355 results about "Cyclohexylamines" patented technology

The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

The invention provides a method for preparing bromhexine hydrochloride, which comprises the steps as follows: (1) 2-amino-3,5-dibromo benzaldehyde and reducing agents are in a reduction reaction to generate 2-amino-3,5-dibromo benzyl alcohol; (2) 2-amino-3, 5-dibromo benzyl alcohol that is obtained in the step (1) reacts with chlorinating agents to generate 2, 4-bromine-6-chloride methylaniline; and (3) 2,4-bromine-6-chloride methylaniline obtained in the step (2) and N-methylcyclohexylamine are in an amination reaction, and then 2, 4-bromine-6-chloride methylaniline and HCl salification agents are in a salification reaction, so that bromhexine hydrochloride is obtained. The preparation method adopts multiple advanced technologies, is easy to get starting materials, and has the advantages of stable property of intermediates, extremely low environment pollution, high yield coefficient of products and high purity.

The invention discloses a method for synthesizing enantiomorphous pure symmetric trans-dialkyl cyclohexylamine, belonging to the field of chemistry. The method comprises the following steps of: carrying out an airtight or reflux reaction on cyclohexene oxide and an aqueous solution of alkylamine for reacting at 80-120 DEG C for 1.5-5h to obtain 2-alkyl-amino cyclohexanol, dropwise adding DEAD (Diethyl Azodicarboxylate) or DIAD (Diisopropyl Azodicarboxylate) to triphenylphosphine, 2-alkyl-amino cyclohexanol and a solvent under an ice bath for reacting for 5-20h at room temperature to obtain N-alkyl-7-azabicyclo[4, 1, 0]heptane, adding a catalyst to the N-alkyl-7-azabicyclo[4, 1, 0]heptane and the aqueous solution of alkylamine at 100-120 DEG C to carry out the airtight or reflux reaction to obtain trans-N,N'-dialkyl-1,2 cyclohexanamine, dissolving the trans-N,N'-dialkyl-1,2 cyclohexanamine in an alcoholic solvent, and adding a tartaric acid type resolving agent with the equivalent weight of 0.5 to the alcoholic solvent to resolve so as to obtain the enantiomorphous pure symmetric trans-dialkyl cyclohexylamine.

The present invention relates to use of (thio)-carbamoyl-cyclohexane derivatives, particularly trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment of acute mania. Furthermore, the present invention relates to the treatment of acute mania through the administration of (thio)-carbamoyl cyclohexane derivatives, particularly trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine and pharmaceutically acceptable salts thereof.

The process of preparing cocrystallized molecular sieve of ZSM-35 accounting for 0-100 wt% and MCM-22 adopts the mixture of hexamethylene imine and cyclohexylamine as template agent. Compound of silicon and aluminum, hydroxide of alkali metal, hexamethylene imine, cyclohexylamine and deionized water as materials are crystallized at 90-200 deg.c for some period and reacted completely to synthesize the molecular sieve hydrothermally. The synthesized molecular sieve is catalyst used widely in the catalytic reaction of converting hydrocarbons, such as hydrocarbon isomerization and aromatization, etc.

The invention discloses a preparation method of 3-aminomethyl-3,5,5-trimethyl cyclohexylamine. The method comprises the steps: a) controlling an acid value of a raw material 3-cyano-3,5,5-trimethyl cyclohexanone at 0.02-0.50 mg KOH/g, carrying out a reaction with liquid ammonia, and thus obtaining a partial-imidization reaction liquid; b) adding an alkaline acid value regulator into the partial-imidization reaction liquid obtained in the step a) with the adding amount of 0.02-0.5% of the molar weight of the raw material 3-cyano-3,5,5-trimethyl cyclohexanone, and continuing to carry out an imidization reaction; and c) carrying out hydrogenation on the product obtained in the step b) in the presence of hydrogen, liquid ammonia and a catalyst, to produce 3-aminomethyl-3,5,5-trimethyl cyclohexylamine. The preparation method has the 3-aminomethyl-3,5,5-trimethyl cyclohexylamine yield close to 99%, the air speed is increased, the reaction efficiency is increased, and the cost of the catalyst and equipment are saved.

The invention discloses a tanshinone IIA derivant and application in pharmacy, which is characterized by the following: the derivant constitutional formula is showed in the right chart; when R1 represents -Ar, R2,R3 represents hydrogen or alkyl with one to eight carbon atoms; or R2-N-R3 represents saturated heterocycle with nitrogen, imidazoline and its derivant, glyoxaline and its derivant, diethylenediamine and its derivant, piperidine and its derivant, morpholine and its derivant; when R1 represents -H, R2,R3 represents alkyl with three to eight carbon atoms, cycloalkyl and aromatic nucleus; or R2-N-R3 represents cyclohexylamine, imidazoline and its derivant, glyoxaline and its derivant, piperazine, piperazine and derivant of derivant. The derivant can improve the bioavailability of original chemical compoundm.

The invention discloses a preparation method and application of a Co and Al2O3 compound nanotube array membrane catalyst. The method comprises the following steps of: carrying out constant-pressure anodic oxidation in a urea-containing electrolyte by taking a Co-Al alloy sheet as an anode and high-purity graphite or an other conducting material as a cathode to prepare an alloy sheet with a Co and Al2O3 compound nanotube array membrane grown on a surface; then crushing the obtained alloy sheet into alloy granules, namely catalyst precursors; reducing the catalyst precursors by using H2 to obtain the Co and Al2O3 compound nanotube array membrane catalyst with uniform apertures, smooth tube walls, controllable pipe lengths and consistent pore path directions. The novel catalyst disclosed by the invention is used for preparing 3-aminomethyl-3,5,5-trimethyl cyclohexylamine (IPDA) by carrying out catalytic hydrogenation on 3-cyano-3,5,5-trimethyl cyclohexanone (IPN) and can achieve the maximal transformation rate of IPN by 100% and achieve the maximal selectivity of IPDA more than 98%.

The invention relates to a new process for the preparation of compounds of general formula (I) wherein

• R₁ and R₂ represent independently hydrogen or
  • C_1-6 alkyl with straight or branched chain optionally substituted with aryl group, or
  • C_2-7 alkenyl containing 1-3 double bonds, or
  • monocyclic, bicyclic or tricyclic aryl optionally substituted with one or more C1-6 alkoxy, trifluoro-C_1-6 alkoxy, C_1-6-alkoxycarbonil, C_1-6alkanoyl, aryl, C_1-6 alkylthio, halogen or cyano, or
  • optionally substituted monocyclic, bicyclic or tricyclic C_3-14 cycloalkyl group,
  • R₁ and R₂ together with the adjacent nitrogen form a saturated or unsaturated optionally substituted monocyclic or bicyclic heterocyclic ring which may contain further heteroatoms selected from oxygen, nitrogen, or sulphur atoms

and hydrochloric acid alts and/or hydrates and/or solvates thereof, by dissolving or suspending trans 4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-il]-ethyl}-cyclohexylamine of formula (III) or a salt or a hydrate or a solvate thereof in an inert solvent in the presence a base then adding a carbonic acid derivative of general formula (VI) wherein R is alkyl with C _1-6 straight or branched chain or C_1-2 fully halogenated alkyl, Z is —O—R or —X, wherein R is as described above, X is halogen, and reacting the compound of general formula (IV) obtained wherein R is as described above, in situ or, optionally in isolated state with an amine of general formula (V) wherein R₁ and R₂ are as described above to obtain the compound of general formula (I) and then optionally forming the hydrochloride salts and/or hydrates and/or solvates thereof.

The invention relates to a rust proofing packaging film, in particular to a gas phase rust proofing industrial composite packaging film and a preparation method thereof. The gas phase rust proofing industrial composite packaging film comprises the compositions by weight proportion: 0 to 0.53 of drewamine, 0.12 to 0.42 of cyclohexane, 0.13 to 0.4 of dicyclohexylamine, 0.09 to 0.28 of phenylformic acid, 0.22 to 0.55 of tert-Butyl benzoic acid, 0 to 0.12 of cinnamylate, 29.5 to 45.1 of low density polyethylente, 29.5 to 45.1 of linear low density polyethylene, 0 to 0.02 of oleamide or erucyl amide and 0 to 0.12 of a diffusing impurity EB-FF. The gas phase rust proofing film has good barrier property and high intensity, saves cost, is nonpoisonous and harmless, prevents the pollution, and can be reused. The preparation method is simple and convenient, the process is easy to control and the production cost is low.

The invention discloses an environment-friendly gasoline additive. The environment-friendly gasoline additive is prepared from, by weight, 40-50 parts of dimethyl carbonate, 5-15 parts of isopropanol,5-15 parts of n-butyl alcohol, 5-15 parts of cyclohexylamine, 5-15 parts of methyl tert-butyl ether, 5-15 parts of liquid paraffin, 0.7-1.6 parts of isoamyl alcohol, 0.7-1.6 parts of petroleum ether,0.7-1.6 parts of ethanolamine, 0.01-0.05 part of benzotriazole and 0.01-0.03 part of 2,6-di-tert-butyl-p-cresol. Dimethyl carbonate has a high oxygen content and can be added to methanol gasoline toreduce the content of hydrocarbon, NOx and CO in automobile exhaust gas, in cooperation with auxiliary materials such as isopropanol, n-butyl alcohol and cyclohexylamine, the carbon deposit coking phenomenon of the methanol gasoline can be reduced, and the octane number is increased. The invention further provides a preparation method of the environment-friendly gasoline additive.

The invention discloses a method for preparing 3-aminomethyl-3, 5, 5-trimethyl cyclohexylamine (isophorone diamine, IPDA) by 3-cyano-3, 5, 5-trimethyl cyclohexanone (IPN, isophorone nitrile), which comprises the following steps: a) 3-cyano-3, 5, 5-trimethyl cyclohexanone and oxyammonia are arranged in an organic solvent for reaction under a temperature ranging from 40 DEG C to 80 DEG C, and 3-cyano-3, 5, 5-trimethyl cyclohexanone oxime is generated; b) 3-cyano-3, 5, 5-trimethyl cyclohexanone oxime, hydrogen and liquid ammonia are arranged in an organic solvent for reaction under a temperature ranging from 50 DEG C to 120 DEG C, a total pressure ranging from 5 MPa to 15 MPa and the effect of a hydrogenation catalyst, and 3-aminomethyl-3, 5, 5-trimethyl cyclohexylamine is obtained. The method has the advantages that, the production of a by-product 3-aminomethyl-3, 5, 5-trimethyl cyclohexanol (IPAA) which is hard to be separated from IPDA is avoided; simultaneously, the amount of liquid ammonia is largely decreased.

The invention discloses a hybrid rice pre-harvest sprouting inhibitor, a preparation method thereof and a method for inhibiting hybrid rice pre-harvest sprouting, and the hybrid rice pre-harvest sprouting inhibitor takes water as a solvent and contains abscisic acid with the concentration of 20-60mg/kg, cyclohexylamine with the concentration of 40-160mM and eugenol with the concentration of 10-60mg/kg. The abscisic acid, the cyclohexylamine and the eugenol are combined, so that the sprouting rate of the hybrid rice is effectively reduced, the growth of harvested rice seed buds and roots and the dry weight are remarkably promoted, and the comprehensive quality is improved.

The low corrosion fire retardant heat insulating polyurethane composition material includes two components, component A and component B. The component A consists of polyether polyol, cyclohexane, silicone oil, potassium acetate, dimethylethanolamine, 2, 4, 6-tri(dimethylaminomethyl) phenol, water, monofluoro trichloroethanone, trichloroethyl phosphate and silicate hydrate; and the component B is isocyanate. When the composition material is used, the component A and the component B are mixed to form the foamed heat insulating polyurethane material with low corrosion, high fire retarding performance and simple production process. The foamed heat insulating polyurethane material is used for oil and gas pipeline.

The invention discloses a high-flame retardation polyurethane composite heat insulation plate. The high-flame retardation polyurethane composite heat insulation plate comprises two backing layers and a polyurethane heat insulation layer positioned between the two backing layers, the polyurethane heat insulation layer is made of a high-performance polyurethane foam material, and raw materials of the high-performance polyurethane foam material comprise polyether polyol, polyphenylpolymethylene polyisocyanate, hexamethylene diisocyanate, polyacrylate, liquid styrene butadiene rubber, cyclohexylamine, N,N-dimethylcyclohexylamine, dibutyltin dilaurate, methyl formate, water, hydroxy silicone oil, a fire retardant, expanded perlite, hollow glass micro-beads, pentaerythritol and sorbitol; and raw materials of the fire retardant comprise nanometer aluminum hydroxide, nanometer magnesium hydroxide, melamine phosphate, expandable graphite, hydroxy silicone oil, and a phosphamide fire retardant. The high-flame retardation polyurethane composite heat insulation plate has the advantages of high strength, excellent heat and flame retardation, and long service life.

The invention relates to a method for preparing a trandolapril intermediate in the field of biomedicines, i.e. a method for synthesizing (2S, 3aR, 7aS)-octahydroindole-2-carboxyl benzyl ester. Firstly, cyclohexene and chloramine T are taken as initial raw materials to react so that cyclohexane ethylene imine is obtained; cyclohexane ethylene imine and allylmagnesium bromide are reacted with each other to obtain trans-N-(p-toluene sulphonyl)-2-(2-allyl)-cyclohexylamine which is peroxidized so as to obtain racemic N-protecting octahydroindole-2-carboxylic acid under the action of an oxidizing agent; after a protecting group on nitrogen is removed, racemic octahydroindole-2-carboxyl benzyl ester is obtained through esterification reaction; and the racemic octahydroindole-2-carboxyl benzyl ester is recrystallized and separated to obtain the trandolapril key intermediate (2S, 3aR, 7aS)-octahydroindole-2-carboxyl benzyl ester. According to the method, raw materials are low in cost and easy to obtain, the preparation process is environmental-friendly, the operation and post-treatment are simple, separation and purification are easy and the like.