Belonging to the technical field of
organic synthesis, the invention relates to an efficient synthesis method of trifluoromethoxycarb, which comprises the following synthesis steps: taking a 3-methyl-2-
butanone compound as a
raw material for bromination to obtain 1-bromo-3-methylbutane-2-
ketone; the method comprises the following steps: carrying out
reductive amination on 1-
bromine-3-methyl
butane-2-
ketone under the
catalysis of
transaminase to obtain (s)-1-
bromine-3-methyl
butane-2-amine; the (S)-1-
bromine-3-methyl
butane-2-amine is subjected to condensation with trifluoroethyl
chloroformate, and 2, 2, 2-trifluoroethyl (s)-(1-bromine-3-methyl butane-2-yl)
carbamate is obtained through condensation of the (S)-1-bromine-3-methyl butane-2-amine and trifluoroethyl
chloroformate; the preparation method comprises the following steps: carrying out
substitution reaction on 2, 2, 2, 2-trifluoroethyl (s)-(1-bromo-3-methylbutane-2-yl)
carbamate and 4-methyl benzyl to obtain the trifluoromethoxycarb. The synthesis process is simple, efficient, green and safe.