A kind of sarafloxacin hydrochloride water-soluble granule and preparation method thereof

A technology for salafloxacin hydrochloride and water-soluble granules, which is applied in the field of salafloxacin hydrochloride water-soluble granules and their preparation, can solve the problems of ineffective treatment effect, drug residues, prolonged drug withdrawal period, etc. The effect of withdrawal period, strong drug load, good therapeutic effect

Active Publication Date: 2022-04-22
SHANDONG GUOBANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, sarafloxacin hydrochloride has strong permeability into animals and fast absorption and metabolism. Existing products are made into sustained-release preparations, but it is not considered that sarafloxacin hydrochloride is a concentration-dependent drug, and conventional liposomes and coating materials will reduce the concentration of the drug. If the blood concentration of the drug is too high, it will not achieve a good therapeutic effect, and it will also lead to the extension of the withdrawal period of the drug, and the problem of drug residue is serious, and there is still drug residue after 24 hours

Method used

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  • A kind of sarafloxacin hydrochloride water-soluble granule and preparation method thereof
  • A kind of sarafloxacin hydrochloride water-soluble granule and preparation method thereof
  • A kind of sarafloxacin hydrochloride water-soluble granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The present embodiment proposes a kind of method of sarafloxacin hydrochloride water-soluble granule, comprises the steps:

[0024] (1) Weigh 15 g of diethylenediamine and 150 g of cyclodextrin-methyl vinyl ether / maleic anhydride copolymer respectively, add them into hot water at 55°C, stir and mix evenly, and obtain mixture 1;

[0025] (2) Weigh 100 g of sarafloxacin hydrochloride and 735 g of anhydrous glucose respectively, and stir and mix evenly to obtain mixture 2;

[0026] (3) Throw the mixture 2 obtained in the step (2) into a three-dimensional fluidized bed, and use the mixture 1 obtained in the step (1) as a binder for fluidized bed granulation; during this period, control the inlet air temperature, Inlet air volume, atomization pressure, and finally obtain sarafloxacin hydrochloride granules.

Embodiment 2

[0028] The present embodiment proposes a kind of method of sarafloxacin hydrochloride water-soluble granule, comprises the steps:

[0029] (1) Weigh 30g of diethylenediamine and 200g of cyclodextrin-methyl vinyl ether / maleic anhydride copolymer respectively, add them into hot water at 58°C and stir and mix evenly to obtain mixture 1;

[0030] (2) Weigh 100 g of sarafloxacin hydrochloride and 670 g of anhydrous glucose respectively, and stir and mix evenly to obtain mixture 2;

[0031] (3) Throw the mixture 2 obtained in the step (2) into a three-dimensional fluidized bed, and use the mixture 1 obtained in the step (1) as a binder for fluidized bed granulation; during this period, control the inlet air temperature, Inlet air volume, atomization pressure, and finally obtain sarafloxacin hydrochloride granules.

Embodiment 3

[0033] The present embodiment proposes a kind of method of sarafloxacin hydrochloride water-soluble granule, comprises the steps:

[0034] (1) Weigh 45g of diethylenediamine and 220g of cyclodextrin-methyl vinyl ether / maleic anhydride copolymer respectively, add them into hot water at 60°C, stir and mix evenly, and obtain mixture 1;

[0035] (2) Weigh 100 g of sarafloxacin hydrochloride and 635 g of anhydrous glucose respectively, and stir and mix evenly to obtain mixture 2;

[0036] (3) Throw the mixture 2 obtained in the step (2) into a three-dimensional fluidized bed, and use the mixture 1 obtained in the step (1) as a binder for fluidized bed granulation; during this period, control the inlet air temperature, Inlet air volume, atomization pressure, and finally obtain sarafloxacin hydrochloride granules.

[0037] For the above-mentioned Examples 1 to 3, in order to facilitate comparative analysis, the stirring speed in step (1) was 150 r / min, and the stirring time was 30 m...

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Abstract

The invention provides a sarafloxacin hydrochloride water-soluble granule and a preparation method thereof, which solves the technical problems of the existing sarafloxacin hydrochloride drug with poor therapeutic effect and serious drug residue problem. It is composed of the following raw materials in parts by weight Composition: 15-45 parts of diethylenediamine, 150-220 parts of cyclodextrin-methyl vinyl ether / maleic anhydride copolymer, 100 parts of sarafloxacin hydrochloride, 635-735 parts of anhydrous glucose, appropriate amount of water; The invention also discloses a preparation method of sarafloxacin hydrochloride water-soluble granules: respectively weigh diethylenediamine, cyclodextrin-methyl vinyl ether / maleic anhydride copolymer, add to hot water and mix uniformly to obtain a mixture Weigh sarafloxacin hydrochloride and anhydrous glucose respectively, and mix uniformly to obtain mixture two; throw mixture two into a three-dimensional fluidized bed, and carry out fluidized bed granulation with mixture one as a binder; temperature, etc., to finally obtain sarafloxacin hydrochloride granules; which can be widely used in the technical field of veterinary medicine.

Description

technical field [0001] The application relates to the technical field of veterinary medicine, in particular to a water-soluble sarafloxacin hydrochloride granule and a preparation method thereof. Background technique [0002] Sarafloxacin hydrochloride is a third-generation fluoroquinolone antibacterial drug specially used for animals. It has a broad antibacterial spectrum and strong antibacterial activity. It has good antibacterial activity against Gram-negative bacteria, Gram-positive bacteria and mycoplasma. Antibacterial effect, especially Escherichia coli, Salmonella, Klebsiella, Proteus, Pasteurella multocida, Campylobacter and other enterobacteria. Sarafloxacin hydrochloride absorbs quickly, metabolizes quickly, has almost no residue, and has no cross-resistance with many antibacterial drugs. It is mainly used for the treatment of digestive system, respiratory system, urinary tract infection and mycoplasma caused by sensitive bacteria. [0003] Sarafloxacin hydrochlo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/40A61K31/496A61P31/04
CPCA61K9/1652A61K31/496A61P31/04
Inventor 邱正洲曲俊腾杨俊德王文静刘萃萃
Owner SHANDONG GUOBANG PHARMA
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