Preparation method of sodium cantharidate

A technology of sodium cantharidinium and cantharidinium, which is applied in the direction of organic chemistry, etc., can solve problems such as long production cycle, and achieve the effects of shortening production cycle, reducing solvent usage, and reducing cost

Active Publication Date: 2011-08-10
贵州君之堂制药有限公司
View PDF7 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the extraction step of cantharidin, the above four patents all use the method of soaking to extract the cantharidin. The disadvantage of this extraction method is that the production cycle is relatively long, and usually needs to be soaked for more than 24 hours, and the yield is 74%, which is relatively low.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of sodium cantharidate
  • Preparation method of sodium cantharidate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] Example. Such as figure 1 As shown, the preparation method of the present invention comprises the following steps: (1) high-temperature carbonization of the cantharidin: the cantharidin is picked, and the sundries are removed, then dried and ground into fine powder, so that the fineness of the cantharidin powder is between 40 and 60 mesh, according to the volume ratio of cantharidin powder: water = 1:1, add water to the cantharidin powder and stir to form a paste, put it in an electric oven, adjust the temperature to 205°C, and gradually bake until the cantharidin is charred ; Take it out and gradually cool until white crystals are precipitated in the carbonized powder, and crushed to obtain the carbonized powder of cantharidin crystals.

[0020] (2) Weigh 1kg of cantharidin crystalline carbonized powder, put it in a 3000ml round bottom flask, add 200ml of concentrated hydrochloric acid, then add 3L of ethyl acetate, perform ultrasonic extraction at 60°C for 2 times, e...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a preparation method of sodium cantharidate. The method comprises the following processing steps: performing high temperature carbonization of cantharis, extracting cantharidin, degreasing cantharidin and precipitating, refining cantharidin, synthetizing sodium cantharidate, refining sodium cantharidate, etc. By adopting the preparation method, the extracting time of cantharidin can be greatly shortened, lipidic and peptdic proteins and impurities in crude cantharidin and refined cantharidin can be completely removed, and the yield and purity of cantharidin can be increased. Therefore, sodium cantharidate with higher purity and yield can be obtained, the quality and safety of sodium cantharidate can be further increased and the quality reliability of sodium cantharidate can be increased when used in an injection.

Description

technical field [0001] The invention relates to a preparation process of sodium cantharidinate, which belongs to the technical field of medicines. Background technique [0002] In Chinese patents CN1166669C, CN1586500A, CN101633661A and CN101012230A, the preparation process of sodium cantharidate is disclosed. In the extraction step of cantharidin, the above four patents all use the method of soaking to extract the cantharidin. The disadvantage of this extraction method is that the production cycle is relatively long, and usually needs to be soaked for more than 24 hours, and the yield is 74%, which is relatively low. . Cantharidin is extracted and separated from the cantharidin animal body, and then chemically synthesized into sodium salt to obtain the raw material of sodium cantharidate. The applicant has found through research that the cantharidin extracted and separated from the cantharidin contains various levels of A peptide water-soluble protein (acidic, neutral, ba...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/08
Inventor 张芝庭
Owner 贵州君之堂制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap