45 results about "Diethylenediamine" patented technology

The invention provides a method for synthesizing 4,4'-diphenic acid. In the method, high-boiling-point polyethylene glycol 400 is used as a solvent, cuprous iodide (CuI) is used as a catalyst, and 4,4'-diphenic acid is obtained in the condition of presence of diethylenediamine and potassium hydroxide (KOH) by a reduction coupling new method. The synthesis method has the advantages that the method for synthesizing 4,4'-diphenic acid is simple, the synthesizing condition requirements are not high, the operation is easy, the production cost is low, the yield is very high, the purity is also very high and the repeatability is good, so that the method is suitable for the requirements of large-scale industrialized production; the solvent polyethylene glycol 400 used by the reaction system has high steam pressure, does not pollute the environment and is environment-friendly; and the purification method is simple, column separation purification is not needed, and purification can be carried out just by a common recrystallization method.

The invention discloses a water quality detection agent for detecting lead element in water. The raw materials include 60-80 parts of modified adsorbent, 25-45 parts of modified adsorption enhancing filler, and 4-8 parts of polyacrylamide in parts by weight. , 2-6 parts of epichlorohydrin, 3-6 parts of ferrous sulfate, 6-9 parts of disodium edetate, 1-4 parts of ammonia water, 2-3 parts of potassium iodide, 5-8 parts of sodium sulfite, nano-scale 1‑3 parts of ceramic powder, 9‑12 parts of ammonium citrate, 6‑8 parts of dimethylglyoxime, 5‑9 parts of hexadecyldimethylethylammonium bromide, 0.5‑1.5 parts of glyceryl linoleate , 1.5-2.5 parts of dimethylol dimethyl hydantoin, 25-35 parts of ethanol. The water quality detection agent of the present invention can perform adsorption detection on the lead element in water, and can effectively improve the efficiency and detection accuracy of water quality detection.

The invention relates to an improved synthesis method of the intermediate carboxylic acid segment [4-(4-((2-(4-chlorophenyl)-5,5-dimethyl cyclohexyl-1-polyprolene) methyl) diethylenediamine-1-radical) benzoic acid] of an anticancer compound molecule ABT-263. The synthesis method mainly solves the problems of complicated operation, low yield and high synthesis cost of the existing synthesis method. The synthesis of the intermediate carboxylic acid segment of ABT-263 comprises the following steps: step 1, the reaction takes 4,4-dimethyl cyclohexanone as a raw material to react with phosphorus tribromide, dichloromethane and N,N-dimethylformamide mixed solution, so 2-bromine-5,5-dimethyl cyclohexyl-1-yl-formaldehyde 2 is generated; step 2, reduction reaction: a compound 2 undergoes the reduction reaction under the action of sodium borohydride to generate the corresponding alcoholate; step 3, bromination reaction: the alcoholate undergoes the bromination reaction under the action of phosphorus tribromide to generate the corresponding bromide; and step 4, the reaction is that: the bromide and 4-(diethylenediamine-1-radical) benzoic acid t-butyl ester are subjected to the substitution reaction to generate the intermediate 4-(4-((2-bromine-5,5-dimethyl cyclohexyl-1-alkenyl) diethylenediamine-1-radical) benzoic acid t-butyl ester, and after the Suzuki reaction of a step 5 and the hydrolysis reaction of a step 6, the corresponding carboxylic acid intermediate is generated.

The invention provides a sarafloxacin hydrochloride water-soluble granule and a preparation method thereof, which solves the technical problems of the existing sarafloxacin hydrochloride drug with poor therapeutic effect and serious drug residue problem. It is composed of the following raw materials in parts by weight Composition: 15-45 parts of diethylenediamine, 150-220 parts of cyclodextrin-methyl vinyl ether / maleic anhydride copolymer, 100 parts of sarafloxacin hydrochloride, 635-735 parts of anhydrous glucose, appropriate amount of water; The invention also discloses a preparation method of sarafloxacin hydrochloride water-soluble granules: respectively weigh diethylenediamine, cyclodextrin-methyl vinyl ether / maleic anhydride copolymer, add to hot water and mix uniformly to obtain a mixture Weigh sarafloxacin hydrochloride and anhydrous glucose respectively, and mix uniformly to obtain mixture two; throw mixture two into a three-dimensional fluidized bed, and carry out fluidized bed granulation with mixture one as a binder; temperature, etc., to finally obtain sarafloxacin hydrochloride granules; which can be widely used in the technical field of veterinary medicine.