109results about How to "Guaranteed Dissolution" patented technology

The invention provides a low-energy incineration fly ash innocent treatment method. The low-energy incineration fly ash innocent treatment method and device are provided for solving the problems that an existing incineration fly ash treatment technology is high in cost, true removal of heavy metal cannot be achieved through stabilizing treatment, Dioxin heat treatment energy consumption is high, and treatment is not complete. Fly ash is subject to desalting, heavy metal removal and Dioxin removal in sequence, a one-valent saline solution with very high purity is obtained, and heavy metal sediment and building materials without contaminant can be subject to resource utilization.

The invention discloses a controlled release type potassium ferrate composite as well as a preparation method and application thereof. The preparation method is as follows: by taking a high polymer which is biodegradable and environment-friendly as a framework material, dissolving the high polymer in a low-boiling point organic solvent, adding a pore-foaming agent, a dispersing agent and high-purity potassium ferrate, adding the mixture into a medium for emulsifying and curing, and filtering and drying the cured product to obtain the controlled release type potassium ferrate composite. The composite is in a water environment, so that a net-shaped duct structure is formed in an inert framework material by virtue of the hydrophilcity of the pore-foaming agent, and therefore, the potassium ferrate is effectively aided to release from the composite, and a problem that dissolution of active ingredients is affected due to texture compaction of the framework material is avoided; the composite is different from the conventional disposable oxidant, controllable in release speed in water, uniform in velocity, long in holding time, good in storage stability, and has wide application prospect on in-situ repairing polluted underground water.

The invention relates to a seaweed, fruit and vegetable milk slice and a production method thereof. The production method comprises the following steps: weighing seaweeds, fruits and vegetables in a certain proportion, mixing, adding a proper amount of water, pulping, carrying out flash extraction, and separating to obtain a supernatant; carrying out vacuum concentration on the supernatant to obtain a seaweed, fruit and vegetable water extract; evenly mixing the seaweed, fruit and vegetable water extract with defatted milk powder, dextrin and magnesium stearate; and placing the mixture into a tablet machine for tabletting to obtain the seaweed, fruit and vegetable milk slice which comprises the following components in parts by weight: 30-45% of seaweed, fruit and vegetable water extract, 35-45% of defatted milk powder, 10-15% of xylitol, 5-10% of dextrin and 3-5% of magnesium stearate. The milk slice provided by the invention has the advantages of mixed flavor of seaweed, fruit and vegetable, moderate sweet, rich nutrition, smooth and fine surface and complete piece shape, simple manufacture method, reasonable process and strong program, is convenient in operation and is suitable for industrial scale production.

The invention discloses a preparation method of sodium cantharidate. The method comprises the following processing steps: performing high temperature carbonization of cantharis, extracting cantharidin, degreasing cantharidin and precipitating, refining cantharidin, synthetizing sodium cantharidate, refining sodium cantharidate, etc. By adopting the preparation method, the extracting time of cantharidin can be greatly shortened, lipidic and peptdic proteins and impurities in crude cantharidin and refined cantharidin can be completely removed, and the yield and purity of cantharidin can be increased. Therefore, sodium cantharidate with higher purity and yield can be obtained, the quality and safety of sodium cantharidate can be further increased and the quality reliability of sodium cantharidate can be increased when used in an injection.

The invention discloses a preparation method of dried ginger extract. The preparation method comprises the following steps of crushing dried ginger, carrying out reflux extraction twice by ethanol, concentrating extract obtained from the previous step into paste, extracting three times by at least one solvent, concentrating extract obtained from the previous step into paste, carrying out clathration treatment by an N-C modified starch solution, and carrying out spray drying to obtain dried ginger extract. The content of an active ingredient gingerol in the dried ginger extract prepared by thepreparation method is increased to the content of 15 to 24%. The preparation method has the advantages of simple operation, environmentally friendly characteristics, no toxicity and low production cost.

The invention discloses esomeprazole magnesium enteric capsules and a preparation method thereof. Esomeprazole magnesium is prepared into enteric coated pellets, and the enteric coated pellets are filled into gastric coated capsules. Each enteric coated pellet consists of an empty pellet core, a medicine carrying layer, two isolating layers, an enteric coated layer and a film coating layer. In order to guarantee stability of medicines, alkaline materials are added in the empty pellet cores; alkali stabilizers and antioxidant are added in the medicine carrying layer; and a high-alkalinity modifier and a low-alkalinity modifier are respectively added in the two isolating layers of each enteric coated pellet. In order to guarantee a dissolution effect, surfactant is added in the enteric coated layers; and stability of products is improved owing to the film coating layers wrapping the outer layers of the enteric coated pellets. Owing to optimized formulation and technology of the pellets, smoothness of a technology is improved, work efficiency is also improved, coating time is shortened, consumption of labor and materials is reduced, and production cost is reduced.

The invention relates to a method for preparing drugs for treating hypertension employing dendrobium officinale and semen raphani as main materials. The method comprises the steps of grinding fried semen raphani, radix ophiopogonis and a white peony root into powder, mixing evenly, heating the mixture, extracting and concentrating to obtain a water extract concentrate; grinding dendrobium officinale into powder, adding the powder to the water extract concentrate; and adding auxiliary materials for molding; or grinding the four medicinal materials into powder and then carrying out alcohol extraction: adding 5fold 75% ethanol for extracting at 60 DEG C for 24h, carrying out extraction twice in all and recovering the ethanol; after alcohol extraction, carrying out water extracting treatment on residues, concentrating and merging the alcohol extraction solution and the water extraction solution; and adding the auxiliary materials for molding. The prepared drugs all are suitable for treatment of patients with hypertension, caused by a yin-deficiency syndrome or a yin-deficiency and yang-predominance syndrome, accompanied by restlessness and insomnia, or all are combined with antihypertensive drugs of the Western medicine for treatment to reduce the dosage of the antihypertensive drugs of the Western medicine. Meanwhile, the drugs are suitable for health use of patients with mild hypertension or normal hypertension.

The invention relates to a traditional Chinese medicine composition for treating periodontitis. The composition comprises the following active pharmaceutical ingredients in parts by weight: 200-800 parts of halite, 150-600 parts of tortoise shells, 50-300 parts of Sichuan lovage rhizome, 50-200 parts of nutgrass galingale rhizome, 50-200 parts of pricklyash peel, 50-200 parts of cortex pseudolaricis, 50-150 parts of cortex phellodendri, 30-150 parts of radix angelicae dahuricae, 50-100 parts of fructus amomi villos, and 10-50 parts of mint. The invention provides a traditional Chinese gel preparation of the traditional Chinese medicine composition, and a preparation method thereof. The traditional Chinese medicine composition has a desirable effect on treatment of periodontitis, the traditional Chinese medicine gel preparation is good in absorption effect, and good in adaptability of patients, and the dosage is easily controlled.

The invention discloses an extraction method of dendrobium alkaloid. The method comprises the steps of: 1) crushing: crushing dried dendrobium; 2) extraction: using 95-100% ethanol and 75-80% ethanolsuccessively for reflux extraction; 3) acidification: conducting decompression concentration, using 3-8% dilute hydrochloric acid for dispersion, conducting centrifugation, and taking the supernatant;4) degreasing: adding petroleum ether into the supernatant, conducting liquid separation, and taking the water phase; 5) alkalinization: adding concentrated ammonia for alkalization, performing vacuum concentration, and conducting freeze-drying; 6) dissolution: using a mixed solution of chloroform and n-butanol in a ratio of 1:0.5-2 as the co-solvent to dissolve the freeze-dried sample; 7) chromatography: using a developing solvent composed of petroleum ether, methanol and ammonia water in a volume ratio of 5:2-3:0.5 for sample application, chromatography and color development; and 8) collection: cutting off silica gel, performing redissolving, conducting cold air circulating concentration, and recovering dendrobium alkaloid. The extraction method can selectively extract water-soluble alkaloid and oil-soluble alkaloid synchronously, reduces solvent use and improves the extraction efficiency.

The invention discloses an enzymes fruitcake and a preparation method thereof. The enzymes fruitcake is prepared from the following raw materials in parts by weight: 95 to 100 parts of self-flow residues and flocculating precipitum in an enzyme fermentation process, and 0 to 5 parts of carrageenan. By sufficiently utilizing the enzyme fermentation byproducts, not only is a novel application field added to the enzyme production process, but also the obtained enzyme fruitcake can better maintain natural active functional components in the enzyme byproduct such as pectin, polyphenols and flavonoids, lactobacillus, saccharomycetes and the like, but also the consumption of additives is greatly reduced, no spice and excessive auxiliary material is needed, and a product is environmentally friendly, natural, organic and excellent in taste. The enzyeme fruitcake can be easier to accept by consumers compared with the traditional cakes due to the nutritional healthcare effect of the fruitcake.

The present invention provides calcium hydrophenyl sulfonate capsule and its preparation process. The present invention has new capsule recipe and new preparation process superior to available technological process. The technological process of the present invention is suitable for industrial production and has high product quality and high medicine leaching degree.

The invention discloses helianthus tuberosus ferment as well as a preparation method, preparation and application thereof. The helianthus tuberosus ferment consists of the following raw materials in parts by weight: 60-80 parts of fresh helianthus tuberosus, and 20-40 parts of sugar. The fresh helianthus tuberosus is used as the raw materials, so that on one hand, the prepared helianthus tuberosus ferment has special color and smell and is good in mouth feel, and the fragrances lasts long; and on the other hand, the helianthus tuberosus ferment is rich in special functional components of inulin, polyphenol flavonoid and the like in the helianthus tuberosus, and nutrient components of various natural vitamins, minerals, trace elements, amino acids and the like. According to the preparation method of the helianthus tuberosus ferment, normal-temperature normal-pressure fermentation is adopted, and fermentation microorganisms come from preferable microorganisms in natural raw materials of the helianthus tuberosus, helianthus tuberosus tragon and the like, so that the helianthus tuberosus ferment is green and safe, notable in efficacy and strong in pertinence, has notable efficacy of improving flora of intestinal tracts of human bodies, resisting metabolic diseases of diabetes, high blood lipid and the like, eliminating free radicals, resisting oxidation, enhancing immunity, resisting tumors and the like, effectively strengthens metabolism, and achieves the purpose of strengthening bodies when being used for complementing ferment of the human bodies.

The invention provides an oral solid preparation containing desmodium styracifolium general flavone and application thereof, wherein the oral solid preparation containing the desmodium styracifolium general flavone comprises desmodium styracifolium general flavone which is an alcohol extract of desmodium styracifolium, and medicinal auxiliary materials. The oral solid preparation containing the desmodium styracifolium general flavone disclosed by the invention has the characteristics of being explicit in effective material basis, controllable in quality standard, good in drug dissolution degree, high in bioavailability, good in quality stability, significant in pharmacology and drug efficacy, less in dosage, safe and convenient to take, and completely applicable to industrial massive production.

The invention relates to a sterilizing agent for sterilizing drinking water, in particular to a method for preparing and using an attapulgite-effervescence sterilizing bag foaming agent in rural water wells, which comprises the following steps: firstly, selecting the raw materials of attapulgites, potassium monopersulfate and foaming agent according to a certain weight part; evenly mixing the rawmaterials, crushing the raw materials and sieving with a 120-mesh sieve; subpackaging the sieved raw materials into food grade non-woven fabric bags with 5 to 100g per bag; and packaging the food grade non-woven fabric bags in a vacuum mode into an aluminum-plastic bag after sealing. When the foaming agent is utilized, the vacuum aluminum-plastic bag packaging is torn, and the non-woven fabric bags filled with the sterilizing raw materials are directly put into water. The sterilizing agent is suitable for quantized pouring and convenient in use, and has the advantages of low production cost and high sterilization efficiency by selecting the raw materials and the proportions thereof, the amount of the bag foaming agent and the packaging material of the bag foaming agent.

The invention provides a solid pharmaceutical preparation containing Riociguat, and in parts by weight, 1mg of Riociguat oral solid preparation is prepared from 1mg of Riociguat, 60-80mg of filler, 2-8mg of binder, 2-8mg of disintegrating agent and 0.5-1.5mg of lubricating agent. The solid pharmaceutical preparation adopts a solid dispersion technology, by mixing and grinding main medicine and the filler, solubleness of the main medicine is improved, a dissolving effect is improved, the dissolving speed of the preparation is ensured, the content uniformity is high, and the bioavailability is high. The preparing process is simple in production process, low in cost and suitable for industrial production.

The invention discloses a high-density aquaculture oxygenation purification method and system. The method comprises the following steps of producing ozone through an ozone generator, producing singlet oxygen through a singlet oxygen generator, producing hydrogen peroxide through a hydrogen peroxide generator, respectively inputting the ozone, the singlet oxygen and the hydrogen peroxide in a gas-water mixer through a metering pump, inputting aquaculture water to be treated in an aquaculture water pipeline in the gas-water mixer through a pipeline, and conducting gas-water mixing under 3-5 barometric pressure; leading the aquaculture water after treatment of the gas-water mixer in the aquaculture water pipeline; and enabling quantity of the aquaculture water treated by the gas-water mixer to be 10-15% of the total of the aquaculture water. The high-density aquaculture oxygenation purification method and system can improve water sterilizing effects, efficiently improve water dissolved oxygen and achieve mariculture on the base of obtaining using effects of the ozone in the aquaculture industry. Through optimization design of a gas-water mixing mode, cost is substantially reduced, and oxygenation purification requirements of an aquaculture environment with high density and small water are met.

The invention relates to a drug preparation technology, and aims to provide an application method of radix paeoniae alba and herba dendrobii officinalis to preparation of an antihypertensive drug. Theapplication method comprises the following steps: grinding radix paeoniae alba into powder, performing alcohol extraction on the radix paeoniae alba powder, extracting residual water left after the alcohol extraction, and combining concentrated extracting solutions; grinding the caulis dendrobii officinalis into powder, adding the caulis dendrobii officinalis powder into the combined extracting solution, and adding accessories to obtain the antihypertensive drug. A combination of an extract prepared by alcohol extraction and water extraction of the radix paeoniae alba and the caulis dendrobiiofficinalis powder has an outstanding curative effect on hypertension, and has an antihypertensive effect which can exceed a western medicine of irbesartan. Compared with conventional water extraction, the alcohol-water extraction method for the radix paeoniae alba has the advantages that component loss is reduced, the effectiveness is improved, complete utilization of oral radix paeoniae alba byhuman body is facilitated, and the curative effect is improved. Compared with most western antihypertensive drugs, the antihypertensive drug has a selective regulating effect on people with high blood pressure without influencing normal blood pressure: the antihypertensive drug can lower high blood pressure, but do not lower normal blood pressure or lower the high blood pressure below normal level.

The invention provides a statin oral self-microemulsifying release preparation and a preparation method thereof. The preparation comprises an effective amount of a statin self-microemulsifying concentrated solution and a medically acceptable carrier. The statin self-microemulsifying concentrated solution comprises, by weight, 1-10% of a calcium salt of (3R, 5S, 6E)-7-[6-fluoro-4,7-diphenylsulfo-quinolyl-3]yl-3,5-dihydroxy-6-heptenoic acid, 10-60% of an oil phase, 20-75% of an emulsifier, 2-45% of a co-emulsifier and 0-5% of an additive. The statin oral self-microemulsifying release preparation improves drug solubility, an oral administration absorption degree and a low cost and can be prepared by simple processes. The statin oral self-microemulsifying release preparation has a higher drug carrying amount and guarantees full dissolution of the statin drug. The statin drug is wrapped in a micro-emulsion and is protected so that drug stability in a human body is improved and a drug concentration in the liver as a targeting part is obviously improved without plasma drug concentration improvement.

The invention relates to a fermentation grape extract, a preparing method of the fermentation grape extract and a preparation containing the fermentation grape extract. The fermentation grape extract contains grape polyphenol and resveratrol. A method for fermenting full grapes with saccharomycetes is utilized, polyphenol substances in full grapes are extracted, and the extraction rate is obviously increased. Meanwhile, operation is simple, cost is low, and the fermentation grape extract is suitable for industrial production. Experiments verify that the fermentation grape extract can remarkably improve the activity of antioxidase in rice and has the anti-oxidation function and an effect better than that achieved in the prior art.

The invention discloses a method for improving the content uniformity of entecavir tablets. The prescription is prepared from the following components: entecavir, sodium alginate, a filler, a glidant,a disintegrating agent and pharmaceutically acceptable ingredients, the entecavir and a water solution of the sodium alginate are mixed, and the mixture and the other ingredients are granulated and tableted. By selecting the materials and optimizing the preparation process, the entecavir tablets have good dissolution and high content uniformity, a general preparation process is used, complicatedpreparation equipment is not required to be used, and industrialization and mass production are achieved.

The invention relates to a preparation method of amlodipine besylate tablets. The preparation method is mainly used for solving the technical problems that existing products are low in yield and poorin dissolution rate. The technical scheme adopted by the invention lies in that the preparation method of amlodipine besylate tablets is characterized by comprising the steps of (1) firstly uniformlymixing amlodipine besylate with gum acacia to obtain a mixed material A; enabling microcrystalline cellulose and calcium phosphate dibasic anhydrous to dissolve in anhydrous ethanol, performing stirring, and then performing spray drying so as to obtain a mixed material B; placing the mixed material A, the mixed material B and magnesium stearate in a high-efficiency wet-method mixed granulating machine, and performing stirring to obtain a mixed material C; adding the mixed material C to a dry-method granulating machine, and screening out fine powder so as to obtain granules I; adding the granules I, magnesium stearate and sodium carboxymethyl starch to a three-dimensional movement mixing machine together, and performing mixing so as to obtain granules II; and tabletting the granules II so as to obtain the amlodipine besylate tablets. The amlodipine besylate tablets are mainly applied to the technical field of medicines.

The application provides a preparation method for processing fixed-size granular decoction pieces by using fresh Chinese rhubarb. According to the preparation method, such complex preparation technologies of Chinese rhubarb medicinal material as harvesting and preliminary processing, drying, water-moistening, slicing, drying and processing, are avoided, loss of effective components of the medicinal material in the secondary processing period is avoided, toxic mucedine produced in the long-time airing process of the Chinese rhubarb medicinal material is avoided, and safety of Chinese rhubarb pieces is guaranteed. The fixed-size granular decoction pieces produced by the preparation method in the application are steady in quality, uniform in specification, differentiable in shape, and good for storage; and meanwhile, by using the preparation method, production efficiency of raw rhubarb pieces is increased.

The invention provides calcium dobesilate capsules. The content of the calcium dobesilate capsules consists of the following components by weight: 521.5 grams of calcium dobesilate monohydrate, 4 to 7 grams of carboxymethyl starch sodium, 1 to 2 grams of magnesium stearate and 20 to 40 grams of 95-percent ethanol. The calcium dobesilate capsules are prepared by the steps of sieving, drying, granulating and mixing calcium dobesilate monohydrate, carboxymethyl starch sodium and magnesium stearate respectively, filling the mixture into capsules and the like. According the detection results, the calcium dobesilate capsules obtained by the preparation method of the invention meet the requirements of China Pharmacopeia 2010 on related matters, weight difference, dissolution degree and the like and that the quality of the calcium dobesilate capsules is guaranteed. The method of the invention is simple, avoids increasing cost, is suitable for large-scale production and has a high application value.

The invention discloses o an oral tablet of acotiamide hydrochloride trihydrate and a preparation method thereof. The acotiamide hydrochloride trihydrate disclosed by the invention adopts a water insoluble filler as the first filler, and aims to still maintain the original particle shape when drug particles contact a dissolution medium and other solutions so as to prevent acotiamide hydrochloride from gathering, thus achieving a good dissolution effect. At the same time, through additional adding of a second filler and a disintegrating agent, the material is ensured with good compressibility and dissolution performance. According to the acotiamide hydrochloride tablet and the preparation method provided by the invention, the operation is simple, the dosage of auxiliary materials is significantly reduced, the tablet weight is small, and while the dissolution rate is guaranteed, the patient compliance is also improved.

The invention relates to a preparation technology of a drug and aims at providing an application method of a drug for treating high blood pressure. The preparation technology comprises the following steps: taking radix paeoniae alba, grinding into powder, carrying out alcohol extraction and carrying out water extraction treatment on residues subjected to the alcohol extraction; respectively concentrating an extracting solution and then combining; adding accessories according to a conventional pharmaceutical processing method to obtain a drug dosage form for treating the high blood pressure. According to the preparation method disclosed by the invention, an extract obtained by an alcohol-water extracting method of the radix paeoniae alba has an outstanding curative effect of treating the high blood pressure: after the drug is administrated, the lowering speed of blood pressure is remarkably increased recently, the lowering amplitude is significantly improved, and the antihypertensive effect of the drug can exceed that of western medicine irbesartan. Compared with conventional water extraction, the application method disclosed by the invention has the advantages that the component loss is reduced, further the effectiveness is improved, the radix paeoniae alba is promoted to be completely utilized by a human body through oral medication, and the curative effect is improved. The drug selectively adjusts patients with the high blood pressure and has no influence on normal blood pressure.

The invention discloses meatloaf with the flavor of salted egg yolk and a making method of the meatloaf. The meatloaf is prepared from, by weight, 900-1,000 parts of fish, 400-500 parts of streaky meat, 300-400 parts of water, 500-600 parts of starch, 6-10 parts of fresh ginger, 1-2 parts of sesame oil, 2-3 parts of chicken essence, 80-100 parts of egg white, 80-100 parts of salted egg yolk, 8-10parts of soy sauce, 20-25 parts of edible salt, 6-8 parts of white sugar, 4-5 parts of table vinegar, 6-8 parts of rice wine and 50-60 parts of egg yolk. The meatloaf with the flavor of salted egg yolk is gray white in appearance and has yellow laying pulp on the surface and is attractive in color and luster, the profile of the meatloaf is of a loose and porous structure, meat particles are addedinto the meatloaf, and the meatloaf is elastic and easy to eat, has both freshness and deliciousness of fish and meat and the unique salty flavor of the salted egg yolk, is delicious but not greasy, and palatable in freshness and saltness.

The invention relates to an amlodipine besylate tablet, and mainly solves the technical problems of low yield and poor dissolution rate of existing products. The key point of the technical solution isas follows: the amlodipine besylate tablet is characterized in that the amlodipine besylate tablet comprises amlodipine besylate, micro-powder silica gel, microcrystalline cellulose, anhydrous calcium hydrogen phosphate, magnesium stearate and sodium carboxymethyl starch. The amlodipine besylate tablet is mainly applied to the technical field of medicines.

The invention relates to a preparation method of glimepiride tablets. The preparation method of the glimepiride tablets comprises the following steps: taking micronized glimepiride as a raw material;mixing the micronized glimepiride with auxiliary materials with relatively good solubilization effects, namely lactose and povidone, for a long period of time; and then, adding a certain amount of water or an aqueous ethanol solution as a moistening agent. According to the preparation method of the glimepiride tablets, the time of shearing and mixing is increased, so that the solubilization effects are promoted; and magnesium stearate, which has relatively little influence on dissolution, is added for performing mixed tablet compression, so that the final dissolution rate of the main drug is ensured with similarity of several dissolution curves between the self-made product and the reference preparation improved.

The invention provides a method for testing the content of eutectic phosphorus in ardealite. The method comprises the following steps of: mixing pretreated ardealite with an inorganic acid solution with the concentration of 0.0001-0.01 mol / L, and carrying out solid-liquid separation after reaction to obtain a pickling solution; testing the phosphorus content and the sulfate radical content of the obtained pickling solution; completely dissolving out phosphorus in the ardealite by adopting an acid dissolution method, and measuring the total phosphorus content of the ardealite; and setting the difference value between the total phosphorus content and the phosphorus content is the content of the eutectic phosphorus in the ardealite. According to the method, corresponding pickling process conditions are selected according to the types of phosphorus impurities in the ardealite to ensure that soluble phosphorus and insoluble phosphorus in the ardealite are completely dissolved out, and then the content of the eutectic phosphorus in the ardealite is quantitatively obtained by comparing the content with the total phosphorus content in the ardealite, so that the influence of the content of the eutectic phosphorus on the performance of the ardealite is conveniently researched; and the method is easy and convenient to operate, simple in process, low in cost and wide in application prospect.