148 results about "Cyclohexylamines" patented technology

The invention discloses a method for joint production of cyclohexylamine and dicyclohexylamine, which comprises the following steps: 1) feeding aniline tail gas of a nitrobenzene catalytic hydrogenation production device into a gas-liquid separator for gas-liquid separation to obtain aniline tail hydrogen and aniline condensate; 2) mixing aniline tail hydrogen and new hydrogen as a raw material A, and mixing defective aniline and fresh aniline in proportion as a raw material B; (3) feeding the vaporized raw material B and the vaporized raw material A into a fixed bed reactor according to a certain hydrogen-oil ratio, and carrying out hydrogenation reaction; a hydrogenation reaction product is subjected to heat exchange condensation and then enters a gas-liquid separator for gas-liquid separation, a gas phase serves as recycle hydrogen to be mixed with the raw material A, and a liquid phase is fed into a distillation device; and 4) carrying out primary distillation and rectification purification in sequence to obtain cyclohexylamine and dicyclohexylamine. According to the method, aniline tail gas resources and defective aniline are fully utilized, the three-waste treatment cost is reduced, product benefits can be improved, pollution to the environment can be reduced, and economic benefits and social benefits are remarkable.

The invention discloses a method for preparing cyclohexylamine based on reductive amination of cyclohexanone, and belongs to the technical field of fine chemical engineering. The preparation method comprises the following steps: adding a reactant cyclohexanone into a reaction kettle containing a certain amount of solvent, ammonia water and hydrogen atmosphere, and carrying out reductive amination reaction in the presence of a catalyst to obtain cyclohexylamine. The catalyst is CoyAl-LDHs loaded with metal active components, the CoyAl-LDHs are layered cobalt-aluminum bimetal hydroxides, and cobalt ions and precious metal ions in laminates are subjected to spontaneous oxidation-reduction reaction, so that the precious metal ions can be efficiently reduced into active metal nanoparticles. The layered cobalt-aluminum double-metal hydroxide not only has abundant surface acid-base sites, but also has high dispersity of loaded metal nanoparticles. The catalyst preparation and reductive amination reaction conditions are mild, the yield is high, the reaction system is simple and easy to separate, and the method is suitable for industrial production of cyclohexylamine.

The invention provides a preparation method of cyclohexylamine and dicyclohexylamine and a control method of dicyclohexylamine yield in cyclohexylamine and dicyclohexylamine co-production reaction, the method comprises the following steps: aniline and hydrogen are subjected to hydrogenation reaction in the presence of a catalyst to prepare cyclohexylamine and dicyclohexylamine, the raw materials also contain water, the water content is 0.1 wt%-3.0 wt% of the mass of aniline, and the water content is 0.1 wt%-3.0 wt% of the mass of hydrogen. The yield of cyclohexylamine and dicyclohexylamine is adjusted by adjusting the water content, and the flexibility and market competitiveness of a production device are improved.

There is provided a process for preparing 5,7-dimethyl-N-((1R,4R)-4- (pentyloxy)cyclohexyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, said process comprising at least a step of amide coupling a 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid with trans-4-(pentyloxy)cyclohexanamine using carbonyldiimidazole (CDI).

A method for extracting and analyzing triazole fungicides using a switchable polarity deep eutectic solvent relates to the field of drinking water and food detection, and includes the following operation steps: a. adding a hydrophobic deep eutectic solvent to a sample solution to obtain a mixed solution A; the deep eutectic solvent is prepared from a hydrogen bond acceptor and a hydrogen bond donor; the hydrogen bond acceptor is one of dipropylamine, triethylamine, N,N-dimethylcyclohexylamine, and N,N-dimethylbenzylamine; the hydrogen bond donor is hexafluoroisopropanol; the molar ratio of the hydrogen bond acceptor to the hydrogen bond donor is (2 to 1):(1 to 5); the volume ratio of the deep eutectic solvent to the sample solution is (0.04 to 0.08):1. This method also avoids the large-scale use of traditional organic solvents, follows the standards of contemporary green analytical chemistry, is sensitive, simple, and environmentally friendly, and is suitable for the detection and analysis of triazole insecticides in drinking water and beverages.

The invention discloses a small molecular proteasome agonist as well as a preparation method and application thereof. According to the invention, cyclohexylamine is used as an initial raw material, and 3-(1-(benzo [D] thiazole-2-carbonyl)-2-(furan-2-methylene) hydrazone group)-N-cyclohexylpropanamide and N-cyclohexyl-3-(2-(furan-2-methylene)-1-(quinoline-2-carbonyl) hydrazone group) propanamide are prepared through a five-step reaction. The two compounds provided by the invention have good 20S proteasome agonistic activity and ischemic injury myocardial cell protection activity, do not have obvious cytotoxicity, and are expected to become effective choices for ischemic cardiomyopathy and other proteotoxic diseases.

The invention discloses a method for preparing a perovskite solar cell based on a fused salt doped Spiro-OMeTAD hole transport layer, and the method comprises the steps: dissolving lead iodide and formamidine iodide in a mixed solvent of N, N-dimethylformamide and dimethyl sulfoxide according to a molar ratio of (0.8-1.5): 1 to prepare an FAPbI3 perovskite precursor solution; the method comprises the following steps: mixing cyclohexylamine trifluoroacetic acid and 4-tert-butylpyridine according to a molar ratio of 1: (8-14), dissolving the mixture in a 70-110 mg / mL Spiro-OMeTAD chlorobenzene solution, adding an acetonitrile solution of LiTFSi, and stirring at normal temperature to obtain a hole transport material Spiro-OMeTAD solution; spin-coating the FTO substrate with an electron transport layer material, spin-coating the electron transport layer with the FAPbI3 perovskite precursor solution, and annealing to form a perovskite thin film; the method comprises the following steps: spin-coating an ammonium butyrate iodide solution on a perovskite thin film to obtain an interface modification layer, spin-coating a hole transport material Spiro-OMeTAD solution on the interface modification layer to obtain a cyclohexylamine trifluoroacetic acid doped Spiro-OMeTAD hole transport layer, and evaporating an interface modification layer and a metal electrode on the Spiro-OMeTAD hole transport layer.

The invention relates to a preparation method of an MWW molecular sieve, the MWW molecular sieve and application of the MWW molecular sieve. Comprising the following steps: crystallizing a mixture containing a silicon source, an aluminum source, inorganic alkali or inorganic acid, a crystallization auxiliary agent, water and a structure-directing agent to obtain the MCM-56 molecular sieve, the original molar composition of the mixture is as follows: SiO2 / Al2O3 is equal to 10 to 300, OH <-> / SiO2 is equal to 0.01 to 1, M < + > / SiO2 is equal to 0.01 to 1, R / SiO2 is equal to 0.005 to 1.0, H2O / SiO2 is equal to 2 to 30, and D2O3 / SiO2 is equal to 0.01 to 3; wherein M is an alkali metal element, R is a structure-directing agent, D2O3 is a crystallization auxiliary agent, and D is a boron element or a gallium element; the structure directing agent is cyclohexylamine. Cyclohexylamine which is low in toxicity, low in price and easy to obtain serves as a template agent, and the MCM-56 molecular sieve is synthesized in one step through a hydrothermal crystallization method. The synthesis route is simple and feasible, the operation is controllable, and the production cost can be effectively reduced by using the cheap structure-directing agent.

The invention belongs to the technical field of preparation of 3-cyclohexylamino propanesulfonic acid, and particularly relates to a preparation method of 3-cyclohexylamino propanesulfonic acid. The preparation method of the 3-cyclohexylamino propanesulfonic acid comprises the following steps: (1) preparing a sodium hydroxypropanesulfonate aqueous solution; (2) dissolving cyclohexylamine in an organic solvent, adding a phase transfer catalyst, then stirring and heating until reflux, and then dropwise adding a sodium hydroxypropanesulfonate aqueous solution for reaction; (3) acidification reaction; and (4) preparing the 3-cyclohexylamino propanesulfonic acid. According to the preparation method of the 3-cyclohexylaminopropanesulfonic acid, the adopted phase transfer catalyst can be combined with the hydroxy propanesulfonic acid sodium salt in the aqueous solution, transferred into the organic phase and reacted with cyclohexylamine in the organic phase to generate the 3-cyclohexylaminopropanesulfonic acid, and then the solvent is evaporated out instead of layering, so that the 3-cyclohexylaminopropanesulfonic acid is obtained. And the condition that the 3-cyclohexylamino propanesulfonic acid is taken out when the organic solvent is delaminated and removed is effectively avoided.

To provide arylcyclohexylamine compounds and their use in the treatment of psychiatric disorders.SOLUTION: There are provided arylcyclohexylamine compounds and compositions of a single enantiomer or enantiomerically enriched mixtures of arylcyclohexylamine having significantly higher oral bioavailability, higher antidepressant potency, and / or greater therapeutic index between antidepressant effects and side effects, compared to ketamine.SELECTED DRAWING: None

The present application relates to a kind of catalyst and its preparation method, the refining method of aniline, wherein the catalyst includes core and shell, the core includes acidic microporous-mesoporous composite molecular sieve and metal oxide loaded on the molecular sieve, the shell includes hydrophobic porous carrier layer and metal element loaded on the porous carrier layer.The catalyst of the present application can promote the conversion of cyclohexylamine and phenol in aniline into macromolecule, high-boiling substance, which can be quickly removed by simple rectification subsequently, finally realizing the synchronous efficient removal of phenol and cyclohexylamine, significantly improving the quality of aniline, while reducing the energy consumption of refining system and aniline loss, and no new impurities are introduced throughout.

The present invention provides a catalyst, a preparation method thereof, and an application thereof in the liquid-phase alkylation of benzene and cyclohexene to synthesize cyclohexylbenzene. The catalyst uses MWW molecular sieve synthesized from inexpensive and low-toxic cyclohexylamine as the active component and silica as the binder. The prepared catalyst exhibits excellent catalytic performance in the liquid-phase alkylation reaction of benzene and cyclohexene.

The present application discloses a molecular sieve, a preparation method thereof, and an application thereof in the liquid-phase alkylation reaction of benzene and cyclohexene. It at least includes the following steps: mixing raw materials containing a silicon source and an aluminum source with cyclohexylamine and water, crystallizing and calcining to obtain the molecular sieve. The MWW molecular sieve is synthesized by using cheap and low-toxic cyclohexylamine instead of highly toxic hexamethylenimine, making the synthesis process more green. The MWW molecular sieve synthesized by cyclohexylamine exhibits more excellent catalytic performance. The template agent can be removed during low-temperature calcination.

The invention relates to the technical field of chemistry and chemical engineering, in particular to a treatment method of rubber vulcanization accelerator CBS mother liquor. The treatment method of the rubber vulcanization accelerator CBS mother liquor comprises the following steps: S1, filtering the mother liquor to obtain first filtrate; s2, performing primary phase separation on the first filtrate to obtain a primary water phase and a primary oil phase; s3, mixing the primary oil phase and a sulfuric acid solution, and performing secondary phase separation to obtain a secondary water phase and a secondary oil phase; s4, rectifying the primary water phase, the secondary water phase and alkali to obtain kettle liquid and a cyclohexylamine solution; s5, sequentially performing Fenton oxidation, adsorption and filtration on the kettle liquid to obtain second filtrate; and S6, sequentially carrying out triple-effect evaporation and biochemical treatment on the second filtrate. According to the treatment method, the recovery rate of cyclohexylamine in the CBS mother liquor is increased, and the COD is greatly reduced.

The invention relates to the technical field of boiler water treatment, and particularly provides an energy-saving synergist for boiler water treatment, which is prepared from the following components in percentage by mass: 10 to 17 percent of HEDP, 6 to 13 percent of PESA, 8 to 15 percent of cyclohexylamine, 0.5 to 1.1 percent of carbon fiber yarn, 0.7 to 1.5 percent of 3, 3 '-diphenyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5 The cleaning agent is prepared from the following components in percentage by mass: 2-4% of 2, 4-dihydroxyphenethyl alcohol, 0.8-2.2% of sodium lignin sulfonate, 13-22% of camellia seed extract and the balance of pure water. According to the energy-saving synergist for boiler water treatment, the heat efficiency of a boiler is improved by inhibiting scales and improving the heat exchange efficiency in the boiler.

The invention discloses an aniline and cyclohexylamine co-production device which comprises an aniline tail gas treatment unit, a hydrogenation reaction unit and a product refining unit, the aniline tail gas treatment unit is used for removing liquid organic matters and catalyst particles in aniline tail gas and separating hydrogen and aniline, and the hydrogenation reaction unit is used for carrying out hydrogenation reaction on aniline and defective aniline in the aniline tail gas to obtain a cyclohexylamine and dicyclohexylamine mixture; and evaporating the mixture through a product refining unit to remove low-boiling-point substances such as cyclohexane, cyclohexanol, water and the like, so as to obtain the products cyclohexylamine and dicyclohexylamine. According to the method, aniline tail gas resources and defective aniline are fully utilized, the three-waste treatment cost is reduced, product benefits can be improved, pollution to the environment can be reduced, and economic benefits and social benefits are remarkable.

The utility model discloses a system for co-producing cyclohexylamine and dicyclohexylamine from epsilon-caprolactone, and relates to the technical field of preparation of cyclohexylamine and dicyclohexylamine. The device comprises a first preparation system and a second preparation system, and the first preparation system is used for preparing epsilon-caprolactone through dehydrogenation of 1, 6-hexanediol; the second preparation system is used for preparing cyclohexylamine and dicyclohexylamine; the second preparation system comprises an aniline mixing tank, a hydrogen mixing tank and a first gasification furnace, the first gasification furnace is sequentially connected with a first flash tank, a hydrogenation reactor, a second flash tank, a tar separation tower, a cyclohexylamine product tower and a raw material recovery tower, and the hydrogen mixing tank is connected with the first preparation system; and hydrogen generated in the dehydrogenation section through the first preparation system enters the hydrogen mixing tank. According to the device disclosed by the utility model, hydrogen generated by preparing epsilon-caprolactone through dehydrogenation of 1, 6-hexanediol is utilized and applied to the second preparation system, so that efficient utilization of energy is realized.

To provide a scaled-up synthesis of lomustine under continuous flow conditions.SOLUTION: The present disclosure provides processes and apparatuses for the scaled-up manufacture of lomustine via continuous flow manufacture. Such continuous flow processes may optionally include the crystallization of lomustine and the apparatuses may optionally include crystallization apparatuses / reactors in either batch or continuous flow design. In one aspect of the disclosure, there is provided a process for making lomustine comprising: treating solutions of 2-chloroethylisocyanate with a solution of cyclohexylamine with continuous-flow pumps in a gram-flow reactor to form a combined solution; adding deionized water with a continuous flow-pump to the combined solution to form a liquid-organic phase solution; extracting the organic phase from the solution; and treating with a solution of t-butyl nitrite with a continuous flow pump in a gram flow reactor to form lomustine.SELECTED DRAWING: None

The invention discloses a tissue slice in-situ hybridization pretreatment liquid and a use method, the tissue slice in-situ hybridization pretreatment liquid is characterized in that the tissue slice in-situ hybridization pretreatment liquid is composed of a compound component A solution and a surfactant component B solution, the compound component A solution and the surfactant component B solution have a proper octanol / water partition coefficient and can effectively remove endogenous fluorescent substances, and a solvent is a hydrophilic solvent; wherein the component A is one or a combination of more of bis (hexamethylene) triamine, dodecyl pyridine chloride, cyclohexylamine, isophorone diamine, N-benzylamino ethanol, N, N, N, N-tetramethyl-1, 6-hexamethylenediamine and 1, 3-bis (aminomethyl) cyclohexane; and the component B is one or a combination of more of triton X-100, tween-20, lauryl sodium sulfate and sodium dodecyl benzene sulfonate. The method is used when the FFPE slice is subjected to fluorescence in-situ hybridization or immunofluorescence experiments, autofluorescence can be reduced in a rapid removal mode, the pretreatment effect is remarkably improved, and the hybridization efficiency of samples difficult to hybridize is improved.

The present invention relates to the technical field of pharmaceutical synthesis and development of drugs, and to a process for preparing cyclic 2-amino-1-one derivatives and to the reaction products and intermediates obtainable by this process. The present invention further relates to pharmaceutical compositions, in particular drugs or medicaments, comprising the cyclic 2-amino-1-one derivatives and to their use as medicaments, in particular in the prophylactic or therapeutic treatment of diseases of the human or animal body, preferably of neurodegenerative diseases or psychiatric disorders.

The present invention discloses a scratch-resistant mirror KPU treatment agent and a preparation method thereof, belonging to the technical field of KPU treatment agent preparation, comprising the following steps: calcining and activating white corundum to obtain activated powder; preparing an inorganic-organic modifier: a white corundum / β-cyclodextrin / tetrahydrocurcumin modifier; stirring and reacting a polyether polyol PTMG, a tung oil-based glycol, and an isophorone diisocyanate, then adding the white corundum / β-cyclodextrin / tetrahydrocurcumin modifier and stirring and reacting, and finally adding 4,4'-methylenebiscyclohexylamine for a chain extension reaction to obtain the scratch-resistant mirror KPU treatment agent. The present invention achieves a low viscosity at an initial 0-0.5h, rapidly increases viscosity at 0.5h-2h, and substantially exerts high viscosity characteristics within 2h, thereby improving production efficiency; at the same time, the product can ensure good scratch resistance under normal temperature and low temperature environments.

This invention discloses amine-based polyether polyols and their preparation methods, belonging to the field of chemical synthesis technology. The technical solution includes the following steps: S1, adding a cyclohexylamine compound to a reaction vessel, purging with nitrogen, evacuating, stirring, and heating to the reaction temperature, introducing epoxides into the reaction vessel, and carrying out a polymerization reaction. After the reaction, an intermediate product is obtained; S2, adding an alkanolamine compound and an alkali metal catalyst or an amine catalyst to the intermediate product obtained in step S1, evacuating, adding epoxides, and carrying out a polymerization reaction. After the reaction, the obtained product is post-treated to obtain the amine-based polyether polyol. This invention uses cyclohexylamine compounds as the main initiator, and alkanolamine initiators can be added. Under catalytic conditions, it undergoes a segmented polymerization reaction with epoxides. The prepared special amine-based polyether polyol has the characteristics of high functionality, strong resistance to yellowing, high activity, and good thermal insulation.

The invention relates to the technical field of tin alloy solder, and discloses a preformed soldering lug with high welding strength, which comprises a soldering flux layer and a soldering lug main body, the soldering flux layer comprises esterified rosin, methyl ester, succinic acid, glutaric acid, cyclohexylamine hydrochloride and isopropanol; the soldering lug main body comprises tin, antimony, silver, bismuth, copper and nickel; by adding silver, bismuth, copper, nickel and metal elements in the alloy into the soldering lug, the mechanical strength of the solder alloy can be improved, compared with common tin-copper alloy, the mechanical strength of the soldering lug is greatly improved, the soldering flux is high in activity but low in corrosivity, stable high-mechanical-strength intermediate layer alloy is formed, and the soldering flux can be applied to the field of soldering. The welding strength and the tensile strength are more excellent, the soldering flux layer and the soldering lug main body have the synergistic effect, so that a welded part has high tensile property after being welded, and the mechanical strength of the solder alloy can be improved by adding silver, bismuth, copper and nickel in the alloy into the soldering lug and metal elements.

The invention discloses an azide modified platinum radiotherapy sensitizer as well as a preparation method and application thereof. The azide modified platinum radiotherapy sensitizer is an azide modified platinum complex, comprises a cis platinum complex and a trans platinum complex, and is characterized in that the structure of the azide modified platinum radiotherapy sensitizer is shown in the specification; in the formula I, R1 is cyclohexylamine or 2-methylpyridine; in the formula II, R2 is ammonia molecules or pyridine. The azide modified platinum radiotherapy sensitizer can generate a platinum-nitrogen-bin free radical under the irradiation of X rays, and by utilizing a nitrogen transfer reaction in organic chemistry, the platinum-nitrogen-bin free radical generated after the compound is irradiated by rays can be covalently coupled with some DNA (Deoxyribose Nucleic Acid) or protein, so that the sensitivity of the radiotherapy sensitizer is improved. The radiotherapy sensitization effect in tumor radiotherapy is achieved by directly damaging DNA and hindering DNA repair.

The invention belongs to the technical field of compositions for treating wells, and particularly relates to a nano paraffin inhibitor. The nano paraffin inhibitor provided by the invention is prepared by the following method: carrying out ultrasonic reaction on fatty alcohol-polyoxyethylene ether (3) monoester disodium sulfosuccinate, dicyclohexylamine and nano aluminum oxide powder in a solvent, carrying out solid-liquid separation, and drying. The nano Al2O3 endows the nano paraffin inhibitor with extremely strong surface activity, can penetrate into paraffin in the early stage of paraffin precipitation formation, and is combined with wax crystals through chemical bonds to cause loose paraffin precipitation, and meanwhile, the nano paraffin inhibitor covers the pipe wall to change the surface property of the pipe wall, so that the surface is hydrophilic, the paraffin on the surface of the pipe wall is promoted to fall off, and the paraffin on the surface of the pipe wall is prevented from falling off. The paraffin inhibition performance is further enhanced; in addition, the S = O bond and the wax crystal can inhibit the growth of the wax crystal through the bonding effect, and the S = O bond and the steric effect of the six-membered ring have a synergistic effect, so that the molecular structure of the nano paraffin inhibitor has better scale inhibition performance.

The invention discloses a novel chiral succinate dehydrogenase inhibitor and application thereof, and belongs to the field of pesticide chemistry. The compound shown in the formula (I) is obtained by modifying a fluxapyroxad structure, and an aniline group of fluxapyroxad is mainly replaced by a cyclohexylamine group with a chiral structure. The antibacterial activity of the compound is improved, and the compound can play a better role in preventing and controlling fungal diseases of plants, so that the yield and quality of crops are improved, the application amount of pesticides is reduced, environmental pollution and ecological damage are reduced, and the problems of pesticide resistance and the like are solved. # imgabs0 # is represented by formula (I).

The invention relates to the field of prepregs, in particular to a low-viscosity benzoxazine resin monomer, a preparation method of the low-viscosity benzoxazine resin monomer, a prepreg composition, a preparation method of the prepreg composition, a prepreg and a composite material. The compound amine compound comprises an amine compound and 4, 4 '-diaminodiphenyl methane, the molar ratio of amino groups of the amine compound to amino groups of the 4, 4'-diaminodiphenyl methane is (0.05-0.50): (0.95-0.50), and the amine compound comprises at least one of m-phenylenediamine, hexamethylenediamine, cyclohexanediamine, aniline, benzylamine, ethanolamine, aminophenol and cyclohexylamine. The low-viscosity benzoxazine resin with coexisting multi-molecular structures can be obtained, the prepared resin composition has the characteristics of low curing temperature, good film-forming property and high latency, the prepreg has accurate glue content control, and the composite material has the characteristics of strong mechanical property, good flame retardance, low product porosity and the like, and meets the aviation application requirements.

This invention provides a method for synthesizing N-cyclohexyl-2-benzothiazole, comprising the following steps: reacting cyclohexylamine and 2-halobenzothiazole in an alcohol solvent in the presence of a deacidifying agent at 60-80°C to generate N-cyclohexyl-2-benzothiazole. The method of this invention is simple to operate, uses readily available raw materials, does not use halogen-containing catalysts, has low pollution, and produces products with high purity and yield. It also avoids the use of DMSO as a solvent, thus solving the problem of difficult DMSO recovery and purification.

The application discloses a preparation method of an anode material for treating organic wastewater, and comprises the following steps: (1) dissolving silver nitrate, ammonia water, sodium hydroxide and formaldehyde in deionized water to obtain a precursor solution, then fixing a commercial electrode in the precursor solution, and performing heating and stirring treatment to obtain an Ag / commercial electrode sheet; (2) preparing a plating solution by using nickel salt, ethylenediamine, potassium borohydride and sodium hydroxide, then fixing the Ag / commercial electrode sheet obtained in the step (1) in the plating solution, and performing heating and stirring treatment, and then performing washing and drying to obtain the anode material. When the electrode material is used for electrocatalytic oxidation treatment of 3-aminomethyl-3, 5, 5-trimethylcyclohexylamine wastewater, the ammonia oxidation rate is higher, and the COD and NH4-N values of the organic wastewater can be effectively reduced. The application further discloses the anode material obtained by the preparation method and application thereof.