waste liquid generation, greatly reduces the production cost, improves the production safety, reduces the waste liquid discharge amount, and accords with the idea of green synthesis.

The invention discloses a process method for preparing fluopyram. The process method comprises the following steps: in the presence of a solvent 1, reacting a compound 2-[3-chloro-5-(trifluoromethyl) pyridyl] dimethyl malonate potassium salt with a compound 1-D in a reaction container to obtain an intermediate compound, and distilling to recover the solvent 1 without purification treatment of the intermediate compound; adding water, alkali and a solvent 2 into the reaction container for reaction; adjusting the pH value after the reaction, and continuing the reaction; and after the reaction is finished, carrying out post-treatment to obtain the product fluopyram. Wherein the solvent 1 is selected from acetic ester solvents with the boiling point range of 40-110 DEG C at normal temperature and normal pressure. The process method is simple, convenient, high in total yield, low in cost and stable and qualified in product quality, fluopyram is prepared through a one-pot method, production equipment is reduced, investment is reduced, cost is reduced, efficiency is improved, and commercialized mass production is facilitated.

The invention provides a bromo-pyrrole nitrile-beta-aminobutyric acid derivative as well as a preparation method and application thereof, and belongs to the technical field of preparation of pesticide compounds. The bromopyrrole nitrile-beta-aminobutyric acid derivative disclosed by the invention is a derivative of 3-(2-(3-bromo-5-(4-chlorphenyl)-4-cyano-2-(trifluoromethyl)-1H-pyrrole-1-yl) acetamido)-2-methyl propionic acid and ester of 3-(2-(3-bromo-5-(4-chlorphenyl)-4-cyano-2-(trifluoromethyl)-1H-pyrrole-1-yl) acetamido)-2-methyl propionic According to the invention, bromo-pyrrolo-nitrile is used as a parent structure and is subjected to active substructure splicing with different substituted beta-aminobutyric acid derivatives to synthesize a series of novel compounds, the chemical structure is novel, and the compounds can be used for preventing and treating plant parasitic nematodes such as root-knot nematodes and cyst nematodes; a biological assay result shows that the prevention effect of bromo-pyrrolecarbonitrile-beta-aminobutyric acid on tomato root-knot nematodes is obviously superior to that of a commercial medicament fluopyram and is equivalent to that of a novel nematicide trifluoropyridylamine, and the bromo-pyrrolecarbonitrile-beta-aminobutyric acid has a relatively high commercial prospect.

The invention relates to the technical field of pesticides, and discloses a fluopyram compound and a preparation method thereof. The preparation method of the fluopyram compound comprises the following steps: 1) in the presence of a first organic solvent and first alkali, carrying out nucleophilic substitution reaction on a compound with a structure as shown in a formula (1) and a compound with a structure as shown in a formula (2); 2) carrying out a decarboxylation reaction on the nucleophilic substitution reaction product obtained in the step 1) in the presence of a first solvent and a first acid; 3) in the presence of a second solvent and a second acid, the decarboxylation reaction product obtained in the step 2) is subjected to a decyanation reaction to obtain the fluopyram compound, in the formula (1), X represents halogen, and R1 represents-COOC1-6 alkyl; in formula (2), R2 represents an alkyl group having 1-6 carbon atoms. According to the preparation method of the fluopyram compound, the yield is higher, and the operation is more convenient. # imgabs 0 # formula (1) # imgabs 1 # formula (2).

The invention discloses a compound composition of fluopyram and dsRNA (double-stranded ribonucleic acid) and application of the compound composition in prevention and control of nematodes. The method comprises the following steps: soaking pine wood nematodes by adopting a fluopyram medicament with LC20 concentration, collecting samples at different time points respectively, and carrying out transcriptome analysis. The pesticide compound composition for effectively poisoning and killing the pine wood nematodes is obtained by comparing gene expression differences at different time points, screening out remarkably up-regulated detoxification genes BxCYP, BxCES and BxUDP, designing and synthesizing double-stranded RNA (ds BxCYP, ds BxCES and ds BxUDP) according to the detoxification genes, and compounding the double-stranded RNA with fluopyram. The pesticide compound composition has a remarkable synergistic prevention and control effect on pine wood nematodes, is expected to become a novel and efficient pine wood nematode prevention and control agent, and provides a new strategy and theoretical basis for prevention and control of pine wood nematode diseases.

The invention discloses a preparation method and application of a pydiflumetofen intermediate, and the method comprises the following step: in the presence of cuprous oxide or cuprous salt and acid, synthesizing 2, 4, 6-trichlorobenzene diazonium fluoroborate and isopropenyl acetate into the pydiflumetofen intermediate of formula I, according to the invention, 2, 4, 6-trichloroaniline which is cheap and easy to obtain is used as a raw material to improve a Meerwein arylation reaction method, and finally industrial cheap and mass production of the intermediate I is realized.

This invention belongs to the field of agricultural fungicides, and provides a fungicidal composition containing methamidophos and fluopyram and its application, wherein the mass ratio of methamidophos and fluopyram is 1:2-1:70; the fungicidal composition has excellent synergistic effects on crop diseases; it can effectively reduce the dosage of pesticides, slow down the development of pesticide resistance in diseases, reduce environmental pollution, and is safe for crops in field observations.

The invention belongs to the technical field of toxicity tests, and discloses a method for evaluating zebra fish developmental toxicity by single or combined use of fluopyram and tebuconazole. The method is simple, efficient and accurate, through a combined toxicity test and a single pesticide test, reference data is conveniently increased according to the influence of different environments and different medicaments on animals, the influence of pesticides on zebra fish development is calculated according to the death rate and the median lethal concentration of zebra fish embryos, the data is reasonably analyzed and processed, and the method is suitable for popularization and application. The problems that related evaluation standards formulated by depending on a single effect are not accurate and cannot truly reflect the change of the real environment quality are avoided, the environmental risk of effectively evaluating the pollutants in the environmental water body is improved, and an environmental threshold value safer for aquatic organisms is formulated conveniently.

The invention provides a micro-capsule suspending agent containing fluopyram as well as a preparation method and application of the micro-capsule suspending agent, and belongs to the technical field of pesticide preparations. The micro-capsule suspending agent containing fluopyram is obtained by adopting a suspension polymerization method, and the obtained micro-capsule suspending agent is high in encapsulation efficiency and excellent in dispersity, has good ultraviolet stability and heat storage stability, and has a good prevention and removal effect and a long lasting period when being used for preventing and treating root nematodes. After root-irrigation pesticide application, the micro-capsule suspending agent containing fluopyram provided by the invention can be slowly released in soil and roots, has a good prevention effect on tomato and cucumber root-knot nematode, and has the advantages of long lasting period, multiple prevention and control crops, wide bactericidal spectrum and excellent uptake conductivity.

The invention discloses a mixed suspended seed coating agent for preventing diseases and insect pests in a peanut seedling stage, relates to the technical field of peanut suspended seed coating agents, and aims to solve the technical problems that pungent peculiar smell exists, the insecticidal effect is not comprehensive, the effect of improving soil is not achieved, and rooting and germination of peanuts are not facilitated in the prior art. The mixed suspended seed coating comprises the following components in parts by weight: 10-20 parts of fluopyram, 5-8 parts of a fludioxonil suspending agent, 10-20 parts of difenoconazole, 10-20 parts of trifloxystrobin, 3-5 parts of a plant growth regulator, 3-5 parts of trace elements, 5-10 parts of jatropha curcas biodiesel, 30-45 parts of water, 1-5 parts of an auxiliary agent, 1-3 parts of amino-oligosaccharin, 1-3 parts of lentinan and 1-3 parts of harpin protein. According to the mixed suspended seed coating, 1-3 parts of thiophanate methyl, 1-3 parts of sophocarpidine, 1-3 parts of phoxim, 3-5 parts of herba portulacae, 3-5 parts of tobacco shreds, 3-5 parts of sasangua cake and 3-5 parts of dye are included, the pungent peculiar smell can be reduced, various pests can be effectively killed, and meanwhile the sasangua cake can improve the soil structure.

This invention belongs to the field of pesticide technology, specifically relating to a fungicide composition for controlling grape powdery mildew. The active ingredient of this fungicide composition for controlling grape powdery mildew is a compound of fluopyram and dimethomorph or osthol. Through pot experiments, it was found that within a compounding mass ratio of 1-7:25-1, the combination of fluopyram and dimethomorph showed a synergistic effect on grape powdery mildew; within a compounding mass ratio of 1-19:19-1, the combination of fluopyram and osthol also showed a synergistic effect. This indicates that the compounding of fluopyram with dimethomorph or osthol can improve the control effect against grape powdery mildew, help reduce the dosage of pesticides, and delay the development of resistance, thus providing support for the development of novel pesticides for controlling grape powdery mildew.

The invention relates to a sterilization composition containing fluopyram, in particular to application of the sterilization composition containing fluopyram and iprodione to prevention and treatment of cucumber downy mildew, and the composition is mainly characterized in that the weight ratio of fluopyram to iprodione is 1: 1-1: 12, the composition is prepared into a suspending agent, and the suspending agent is a suspending agent. The dosage of the effective active ingredients is 30-120 g / hectare.

The invention relates to the technical field of nematicides, in particular to application of camellia oleifera cakes in prevention and treatment of meloidogyne incognita. The ethanol extract of the oil tea cake has high biological activity on meloidogyne incognita and has a synergistic effect with fluopyram, and the prevention effect can be remarkably improved by compounding the ethanol extract of the oil tea cake and the fluopyram. The ethanol extract of the oil tea cake has remarkable poisoning activity on meloidogyne incognita J2s, the EC50 value of the ethanol extract is reduced along with the prolonging of treatment time, and the EC50 value reaches 1.43 mg / mL when the treatment time is 72 h; an obvious inhibition effect is achieved on nematode egg incubation, and the inhibition rate of 15 mg / mL treatment at 7 days reaches 85.12%. A compounding experiment shows that when the fluopyram and the ethanol extract of the oil tea cake are prepared according to the ratio of 1: 1-9 or 3: 1, the synergistic index (CI) is less than 1, and an obvious synergistic effect is shown; in a pot experiment, the control effect on luffa rhizosphere J2s reaches 85.41% and the root knot index control effect reaches 82.06% when the luffa is treated according to the compounding ratio of 1: 5, and the control effect and the root knot index control effect are obviously superior to those of single-agent treatment.

The present invention relates to an improved process for the preparation of benzamide compound. More particularly, the present invention relates to an improved process for the preparation of Fluopyram of Formula (VI).

The application relates to the field of pesticide compounding, and specifically discloses a microcapsule suspension-suspension agent containing thiazol phosphorus and fluazacylamide and a preparation method thereof. The preparation method of the microcapsule suspension-suspension agent containing thiazol phosphorus and fluazacylamide comprises the following steps: S1. thiazol phosphorus microcapsule suspension agent preparation; S2. fluazacylamide suspension agent preparation; and S3. compounding: in the finally obtained microcapsule suspension-suspension agent, the thiazol phosphorus content is 6-7 wt%, and the fluazacylamide content is 12-18 wt%. The preparation method breaks through the technical bottleneck that the two components have poor compatibility, the microcapsule is easy to break, and the suspension phase is easy to stratify in the preparation of the existing CS-SC dosage form. Compared with common microcapsule suspensions and suspensions, the method has obvious advantages, the preparation process is simple and controllable, raw materials are easy to obtain, special high-end equipment is not needed, the preparation has a long effective period, the prevention and control effect is excellent, agricultural production efficiency is significantly improved, and planting cost is reduced.

The invention provides a suspending agent containing fluopyram and difenoconazole. The suspending agent comprises the following components in percentage by weight: 15% of fluopyram, 15% of difenoconazole, 1-3% of a wetting agent, 3.5-5.5% of a dispersing agent, 0.5-2% of a thickening agent, 0.1-1% of a preservative, 2-6% of an anti-freezing agent, 0.1-1% of a defoaming agent and the balance of deionized water. The preparation method comprises the following steps: mixing the polycarboxylate dispersing agent, the EO-PO block copolymer wetting dispersing agent, the macromolecular comb copolymer dispersing agent and the defoaming agent according to the formula, adding deionized water, mixing, dispersing and shearing for 5 minutes, then adding fluopyram and difenoconazole active compounds, continuously shearing for 5 minutes, adding the preservative, the magnesium aluminum silicate and the xanthan gum ethylene glycol dispersion liquid, uniformly stirring, and finally adding the defoaming agent. And shearing for 15 minutes to prepare suspension slurry. And transferring the suspension slurry to a sand mill for cooling and sanding, with the first-stage sanding temperature not exceeding 30 DEG C and the second-stage and third-stage sanding temperatures not exceeding 35 DEG C, thereby preparing the qualified suspension.

The invention relates to the technical field of pesticides, and provides a composition containing fluopyram and triazole fungicides, the composition is composed of active components and auxiliary materials, the auxiliary materials comprise a wetting agent, the wetting agent comprises sodium alkyl sulfate and sodium 3-chloro-2-hydroxypropyl sulfonate, and the active components are composed of fluopyram and triazole compounds; the mass of the fluopyram accounts for 10%-85% of the total mass of the active ingredients, and by means of the technical scheme, the problems that in the prior art, a preparation containing the fluopyram and the triazole fungicide is insufficient in dispersity and poor in wettability in the preparation process are solved.

The invention belongs to the field of fluorine-containing pesticide synthesis, and particularly relates to synthesis of fluopyram. The fluopyram is innovatively synthesized by adopting a one-pot catalytic system, and the reaction process is as shown in the formula 1: 2-acetonitrile-3-chloro-5-trifluoromethylpyridine (1) and o-trifluoromethyl benzoyl chloride (2) are used as initial raw materials, a catalyst with a specific structure and an alkali-binding acid agent are added into an ionic liquid, and a reaction is performed at the temperature of 60-80 DEG C for 1-2 hours to obtain the fluopyram. And preparing the target product fluopyram (3) by a high-efficiency one-pot method under the catalytic action of a supported metal catalyst in a hydrogen atmosphere. According to the one-pot synthesis process of fluopyram, the reaction is clean and pollution-free, the operation is simple and convenient, the utilization rate of raw materials is high, and the application frequency of Raney nickel can be increased under the condition that the yield is not influenced through a reaction system formed by combining water and an organic solvent. The o-trifluoromethyl benzoic acid recovered from the water phase can be further converted into o-trifluoromethyl benzoyl chloride, so that the utilization rate of the raw materials is improved. The synthesis process route is effectively shortened, and meanwhile, the use of expensive protection groups for protection in the hydrogenation reduction process is avoided, so that the process is more simplified.

Disclosed in the present invention is a process method for preparing fluopyram. The process method comprises the following steps: in the presence of a solvent 1, the compound potassium dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]malonate reacting with a compound 1-D in a reaction vessel to obtain an intermediate compound, then distilling, and recovering the solvent 1, wherein the intermediate compound does not need to be purified; then adding water, a base, and a solvent 2 to the reaction vessel for reaction; after the reaction is finished, adjusting the pH, and continuing reaction; and after the reaction is finished, performing work-up to obtain the product fluopyram. The solvent 1 is selected from acetate solvents having a boiling point ranging from 40ºC to 110ºC at room temperature and atmospheric pressure. The process method of the present invention is simple, has high overall yield, and low cost, the quality of the product is stable and meets standards, and fluopyram is prepared in one pot, thereby facilitating reduction of the number of production devices, reducing investment, reducing costs, and increasing efficiency, and facilitating large-scale commercial production.

This invention discloses a fungicide composition containing chlorfluazuron, a fungicide formulation containing the fungicide composition, and its uses. The fungicide composition includes chlorfluazuron and a compound fungicide component, wherein the compound fungicide component is selected from any one of fluopyram, cyazofamid, and prochloraz. The uses refer to the application of the fungicide composition in the preparation of agents for the control of crop diseases. The fungicide composition of this invention consists of active ingredients with different mechanisms of action, and when mixed, it exhibits a significant synergistic effect, improving the control efficacy. It also helps to overcome and delay the development of drug resistance in diseases, and can be used to develop novel and highly effective agents for the control of wheat scab and corn ear rot.

This invention belongs to the field of pesticide fungicides and discloses a fungicidal composition. The active ingredients of the fungicidal composition include active ingredient A, active ingredient B, and active ingredient C. Active ingredient A is fluopyram, active ingredient B is prothioconazole, and active ingredient C is chlorothalonil. The mass ratio of active ingredient A, active ingredient B, and active ingredient C is (1-20):(1-20):(10-100). The fungicidal composition of this invention can be used to control plant diseases caused by Basidiomycetes or Mitotic spore-forming fungi, and has good control effects. It features a broad fungicidal spectrum, low dosage, and significant synergistic effect.

The invention provides a high-stability pesticide suspending agent and a preparation method thereof. The high-stability pesticide suspending agent is prepared from the following raw materials in parts by weight: 30 to 40 parts of pyraclostrobin, 10 to 12 parts of modified polycarboxylic acid particles, 15 to 20 parts of pyraclostrobin, 15 to 20 parts of fluopyram, 5 to 8 parts of synergist, 1 to 5 parts of emulsifier, 1 to 2 parts of thickening agent and 80 to 100 parts of deionized water. The preparation method of the stable pesticide suspending agent comprises the following steps: adding the pyraclostrobin, the modified polycarboxylic acid particles, the pyraclostrobin and the fluopyram into the deionized water, stirring and mixing, then adding the synergist, the emulsifier and the thickening agent, and uniformly mixing and stirring to obtain the stable pesticide suspending agent. The high-stability pesticide suspending agent is green, clean, high in stability and good in disease control effect, and has a good application prospect.

The present application belongs to the technical field of agricultural compositions, and relates to an agricultural composition for preventing and treating populus euphratica wood lice. The present application provides an agricultural composition for preventing and treating populus euphratica wood lice, wherein the effective components are composed of fluopyram and echinacoside, and the mass ratio of fluopyram to echinacoside is 1:1-37.5. It is found through insecticidal effect verification that echinacoside has a synergistic effect on the chemical insecticidal component fluopyram, and the combination of the two can effectively reduce the effective component dosage of chemical pesticides, fully exert the efficacy of fluopyram, as much as possible reduce the probability of populus euphratica wood lice developing drug resistance, reduce environmental pollution, and improve the effect of fluopyram.

The application discloses a pesticide composition containing fluopyram and application of the pesticide composition in prevention and treatment of apple alternaria leaf spot, and belongs to the technical field of pesticides. A volatile oil extract of Alpinia galanga and a volatile oil extract of Eupatorium fortunei are obtained, and in indoor tests, the colony diameters of apple Alternaria alternata are all reduced, which indicates that the volatile oil extract of Alpinia galanga and the volatile oil extract of Eupatorium fortunei can inhibit the mycelium growth of apple Alternaria alternata. The volatile oil extract is used as a synergistic extract, combined with fluopyram, and added with various additives to prepare the pesticide composition containing fluopyram. In field tests, the disease index of fruit trees is all reduced, which indicates that apple Alternaria alternata is inhibited, and the relative prevention and treatment efficiency of the compound group is the highest and reaches 80.05%. The pesticide composition containing fluopyram is prepared by compounding fluopyram and the synergistic extract containing the volatile oil extract of Alpinia galanga and the volatile oil extract of Eupatorium fortunei, the pesticide composition can better inhibit apple Alternaria alternata, and is suitable for development of a pesticide for preventing and treating apple alternaria leaf spot.

The invention relates to the field of pesticide insecticides, in particular to a fluopyram microcapsule suspending agent and a preparation method thereof.The fluopyram microcapsule suspending agent is prepared from, by mass, 8-12 parts of fluopyram, 18-22 parts of 150 # solvent oil, 1-3 parts of polyisocyanate, 0.2-0.4 part of modified polyamine, 10-12 parts of auxiliaries and 40-50 parts of deionized water. A microcapsule system which is high in environmental adaptability and long-acting and stable is constructed by introducing a special release mechanism and combining a curing process and a green material, and compared with the prior art, the technology can accurately match disease high-incidence environmental conditions, prolong the pesticide lasting period and improve the pesticide effect. Meanwhile, according to the scheme, the release controllability, the structural stability and the environmental protection property are remarkably improved, the method is suitable for various crop disease prevention and control scenes, reliable technical support is provided for precision agriculture and green plant protection, and the wide market application prospect is achieved.

The present application relates to the technical field of compound pesticide, in particular to a kind of composite insecticide based on fluopyram and a preparation method thereof, the present application is obtained by the combination of fluopyram composition, insecticidal active substance, insecticide adjuvant and dispersant, emulsifier and defoaming agent, a kind of composite insecticide with good stability, high utilization rate, good insecticidal effect;In the present application, polylactic acid with high thermal stability and biodegradability and cellulose nanocrystal with emulsifying capacity are used to load fluopyram, obtaining fluopyram microspheres with high photothermal stability, high utilization rate and slow-release performance, and the fluopyram microspheres are mixed with fluopyram, so that the fluopyram composition can rapidly kill insects and continuously exert insecticidal effect;Insecticide adjuvant prevents and controls nematode from multiple dimensions, and has wide application prospect.

The invention relates to the technical field of pesticide preparations, and provides a fluopyram-containing pesticide preparation and application thereof in prevention and treatment of crop diseases, the fluopyram-containing pesticide preparation comprises the following raw materials by weight: 30-40 parts of fluopyram, 10-20 parts of menthyl acetate, 8-10 parts of a dispersant, 1-3 parts of a disintegrating agent, 2-4 parts of a wetting agent, 1-2 parts of a binder, and 20-30 parts of a filler; the filler comprises a carrier and 4-hydroxycyclohexanecarboxylic acid; the mass ratio of the carrier to the 4-hydroxycyclohexanecarboxylic acid is 10: (0.2-1). According to the technical scheme, the problem of poor dispersity of the fluopyram pesticide preparation in the related technology is solved.

The present invention relates to a fluopyram synthesis method, and belongs to the technical field of organic synthesis, the method comprises the following steps: Step 1, adding a solvent represented by a formula I and a solvent represented by a formula II into a reaction flask, adding an alkali, and carrying out a heat preservation reaction after the addition; step 2, removing the solvent under reduced pressure, adding water, and carrying out heat preservation reaction; 3, acid is added, and heat preservation reaction is carried out after addition; and Step 4, after the reaction is finished, cooling to 0-10 DEG C, filtering, washing a filter cake with clear water, and drying the filter cake to obtain the fluopyram. According to the invention, the three-step reaction is integrated in a single reactor, the raw materials which are economical and easy to obtain are selected, and the reaction is carried out under milder and safer conditions, so that the purposes of shortening the route, simplifying the operation, expanding the yield, reducing the cost and optimizing the safety are successfully realized, and the technical problems of lengthy route, low yield, high cost, harsh conditions and difficulty in industrialization in the prior art are solved; the invention provides a new way for producing fluopyram, which is efficient, economical, safe and simple and has extremely high industrial competitiveness, and has extremely high practical value and market potential.

The invention relates to the technical field of compound pesticides, in particular to a fluopyram-based compound pesticide and a preparation method thereof.A fluopyram composition, an insecticidal active matter, an insecticidal auxiliary agent, a dispersing agent, an emulsifying agent and a defoaming agent are compounded, and the compound pesticide which is good in stability, high in utilization rate and good in insecticidal effect is obtained; polylactic acid with high thermal stability and biodegradability and cellulose nanocrystals with emulsifying capacity are adopted to load fluopyram, the fluopyram microspheres with high photo-thermal stability, high utilization rate and slow release performance are obtained, and the fluopyram microspheres are mixed with fluopyram, so that the sustained release effect is improved. The fluopyram composition is capable of rapidly killing insects and continuously exerting an insecticidal effect at the same time; the insecticidal auxiliary agent can prevent and treat nematodes from multiple dimensions, and has a wide application prospect.