65 results about "Fluopyram" patented technology

The invention discloses a compound composition of fluopyram and dsRNA (double-stranded ribonucleic acid) and application of the compound composition in prevention and control of nematodes. The method comprises the following steps: soaking pine wood nematodes by adopting a fluopyram medicament with LC20 concentration, collecting samples at different time points respectively, and carrying out transcriptome analysis. The pesticide compound composition for effectively poisoning and killing the pine wood nematodes is obtained by comparing gene expression differences at different time points, screening out remarkably up-regulated detoxification genes BxCYP, BxCES and BxUDP, designing and synthesizing double-stranded RNA (ds BxCYP, ds BxCES and ds BxUDP) according to the detoxification genes, and compounding the double-stranded RNA with fluopyram. The pesticide compound composition has a remarkable synergistic prevention and control effect on pine wood nematodes, is expected to become a novel and efficient pine wood nematode prevention and control agent, and provides a new strategy and theoretical basis for prevention and control of pine wood nematode diseases.

The invention discloses a preparation method and application of a pydiflumetofen intermediate, and the method comprises the following step: in the presence of cuprous oxide or cuprous salt and acid, synthesizing 2, 4, 6-trichlorobenzene diazonium fluoroborate and isopropenyl acetate into the pydiflumetofen intermediate of formula I, according to the invention, 2, 4, 6-trichloroaniline which is cheap and easy to obtain is used as a raw material to improve a Meerwein arylation reaction method, and finally industrial cheap and mass production of the intermediate I is realized.

This invention belongs to the field of agricultural fungicides, and provides a fungicidal composition containing methamidophos and fluopyram and its application, wherein the mass ratio of methamidophos and fluopyram is 1:2-1:70; the fungicidal composition has excellent synergistic effects on crop diseases; it can effectively reduce the dosage of pesticides, slow down the development of pesticide resistance in diseases, reduce environmental pollution, and is safe for crops in field observations.

The invention belongs to the technical field of toxicity tests, and discloses a method for evaluating zebra fish developmental toxicity by single or combined use of fluopyram and tebuconazole. The method is simple, efficient and accurate, through a combined toxicity test and a single pesticide test, reference data is conveniently increased according to the influence of different environments and different medicaments on animals, the influence of pesticides on zebra fish development is calculated according to the death rate and the median lethal concentration of zebra fish embryos, the data is reasonably analyzed and processed, and the method is suitable for popularization and application. The problems that related evaluation standards formulated by depending on a single effect are not accurate and cannot truly reflect the change of the real environment quality are avoided, the environmental risk of effectively evaluating the pollutants in the environmental water body is improved, and an environmental threshold value safer for aquatic organisms is formulated conveniently.

The invention provides a micro-capsule suspending agent containing fluopyram as well as a preparation method and application of the micro-capsule suspending agent, and belongs to the technical field of pesticide preparations. The micro-capsule suspending agent containing fluopyram is obtained by adopting a suspension polymerization method, and the obtained micro-capsule suspending agent is high in encapsulation efficiency and excellent in dispersity, has good ultraviolet stability and heat storage stability, and has a good prevention and removal effect and a long lasting period when being used for preventing and treating root nematodes. After root-irrigation pesticide application, the micro-capsule suspending agent containing fluopyram provided by the invention can be slowly released in soil and roots, has a good prevention effect on tomato and cucumber root-knot nematode, and has the advantages of long lasting period, multiple prevention and control crops, wide bactericidal spectrum and excellent uptake conductivity.

This invention belongs to the field of pesticide technology, specifically relating to a fungicide composition for controlling grape powdery mildew. The active ingredient of this fungicide composition for controlling grape powdery mildew is a compound of fluopyram and dimethomorph or osthol. Through pot experiments, it was found that within a compounding mass ratio of 1-7:25-1, the combination of fluopyram and dimethomorph showed a synergistic effect on grape powdery mildew; within a compounding mass ratio of 1-19:19-1, the combination of fluopyram and osthol also showed a synergistic effect. This indicates that the compounding of fluopyram with dimethomorph or osthol can improve the control effect against grape powdery mildew, help reduce the dosage of pesticides, and delay the development of resistance, thus providing support for the development of novel pesticides for controlling grape powdery mildew.

The invention relates to the technical field of nematicides, in particular to application of camellia oleifera cakes in prevention and treatment of meloidogyne incognita. The ethanol extract of the oil tea cake has high biological activity on meloidogyne incognita and has a synergistic effect with fluopyram, and the prevention effect can be remarkably improved by compounding the ethanol extract of the oil tea cake and the fluopyram. The ethanol extract of the oil tea cake has remarkable poisoning activity on meloidogyne incognita J2s, the EC50 value of the ethanol extract is reduced along with the prolonging of treatment time, and the EC50 value reaches 1.43 mg / mL when the treatment time is 72 h; an obvious inhibition effect is achieved on nematode egg incubation, and the inhibition rate of 15 mg / mL treatment at 7 days reaches 85.12%. A compounding experiment shows that when the fluopyram and the ethanol extract of the oil tea cake are prepared according to the ratio of 1: 1-9 or 3: 1, the synergistic index (CI) is less than 1, and an obvious synergistic effect is shown; in a pot experiment, the control effect on luffa rhizosphere J2s reaches 85.41% and the root knot index control effect reaches 82.06% when the luffa is treated according to the compounding ratio of 1: 5, and the control effect and the root knot index control effect are obviously superior to those of single-agent treatment.

The present invention relates to an improved process for the preparation of benzamide compound. More particularly, the present invention relates to an improved process for the preparation of Fluopyram of Formula (VI).

The application relates to the field of pesticide compounding, and specifically discloses a microcapsule suspension-suspension agent containing thiazol phosphorus and fluazacylamide and a preparation method thereof. The preparation method of the microcapsule suspension-suspension agent containing thiazol phosphorus and fluazacylamide comprises the following steps: S1. thiazol phosphorus microcapsule suspension agent preparation; S2. fluazacylamide suspension agent preparation; and S3. compounding: in the finally obtained microcapsule suspension-suspension agent, the thiazol phosphorus content is 6-7 wt%, and the fluazacylamide content is 12-18 wt%. The preparation method breaks through the technical bottleneck that the two components have poor compatibility, the microcapsule is easy to break, and the suspension phase is easy to stratify in the preparation of the existing CS-SC dosage form. Compared with common microcapsule suspensions and suspensions, the method has obvious advantages, the preparation process is simple and controllable, raw materials are easy to obtain, special high-end equipment is not needed, the preparation has a long effective period, the prevention and control effect is excellent, agricultural production efficiency is significantly improved, and planting cost is reduced.

The invention relates to the technical field of pesticides, and provides a composition containing fluopyram and triazole fungicides, the composition is composed of active components and auxiliary materials, the auxiliary materials comprise a wetting agent, the wetting agent comprises sodium alkyl sulfate and sodium 3-chloro-2-hydroxypropyl sulfonate, and the active components are composed of fluopyram and triazole compounds; the mass of the fluopyram accounts for 10%-85% of the total mass of the active ingredients, and by means of the technical scheme, the problems that in the prior art, a preparation containing the fluopyram and the triazole fungicide is insufficient in dispersity and poor in wettability in the preparation process are solved.

The invention belongs to the field of fluorine-containing pesticide synthesis, and particularly relates to synthesis of fluopyram. The fluopyram is innovatively synthesized by adopting a one-pot catalytic system, and the reaction process is as shown in the formula 1: 2-acetonitrile-3-chloro-5-trifluoromethylpyridine (1) and o-trifluoromethyl benzoyl chloride (2) are used as initial raw materials, a catalyst with a specific structure and an alkali-binding acid agent are added into an ionic liquid, and a reaction is performed at the temperature of 60-80 DEG C for 1-2 hours to obtain the fluopyram. And preparing the target product fluopyram (3) by a high-efficiency one-pot method under the catalytic action of a supported metal catalyst in a hydrogen atmosphere. According to the one-pot synthesis process of fluopyram, the reaction is clean and pollution-free, the operation is simple and convenient, the utilization rate of raw materials is high, and the application frequency of Raney nickel can be increased under the condition that the yield is not influenced through a reaction system formed by combining water and an organic solvent. The o-trifluoromethyl benzoic acid recovered from the water phase can be further converted into o-trifluoromethyl benzoyl chloride, so that the utilization rate of the raw materials is improved. The synthesis process route is effectively shortened, and meanwhile, the use of expensive protection groups for protection in the hydrogenation reduction process is avoided, so that the process is more simplified.

Disclosed in the present invention is a process method for preparing fluopyram. The process method comprises the following steps: in the presence of a solvent 1, the compound potassium dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]malonate reacting with a compound 1-D in a reaction vessel to obtain an intermediate compound, then distilling, and recovering the solvent 1, wherein the intermediate compound does not need to be purified; then adding water, a base, and a solvent 2 to the reaction vessel for reaction; after the reaction is finished, adjusting the pH, and continuing reaction; and after the reaction is finished, performing work-up to obtain the product fluopyram. The solvent 1 is selected from acetate solvents having a boiling point ranging from 40ºC to 110ºC at room temperature and atmospheric pressure. The process method of the present invention is simple, has high overall yield, and low cost, the quality of the product is stable and meets standards, and fluopyram is prepared in one pot, thereby facilitating reduction of the number of production devices, reducing investment, reducing costs, and increasing efficiency, and facilitating large-scale commercial production.

This invention discloses a fungicide composition containing chlorfluazuron, a fungicide formulation containing the fungicide composition, and its uses. The fungicide composition includes chlorfluazuron and a compound fungicide component, wherein the compound fungicide component is selected from any one of fluopyram, cyazofamid, and prochloraz. The uses refer to the application of the fungicide composition in the preparation of agents for the control of crop diseases. The fungicide composition of this invention consists of active ingredients with different mechanisms of action, and when mixed, it exhibits a significant synergistic effect, improving the control efficacy. It also helps to overcome and delay the development of drug resistance in diseases, and can be used to develop novel and highly effective agents for the control of wheat scab and corn ear rot.

This invention belongs to the field of pesticide fungicides and discloses a fungicidal composition. The active ingredients of the fungicidal composition include active ingredient A, active ingredient B, and active ingredient C. Active ingredient A is fluopyram, active ingredient B is prothioconazole, and active ingredient C is chlorothalonil. The mass ratio of active ingredient A, active ingredient B, and active ingredient C is (1-20):(1-20):(10-100). The fungicidal composition of this invention can be used to control plant diseases caused by Basidiomycetes or Mitotic spore-forming fungi, and has good control effects. It features a broad fungicidal spectrum, low dosage, and significant synergistic effect.

The present application belongs to the technical field of agricultural compositions, and relates to an agricultural composition for preventing and treating populus euphratica wood lice. The present application provides an agricultural composition for preventing and treating populus euphratica wood lice, wherein the effective components are composed of fluopyram and echinacoside, and the mass ratio of fluopyram to echinacoside is 1:1-37.5. It is found through insecticidal effect verification that echinacoside has a synergistic effect on the chemical insecticidal component fluopyram, and the combination of the two can effectively reduce the effective component dosage of chemical pesticides, fully exert the efficacy of fluopyram, as much as possible reduce the probability of populus euphratica wood lice developing drug resistance, reduce environmental pollution, and improve the effect of fluopyram.

The application discloses a pesticide composition containing fluopyram and application of the pesticide composition in prevention and treatment of apple alternaria leaf spot, and belongs to the technical field of pesticides. A volatile oil extract of Alpinia galanga and a volatile oil extract of Eupatorium fortunei are obtained, and in indoor tests, the colony diameters of apple Alternaria alternata are all reduced, which indicates that the volatile oil extract of Alpinia galanga and the volatile oil extract of Eupatorium fortunei can inhibit the mycelium growth of apple Alternaria alternata. The volatile oil extract is used as a synergistic extract, combined with fluopyram, and added with various additives to prepare the pesticide composition containing fluopyram. In field tests, the disease index of fruit trees is all reduced, which indicates that apple Alternaria alternata is inhibited, and the relative prevention and treatment efficiency of the compound group is the highest and reaches 80.05%. The pesticide composition containing fluopyram is prepared by compounding fluopyram and the synergistic extract containing the volatile oil extract of Alpinia galanga and the volatile oil extract of Eupatorium fortunei, the pesticide composition can better inhibit apple Alternaria alternata, and is suitable for development of a pesticide for preventing and treating apple alternaria leaf spot.

The present application relates to the technical field of compound pesticide, in particular to a kind of composite insecticide based on fluopyram and a preparation method thereof, the present application is obtained by the combination of fluopyram composition, insecticidal active substance, insecticide adjuvant and dispersant, emulsifier and defoaming agent, a kind of composite insecticide with good stability, high utilization rate, good insecticidal effect;In the present application, polylactic acid with high thermal stability and biodegradability and cellulose nanocrystal with emulsifying capacity are used to load fluopyram, obtaining fluopyram microspheres with high photothermal stability, high utilization rate and slow-release performance, and the fluopyram microspheres are mixed with fluopyram, so that the fluopyram composition can rapidly kill insects and continuously exert insecticidal effect;Insecticide adjuvant prevents and controls nematode from multiple dimensions, and has wide application prospect.

The invention relates to the technical field of compound pesticides, in particular to a fluopyram-based compound pesticide and a preparation method thereof.A fluopyram composition, an insecticidal active matter, an insecticidal auxiliary agent, a dispersing agent, an emulsifying agent and a defoaming agent are compounded, and the compound pesticide which is good in stability, high in utilization rate and good in insecticidal effect is obtained; polylactic acid with high thermal stability and biodegradability and cellulose nanocrystals with emulsifying capacity are adopted to load fluopyram, the fluopyram microspheres with high photo-thermal stability, high utilization rate and slow release performance are obtained, and the fluopyram microspheres are mixed with fluopyram, so that the sustained release effect is improved. The fluopyram composition is capable of rapidly killing insects and continuously exerting an insecticidal effect at the same time; the insecticidal auxiliary agent can prevent and treat nematodes from multiple dimensions, and has a wide application prospect.

The invention discloses a pesticide preparation containing fluopyram and abamectin as well as a preparation method and application of the pesticide preparation, and belongs to the technical field of pesticide preparations. The active ingredients of the pesticide preparation provided by the invention comprise fluopyram, abamectin, caryophyllene and caryophyllene, the pesticide preparation is prepared by adopting a complex coacervation technology of'acid first and alkali second ', and the pesticide preparation has pH and enzyme dual stimulation response characteristics, and can realize targeted release of infected parts of diseases and insect pests. According to the invention, plant source active substances including caryophyllene and caryophyllene and efficient chemical pesticides including fluopyram and abamectin are scientifically matched, so that synergistic interaction is realized, and the co-toxicity coefficient of the prepared pesticide preparation is greater than 130; the obtained product is good in stability and long in lasting period, the dosage of chemical pesticides can be effectively reduced, and the risk of environmental pollution is reduced.

The invention relates to the technical field of pesticide preparation, and particularly discloses a novel preparation method of a key intermediate 1-(2, 4, 6-trichlorophenyl)-propyl-2-ketone of a bactericide pydiflumetofen. The method comprises the following steps: by taking 3, 5-dichloro-4-fluoronitrobenzene as a starting raw material, sequentially carrying out four-step unit reactions: reacting with ethyl acetoacetate under an alkaline condition to prepare 2-(2, 6-dichloro-4-nitrophenyl)-3-oxobutyric acid ethyl ester, and reacting with ethyl acetoacetate under an alkaline condition to prepare 2-(2, 6-dichloro-4-nitrophenyl)-3-oxobutyric acid ethyl ester; carrying out degreasing under an acidic condition, so as to obtain 1-(2, 6-dichloro-4-nitrophenyl)-propyl-2-ketone; reducing the nitro group to obtain 1-(4-amino-2, 6-dichlorophenyl)-propyl-2-ketone; and performing Sandmeyer reaction to obtain a target product. The preparation method is novel in synthetic route, few in side reaction and high in total yield, the content of a target product is larger than 99%, the preparation method is suitable for industrial production, and a key support is provided for industrialization of pydiflumetofen.

The invention discloses a synthesis method of pesticide fluopyram, which comprises the following steps: under protective gas, mixing 2-trifluoromethyl benzamide, 3-chloro-5-(trifluoromethyl)-2-vinylpyridine and alkali, vacuumizing, filling the protective gas, adding an organic solvent, heating and stirring until the reaction is complete, cooling to room temperature, filtering, washing, and drying to obtain the fluopyram. And performing post-treatment to obtain the pesticide fluopyram. According to the synthesis method of the pesticide fluopyram, the target product is directly and efficiently synthesized through one-step reaction, and the yield is good. Compared with existing synthesis routes, the route is short, the atom utilization rate is high, the requirement for equipment is simple, and a foundation is laid for further pilot scale production.

The application discloses a preparation method of fluopyram, which comprises the following steps: step 1: in the presence of solvent 1 and a base, dimethyl malonate and 2,3-dichloro-5-trifluoromethyl pyridine are added to react, a salt reaction is carried out by adjusting pH, and 2-[3-chloro-5-(trifluoromethyl) pyridyl] dimethyl malonate potassium salt, namely intermediate 1, is obtained; step 2: o-trifluoromethyl benzoyl chloride, an organic base and chloromethylamine are added to react, and intermediate 2 is obtained; step 3: solvent 3, intermediate 1 and intermediate 2 are added to react, and intermediate 3 is obtained; step 4: water, a base, solvent 4 and intermediate 3 are added, pH is adjusted after reaction, and continuous reaction is carried out, and fluopyram is obtained. By adopting the preparation method, the yield of fluopyram is high, the purity is high, the reaction time is short, the reaction condition is mild, and the method is suitable for mass production.

The invention belongs to the field of chemical synthesis. The invention particularly relates to a synthesis method of fluopyram. A synthesis method of fluopyram comprises the following steps: reacting a compound shown in a formula III under the action of a hydrogenation catalyst to generate a compound shown in a formula II, and carrying out aminolysis reaction on the compound shown in the formula II and a compound shown in a formula VIII under the action of a catalyst alkali to generate fluopyram. According to the method disclosed by the invention, the use of a noble metal catalyst such as palladium carbon is avoided, the complicated operation of ammonia charging and discharging when cobalt or nickel is used for hydrogenation reduction of cyano groups is avoided, and the three-waste cost is reduced. The operation procedures are reduced, and economic and environment-friendly benefits are generated.

This invention relates to a method of controlling, limiting or preventing an infestation of a plant by Oomycetes, which comprises applying to propagation material of said plant, a pesticidal combination comprising a phosphorus-based compound as active ingredient A, and an active ingredient B selected from acibenzolar-S-methyl, fludioxonil, fluxapyroxad, inpyrfluxam, mefentrifluconazole, prothioconazole, sedaxane, triticonazole, oxathiapiprolin, fluoxapiprolin, azoxystrobin, difenoconazole, fluopyram, ipconazole, metyltetraprole, silthiofam, dimethomorph, thiophanate-methyl, natamycin, benzovindiflupyr, pydiflumetofen, picarbutrazox, isocycloseram, cyclobutrifluram, broflanilide, thiamethoxam, imidacloprid, clothianidin, cyantraniliprole, chlorantraniliprole, tetraniliprole, fipronil, and any mixture thereof.

The application discloses a soil treatment composition, a preparation method and an application scheme thereof, and discloses a composition comprising methyl isothiocyanate compounds and fluopyram, wherein the methyl isothiocyanate compounds are selected from dithiocarbamates or metam, the weight ratio of the two is 400:1-1400:1, and the weight percentage of active ingredients in the soil treatment composition is 5%-99%. The composition has high activity on a series of nematodes and soil-borne fungal diseases which invade crops, and has significant synergistic performance on Fusarium and Meloidogyne in particular, and meanwhile, the composition can meet the basic prevention and treatment requirements while reducing the amount of application.

This invention provides an amidase mutant and its application in the preparation of ( S The application of )-fluopyrazopyr in aniline belongs to the fields of genetic engineering and enzyme catalysis technology. Compared with the amidase shown in SEQ ID No. 1, the amidase mutant of this invention has a mutation at position 109 (alanine) to valine and / or position 232 (leucine) to arginine. Compared with the wild-type amidase, the amidase mutant of this invention has a higher optimum temperature and thermal stability, and can catalyze the enzymatic reaction of racemic substrate M-1 (Formula I) in an aqueous phase to generate the key chiral intermediate (…). S )-M-2 (Formula II), further reacted with compound M-3 (Formula III), to efficiently prepare ( S The method for preparing 1-fluopyrazoline is characterized by mild reaction conditions, simple operation, and promising prospects for industrial application.

The invention provides the bactericidal composition containing the fluroxafen and the fluopyram, the composition has an obvious synergistic effect, and the inventor confirms that the optimal weight ratio of the fluroxafen to the fluopyram is 2: 3 through experimental verification. The invention provides a seed treatment suspending agent of a bactericidal composition, wherein the active components account for 25% of the total weight of the composition. The bactericidal composition can be used for preventing and treating wheat stem rot, has a remarkable synergistic effect, and can reduce the dosage and slow down the generation of drug resistance of diseases.

Disclosed in the present invention is a process for preparing a key intermediate of fluopyram. The key intermediate is dimethyl [3-chloro-5-(trifluoromethyl)pyridin-2-yl]({[2-(trifluoromethyl)benzoyl]amino}methyl)malonate. The process comprises the following steps: in the presence of a solvent 1, reacting the compound potassium dimethyl 2-[3-chloro-5-(trifluoromethyl)pyridyl]malonate with the compound 1-D in a reaction container, and recovering the solvent 1 by means of distillation, so as to obtain the intermediate compound, wherein the solvent 1 is selected from acetic ester solvents having a boiling point range of 40-110°C at a normal temperature and a normal pressure. The process of the present invention is simple and convenient, the total yield is high, the solvent is easy to recover, and the product purity is high; the intermediate does not require any post-purification treatment, and can be directly used for the synthesis of fluopyram; and the process can be amplified, and is beneficial for cost reduction, efficiency improvement and commercial mass production.

1. Name of the designed product: Pesticide packaging bottle (Doyun Ba Gen Liusheng Yipingsuizuo Fluoropyrimidines). 2. Use of the designed product: Pesticide packaging. 3. Design points of the designed product: Combination of shape, pattern and color. 4. Picture or photo best indicating the design points: Front view. 5. The design claimed contains color.

The invention discloses a preparation method of fluopyram, which comprises the following steps: mixing 2, 3-dichloro-5-trifluoromethylpyridine, a solvent and alkali, dropwise adding cyanoacetate for reaction, adding an N-acetoxymethyl-2-trifluoromethyl benzamide solution for reaction, adding methanol, a sodium hydroxide solution and a hydrogen peroxide solution for catalytic hydrolysis, adding a sodium hydroxide solution and a hydrogen peroxide solution for reaction, and performing reduced pressure distillation to obtain the fluopyram. And performing hydrochloric acid acidification and decarboxylation on the catalytic hydrolysis product to obtain the fluopyram. According to the preparation method of the fluopyram, the 2, 3-dichloro-5-trifluoromethylpyridine, the cyanoacetate and the N-acetoxymethyl-2-trifluoromethyl benzamide are taken as raw materials, and under the action of the hydrogen peroxide, not only can the preparation efficiency be improved, but also the fluopyram with high yield and high purity can be prepared; the method has the advantages of simple process, low cost, high preparation efficiency, high product yield, high purity, environmental protection and the like, can improve the product competitiveness, and is convenient for realizing industrial application.