The invention provides a mycophenolate mofetil capsule and a preparation method thereof. The mycophenolate mofetil capsule comprises, by weight, 1100-1400 parts of mycophenolate mofetil, 150-170 parts of filler and 75-110 parts of pharmaceutical acceptable auxiliary materials; the filler is selectively prepared from a mixture of one or more optional proportions of pregelatinized starch, corn starch or lactose; the pharmaceutical acceptable auxiliary materials include adhesive, disintegrant and lubricant. A fluidized-bed granulation technology is adopted, the process is simplified, time is saved, labor intensity is low, obtained particles are porous soft particles, low density and low strength are achieved, the particles are evenly distributed in particle size, and good fluxility is achieved; the mycophenolate mofetil capsule has the advantages of high disintegration speed, good absorptivity, convenience in taking, small in intestinal irritation, stable in long-term storage quality and the like; the advantages of both simpleness in production equipment for ordinary capsules and convenience in package storage and transportation as well as carrying are achieved, and the mycophenolate mofetil capsule is convenient for patients to take.