55results about How to "Uniform release rate" patented technology

The invention discloses a controlled release type potassium ferrate composite as well as a preparation method and application thereof. The preparation method is as follows: by taking a high polymer which is biodegradable and environment-friendly as a framework material, dissolving the high polymer in a low-boiling point organic solvent, adding a pore-foaming agent, a dispersing agent and high-purity potassium ferrate, adding the mixture into a medium for emulsifying and curing, and filtering and drying the cured product to obtain the controlled release type potassium ferrate composite. The composite is in a water environment, so that a net-shaped duct structure is formed in an inert framework material by virtue of the hydrophilcity of the pore-foaming agent, and therefore, the potassium ferrate is effectively aided to release from the composite, and a problem that dissolution of active ingredients is affected due to texture compaction of the framework material is avoided; the composite is different from the conventional disposable oxidant, controllable in release speed in water, uniform in velocity, long in holding time, good in storage stability, and has wide application prospect on in-situ repairing polluted underground water.

A coated layer for modifying the surface of vascular scaffold by controlling the content of polyoxyethene in the coated layer to regulate its medicine-carrying performance and the release of medicinal is a polysulfone-polyoxyethene block copolymer with 10000-300000 for its number average molecular weight. Its preparing process features that said block copolymer is coated on the surface of said vascular scaffold directly or after the medicine is added to its solution.

The invention discloses an aerogel material. According to performance parameters of the aerogel material, the average hole diameter ranges from 5 nm to 80 nm, the specific surface area ranges from 5 m<2>/g to 300 m<2>/g, the density ranges from 50 kg/m<3> to 500 kg/m<3>, the coefficient of thermal conductivity ranges from 0.018 W/mK to 0.060 W/mK, the porosity ranges from 60% to 99%, the water absorptivity is less than 5%, and the liquid adsorption capacity is 5-15 times of gravimetric absorption. The aerogel material is good in liquid adsorption capacity and has excellent slow release performance, liquid release speed is uniform, liquid release time is long, and the aerogel material is safe, has no toxic or side effects and can be widely applied to slow release materials of parasiticides or perfume.

The invention provides a lycium ruthenicum anthocyanin crude extract and a controlled-release microcapsule thereof. The anthocyanin crude extract has good antioxidant activity, so that the further purification for an anthocyanin monomeric compound is prevented, and meanwhile, a preparation method is simple and convenient, production materials are easily available, and the production and use costs of the lycium ruthenicum anthocyanin are reduced. The controlled-release microcapsule is an eight-hour controlled-release capsule, the drug release is uniform in speed and complete, the bioavailability of the drug is improved, and the utilization ratio of the drug is guaranteed.

The invention relates to a superfine fiber formulation of Paclitaxel, its preparation process and apparatus, wherein the preparing process comprises dissolving the Paclitaxel into biologically degradable macromolecular solution, carrying out electrical spinning, forming superfine fiber nonwoven fabrics or fabric felt coated by Paclitaxel. The formulation is specially adapted for the localized treatment after tumor operation.

The invention relates to the field of medicinal preparations, in particular to poly-L-lactic acid and polyethyleneglycol block copolymer (PLLA-PEG) supported 5-fluorouracil (5-FU) nanoparticles and a preparation method thereof. The preparation comprises the following components in percentage by weight: 50 to 80 percent of PLLA-PEG, 5 to 20 percent of 5-FU, 1 to 5 percent of beta-cyclodextrin (Beta-CD), 5 to 15 percent of polyvinyl alcohol (PVA) and 5 to 25 percent of PEG. The PLLA-PEG supported 5-FU nanoparticles have the advantages of small average particle size, narrow particle size distribution, high medicine-loading capacity, low toxicity, good targeting performance and the like.

The invention provides a trimetazidine hydrochloride bi-layer osmotic pump controlled release tablet and a preparation method thereof. The osmotic pump controlled release tablet is formed by a drug-containing layer, a booster layer and a coating film, wherein the drug-containing layer comprises the following components in percentage by weight: 10-50% of trimetazidine hydrochloride, 30-80% of suspension agent and the balance of other auxiliary materials; the booster layer comprises the following components in percentage by weight: 20-90% of swelling agent, 5-70% of osmotic active substance and 0.5-5% of lubricating agent; the semipermeable coating film comprises 10-20g of semipermeable high polymer material and 1-5g of water-soluble pore-forming agent every 100 tablets. The trimetazidine hydrochloride bi-layer osmotic pump controlled release tablet can realizes constant release of drug in the body of a patient without being affected by pH value of a medium environment, enzyme, gastrointestinal motility and food, and is capable of maintaining the stability of plasma concentration of drug, reducing toxic and side effects of drug, decreasing dosing frequency and improving compliance of the patient.

The invention belongs to the field of a tobacco product, and discloses a buccal cigarette containing a tobacco full-component extract and a preparation method of the buccal cigarette. The buccal cigarette containing the tobacco full-component extract consists of functional ingredients, a filling agent, a flavoring agent, a lubricating agent and a binding agent, wherein the functional ingredients include a tobacco extract and tobacco extract particles; the tobacco extract particle comprises at least two substrate layers different in tobacco extract content; the surfaces of the substrate layers are coated with coatings layer by layer, and the substrate layers contain excipient; and in the tobacco extract particle, the tobacco extract content in the substrate layers from inside to outside is gradually reduced. In the buccal cigarette containing the tobacco full-component extract, the tobacco component is provided by the tobacco extract and the tobacco extract particle which are complementary during releasing, so as to keep the content of the tobacco component in the aromatized cigarette and to offer durable and uniform taste to consumers.

The invention discloses tablet covering equipment. The tablet covering equipment comprises an operation chamber, a spray gun, an air injection device, a feed inlet device and a recycling device; the spray gun is arranged at the bottom of the operation chamber, and the air injection device comprises a sleeve sleeving the spray gun, an air injection channel arranged in the sleeve and injecting partsconnected with the air injection channel; the air injection part is aslant arranged; since the air injection part is aslant arranged, the tilting directions among the injection parts are the same. Byaslant arranging the air injection part, after being injected, feed can rotate in the sky, and it is guaranteed that covering is uniformly conducted; the time for the feed to stay in the sky is long,the time for the feed to be in contact with a covering material is also longer, and the covering effect is good; uniform covering makes the releasing speed of tablets in gastric juice constant, and people's intestinal health is effectively protected.

The present invention relates to a slow-releasing preparation of Tamoxifen citrate as an anti-tumor medicine and its preparation method. Every tablet of Tamoxifen citrate contains 1 mg-100 mg, and the rest is slow-releasing material and auxiliary material.

The invention discloses chloroacetamide herbicide capsule suspension and a production method thereof. The produced hloroacetamide herbicide capsule suspension is stable in quality and controllable inrelease rate, and has quick release efficacy and slow release efficacy at the same time; and the production method is simple to operate, easy to control, high in production efficiency and short in production time.

The invention belongs to the technical field of medicine preparations, and discloses preparation of lisinopril sustained-release tablets. The lisinopril sustained-release tablets comprise, by weight, 1%-4% of lisinopril, 54%-66% of matrix materials, 18%-24% of pregelatinized starch, 14.2%-17.6% of microcrystalline cellulose and 0.4%-0.8% of magnesium stearate. The matrix materials are carbomer. The preparation of the lisinopril sustained-release tablets includes smashing the lisinopril according to the weight percentage, filtering the lisinopril via a 100-mesh sieve and then adding the lisinopril into a three-dimensional movable mixer; smashing the carbomer, the pregelatinized starch, the microcrystalline cellulose and the magnesium stearate, filtering the carbomer, the pregelatinized starch, the microcrystalline cellulose and the magnesium stearate via an 80-mesh sieve and then adding the carbomer, the pregelatinized starch, the microcrystalline cellulose and the magnesium stearate into the three-dimensional movable mixer; mixing the lisinopril, the carbomer, the pregelatinized starch, the microcrystalline cellulose and the magnesium stearate with one another by the three-dimensional movable mixer for 30 minutes to obtain mixtures and then directly compressing the mixtures to obtain the lisinopril sustained-release tablets. The preparation has the advantages that the mixtures are directly compressed without coating, so that sustained-release effects can be realized; technologies are simple, and medicine is uniform in release speed.

The invention discloses finasteride sustained release tablets. The finasteride sustained release tablets are prepared from the following raw materials: 100 to 150 mg of phospholipid, 40 to 70 mg of glyceride, 50 to 60 mg of ethanol, 2 to 5 mg of finasteride, 10 to 50 mg of micropowder silica gel, 20 to 60 mg of chitosan, 20 to 60 mg of an adhesive, 2 to 10 mg of low-substituted hydroxypropyl cellulose, 0.5 to 5 mg of a lubricant and 0.2 to 2 mg of a sweetening agent. The preparation method comprises the following steps: mixing the phospholipid, the glyceride and the finasteride; adding the ethanol and mixing uniformly; adding the micropowder silica gel, the chitosan and the adhesive and mixing uniformly; performing wet granulation; drying; adding the low-substituted hydroxypropyl cellulose, the lubricant and the sweetening agent and mixing uniformly; and tabletting. The finasteride sustained release tablets provided by the invention have a remarkable sustained-release effect, are uniform in release speed and can reduce the use times; the tablets have high uniform strength and good taste; and the tablets can be used for treating male pattern alopecia and benign prostatic hyperplasia.

The invention relates to drugs for treating mouth mucosa diseases and the manufacture field of the drugs for treating mouth mucosa diseases, in particular to a mouth mucosa drug sustained release preparation for treating a mouth periodontal disease by doxycycline. The preparation is composed of a mouth mucosa contacted layer and a non-adhesiveness sealing layer. The mouth mucosa contacted layer comprises, by weight, 2-20/80-98 of antibiotic drugs and auxiliary materials. The components of the non-adhesiveness sealing layer are non-adhesiveness low water-solubility high-molecular polymers. The non-adhesiveness low water-solubility high-molecular polymers are chosen from polyvinyl alcohol. The components of mouth mucosa drug sustained release preparation comprise 2.0g of methyl vinyl ether-maleic anhydride copolymers, 2.0g of polyoxyethylene, 2.0g of carboxymethyl cellulose sodium, 12.0g of natural starch, 2.0g of menthol and 0.5g of doxycycline, and the rest is poval. The mouth mucosa drug sustained release preparation has the advantages that drug delivering is convenient, drug releasing time is long, drug releasing speed is even, targeting is strong, and adhesive force with mucosas is strong. In addition, the manufacturing method is simple in operation, low in cost, environment-friendly and suitable for industrial production.

The invention relates to the technical field of biological fertilizers, and especially relates to a biological fertilizer and a preparation method thereof. An arc-shaped disc used for bearing the biological fertilizer comprises a carbon cover barrel, a carbon column barrel and an arc-shaped frame. Due to the fact that the added biological fertilizer is prone to loss to all positions in soil blocksunder the rainwater condition, the content of nutrients absorbed by crop root areas is reduced, nutrient supply in the crop growth process is affected, and then the use effect of the biological fertilizer is weakened. Therefore, the storage state of the biological fertilizer under different conditions of the natural environment is protected through the carbon structure of the arc-shaped disc, itis ensured that the biological fertilizer acts on a crop root system area in a land parcel, the release rate of nutrients in the biological fertilizer is balanced through gradual conversion of biological carbon nutrient substances by microbial florae in the crop growth process, the yield of the biological fertilizer is increased. and the time for finally decomposing the carbon structure of the mechanism is controlled to completely decompose the carbon structure in the biological fertilizer, so that the application effect of the biological fertilizer is improved.

The invention provides a flocculating agent. The flocculating agent contains a graphene quantum dot and a polymer linked with the graphene quantum dot, wherein the graphene quantum dot is a graphene oxide quantum dot and contains a first active functional group, the polymer contains a second active functional group, and the graphene quantum dot and the polymer are linked through the condensation of the first active functional group and the second active functional group.

The invention discloses a standard plate for detecting pollution release of a decoration material as well as preparation and application of the standard plate. The standard plate comprises a sealing outer sleeve, a wood plate assembly, a sealing upper cover and a sealing plug, a hole is formed in the bottom surface of the sealing outer sleeve, and the wood plate assembly is composed of a bottom plate, a core plate and a top plate, nested in the sealing outer sleeve and pressed and fixed by the sealing upper cover; the core plate contains a porous material, and radial channels are formed in the core plate; through holes are formed in the centers of the top plate and the sealing upper cover; a sealing plug is inserted into the through holes for sealing. When the standard plate is used, target pollutants are dropped into the through holes, and the target pollutants are diffused and dispersed into the porous material and other interstitial substances in the core plate through the channels by centrifugation and oscillation, so that the standard plate capable of uniformly and stably releasing the target pollutants is obtained. By changing the types and concentrations of the added target pollutants, the pollution release conditions of different product control materials can be detected.