65 results about "Fluidized bed granulation" patented technology

The present application provides a kind of online quality monitoring method of traditional Chinese medicine in near infrared combined fluidized bed granulation process, the monitoring method will near infrared spectrum (NIRs) technology be combined with partial least squares (PLSr), and the online monitoring model of key quality attribute (CQAs) in granulation process of Buqi Tongluo Granules (BQTL-G) is constructed.Based on the real-time monitoring data of the model, the key process parameter of peristaltic pump speed is dynamically regulated by negative feedback mechanism through PID controller, the bed collapse problem caused by excessive moisture content in the granulation process is accurately intervened, and the granulation process state is stabilized.The online quality monitoring method of the present application solves the quality uniformity problem commonly existing in the production process of traditional Chinese medicine granules.

The invention provides a fluidized bed granulation method of coal-based quantum carbon dot intercalation adsorption type slow-release urea, and relates to the technical field of slow-release fertilizer preparation, and the fluidized bed granulation method comprises the following steps: S1, taking low-rank coal as a raw material, crushing the low-rank coal, mixing the crushed low-rank coal with a deep eutectic solvent DES, and carrying out a stripping reaction under a microwave-assisted condition to prepare coal-based quantum carbon dots CQDs; s2, urea powder is mixed with the coal-based quantum carbon dots CQDs dispersion liquid prepared in the step S1, and a urea-CQDs premix is obtained; according to the method, the coal-based quantum carbon dots are prepared from the low-rank coal, the cost of the low-rank coal raw material is only 1 / 10 of that of traditional activated carbon, the stripping degree of a carbon skeleton can be directionally regulated and controlled through a microwave-assisted deep eutectic solvent stripping method, the specific surface area of CQDs is increased to 1800-2500m / g, the content of surface hydroxyl and amino functional groups reaches 8-18mmol / g, and the adsorption capacity to urea is increased to 150-200mg / g.

The invention relates to the technical field of functional food preparation, in particular to a composition capable of improving colitis and a preparation method thereof, and the composition comprises glutamine, a composite plant extract, a zinc source and soluble dietary fibers. Wherein the compound plant extract comprises hericium erinaceus extract, ginseng extract and astragalus extract; the zinc source is zinc glycinate, zinc gluconate and the like; the soluble dietary fiber is fructo-oligosaccharide, inulin, galactomannan oligosaccharide and the like. The preparation method comprises the following steps: directly carrying out dry mixing or carrying out fluidized bed granulation on glutamine to obtain particles A, mixing the composite plant extract and the dietary fibers with ethanol, carrying out spray drying to obtain particles B, and carrying out three-dimensional mixing on the particles B and the zinc source. The composition can maintain the homeostasis of intestinal epithelial cells, reduce oxidative stress and inflammatory response, promote mucosal repair and effectively improve ulcerative colitis, Crohn's disease and chemoradiotherapy-related intestinal mucositis through multi-target action.

This application discloses a jujube seed and Ganoderma lucidum film-coated tablet and its preparation method. The film-coated tablet uses jujube seed and Ganoderma lucidum in a weight ratio of (2.9–3.1):2 as active raw materials, employs a microcrystalline cellulose and erythritol compound as fillers, and combines them with silica, magnesium stearate, and a specific composite film-coating agent. The preparation method includes raw material pretreatment, water extraction, vacuum concentration, vacuum drying, fluidized bed granulation, total mixing and tableting, and film coating, optimizing each process parameter. This application solves the technical problems of existing traditional Chinese medicine extracts, such as high hygroscopicity, poor compressibility, poor stability, and unclear synergistic effects. The prepared product has high active ingredient content, good stability, rapid disintegration, and good patient compliance, making it suitable for large-scale industrial production and possessing good market application prospects.

A fluidized bed granulation and drying device for traditional Chinese medicine preparations belongs to the field of fluidized bed granulation and drying technology. This invention solves the technical problem of low output quality caused by dead zones and channeling in existing multi-functional granulation devices due to their structural design. An air distribution plate is installed at the bottom of the granulation chamber, and an air ring is installed on the lower part of the top surface of the granulation chamber. The air ring is annular with an arc-shaped longitudinal section. The top side of the air ring's longitudinal section is tangent to the top surface of the granulation chamber, and the bottom side of the air ring's longitudinal section is tangent to the side of the granulation chamber. An air equalization component is laid on the upper side of the air distribution plate. The air equalization component includes an air equalization net and a spiral scraper. The spiral scraper is rotatably installed on the lower bottom surface of the air equalization net along a horizontal circumferential direction. The spiral scraper includes a sleeve and blades, with three blades evenly installed on the outside of the sleeve. A rotating shaft is fixedly installed at the center of the lower bottom surface of the air equalization net, and the sleeve is fitted onto the outside of the rotating shaft. This improves the output quality. This invention is used for the granulation of traditional Chinese medicine.

This invention belongs to the field of fluidized bed granulation technology, and specifically discloses a fluidized bed-based carbon nanotube granulation device, including a fluidized tower, a bent pipe connected to the top of the fluidized tower, a buffer cover connected to one end of the bent pipe, a distribution hopper fixed to the bottom of the buffer cover, and a return device inside the distribution hopper. In this invention, fine carbon nanotube particles are filtered and screened through a filter port inside the distribution hopper. The particles attached to one side of the filter port are scraped off by a uniform material device and collected by the return device. When the return device is full of material, the material can be discharged to the bottom of the distribution hopper and re-enter the fluidized tower for refining through a return pipe. When the return device is working, it triggers a feedback device to intermittently apply high-pressure pulses of external high-pressure gas to the filter port to clean it. At the same time, it can push the material inside the return device out to assist in its discharge.

A particulate composition of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-1-methyl-1h-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile comprising: a crystalline form of said compound comprising: a first chiral crystalline form present in an amount of at least 85 wt%, based on the weight of said crystalline form; and a filler. The present invention relates to a pharmaceutical composition comprising a crystalline form of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile comprising at least 95 wt% of a first chiral crystalline form, a process for preparing said composition, the process comprising: providing a crystalline form of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile comprising at least 95 wt% of a first chiral crystalline form; providing a filler; mixing the crystalline form and the filler in a weight ratio of at least 1: 10; subjecting the mixture to a granulation process selected from fluidized bed granulation, high or low shear granulation and dry granulation to obtain a particulate composition; wherein the particulate composition has an amorphous form of not more than 10 wt% of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile, and wherein the particulate composition has an amorphous form of not more than 5 wt% of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile, and wherein the particulate composition has an amorphous form of not more than 5 wt% of 2-(4-(4-(aminomethyl)-1-oxo-1, 2-dihydrophthalazin-6-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile. The present invention relates to a second chiral form of 4-chloro-6-cyclopropoxy-3-fluorobenzonitrile in the form of 4-(2, 2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile.

A fluidized bed granulator for granulating with urea or a urea-containing liquid is described, wherein the granulating liquid is supplied via a supply manifold comprising a header and a standpipe. The standpipe is arranged at least partially inside the channel for the secondary gas.

This invention relates to a paraquat granule and its preparation method, belonging to the field of pesticide technology. The granule consists of paraquat salt, a layered double hydroxide carrier, a disintegrant, microcrystalline cellulose, an outer coating of an emetic / odorant / tracking agent, and the remainder being water-soluble filler. The granule wear rate is ≤2%, it completely disintegrates within 60 seconds in standard hard water at 25℃, and the suspension rate is ≥90%. Preparation employs a one-step process of screw extrusion-centrifugal granulation-vacuum belt drying or fluidized bed granulation, resulting in high content retention. The product is dust-free and non-caking, suitable for drone-based aerial spraying and long-distance sea transport, facilitating large-scale application in overseas registered areas.

A fluidized bed granulation (FBG) system includes a pre-wetting subsystem, wherein feedstock is pre-wet to a predetermined % value, a fluidization chamber (FC), an inlet coupled to the FC, a plenum coupled to the FC by a distributor plate having slots through which a fluidization gas is passed to the FC at a velocity and a direction, an outlet compartment coupled to the FC by a termination plate having one or more filter bags, a liquid binder system adapted to introduce a liquid binder into the FC, and an outlet configured to eject granulated product, and a plurality of sensors adapted to inform a processor executing instructions maintained on a non-transitory memory, wherein the processor using a mass, energy, and fluidization balance model is adapted to optimize the FBG system to provide the granulated product having an optimized geometric mean and geometric standard deviation between about 2.0 and about 1.0.

The utility model relates to the technical field of urea granulation, in particular to a fluidized bed granulation device for urea granule production, which comprises a fluidized bed body, one side of the fluidized bed body is fixedly connected with a first blanking plate, and one side of the fluidized bed body is provided with a base. A first vibration frame is installed at the top of the base, a first screening net is fixedly connected into the first vibration frame, a second screening net is installed in the vibration frame, a rotary drum granulator is arranged on one side of the base, a support is arranged on one side of the rotary drum granulator, a second vibration frame is slidably connected to the top of the support, and a third screening net is fixedly connected into the second vibration frame. A first driving assembly is installed at the top of the base, a second driving assembly is installed at the top of the support, and the fluidized bed granulation device for urea particle production has the advantages that the product particle size qualification rate is increased, the technological process is stabilized, and efficient screening and grading are achieved.

This invention discloses an amoxicillin capsule and its preparation method, relating to the field of pharmaceutical technology. The preparation method includes the following steps: S1: Wet ball milling of amoxicillin trihydrate and hydroxypropyl methylcellulose E5, followed by spray drying to obtain surface-modified amoxicillin trihydrate micropowder; S2: Mixing the surface-modified amoxicillin trihydrate with a filler; S3: Fluidized bed granulation, including spray granulation using aqueous ethanol as a wetting agent followed by drying; S4: Granulation and mixing, including granulating the dried particles and then adding a disintegrant, a flow aid, and a lubricant; S5: Capsule filling, including capsule filling with controlled ambient humidity. This invention achieves the goals of maintaining the crystal stability of amoxicillin trihydrate, inhibiting hydrothermal degradation, and ensuring dissolution behavior consistent with the original drug by combining wet ball milling of hydroxypropyl methylcellulose E5 with spray drying for surface modification, fluidized bed granulation with aqueous ethanol, and controlling the humidity of the filling environment.

The application provides a preparation method of astaxanthin cordyceps militaris fine tablets, comprising the following steps: subjecting cordyceps militaris fruiting bodies to supercritical CO2 extraction treatment to separate a cordyceps militaris terpene component; mixing Haematococcus pluvialis powder and edible vegetable oil, adding the cordyceps militaris terpene component and rosemary extract, and cooling and forming to obtain an astaxanthin-cordyceps militaris terpene blend; crushing the residue after extraction, adding purified water and a composite enzyme preparation to perform enzymolysis to obtain an enzymolysis liquid; adding a chitosan quaternary ammonium salt solution, centrifuging after flocculation, vacuum drying, and crushing to obtain cordyceps militaris active powder; mixing and granulating raw materials to obtain granulation particles; uniformly mixing the granulation particles with xylitol and microcrystalline cellulose, and pressing into tablets; and placing the tablets in a coating machine for coating. The application realizes efficient retention of active ingredients, improvement of safety and stability of product quality through the cooperation of multiple technologies such as supercritical CO2 extraction, enzymolysis flocculation, low-temperature fluidized bed granulation and hot melt coating.

The invention provides a method for preparing coal-based quantum carbon dot slow-release urea through sectional drying-fluidized bed granulation, and relates to the technical field of slow-release fertilizer preparation, the method comprises the following steps: S1, coal-based waste is used as a raw material, coal-based quantum carbon dots MCQDs are prepared through a hydrothermal method, a silane coupling agent is added for surface functional modification, and a functional MCQDs dispersion liquid is obtained; s2, industrial urea is smashed and screened, and urea master batches with the particle size ranging from 1.0 mm to 3.0 mm are obtained; in the pre-drying stage, moisture on the surfaces of urea master batches is thoroughly removed through a low-humidity environment, and particle aggregation caused by moisture during MCQDs spraying is avoided; in the medium-temperature setting stage, in an interval lower than the urea decomposition temperature, MCQDs are promoted to form a covalent bond with a urea crystal face through a silane coupling agent, and the bonding stability is improved; the formed bonding structure is locked in the low-temperature curing stage, structural damage caused by temperature fluctuation is avoided, and the problem of decomposition or agglomeration is solved.

This invention discloses a method for preparing a gastroenteritis preparation with good taste. The steps include: (1) chopping and mixing jujube pulp and ginger, enzymatically hydrolyzing them, separating them to obtain filtrate and residue, concentrating the filtrate under reduced pressure to obtain component I; (2) adding the residue to deionized water, collecting the oil phase by steam distillation to obtain component II; (3) preparing intermediate extract powder; (4) mixing the intermediate extract powder, component I, and component II evenly, adding a binder for fluidized bed granulation, drying to obtain intermediate particles; mixing the intermediate particles with magnesium stearate evenly, compressing into tablets to obtain the gastroenteritis preparation. Adding the excipients prepared in this invention to traditional formulations can improve antibacterial activity, and by adding jujube and ginger extracts, the taste can be improved, infused with fruity aroma, and the ginger extract can mask some of the bitterness of the medicinal materials, making the gastroenteritis preparation taste better.

The invention relates to a method and device for preparing a chemical looping combustion oxygen carrier by using vanadium-titanium blast furnace slag titanium extraction tailings, and the method comprises the following steps: S1, sequentially carrying out first screening and dechlorination on the vanadium-titanium blast furnace slag titanium extraction tailings to obtain a first material; s2, crushing the first material obtained in the step S1 to obtain a second material; s3, mixing the second material obtained in the step S2, an active filler and a binder, and performing fluidized bed granulation to obtain a third material; s4, the third material obtained in the step S3 is subjected to second screening and calcination in sequence, and the chemical looping combustion oxygen carrier is obtained. According to the method, the titanium extraction tailings of the vanadium-titanium blast furnace slag are used as a substance for transferring oxygen in the chemical looping combustion process, the problem of heavy metal pollution caused by waste of the titanium extraction tailings of the vanadium-titanium blast furnace slag is solved, and resource utilization and environmental protection are achieved.

The invention relates to liver-protecting konjac, radix puerariae and semen hoveniae granules and a production control method, and belongs to the technical field of food processing and medicines.The production control method comprises the steps that active ingredients are extracted in a graded mode through a multi-stage separation device, and an initial functional ingredient set is generated; optimizing the raw material proportion by adopting a dynamic proportion algorithm to generate an optimized formula; carrying out ultrasonic-assisted extraction and low-temperature vacuum concentration technology treatment to generate a high-purity functional extract; generating a particle primary product by using a fluidized bed granulation technology, and detecting the content of functional components on line by using a near infrared spectrum analysis technology; a feedback control algorithm is adopted to adjust granulation process parameters, and an optimized path is generated; the components are verified through a gas chromatography-mass spectrometry technology, and a verification report is generated; and recording the key data based on the distributed storage system, and generating a complete production control file. According to the method, efficient extraction, stable production and accurate quality control can be realized, and the product consistency and the market competitiveness are remarkably improved.

The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation method of upatinib sustained release tablets based on fluidized bed granulation. The invention provides a method for preparing upatinib sustained release tablets by adopting a fluidized bed one-step granulation process. The method is suitable for upatinib semihydrate (C crystal form), anhydride (D crystal form) and amorphous raw materials. Through fluidized bed granulation, the main component upatinib is irregularly and uniformly dispersed in the auxiliary materials, the problems of mixing uniformity and content uniformity of the low-proportion main component are solved, the concentration of the main component is diluted by optimizing the adding sequence of the auxiliary materials, and the contact risk of upatinib and tartaric acid is reduced, so that the compatibility problem of upatinib and tartaric acid is solved.

The present invention relates to an oral formulation comprising sevelamer or a pharmaceutically acceptable salt thereof, and a method for preparing the same. Since the formulation is prepared through fluidized bed granulation, damage to the formulation is reduced and variation caused by abrasion is decreased, such that superior quality can be maintained. In particular, the formulation of the present invention has a smaller granule size while exhibiting increased uniformity, thereby improving medication convenience through reduction in the size of the formulation.

The invention provides a gastrointestinal tract adhesion type retention tablet and a preparation method thereof. The retention tablet is prepared from the following components in parts by mass: 0.01-1 part of a nano-drug compound, 2-3.5 parts of a filler, 1.5-2.5 parts of a disintegrating agent, 0.7-1.5 parts of an adhesive mixture and 0.3-0.9 part of carbonate coated Fe3O4 microspheres. Wherein the nano-drug compound is a compound of a gastroenteritis treatment drug wrapped by PLGA and DHA; the adhesive mixture is prepared by mixing an adhesive and polydopamine according to the ratio of 1: 1; the carbonate coated Fe3O4 microspheres have the characteristics of magnetic targeting and sonokinetic response through a Fe3O4 coated sonokinetic response agent. The preparation method comprises a direct tabletting method or an indirect tabletting method, and the indirect tabletting method comprises wet granulation and fluidized bed granulation and is realized by controlling pressure and process parameters. The retention tablet has the characteristics of intragastric adhesion, magnetic targeting and sonokinetic response, so that a medicinal preparation is firmly attached to the surface of gastrointestinal mucosa, and the gastrointestinal tract retention time of the medicine is prolonged.

A user interface (UI) for providing optimal parameters for a fluidized bed granulation process may include a first user input field for receiving the intrinsic properties of the input powder, a second user input field for receiving granulation requirements for the granules formed from the input powder during the fluidized bed granulation process, a third user input field for receiving the operational capabilities of the fluidized bed granulation system, and an output field configured to display the optimal process parameters for the fluidized bed granulation system. The optimal process parameters can be determined by thermodynamically modeling the granulation of the input powder in the fluidized bed granulation system.

The invention belongs to the technical field of traditional Chinese medicine manufacturing, and particularly relates to a traditional Chinese medicine fluidized bed granulation end point detection system, method and device. The method comprises the following steps: receiving traditional Chinese medicine particle spectrum data collected at at least three preset sites; the spectral data are converted into predicted values of key quality attributes of the traditional Chinese medicine particles at all sites on the basis of a quantitative analysis model, the key quality attributes at least comprise the moisture content and the particle size, and the quantitative analysis model is a partial least square regression model; respectively calculating relative standard deviations of the key quality attributes of all sites; and if the key quality attribute predicted values of all the sites reach a preset target range and the relative standard deviation of each key quality attribute predicted value is lower than a set threshold value, generating a granulation end point signal. The invention provides an intelligent and accurate traditional Chinese medicine fluidized bed granulation end point detection scheme.

The invention discloses stable diuron granules and a preparation method thereof, and belongs to the technical field of pesticide preparations. The invention aims to solve the problems of poor water solubility, insufficient photo-thermal stability, out-of-control release and serious dust dissipation of the existing diuron preparation. The core of the preparation method is as follows: micronized diuron, sodium bentonite, pregelatinized starch and nano silicon dioxide are mixed by a dry method to obtain dry-mixed powder; dissolving the modified lignosulfonate and polyethylene glycol in water to prepare a bonding solution; a finished product is obtained by adopting staged fluidized bed granulation (nucleation-growth-surface strengthening) and combining stepped heating drying and screening. The synergistic advantages of low dust, slow release and high photo-thermal stability are realized. The modified lignosulfonate and the staged granulation process are the key core, the comprehensive performance of the embodiment is obviously superior to that of the contrast, the advancement of the formula and the process is proved, and the method has important practical application value.

The utility model belongs to a system capable of simultaneously producing two compound fertilizers with different formulas. Comprising a urea melt pipeline and a compound fertilizer high-tower granulation unit, the compound fertilizer high-tower granulation unit comprises a granulation tower, an outlet of the granulation tower is connected with an inlet of a first screening machine used for screening large-particle fertilizer, and a qualified product outlet of the first screening machine is connected with an inlet of a second screening machine used for screening small-particle fertilizer; a small granular fertilizer outlet of the second screening machine is connected with the roller fluidized bed granulation unit; the urea melt liquid pipeline is respectively connected with the compound fertilizer high tower granulation unit and the roller fluidized bed granulation unit; the fertilizer with unqualified particle size in the high-tower granulation unit of the compound fertilizer is shunted, the returned material is heated by using the molten urea, so that the characteristics of energy conservation and consumption reduction are achieved, and meanwhile, the small-particle fertilizer is used as the seed crystal and is matched with the roller fluidized bed granulation unit to produce a second variety of formula compound fertilizer; therefore, the characteristic of variety diversification of the compound fertilizer is achieved.

The present application relates to the technical field of food processing, in particular to a solid beverage based on edible bird's nest sialic acid derivative and a preparation method thereof, which solves the problems of single functional factor, poor stability and poor brewing property in existing intelligence drinks; by using edible bird's nest stewing material as a natural nutritional wall material, the sialic acid-glycoprotein therein and algal oil form an intelligence "synergistic functional matrix", produce an enhancing effect, and combined with freeze-drying and low-temperature fluidized bed granulation technology, the low-temperature stable embedding of active components is realized, the intelligence activity of nutritional factors of the product, the storage stability and the use convenience are improved, and the product is suitable for brain health conditioning and daily supplement of different people.

The invention relates to a preparation method of a high-purity polycrystalline silicon carbide substrate, which comprises the steps of protective balloon milling, fluidized bed granulation, isostatic pressing, rubber discharging, SPS sintering and machining, and through the protective balloon milling of degassed water and powder, oxidation caused by contact between the powder and oxygen can be effectively avoided; in the fluidized bed granulation process, flowing nitrogen continuously blows over the surface of the nano powder, and oxygen adsorbed on the surface of the nano powder can be gradually replaced with nitrogen. According to the method, high sintering activity of the nano silicon carbide can be kept, sintering densification is easy, high purity of the raw materials can be kept, and preparation of the high-purity polycrystalline silicon carbide substrate can be achieved.

This utility model relates to the field of fertilizer processing technology, and more particularly to a fluidized bed granulation system that can improve granulation efficiency. The fluidized bed granulation system includes a fluidized bed granulation device, within which a granulation section and a cooling section are formed. The granulation section is equipped with at least one sorting extractor, which is used to sort large-particle fertilizer within the granulation section and output it from the fluidized bed granulation device. Small-particle fertilizer seed crystals are added to the granulation section, and then molten fertilizer is sprayed into the granulation section, converting the small-particle fertilizer seed crystals into large-particle fertilizer, which then flows into the cooling section of the fluidized bed granulation device. During this process, the sorting extractor separates qualified particles, increasing the amount of molten fertilizer sprayed onto the small-particle fertilizer per unit area, improving the efficiency of converting small-particle fertilizer into large-particle fertilizer, and ultimately outputting more large-particle fertilizer, thus improving the efficiency of fluidized bed granulation for producing large particles.

The invention discloses a preparation method of a nicotine bag and a nicotine filling particle, and the preparation method comprises the following steps: step A, mixing nicotine nicotine salt powder with additive powder to obtain a powder mixture; step B, carrying out pre-wetting treatment on the powder mixture by utilizing pure water to obtain a premix; and step C, placing the premix and the adhesive solution in a fluidized bed granulator to prepare the nicotine filled particles. According to the nicotine filled particles, under the condition that no other pellet core exists, powdery nicotine is used as a material, accurate regulation and control are carried out through key process parameters in the fluidized bed granulation process, the abnormal conditions of adhesion, caking, excessive dust and the like in the granulation process are reduced, and the stability is improved. And the nicotine bag prepared by taking the nicotine filling particles as contents is better in dissolution effect, relatively stable in nicotine release, full and consistent in flavor in the oral cavity, free of'cliff type 'stimulation or attenuation, and strong in consumer experience feeling.

A fluidized bed granulator for production of urea-containing or nitrate-containing granules may include a granulator interior having granulator interior walls with a first granulator side wall, a second granulator side wall, a granulator front wall that extends transversely to the granulator side walls, and a granulator back wall that likewise extends transversely at the opposite end of the granulator interior from the granulator front wall, a horizontal perforated plate that bounds the granulator interior in a downward direction, a seed entry opening, and a granule exit opening that is disposed at a distance in front of the granulator back wall. A process for producing urea-containing or nitrate-containing granules may utilize the fluidized bed granulator.

The invention discloses a compound medicine composition for treating hyperuricemia, the compound medicine composition comprises a quick-release layer medicine and a slow-release layer medicine, the quick-release layer medicine comprises 0.5-2 parts by mass of dotenorad, and the slow-release layer medicine comprises 20-40 parts by mass of febuxostat; the quick-release layer medicine is quick-release layer particles obtained by dry granulation, the slow-release layer medicine is slow-release layer particles obtained by fluidized bed granulation, and the composite medicine composition is a double-layer tablet prepared by performing double-layer tabletting and film coating on the quick-release layer medicine and the slow-release layer medicine. According to the invention, the selected compound main components are dotenorad and febuxostat which are relatively small in side effect and excellent in curative effect in two channels for reducing uric acid, so that the relative dosage of febuxostat is reduced, and the incidence rate of damage of febuxostat to cardiovascular and liver is reduced in a slow release manner; through mechanism synergy, the curative effect is enhanced, and the traditional Chinese medicine composition has remarkable clinical advantages in treatment of hyperuricemia.