The invention discloses a double-component silicone structural sealant for heat mirror hollow glass and a preparation method of the sealant. The sealant comprises a component A and a component B, wherein the component A comprises hydroxyl-terminated polydimethylsiloxane, alkyl-terminated polydimethylsiloxane, hollow microsphere, ceramic microbead, metal hydroxide, metal oxide, activated calcium carbonate, inorganic pigment and a surfactant; the component B comprises alkyl-terminated polydimethylsiloxane, a coupling agent, a cross-linking agent, a catalyst, an inhibitor, a thickening agent, and silicon dioxide. The preparation method of the sealant comprises the following steps: 1) taking each ingredient in the component A to be mixed uniformly under the vacuum condition; 2) taking each ingredient in the component B to be mixed uniformly under the vacuum condition; 3) mixing the component A and the component B at room temperature according to the weight ratio of (8:1) to (20:1), and at last obtaining the sealant. The double-component silicone structural sealant is good in adhesiveness, high in curing speed, good in sealing performance, high in hardness and modulus, and excellent in thermal barrier effect, and suitable for sealing and bonding of heat mirror film, glass and metal materials etc.