Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

130 results about "Fluidized bed granulation" patented technology

Ecological balance fertilizer for yield increase and disease resistance of peanuts and preparation method of ecological balance fertilizer

The invention relates to the technical field of fertilizer preparation, and discloses an ecological balance fertilizer for yield increase and disease resistance of peanuts and a preparation method of the ecological balance fertilizer. The preparation process comprises the following steps: constructing a PLGA core containing trichoderma harzianum spores and magnesium carbonate through a micro-fluidic chip low-temperature water-in-oil emulsion method; coating bacillus amyloliquefaciens and potassium silicate with ultraviolet-induced cross-linked temperature-sensitive hydrogel to form a middle layer; loading rhizobium by using aminated mesoporous S < iO2 >, and spraying and assembling an enzyme response shell through a fluidized bed; finally, the hydroxyapatite nanorod and a binder are combined and granulated and formed through a fluidized bed. Precise controlled release of functional bacteria and nutrients is realized by constructing a temperature-sensitive-enzyme response type release system, and the activity of a fungicide is guaranteed to be preserved by virtue of trichoderma harzianum-rhizobium synergistic interaction and silicon bond linkage soil remediation in combination with a low-temperature fluidized bed process, so that a'fertilizer-bacterium-soil 'ecological cycle system is finally constructed.
Owner:ZHONGSHENG NANYANG BIOTECHNOLOGY CO LTD

Softened water treatment device of induced crystallization granulation fluidized bed

The invention relates to the technical field of softened water treatment devices, in particular to an induced crystallization granulation fluidized bed softened water treatment device. Comprising a cylinder, a stainless steel cathode layer is arranged on the inner side of the cylinder, the stainless steel cathode layer is electrically connected with a negative electrode of a power supply, an excitation system is mounted on the cylinder, a vertical vibration frame capable of vertically reciprocating is connected to the excitation system, a translation frame is slidably connected to the vertical vibration frame, and a synchronizing system for driving the vertical vibration frame and the translation frame to synchronously displace is arranged on the vertical vibration frame. The synchronous system is in transmission connection with a transmission shaft capable of alternately rotating forwards and backwards, a micro-filtration cylinder is rotationally mounted on the translation frame, an insulating shaft is rotationally mounted in the micro-filtration cylinder, the micro-filtration cylinder and the insulating shaft are driven by the transmission shaft, a plurality of guide rings are mounted on the micro-filtration cylinder, and an anode bar slides on the insulating shaft. According to the device, grain fluidization is strengthened through synchronous multi-dimensional excitation, the problem of local reaction dead angles is solved, the problems that a traditional device is low in crystallization efficiency and uneven in particle size are effectively solved, and the stability of grain settling separation is guaranteed.
Owner:SHANDONG LASHAN ENVIRONMENTAL PROTECTION TECH CO LTD

Fluidized bed granulation device and granulation method thereof

The invention relates to the technical field of fertilizer processing, and provides a fluidized bed granulation device and a granulation method.The fluidized bed granulation device comprises a fluidized bed granulator, a cooler, a molten liquid conveying pump and a seed crystal making machine, and the molten liquid conveying pump is communicated with the fluidized bed granulator and the cooler through a first flow path; the molten liquid conveying pump is used for pumping molten liquid to the fluidized bed granulator and the cooler through the first flow path; the seed crystal making machine is respectively communicated with the fluidized bed granulator, the cooler and the molten liquid delivery pump through a second flow path, and is used for making the molten liquid pumped by the molten liquid delivery pump through the second flow path into seed crystals; and the seed crystal is conveyed to the fluidized bed granulator and the cooler through the second flow path. According to the invention, large-particle products with good roundness and good hardness can be produced without crushing of a crusher, and the product quality is improved.
Owner:BEIJING CHRYSAN TECHNOLOGY CO LTD

Fluidized bed granulation dryer

The utility model relates to the technical field of fluidized bed granulation, in particular to a fluidized bed granulation dryer, which comprises a bed body, a spray gun and a spray gun driving mechanism, an air inlet chamber, a fluidization chamber and a settling chamber are sequentially arranged in the bed body from bottom to top, and an air distribution plate is arranged between the air inlet chamber and the fluidization chamber. In the granulating and drying process, the spray gun is driven by the spray gun driving mechanism to move, so that an atomized liquid drop receiving area which continuously and periodically moves circularly is formed in a top material layer area of the fluidized bed layer. The material is periodically and intermittently subjected to liquid in the granulation area covered by the atomization area of each spray gun, so that the contradiction that the drying rate of the biomass type material difficult to dry is lower than the granulation rate can be effectively solved, and the problem that the material in the granulation area is too high in humidity and too long in viscidity duration time to form coarse particles or cakes is prevented.
Owner:SHANDONG HONOR ENERGY TECH CO LTD

Formula and preparation process of medicinal and edible walnut milk with sleep improving effect

The invention relates to the field of functional foods, and discloses a formula and a preparation process of medicinal and edible walnut milk with a sleep improving effect, and the composition comprises a formula A and a formula B which are physically separated from each other. The formula A is used as a substrate, contains walnut powder, a dairy product, pH sensitive food colloid and a pH regulator, and is prepared into porous particles with relatively large particle sizes through a fluidized bed granulation process; the formula B is used as a functional component, contains gamma-aminobutyric acid, theanine and various medicinal and edible plant extracts, and is prepared into fine powder through a low-temperature spray drying process. During brewing, pH change generated after the two formulas are mixed can trigger colloid thickening, and homogeneous and stable suspension liquid is formed; and due to the structural difference between the particles and the micro powder, ordered graded dissolution is realized, and the reconstituability is improved. The product disclosed by the invention has the beneficial effects of stable functional components, good brewing dispersity and high physical stability of brewed liquid.
Owner:SHANXI REED WALNUT MILK & RHYME TECHNOLOGY CO LTD

A process online quality monitoring method for near-infrared combined fluidized bed granulation of traditional Chinese medicine

The present application provides a kind of online quality monitoring method of traditional Chinese medicine in near infrared combined fluidized bed granulation process, the monitoring method will near infrared spectrum (NIRs) technology be combined with partial least squares (PLSr), and the online monitoring model of key quality attribute (CQAs) in granulation process of Buqi Tongluo Granules (BQTL-G) is constructed.Based on the real-time monitoring data of the model, the key process parameter of peristaltic pump speed is dynamically regulated by negative feedback mechanism through PID controller, the bed collapse problem caused by excessive moisture content in the granulation process is accurately intervened, and the granulation process state is stabilized.The online quality monitoring method of the present application solves the quality uniformity problem commonly existing in the production process of traditional Chinese medicine granules.
Owner:SHANXI BUCHANG PHARMA CO LTD +1

Gas vortex distribution plate of medicinal fluidized bed granulation dryer

The utility model relates to the technical field of distribution plates, in particular to an air vortex distribution plate of a medicinal fluidized bed granulation dryer, which comprises a mounting frame, a distribution plate body, a plurality of separation blades and a replacement mechanism, and the replacement mechanism comprises a rotating component, a plurality of tooth blocks, a plurality of mounting plates and a plurality of clamping plates. The distribution plate body is matched with the multiple blocking pieces, the boiling effect of the airflow distribution plate of the fluidized bed can be improved, when the distribution plate body needs to be replaced, the rotating assembly is rotated, the rotating assembly drives the multiple tooth blocks to move towards the side close to the mounting frame, and the multiple tooth blocks drive the multiple mounting plates to move towards the side away from the distribution plate body; according to the airflow distribution plate, the clamping plates are driven to move towards the side away from the distribution plate body, limiting on the distribution plate body is relieved, the distribution plate body can be replaced at the moment, the distribution plate body can be replaced by resetting the clamping plates, and therefore the problem that an existing airflow distribution plate is not convenient to replace is solved.
Owner:CHONGQING SOUTHERN PHARMACEUTICAL MACHINERY FACTORY

Fluidized bed granulation method of coal-based quantum carbon dot intercalation adsorption type slow-release urea

The invention provides a fluidized bed granulation method of coal-based quantum carbon dot intercalation adsorption type slow-release urea, and relates to the technical field of slow-release fertilizer preparation, and the fluidized bed granulation method comprises the following steps: S1, taking low-rank coal as a raw material, crushing the low-rank coal, mixing the crushed low-rank coal with a deep eutectic solvent DES, and carrying out a stripping reaction under a microwave-assisted condition to prepare coal-based quantum carbon dots CQDs; s2, urea powder is mixed with the coal-based quantum carbon dots CQDs dispersion liquid prepared in the step S1, and a urea-CQDs premix is obtained; according to the method, the coal-based quantum carbon dots are prepared from the low-rank coal, the cost of the low-rank coal raw material is only 1 / 10 of that of traditional activated carbon, the stripping degree of a carbon skeleton can be directionally regulated and controlled through a microwave-assisted deep eutectic solvent stripping method, the specific surface area of CQDs is increased to 1800-2500m / g, the content of surface hydroxyl and amino functional groups reaches 8-18mmol / g, and the adsorption capacity to urea is increased to 150-200mg / g.
Owner:BEIJING TIANZHONGSHU TECH DEV CO LTD

Composition capable of improving colitis and preparation method thereof

The invention relates to the technical field of functional food preparation, in particular to a composition capable of improving colitis and a preparation method thereof, and the composition comprises glutamine, a composite plant extract, a zinc source and soluble dietary fibers. Wherein the compound plant extract comprises hericium erinaceus extract, ginseng extract and astragalus extract; the zinc source is zinc glycinate, zinc gluconate and the like; the soluble dietary fiber is fructo-oligosaccharide, inulin, galactomannan oligosaccharide and the like. The preparation method comprises the following steps: directly carrying out dry mixing or carrying out fluidized bed granulation on glutamine to obtain particles A, mixing the composite plant extract and the dietary fibers with ethanol, carrying out spray drying to obtain particles B, and carrying out three-dimensional mixing on the particles B and the zinc source. The composition can maintain the homeostasis of intestinal epithelial cells, reduce oxidative stress and inflammatory response, promote mucosal repair and effectively improve ulcerative colitis, Crohn's disease and chemoradiotherapy-related intestinal mucositis through multi-target action.
Owner:WUXI LICHENG MEDICAL NUTRITION CO LTD +1

A film-coated tablet of jujube seed and Ganoderma lucidum and its preparation method

This application discloses a jujube seed and Ganoderma lucidum film-coated tablet and its preparation method. The film-coated tablet uses jujube seed and Ganoderma lucidum in a weight ratio of (2.9–3.1):2 as active raw materials, employs a microcrystalline cellulose and erythritol compound as fillers, and combines them with silica, magnesium stearate, and a specific composite film-coating agent. The preparation method includes raw material pretreatment, water extraction, vacuum concentration, vacuum drying, fluidized bed granulation, total mixing and tableting, and film coating, optimizing each process parameter. This application solves the technical problems of existing traditional Chinese medicine extracts, such as high hygroscopicity, poor compressibility, poor stability, and unclear synergistic effects. The prepared product has high active ingredient content, good stability, rapid disintegration, and good patient compliance, making it suitable for large-scale industrial production and possessing good market application prospects.
Owner:HEBEI JINMU PHARM GRP CO LTD

Preparation method of tablets for relaxing muscles and stimulating blood circulation

The invention belongs to the technical field of preparation processes, and particularly relates to a preparation method of a tendon-relaxing and blood-activating tablet. The invention provides a preparation method of tablets for relaxing muscles and stimulating blood circulation. The method comprises the following steps: a, carrying out superfine grinding on safflower, vinegar-processed rhizoma cyperi, scalded rhizoma cibotii and cortex periplocae into fine powder; b, adding water into calcined natural copper, decocting, adding Chinese starjasmine stem, lycopodium clavatum, herba lycopi, mistletoe and caulis spatholobi, decocting, combining decoction, filtering, standing, concentrating supernate into extract, drying, crushing and sieving to obtain dry extract powder; and c, placing the fine powder and the dry extract powder in a fluidization chamber of a fluidized bed, carrying out top spraying of an adhesive solution, carrying out fluidized bed granulation, drying, and tabletting to obtain the product. The tablet prepared by the method is regular in shape, tidy in edge and free of unfilled corners and tablet cracking phenomena. The tablet is smooth in surface, free of granular sensation and roughness, uniform in color and free of color spots. The tablet has the advantages of moderate hardness, toughness, no loosening phenomenon, compact overall structure, no damage, no stripping, no crack and no scratch, and friability, disintegration time limit and content result all accord with regulations.
Owner:SHANXI JIANENG DAHUAYU PHARMA CO LTD

Fluidized bed granulation and drying device for traditional Chinese medicine preparation

A fluidized bed granulation and drying device for traditional Chinese medicine preparations belongs to the field of fluidized bed granulation and drying technology. This invention solves the technical problem of low output quality caused by dead zones and channeling in existing multi-functional granulation devices due to their structural design. An air distribution plate is installed at the bottom of the granulation chamber, and an air ring is installed on the lower part of the top surface of the granulation chamber. The air ring is annular with an arc-shaped longitudinal section. The top side of the air ring's longitudinal section is tangent to the top surface of the granulation chamber, and the bottom side of the air ring's longitudinal section is tangent to the side of the granulation chamber. An air equalization component is laid on the upper side of the air distribution plate. The air equalization component includes an air equalization net and a spiral scraper. The spiral scraper is rotatably installed on the lower bottom surface of the air equalization net along a horizontal circumferential direction. The spiral scraper includes a sleeve and blades, with three blades evenly installed on the outside of the sleeve. A rotating shaft is fixedly installed at the center of the lower bottom surface of the air equalization net, and the sleeve is fitted onto the outside of the rotating shaft. This improves the output quality. This invention is used for the granulation of traditional Chinese medicine.
Owner:HEILONGJIANG JIREN PHARMACEUTICAL CO LTD

Method for preparing large baical skullcap root fish effervescent tablets through non-aqueous granulation and tabletting

The invention discloses a method for preparing large baical skullcap root fish effervescent tablets through non-aqueous granulation and tabletting. The method comprises the following steps: 1, raw material pretreatment: mixing a rhubarb extract, a baical skullcap root extract, heartleaf houttuynia herb volatile oil, a disintegrating agent and auxiliary materials in proportion; 2, non-aqueous bonding granulation: using 5% PVP-absolute ethyl alcohol atomized spray as an adhesive, and bonding the adhesive with the mixed powder in a fluidized bed granulator to form particles; 3, tabletting and packaging: feeding the granules obtained in the step 2 into a rotary tabletting machine for tabletting; and 4, aluminum-plastic packaging: carrying out aluminum-plastic packaging on the tablets obtained in the step 3, and controlling the environment humidity to be less than or equal to 30%. The invention has the following advantages: 1, active ingredients of traditional Chinese medicines are protected, and the retention rate of key ingredients such as baicalin is greater than or equal to 95%; 2, the process chain is simplified; 3, the cost is reduced and the benefit is increased in economic benefit; the moisture content in the whole process is smaller than or equal to 0.5%.
Owner:JINZHOU MEDICAL UNIV

Double-laying-collecting-chamber bag shaking pneumatic claw type locking mechanism of medicinal fluidized bed granulation drying machine

The utility model relates to the technical field of pharmaceutical equipment, in particular to a double-laying-collection-chamber bag shaking pneumatic claw type locking mechanism of a medicinal fluidized bed granulation drying machine. The device is applied to a boiling bed body, a hanging bracket device is installed on the boiling bed body, the claw type locking device comprises an action air cylinder, an air cylinder fixing plate, a claw tooth body and an elastic piece, the action air cylinder is detachably connected with the hanging bracket device and the air cylinder fixing plate, and the claw tooth body is arranged on the side, away from the air cylinder fixing plate, of the action air cylinder. During work, an air source and a power source are connected firstly, then the hanging bracket device is controlled to act, a left-right cavity cloth bag locking automatic control button on the display screen is operated and clicked, a piston rod in the acting air cylinder can stretch out, and therefore the air cylinder fixing plate is pushed, and the cloth bag locking automatic control button is locked through the elastic force in the elastic piece. And the claw teeth of the claw tooth body are clamped on the hanging bracket device to finish the positioning and locking functions, so that the fluidized bed bag shaking hanging bracket can be quickly locked.
Owner:CHONGQING SOUTHERN PHARMACEUTICAL MACHINERY FACTORY

Fluidized bed based carbon nanotube granulation forming device

PendingCN122124700AAuxiliary nestingachieve the purpose of cleaningSievingCarbon compoundsCarbon nanotubeFluidized bed granulation
This invention belongs to the field of fluidized bed granulation technology, and specifically discloses a fluidized bed-based carbon nanotube granulation device, including a fluidized tower, a bent pipe connected to the top of the fluidized tower, a buffer cover connected to one end of the bent pipe, a distribution hopper fixed to the bottom of the buffer cover, and a return device inside the distribution hopper. In this invention, fine carbon nanotube particles are filtered and screened through a filter port inside the distribution hopper. The particles attached to one side of the filter port are scraped off by a uniform material device and collected by the return device. When the return device is full of material, the material can be discharged to the bottom of the distribution hopper and re-enter the fluidized tower for refining through a return pipe. When the return device is working, it triggers a feedback device to intermittently apply high-pressure pulses of external high-pressure gas to the filter port to clean it. At the same time, it can push the material inside the return device out to assist in its discharge.
Owner:JIANGSU TENGLONG BIOLOGICAL PHARMA

Automatic cooling method for fluidized drying granulator

The invention discloses an automatic cooling method for a fluidized drying granulator. The automatic cooling method comprises the following steps: S1, building an intelligent temperature control granulation system; s2, the air inlet humidity is set, and air dehumidification is conducted; s3, setting a granulation temperature, and starting boiling granulation; s4, the drying temperature is set, air heating is conducted, and the materials are dried for t1 min; s5, the air inlet system stops air heating, air dehumidification is kept, and the materials are cooled for t2 minutes; s6, setting a discharging temperature, and performing discharging judgment: when the material temperature is less than or equal to a discharging temperature set value, entering S7; when the material temperature is smaller than or equal to the discharging temperature set value, returning to S5; and S7, shutdown is conducted, and materials are output. The method has the beneficial effects that the temperature of the finished medicine particles is reduced, the finished medicine particles are prevented from absorbing moisture and caking, it is guaranteed that the quality of the finished medicine particles meets the production requirement, the rework rate and the rejection rate of the finished medicine particles are reduced, and the production cost is reduced.
Owner:SICHUAN JIAMA MECHANICAL MFG CO LTD +1

Stable 4-(aminomethyl)-6-(phenylpyrazolyl) phthalazinone composition and preparation method thereof

A particulate composition of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-1-methyl-1h-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile comprising: a crystalline form of said compound comprising: a first chiral crystalline form present in an amount of at least 85 wt%, based on the weight of said crystalline form; and a filler. The present invention relates to a pharmaceutical composition comprising a crystalline form of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile comprising at least 95 wt% of a first chiral crystalline form, a process for preparing said composition, the process comprising: providing a crystalline form of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile comprising at least 95 wt% of a first chiral crystalline form; providing a filler; mixing the crystalline form and the filler in a weight ratio of at least 1: 10; subjecting the mixture to a granulation process selected from fluidized bed granulation, high or low shear granulation and dry granulation to obtain a particulate composition; wherein the particulate composition has an amorphous form of not more than 10 wt% of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile, and wherein the particulate composition has an amorphous form of not more than 5 wt% of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile, and wherein the particulate composition has an amorphous form of not more than 5 wt% of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile. The present invention relates to a second chiral form of 4-chloro-6-cyclopropoxy-3-fluorobenzonitrile in the form of 4-(2, 2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile.
Owner:MIRATI THERAPEUTICS INC

Application of dimethyl fumarate in preparation of medicine for treating depression

The invention discloses application of dimethyl fumarate in preparation of a medicine for treating depression, and relates to the technical field of medicine research and development. Comprising experimental verification and medicine preparation, and the medicine preparation comprises the following steps: raw material preparation: weighing a dimethyl fumarate raw material and a medicinal carrier in proportion; uniformly mixing: fully mixing the dimethyl fumarate and the medicinal carrier by using a three-dimensional mixer or a double-cone mixer; granulating: adding a wetting agent for fluidized bed granulation or wet granulation to form granules with set sizes; granulating and drying: granulating the wet granules, drying, and controlling the water content of the granules; forming is conducted; and packaging: packaging the prepared medicine, and labeling information. The dimethyl fumarate is applied to the field of depression treatment, experiments verify that the dimethyl fumarate has a remarkable improvement effect on depression-like behaviors induced by chronic social contusion stress, and a new direction is provided for development of anti-depression drugs.
Owner:THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY

Edaravone dispersible tablet and preparation method thereof

The invention provides an edaravone dispersible tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, and the preparation method comprises the following steps: taking 52.5% by weight of edaravone, 0.5-5% by weight of a disintegrating agent, 0.5-5% by weight of a flow aid, 0.5-5% by weight of a sweetening agent, 0.25-5% by weight of a lubricant and the balance of a lactose microcrystalline cellulose co-treatment substance, directly and uniformly mixing, and tabletting to obtain the edaravone dispersible tablet. The lactose and microcrystalline cellulose co-treatment material integrates the advantages of lactose and cellulose, the fluidity and compressibility of total mixed powder can be guaranteed, the tablet weight difference of the tabletting process is reduced, the feasibility of mass production is guaranteed, and the production efficiency and the qualification rate of the tabletting process are improved; compared with a traditional solid dispersion process, the method has the advantages that solvent treatment, fluidized bed granulation or high-temperature drying steps are not needed, and preparation production can be completed only through direct mixing and tabletting processes, so that the influence of a humid and hot environment on the API stability is fundamentally avoided, and the product is more stable.
Owner:런허 이캉 그룹 컴퍼니 리미티드 +1

Urea granulating equipment

A fluidized bed granulator for granulating with urea or a urea-containing liquid is described, wherein the granulating liquid is supplied via a supply manifold comprising a header and a standpipe. The standpipe is arranged at least partially inside the channel for the secondary gas.
Owner:STAMICARBON BV

Automatic granulation process of boiling granulation dryer

The invention discloses an automatic granulation process of a boiling granulation dryer. The automatic granulation process comprises the following steps: S1, building a granulation system; s2, when a fluidized bed is preheated to the feeding temperature, powder is fed into the fluidized bed, and then the powder is heated to the set material temperature; s3, starting automatic segmented granulation; s4, the materials are dried for t5 minutes in a delayed mode; s5, starting material coloring; s6, drying the materials for t7 minutes; and S7, the air inlet temperature is reduced, dry cold air is conveyed into the fluidized bed, the material temperature is reduced, and when the material temperature is smaller than or equal to the discharging temperature value, shutdown is conducted, and the materials are output. According to the invention, the traceability and reducibility of batch products are ensured, and the defects of manual operation are overcome; in the granulating process, the material bed collapse is avoided, and the fullness and uniformity of the medicine component of each granule are ensured.
Owner:SICHUAN JIAMA MECHANICAL MFG CO LTD +1

Novel fluidized bed for circular granulation in industrial sewage treatment

The utility model belongs to the technical field of fluidized bed granulation, particularly relates to a novel fluidized bed for circulating granulation in industrial sewage treatment, and aims to solve the problems that when the fluidized bed is used, hot air is directly discharged from an output port, so that the working environment is easy to be humid, and the hot air contains some particle impurities, so that a certain influence is caused to workers. According to the scheme, the fluidized bed granulator comprises a bottom plate, the top of the bottom plate is fixedly provided with a fluidized bed granulator body, a control host and a hot air blower which are matched for use, and the other end of an output pipe of the hot air blower is communicated with the inner wall of the fluidized bed granulator body. When the device is used, hot gas generated in the granulation process is recycled and reused through the hot gas recycling assembly, the energy utilization efficiency is improved, particle impurities and harmful gas in the gas are effectively removed through the arrangement of the filtering assembly, potential hazards to the surrounding environment and the health of workers are avoided, and the environment protection requirement is met.
Owner:YIXING LIANHUA ENVIRONMENTAL PROTECTION CO LTD

Doxofylline granules and preparation method thereof

The invention discloses a doxofylline particle and a preparation method thereof, the doxofylline particle has a porous microsphere structure and contains doxofylline and hydrophilic polymer auxiliary materials, and the hydrophilic polymer auxiliary materials are uniformly distributed in the doxofylline particle. The preparation method of the doxofylline particles comprises the step of carrying out fluidized bed granulation on an aqueous solution containing doxofylline solid and at least one hydrophilic polymer auxiliary material. Aiming at the technical bottlenecks of poor solubility and low dissolution rate of doxofylline, the doxofylline particles are prepared through a fluidized bed granulation process in combination with hydrophilic auxiliary materials, the formed particles are good in flowability and suitable for direct tabletting or capsule filling, and the preparation development efficiency is remarkably improved. Compared with the traditional process, the method has the advantages of simple process, low cost, low energy consumption, less pollution and easiness in industrial production.
Owner:JIANGSU POLYTECHNIC COLLEGE OF AGRI & FORESTRY

Preparation method of Fuganning tablet

The invention relates to a preparation method of Fuganning tablets. The preparation method comprises the steps of raw material pretreatment, gradient extraction, composite purification, granulation, drying and granule finishing, tabletting and coating. The wall breaking rate of medicinal materials is increased by adopting low-temperature superfine grinding, the yield of effective components is increased by adopting a gradient extraction process combining microwave-ultrasonic synergistic extraction and constant-temperature reflux, impurities are reduced by virtue of acid precipitation-macroporous resin composite purification, and the disintegration performance and stability of the tablet are optimized in cooperation with fluidized bed granulation and functional coating technologies. The method can improve the purity and bioavailability of active ingredients, enhance the stability of the preparation and realize accurate quality control, and is suitable for industrial production of the Fuganning tablets.
Owner:GUANGDONG DEXIN PHARM CO LTD

Betahistine hydrochloride tablet and preparation method thereof

The invention provides a betahistine hydrochloride tablet and a preparation method thereof, the auxiliary materials of the betahistine hydrochloride tablet are microcrystalline cellulose, mannitol, citric acid monohydrate, colloidal silicon dioxide and talcum powder, a method for preparing the betahistine hydrochloride tablet by utilizing fluidized bed one-step granulation is provided, the fluidized bed is adopted for mixing, specific fluidized bed parameters are set, and the betahistine hydrochloride tablet is prepared. Compared with traditional wet granulation and fluidized bed granulation, the preparation method has the advantages of fewer procedures, short preparation period, low cost, high production efficiency, high controllability of technological parameters in the production process, and stable and reliable quality of the produced product.
Owner:珠海润都制药股份有限公司

Fluidized bed granulation system and method

The invention relates to the technical field of fertilizer processing, in particular to a fluidized bed granulation system and method.The fluidized bed granulation system comprises fluidized bed granulation equipment, a granulation section and a cooling section are formed in the fluidized bed granulation equipment, the granulation section is used for generating small-particle fertilizer seed crystals and converting the small-particle fertilizer seed crystals into large-particle fertilizer, and the cooling section is used for cooling the large-particle fertilizer seed crystals; the cooling section is used for receiving and cooling the large-particle fertilizer converted by the granulation section. The granulation section is provided with a seed crystal making spray head and a granulation spray head, the fertilizer molten liquid source sprays fertilizer molten liquid to the granulation section through the seed crystal making spray head, small-particle fertilizer seed crystals are formed in the granulation section, the fertilizer molten liquid source sprays the fertilizer molten liquid on the surfaces of the small-particle fertilizer seed crystals through the granulation spray head, and large-particle fertilizer is formed through conversion. The small-particle fertilizer seed crystal used in the invention can be automatically generated and has good roundness, the small-particle seed crystal does not need to be crushed by a crusher, the large-particle fertilizer with good roundness and high hardness can be produced, the process flow is simplified, and the equipment, installation and operation costs are reduced.
Owner:BEIJING CHRYSAN TECHNOLOGY CO LTD

A granule of paraquat and a preparation method thereof

PendingCN122162791ABiocideAnimal repellantsParaquatDrone flies
This invention relates to a paraquat granule and its preparation method, belonging to the field of pesticide technology. The granule consists of paraquat salt, a layered double hydroxide carrier, a disintegrant, microcrystalline cellulose, an outer coating of an emetic / odorant / tracking agent, and the remainder being water-soluble filler. The granule wear rate is ≤2%, it completely disintegrates within 60 seconds in standard hard water at 25℃, and the suspension rate is ≥90%. Preparation employs a one-step process of screw extrusion-centrifugal granulation-vacuum belt drying or fluidized bed granulation, resulting in high content retention. The product is dust-free and non-caking, suitable for drone-based aerial spraying and long-distance sea transport, facilitating large-scale application in overseas registered areas.
Owner:JIANGSU NOON CROP SCI CO LTD

Fluidized bed granulation and coating systems and methods

A fluidized bed granulation (FBG) system includes a pre-wetting subsystem, wherein feedstock is pre-wet to a predetermined % value, a fluidization chamber (FC), an inlet coupled to the FC, a plenum coupled to the FC by a distributor plate having slots through which a fluidization gas is passed to the FC at a velocity and a direction, an outlet compartment coupled to the FC by a termination plate having one or more filter bags, a liquid binder system adapted to introduce a liquid binder into the FC, and an outlet configured to eject granulated product, and a plurality of sensors adapted to inform a processor executing instructions maintained on a non-transitory memory, wherein the processor using a mass, energy, and fluidization balance model is adapted to optimize the FBG system to provide the granulated product having an optimized geometric mean and geometric standard deviation between about 2.0 and about 1.0.
Owner:PURDUE RES FOUND

Boiling granulation drying machine with material barrel convenient to replace

The utility model discloses a boiling granulation dryer convenient to replace a material barrel, which belongs to the technical field of dryers, and comprises a base, a bearing table is fixedly connected to one side surface of the base, clamping components are arranged on the bearing table, a rotating component is arranged on one side of each clamping component, the material barrel is arranged between the clamping components, and the rotating component is arranged on the other side of each clamping component. A collecting box is arranged on the surface of one side of the base, a handle is fixedly connected to the surface of one side of the collecting box, and supporting columns are fixedly connected to the peripheral surface of one side of the base; the material barrel can be driven to rotate through the rotating assembly, so that materials in the material barrel can be dried more comprehensively, the qualification of material drying is guaranteed, and the practicability of equipment is greatly improved. And through the clamping assembly, a worker can conveniently replace the material barrel, the requirements of the worker are met, and the working efficiency is improved.
Owner:TIANJIN HEZHI GUANGPING PHARM CO LTD

Fluidized bed granulation device for urea granule production

ActiveCN224194640UImprove particle size qualification rateMeets stringent requirements for granularitySievingScreeningProcess engineeringFluidized bed granulation
The utility model relates to the technical field of urea granulation, in particular to a fluidized bed granulation device for urea granule production, which comprises a fluidized bed body, one side of the fluidized bed body is fixedly connected with a first blanking plate, and one side of the fluidized bed body is provided with a base. A first vibration frame is installed at the top of the base, a first screening net is fixedly connected into the first vibration frame, a second screening net is installed in the vibration frame, a rotary drum granulator is arranged on one side of the base, a support is arranged on one side of the rotary drum granulator, a second vibration frame is slidably connected to the top of the support, and a third screening net is fixedly connected into the second vibration frame. A first driving assembly is installed at the top of the base, a second driving assembly is installed at the top of the support, and the fluidized bed granulation device for urea particle production has the advantages that the product particle size qualification rate is increased, the technological process is stabilized, and efficient screening and grading are achieved.
Owner:SHANXI LUAN COAL BASED SYNTHETIC OIL