95 results about "Fluidized bed granulation" patented technology

The invention relates to the technical field of softened water treatment devices, in particular to an induced crystallization granulation fluidized bed softened water treatment device. Comprising a cylinder, a stainless steel cathode layer is arranged on the inner side of the cylinder, the stainless steel cathode layer is electrically connected with a negative electrode of a power supply, an excitation system is mounted on the cylinder, a vertical vibration frame capable of vertically reciprocating is connected to the excitation system, a translation frame is slidably connected to the vertical vibration frame, and a synchronizing system for driving the vertical vibration frame and the translation frame to synchronously displace is arranged on the vertical vibration frame. The synchronous system is in transmission connection with a transmission shaft capable of alternately rotating forwards and backwards, a micro-filtration cylinder is rotationally mounted on the translation frame, an insulating shaft is rotationally mounted in the micro-filtration cylinder, the micro-filtration cylinder and the insulating shaft are driven by the transmission shaft, a plurality of guide rings are mounted on the micro-filtration cylinder, and an anode bar slides on the insulating shaft. According to the device, grain fluidization is strengthened through synchronous multi-dimensional excitation, the problem of local reaction dead angles is solved, the problems that a traditional device is low in crystallization efficiency and uneven in particle size are effectively solved, and the stability of grain settling separation is guaranteed.

The invention relates to the field of functional foods, and discloses a formula and a preparation process of medicinal and edible walnut milk with a sleep improving effect, and the composition comprises a formula A and a formula B which are physically separated from each other. The formula A is used as a substrate, contains walnut powder, a dairy product, pH sensitive food colloid and a pH regulator, and is prepared into porous particles with relatively large particle sizes through a fluidized bed granulation process; the formula B is used as a functional component, contains gamma-aminobutyric acid, theanine and various medicinal and edible plant extracts, and is prepared into fine powder through a low-temperature spray drying process. During brewing, pH change generated after the two formulas are mixed can trigger colloid thickening, and homogeneous and stable suspension liquid is formed; and due to the structural difference between the particles and the micro powder, ordered graded dissolution is realized, and the reconstituability is improved. The product disclosed by the invention has the beneficial effects of stable functional components, good brewing dispersity and high physical stability of brewed liquid.

The present application provides a kind of online quality monitoring method of traditional Chinese medicine in near infrared combined fluidized bed granulation process, the monitoring method will near infrared spectrum (NIRs) technology be combined with partial least squares (PLSr), and the online monitoring model of key quality attribute (CQAs) in granulation process of Buqi Tongluo Granules (BQTL-G) is constructed.Based on the real-time monitoring data of the model, the key process parameter of peristaltic pump speed is dynamically regulated by negative feedback mechanism through PID controller, the bed collapse problem caused by excessive moisture content in the granulation process is accurately intervened, and the granulation process state is stabilized.The online quality monitoring method of the present application solves the quality uniformity problem commonly existing in the production process of traditional Chinese medicine granules.

The invention provides a fluidized bed granulation method of coal-based quantum carbon dot intercalation adsorption type slow-release urea, and relates to the technical field of slow-release fertilizer preparation, and the fluidized bed granulation method comprises the following steps: S1, taking low-rank coal as a raw material, crushing the low-rank coal, mixing the crushed low-rank coal with a deep eutectic solvent DES, and carrying out a stripping reaction under a microwave-assisted condition to prepare coal-based quantum carbon dots CQDs; s2, urea powder is mixed with the coal-based quantum carbon dots CQDs dispersion liquid prepared in the step S1, and a urea-CQDs premix is obtained; according to the method, the coal-based quantum carbon dots are prepared from the low-rank coal, the cost of the low-rank coal raw material is only 1 / 10 of that of traditional activated carbon, the stripping degree of a carbon skeleton can be directionally regulated and controlled through a microwave-assisted deep eutectic solvent stripping method, the specific surface area of CQDs is increased to 1800-2500m / g, the content of surface hydroxyl and amino functional groups reaches 8-18mmol / g, and the adsorption capacity to urea is increased to 150-200mg / g.

The invention relates to the technical field of functional food preparation, in particular to a composition capable of improving colitis and a preparation method thereof, and the composition comprises glutamine, a composite plant extract, a zinc source and soluble dietary fibers. Wherein the compound plant extract comprises hericium erinaceus extract, ginseng extract and astragalus extract; the zinc source is zinc glycinate, zinc gluconate and the like; the soluble dietary fiber is fructo-oligosaccharide, inulin, galactomannan oligosaccharide and the like. The preparation method comprises the following steps: directly carrying out dry mixing or carrying out fluidized bed granulation on glutamine to obtain particles A, mixing the composite plant extract and the dietary fibers with ethanol, carrying out spray drying to obtain particles B, and carrying out three-dimensional mixing on the particles B and the zinc source. The composition can maintain the homeostasis of intestinal epithelial cells, reduce oxidative stress and inflammatory response, promote mucosal repair and effectively improve ulcerative colitis, Crohn's disease and chemoradiotherapy-related intestinal mucositis through multi-target action.

This application discloses a jujube seed and Ganoderma lucidum film-coated tablet and its preparation method. The film-coated tablet uses jujube seed and Ganoderma lucidum in a weight ratio of (2.9–3.1):2 as active raw materials, employs a microcrystalline cellulose and erythritol compound as fillers, and combines them with silica, magnesium stearate, and a specific composite film-coating agent. The preparation method includes raw material pretreatment, water extraction, vacuum concentration, vacuum drying, fluidized bed granulation, total mixing and tableting, and film coating, optimizing each process parameter. This application solves the technical problems of existing traditional Chinese medicine extracts, such as high hygroscopicity, poor compressibility, poor stability, and unclear synergistic effects. The prepared product has high active ingredient content, good stability, rapid disintegration, and good patient compliance, making it suitable for large-scale industrial production and possessing good market application prospects.

The invention belongs to the technical field of preparation processes, and particularly relates to a preparation method of a tendon-relaxing and blood-activating tablet. The invention provides a preparation method of tablets for relaxing muscles and stimulating blood circulation. The method comprises the following steps: a, carrying out superfine grinding on safflower, vinegar-processed rhizoma cyperi, scalded rhizoma cibotii and cortex periplocae into fine powder; b, adding water into calcined natural copper, decocting, adding Chinese starjasmine stem, lycopodium clavatum, herba lycopi, mistletoe and caulis spatholobi, decocting, combining decoction, filtering, standing, concentrating supernate into extract, drying, crushing and sieving to obtain dry extract powder; and c, placing the fine powder and the dry extract powder in a fluidization chamber of a fluidized bed, carrying out top spraying of an adhesive solution, carrying out fluidized bed granulation, drying, and tabletting to obtain the product. The tablet prepared by the method is regular in shape, tidy in edge and free of unfilled corners and tablet cracking phenomena. The tablet is smooth in surface, free of granular sensation and roughness, uniform in color and free of color spots. The tablet has the advantages of moderate hardness, toughness, no loosening phenomenon, compact overall structure, no damage, no stripping, no crack and no scratch, and friability, disintegration time limit and content result all accord with regulations.

A fluidized bed granulation and drying device for traditional Chinese medicine preparations belongs to the field of fluidized bed granulation and drying technology. This invention solves the technical problem of low output quality caused by dead zones and channeling in existing multi-functional granulation devices due to their structural design. An air distribution plate is installed at the bottom of the granulation chamber, and an air ring is installed on the lower part of the top surface of the granulation chamber. The air ring is annular with an arc-shaped longitudinal section. The top side of the air ring's longitudinal section is tangent to the top surface of the granulation chamber, and the bottom side of the air ring's longitudinal section is tangent to the side of the granulation chamber. An air equalization component is laid on the upper side of the air distribution plate. The air equalization component includes an air equalization net and a spiral scraper. The spiral scraper is rotatably installed on the lower bottom surface of the air equalization net along a horizontal circumferential direction. The spiral scraper includes a sleeve and blades, with three blades evenly installed on the outside of the sleeve. A rotating shaft is fixedly installed at the center of the lower bottom surface of the air equalization net, and the sleeve is fitted onto the outside of the rotating shaft. This improves the output quality. This invention is used for the granulation of traditional Chinese medicine.

The utility model relates to the technical field of pharmaceutical equipment, in particular to a double-laying-collection-chamber bag shaking pneumatic claw type locking mechanism of a medicinal fluidized bed granulation drying machine. The device is applied to a boiling bed body, a hanging bracket device is installed on the boiling bed body, the claw type locking device comprises an action air cylinder, an air cylinder fixing plate, a claw tooth body and an elastic piece, the action air cylinder is detachably connected with the hanging bracket device and the air cylinder fixing plate, and the claw tooth body is arranged on the side, away from the air cylinder fixing plate, of the action air cylinder. During work, an air source and a power source are connected firstly, then the hanging bracket device is controlled to act, a left-right cavity cloth bag locking automatic control button on the display screen is operated and clicked, a piston rod in the acting air cylinder can stretch out, and therefore the air cylinder fixing plate is pushed, and the cloth bag locking automatic control button is locked through the elastic force in the elastic piece. And the claw teeth of the claw tooth body are clamped on the hanging bracket device to finish the positioning and locking functions, so that the fluidized bed bag shaking hanging bracket can be quickly locked.

This invention belongs to the field of fluidized bed granulation technology, and specifically discloses a fluidized bed-based carbon nanotube granulation device, including a fluidized tower, a bent pipe connected to the top of the fluidized tower, a buffer cover connected to one end of the bent pipe, a distribution hopper fixed to the bottom of the buffer cover, and a return device inside the distribution hopper. In this invention, fine carbon nanotube particles are filtered and screened through a filter port inside the distribution hopper. The particles attached to one side of the filter port are scraped off by a uniform material device and collected by the return device. When the return device is full of material, the material can be discharged to the bottom of the distribution hopper and re-enter the fluidized tower for refining through a return pipe. When the return device is working, it triggers a feedback device to intermittently apply high-pressure pulses of external high-pressure gas to the filter port to clean it. At the same time, it can push the material inside the return device out to assist in its discharge.

The invention discloses an automatic cooling method for a fluidized drying granulator. The automatic cooling method comprises the following steps: S1, building an intelligent temperature control granulation system; s2, the air inlet humidity is set, and air dehumidification is conducted; s3, setting a granulation temperature, and starting boiling granulation; s4, the drying temperature is set, air heating is conducted, and the materials are dried for t1 min; s5, the air inlet system stops air heating, air dehumidification is kept, and the materials are cooled for t2 minutes; s6, setting a discharging temperature, and performing discharging judgment: when the material temperature is less than or equal to a discharging temperature set value, entering S7; when the material temperature is smaller than or equal to the discharging temperature set value, returning to S5; and S7, shutdown is conducted, and materials are output. The method has the beneficial effects that the temperature of the finished medicine particles is reduced, the finished medicine particles are prevented from absorbing moisture and caking, it is guaranteed that the quality of the finished medicine particles meets the production requirement, the rework rate and the rejection rate of the finished medicine particles are reduced, and the production cost is reduced.

A particulate composition of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-1-methyl-1h-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile comprising: a crystalline form of said compound comprising: a first chiral crystalline form present in an amount of at least 85 wt%, based on the weight of said crystalline form; and a filler. The present invention relates to a pharmaceutical composition comprising a crystalline form of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile comprising at least 95 wt% of a first chiral crystalline form, a process for preparing said composition, the process comprising: providing a crystalline form of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile comprising at least 95 wt% of a first chiral crystalline form; providing a filler; mixing the crystalline form and the filler in a weight ratio of at least 1: 10; subjecting the mixture to a granulation process selected from fluidized bed granulation, high or low shear granulation and dry granulation to obtain a particulate composition; wherein the particulate composition has an amorphous form of not more than 10 wt% of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile, and wherein the particulate composition has an amorphous form of not more than 5 wt% of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile, and wherein the particulate composition has an amorphous form of not more than 5 wt% of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile. The present invention relates to a second chiral form of 4-chloro-6-cyclopropoxy-3-fluorobenzonitrile in the form of 4-(2, 2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile.

The invention discloses application of dimethyl fumarate in preparation of a medicine for treating depression, and relates to the technical field of medicine research and development. Comprising experimental verification and medicine preparation, and the medicine preparation comprises the following steps: raw material preparation: weighing a dimethyl fumarate raw material and a medicinal carrier in proportion; uniformly mixing: fully mixing the dimethyl fumarate and the medicinal carrier by using a three-dimensional mixer or a double-cone mixer; granulating: adding a wetting agent for fluidized bed granulation or wet granulation to form granules with set sizes; granulating and drying: granulating the wet granules, drying, and controlling the water content of the granules; forming is conducted; and packaging: packaging the prepared medicine, and labeling information. The dimethyl fumarate is applied to the field of depression treatment, experiments verify that the dimethyl fumarate has a remarkable improvement effect on depression-like behaviors induced by chronic social contusion stress, and a new direction is provided for development of anti-depression drugs.

A fluidized bed granulator for granulating with urea or a urea-containing liquid is described, wherein the granulating liquid is supplied via a supply manifold comprising a header and a standpipe. The standpipe is arranged at least partially inside the channel for the secondary gas.

The invention discloses an automatic granulation process of a boiling granulation dryer. The automatic granulation process comprises the following steps: S1, building a granulation system; s2, when a fluidized bed is preheated to the feeding temperature, powder is fed into the fluidized bed, and then the powder is heated to the set material temperature; s3, starting automatic segmented granulation; s4, the materials are dried for t5 minutes in a delayed mode; s5, starting material coloring; s6, drying the materials for t7 minutes; and S7, the air inlet temperature is reduced, dry cold air is conveyed into the fluidized bed, the material temperature is reduced, and when the material temperature is smaller than or equal to the discharging temperature value, shutdown is conducted, and the materials are output. According to the invention, the traceability and reducibility of batch products are ensured, and the defects of manual operation are overcome; in the granulating process, the material bed collapse is avoided, and the fullness and uniformity of the medicine component of each granule are ensured.

The utility model belongs to the technical field of fluidized bed granulation, particularly relates to a novel fluidized bed for circulating granulation in industrial sewage treatment, and aims to solve the problems that when the fluidized bed is used, hot air is directly discharged from an output port, so that the working environment is easy to be humid, and the hot air contains some particle impurities, so that a certain influence is caused to workers. According to the scheme, the fluidized bed granulator comprises a bottom plate, the top of the bottom plate is fixedly provided with a fluidized bed granulator body, a control host and a hot air blower which are matched for use, and the other end of an output pipe of the hot air blower is communicated with the inner wall of the fluidized bed granulator body. When the device is used, hot gas generated in the granulation process is recycled and reused through the hot gas recycling assembly, the energy utilization efficiency is improved, particle impurities and harmful gas in the gas are effectively removed through the arrangement of the filtering assembly, potential hazards to the surrounding environment and the health of workers are avoided, and the environment protection requirement is met.

The invention relates to a preparation method of Fuganning tablets. The preparation method comprises the steps of raw material pretreatment, gradient extraction, composite purification, granulation, drying and granule finishing, tabletting and coating. The wall breaking rate of medicinal materials is increased by adopting low-temperature superfine grinding, the yield of effective components is increased by adopting a gradient extraction process combining microwave-ultrasonic synergistic extraction and constant-temperature reflux, impurities are reduced by virtue of acid precipitation-macroporous resin composite purification, and the disintegration performance and stability of the tablet are optimized in cooperation with fluidized bed granulation and functional coating technologies. The method can improve the purity and bioavailability of active ingredients, enhance the stability of the preparation and realize accurate quality control, and is suitable for industrial production of the Fuganning tablets.

This invention relates to a paraquat granule and its preparation method, belonging to the field of pesticide technology. The granule consists of paraquat salt, a layered double hydroxide carrier, a disintegrant, microcrystalline cellulose, an outer coating of an emetic / odorant / tracking agent, and the remainder being water-soluble filler. The granule wear rate is ≤2%, it completely disintegrates within 60 seconds in standard hard water at 25℃, and the suspension rate is ≥90%. Preparation employs a one-step process of screw extrusion-centrifugal granulation-vacuum belt drying or fluidized bed granulation, resulting in high content retention. The product is dust-free and non-caking, suitable for drone-based aerial spraying and long-distance sea transport, facilitating large-scale application in overseas registered areas.

A fluidized bed granulation (FBG) system includes a pre-wetting subsystem, wherein feedstock is pre-wet to a predetermined % value, a fluidization chamber (FC), an inlet coupled to the FC, a plenum coupled to the FC by a distributor plate having slots through which a fluidization gas is passed to the FC at a velocity and a direction, an outlet compartment coupled to the FC by a termination plate having one or more filter bags, a liquid binder system adapted to introduce a liquid binder into the FC, and an outlet configured to eject granulated product, and a plurality of sensors adapted to inform a processor executing instructions maintained on a non-transitory memory, wherein the processor using a mass, energy, and fluidization balance model is adapted to optimize the FBG system to provide the granulated product having an optimized geometric mean and geometric standard deviation between about 2.0 and about 1.0.

The utility model relates to the technical field of urea granulation, in particular to a fluidized bed granulation device for urea granule production, which comprises a fluidized bed body, one side of the fluidized bed body is fixedly connected with a first blanking plate, and one side of the fluidized bed body is provided with a base. A first vibration frame is installed at the top of the base, a first screening net is fixedly connected into the first vibration frame, a second screening net is installed in the vibration frame, a rotary drum granulator is arranged on one side of the base, a support is arranged on one side of the rotary drum granulator, a second vibration frame is slidably connected to the top of the support, and a third screening net is fixedly connected into the second vibration frame. A first driving assembly is installed at the top of the base, a second driving assembly is installed at the top of the support, and the fluidized bed granulation device for urea particle production has the advantages that the product particle size qualification rate is increased, the technological process is stabilized, and efficient screening and grading are achieved.

This invention discloses an amoxicillin capsule and its preparation method, relating to the field of pharmaceutical technology. The preparation method includes the following steps: S1: Wet ball milling of amoxicillin trihydrate and hydroxypropyl methylcellulose E5, followed by spray drying to obtain surface-modified amoxicillin trihydrate micropowder; S2: Mixing the surface-modified amoxicillin trihydrate with a filler; S3: Fluidized bed granulation, including spray granulation using aqueous ethanol as a wetting agent followed by drying; S4: Granulation and mixing, including granulating the dried particles and then adding a disintegrant, a flow aid, and a lubricant; S5: Capsule filling, including capsule filling with controlled ambient humidity. This invention achieves the goals of maintaining the crystal stability of amoxicillin trihydrate, inhibiting hydrothermal degradation, and ensuring dissolution behavior consistent with the original drug by combining wet ball milling of hydroxypropyl methylcellulose E5 with spray drying for surface modification, fluidized bed granulation with aqueous ethanol, and controlling the humidity of the filling environment.

The invention relates to the technical field of casting materials, in particular to ceramic sand for resin sand mold casting and a preparation method of the ceramic sand. The coating is prepared from the following raw materials in parts by weight: 80%-90% of a component A, 9.95%-19.8% of a component B and 0.05%-0.2% of a component C, the component A is composed of bauxite and graphite, the component B is composed of bauxite and graphite according to a mass ratio of (70-90): (10-30), the particle size of the component B is 600 meshes, the component A is the bauxite with the particle size of 600 meshes, and the component C is tungsten carbide particles with the particle size of 300 meshes. The ceramic sand disclosed by the invention is prepared by adopting a multi-stage fluidized bed granulation system for granulation and an activated sintering process, has the characteristics of high refractoriness, low thermal expansion rate, high collapsibility and low sand burning incidence rate, effectively solves the problem of sand removal of a thin-wall complex sand core, and improves the casting quality and the production efficiency.

The application provides a preparation method of astaxanthin cordyceps militaris fine tablets, comprising the following steps: subjecting cordyceps militaris fruiting bodies to supercritical CO2 extraction treatment to separate a cordyceps militaris terpene component; mixing Haematococcus pluvialis powder and edible vegetable oil, adding the cordyceps militaris terpene component and rosemary extract, and cooling and forming to obtain an astaxanthin-cordyceps militaris terpene blend; crushing the residue after extraction, adding purified water and a composite enzyme preparation to perform enzymolysis to obtain an enzymolysis liquid; adding a chitosan quaternary ammonium salt solution, centrifuging after flocculation, vacuum drying, and crushing to obtain cordyceps militaris active powder; mixing and granulating raw materials to obtain granulation particles; uniformly mixing the granulation particles with xylitol and microcrystalline cellulose, and pressing into tablets; and placing the tablets in a coating machine for coating. The application realizes efficient retention of active ingredients, improvement of safety and stability of product quality through the cooperation of multiple technologies such as supercritical CO2 extraction, enzymolysis flocculation, low-temperature fluidized bed granulation and hot melt coating.

The invention provides a method for preparing coal-based quantum carbon dot slow-release urea through sectional drying-fluidized bed granulation, and relates to the technical field of slow-release fertilizer preparation, the method comprises the following steps: S1, coal-based waste is used as a raw material, coal-based quantum carbon dots MCQDs are prepared through a hydrothermal method, a silane coupling agent is added for surface functional modification, and a functional MCQDs dispersion liquid is obtained; s2, industrial urea is smashed and screened, and urea master batches with the particle size ranging from 1.0 mm to 3.0 mm are obtained; in the pre-drying stage, moisture on the surfaces of urea master batches is thoroughly removed through a low-humidity environment, and particle aggregation caused by moisture during MCQDs spraying is avoided; in the medium-temperature setting stage, in an interval lower than the urea decomposition temperature, MCQDs are promoted to form a covalent bond with a urea crystal face through a silane coupling agent, and the bonding stability is improved; the formed bonding structure is locked in the low-temperature curing stage, structural damage caused by temperature fluctuation is avoided, and the problem of decomposition or agglomeration is solved.

This invention discloses a method for preparing a gastroenteritis preparation with good taste. The steps include: (1) chopping and mixing jujube pulp and ginger, enzymatically hydrolyzing them, separating them to obtain filtrate and residue, concentrating the filtrate under reduced pressure to obtain component I; (2) adding the residue to deionized water, collecting the oil phase by steam distillation to obtain component II; (3) preparing intermediate extract powder; (4) mixing the intermediate extract powder, component I, and component II evenly, adding a binder for fluidized bed granulation, drying to obtain intermediate particles; mixing the intermediate particles with magnesium stearate evenly, compressing into tablets to obtain the gastroenteritis preparation. Adding the excipients prepared in this invention to traditional formulations can improve antibacterial activity, and by adding jujube and ginger extracts, the taste can be improved, infused with fruity aroma, and the ginger extract can mask some of the bitterness of the medicinal materials, making the gastroenteritis preparation taste better.

The invention relates to a method and device for preparing a chemical looping combustion oxygen carrier by using vanadium-titanium blast furnace slag titanium extraction tailings, and the method comprises the following steps: S1, sequentially carrying out first screening and dechlorination on the vanadium-titanium blast furnace slag titanium extraction tailings to obtain a first material; s2, crushing the first material obtained in the step S1 to obtain a second material; s3, mixing the second material obtained in the step S2, an active filler and a binder, and performing fluidized bed granulation to obtain a third material; s4, the third material obtained in the step S3 is subjected to second screening and calcination in sequence, and the chemical looping combustion oxygen carrier is obtained. According to the method, the titanium extraction tailings of the vanadium-titanium blast furnace slag are used as a substance for transferring oxygen in the chemical looping combustion process, the problem of heavy metal pollution caused by waste of the titanium extraction tailings of the vanadium-titanium blast furnace slag is solved, and resource utilization and environmental protection are achieved.

The invention relates to liver-protecting konjac, radix puerariae and semen hoveniae granules and a production control method, and belongs to the technical field of food processing and medicines.The production control method comprises the steps that active ingredients are extracted in a graded mode through a multi-stage separation device, and an initial functional ingredient set is generated; optimizing the raw material proportion by adopting a dynamic proportion algorithm to generate an optimized formula; carrying out ultrasonic-assisted extraction and low-temperature vacuum concentration technology treatment to generate a high-purity functional extract; generating a particle primary product by using a fluidized bed granulation technology, and detecting the content of functional components on line by using a near infrared spectrum analysis technology; a feedback control algorithm is adopted to adjust granulation process parameters, and an optimized path is generated; the components are verified through a gas chromatography-mass spectrometry technology, and a verification report is generated; and recording the key data based on the distributed storage system, and generating a complete production control file. According to the method, efficient extraction, stable production and accurate quality control can be realized, and the product consistency and the market competitiveness are remarkably improved.

This application discloses a rapidly dispersible and soluble hyaluronic acid salt and its preparation method. The method includes: granulating the hyaluronic acid salt in a fluidized bed, and spraying an aqueous ethanol solution into the granulation process to obtain rapidly dispersible and soluble hyaluronic acid or its salt. The hyaluronic acid salt prepared by this method solves the problem of hyaluronic acid salt easily agglomerating and being difficult to dissolve in water, and can be rapidly dispersed and dissolved; moreover, the obtained hyaluronic acid salt does not contain any excipients other than the raw material itself, and has a wide range of applications.

The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation method of upatinib sustained release tablets based on fluidized bed granulation. The invention provides a method for preparing upatinib sustained release tablets by adopting a fluidized bed one-step granulation process. The method is suitable for upatinib semihydrate (C crystal form), anhydride (D crystal form) and amorphous raw materials. Through fluidized bed granulation, the main component upatinib is irregularly and uniformly dispersed in the auxiliary materials, the problems of mixing uniformity and content uniformity of the low-proportion main component are solved, the concentration of the main component is diluted by optimizing the adding sequence of the auxiliary materials, and the contact risk of upatinib and tartaric acid is reduced, so that the compatibility problem of upatinib and tartaric acid is solved.

The present invention relates to an oral formulation comprising sevelamer or a pharmaceutically acceptable salt thereof, and a method for preparing the same. Since the formulation is prepared through fluidized bed granulation, damage to the formulation is reduced and variation caused by abrasion is decreased, such that superior quality can be maintained. In particular, the formulation of the present invention has a smaller granule size while exhibiting increased uniformity, thereby improving medication convenience through reduction in the size of the formulation.