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Surface modified coat of bracket of blood vessel, and preparation method

A vascular stent and surface modification technology, applied in the coating and other directions, can solve the problems of local inflammatory reaction and vascular occlusion caused by degradation products, and achieve the effect of large application value, smooth drug release rate and uniform coating.

Inactive Publication Date: 2007-10-10
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the materials used in drug-eluting stents cannot have all the above advantages at the same time. Therefore, although drug-eluting stents have been successfully used in humans, there are still some problems, especially late thrombotic vascular occlusion, which is a fatal late complication. Symptoms are closely related to the non-degradable polymer materials used
Some scholars pin their hopes on the application of degradable materials, but the degradation products also have problems such as easy to cause local inflammatory reactions

Method used

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  • Surface modified coat of bracket of blood vessel, and preparation method
  • Surface modified coat of bracket of blood vessel, and preparation method
  • Surface modified coat of bracket of blood vessel, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1) Cleaning of the stent: Put the stent in acetone for 20 minutes for ultrasonic cleaning, then put it in hot water at 60-100 degrees Celsius for 20 minutes, then put it in medical disinfectant alcohol for 10 minutes, and finally take it out and dry it for later use.

[0044] 2) Preparation of coating solution: measure 15 milliliters of tetrahydrofuran and put it into a stoppered flask, then weigh 560 mg of polysulfone-polyoxyethylene block copolymer with a polyethylene oxide content of 35%, stopper the bottle tightly, and fix Shake on a shaker for 20-60 minutes until the copolymer is completely dissolved.

[0045] 3) Fix one end of the cleaned bracket on the rotating shaft of the stepper motor capable of rotating and moving back and forth.

[0046] 4) The syringe pump draws the solution prepared in step 2), atomizes it with an ultrasonic nozzle, and then coats it on the surface of the stent. Utilize the reciprocating movement of the support to complete its 10 spraying...

Embodiment 2

[0050] 1) Cleaning of the stent: Put the stent in acetone for 20 minutes for ultrasonic cleaning, then put it in hot water at 60-100 degrees Celsius for 20 minutes, then put it in medical disinfectant alcohol for 10 minutes, and finally take it out and dry it for later use.

[0051] 2) Preparation of the coating solution: measure 15 milliliters of tetrahydrofuran and put it into a stoppered flask, then weigh 600 mg of polysulfone-polyoxyethylene block copolymer with a polyethylene oxide content of 35%, stopper the bottle tightly, and fix Shake on a shaker for 20-60 minutes until the copolymer is completely dissolved; add 200 mg of drug rapamycin to the solution, then shake on a shaker until dissolved.

[0052] 3) Fix one end of the cleaned bracket on the rotating shaft of the stepper motor capable of rotating and moving back and forth.

[0053] 4) The syringe pump draws the solution prepared in step 2), atomizes it with an ultrasonic nozzle, and then coats it on the surface of...

Embodiment 3

[0057] 1) Cleaning of the stent: Put the stent in acetone for 20 minutes for ultrasonic cleaning, then put it in hot water at 60-100 degrees Celsius for 20 minutes, then put it in medical disinfectant alcohol for 10 minutes, and finally take it out and dry it for later use.

[0058] 2) Preparation of coating solution: measure 15 milliliters of tetrahydrofuran and put it into a stoppered flask, then weigh 500 mg of polysulfone-polyoxyethylene block copolymer with a polyethylene oxide content of 45%, stopper the bottle tightly, and fix Shake on a shaker for 20-60 minutes until the copolymer is completely dissolved; add 150 mg of ligustrazine to the solution and shake it on a shaker until dissolved.

[0059] 3) Fix one end of the cleaned bracket on the rotating shaft of the stepper motor capable of rotating and moving back and forth.

[0060] 4) The syringe pump draws the solution prepared in step 2), atomizes it with an ultrasonic nozzle, and then coats it on the surface of the ...

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Abstract

A coated layer for modifying the surface of vascular scaffold by controlling the content of polyoxyethene in the coated layer to regulate its medicine-carrying performance and the release of medicinal is a polysulfone-polyoxyethene block copolymer with 10000-300000 for its number average molecular weight. Its preparing process features that said block copolymer is coated on the surface of said vascular scaffold directly or after the medicine is added to its solution.

Description

technical field [0001] The invention specifically relates to a surface-modified coating of a vascular stent capable of controlling drug release. Belonging to the technical field of medical device manufacturing, Background technique [0002] The technique of treating vascular stenosis by intervention is called angioplasty, English abbreviation PTCA (Percutaneous Transluminal Coronary Angioplasty). The entire operation lasts about 1 to 2 hours. Generally, the symptoms of the patient can disappear immediately after the operation, and the patient can go home to live a normal life the next day after the operation. Compared with the traditional thoracotomy for the treatment of vascular lesions, interventional angioplasty has the advantages of low risk, minimal trauma, fast postoperative recovery, reliable curative effect, low recurrence rate, simple and easy operation, and relatively low operation cost, etc. advantage. After the appearance of this technology, it was welcomed by...

Claims

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Application Information

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IPC IPC(8): A61L29/08
Inventor 顾兴中倪中华易红房建华郭晓霞况永波
Owner SOUTHEAST UNIV
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