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Application method of radix paeoniae alba and caulis dendrobii officinalis to preparation of antihypertensive drug

A technology of Dendrobium officinale and high blood pressure is applied in the application field of white peony root and Dendrobium officinale in the preparation of drugs for treating hypertension, can solve problems such as the compatibility and use of traditional Chinese medicines, and achieves the improvement of quick-acting antihypertensive effect, the improvement of antihypertensive curative effect, and the improvement of long-term effects. antihypertensive effect

Active Publication Date: 2018-10-12
HANGZHOU DANHE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the use of traditional Chinese medicine, these two traditional Chinese medicines have never been used in combination

Method used

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  • Application method of radix paeoniae alba and caulis dendrobii officinalis to preparation of antihypertensive drug
  • Application method of radix paeoniae alba and caulis dendrobii officinalis to preparation of antihypertensive drug
  • Application method of radix paeoniae alba and caulis dendrobii officinalis to preparation of antihypertensive drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Dendrobium officinale 8 parts, white peony 6 parts:

[0038] Take 400g of Dendrobium officinale and 300g of Radix Paeoniae Alba in accordance with the 2015 edition of "Chinese Pharmacopoeia".

[0039] Grind Radix Paeoniae Alba into powder, add 70% ethanol of 7 times the total crude drug amount, and extract under reflux for 1 hour, extract twice, and extract the residue with water after alcohol extraction;

[0040] The residue after alcohol extraction of Paeoniae Alba was extracted twice with water: the first water extraction: add 10 times the amount of crude drug in water, extract at 100°C for 1 hour; the second water extraction: add 10 times the total amount of crude drug in water, Extract at 100°C for 1 hour. The aqueous extracts were combined and concentrated. Combine Paeoniae Alba Alcoholic Extract and Water Extract.

[0041] Grinding Dendrobium officinale into powder, adding Dendrobium officinale powder to the combined extract of Paeoniae Alba and water, and add...

Embodiment 2

[0043] Dendrobium officinale 8 parts, white peony root 2 parts:

[0044] Take 400g of Dendrobium officinale and 100g of Radix Paeoniae Alba in accordance with the 2015 edition of "Chinese Pharmacopoeia".

[0045] Grind Radix Paeoniae Alba into powder, add 70% ethanol of 7 times the total crude drug amount, and extract under reflux for 1 hour, extract twice, and extract the residue with water after alcohol extraction;

[0046] The residue after alcohol extraction of Paeoniae Alba was extracted twice with water: the first water extraction: add 10 times the amount of crude drug in water, extract at 100°C for 1 hour; the second water extraction: add 10 times the total amount of crude drug in water, Extract at 100°C for 1 hour. The aqueous extracts were combined and concentrated. Combine Paeoniae Alba Alcoholic Extract and Water Extract.

[0047] Grinding Dendrobium officinale into powder, adding Dendrobium officinale powder to the combined extract of Paeoniae Alba and water, an...

Embodiment 3

[0049] Dendrobium officinale 8 parts, white peony root 32 parts:

[0050] Take 100g of Dendrobium officinale and 400g of Radix Paeoniae Alba in accordance with the 2015 edition of "Chinese Pharmacopoeia".

[0051] Grind Radix Paeoniae Alba into powder, add 70% ethanol of 7 times the total crude drug amount, and extract under reflux for 1 hour, extract twice, and extract the residue with water after alcohol extraction;

[0052] The residue after alcohol extraction of Paeoniae Alba was extracted twice with water: the first water extraction: add 10 times the amount of crude drug in water, extract at 100°C for 1 hour; the second water extraction: add 10 times the total amount of crude drug in water, Extract at 100°C for 1 hour. The aqueous extracts were combined and concentrated. Combine Paeoniae Alba Alcoholic Extract and Water Extract.

[0053] Grinding Dendrobium officinale into powder, adding Dendrobium officinale powder to the combined extract of Paeoniae Alba and water, a...

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Abstract

The invention relates to a drug preparation technology, and aims to provide an application method of radix paeoniae alba and herba dendrobii officinalis to preparation of an antihypertensive drug. Theapplication method comprises the following steps: grinding radix paeoniae alba into powder, performing alcohol extraction on the radix paeoniae alba powder, extracting residual water left after the alcohol extraction, and combining concentrated extracting solutions; grinding the caulis dendrobii officinalis into powder, adding the caulis dendrobii officinalis powder into the combined extracting solution, and adding accessories to obtain the antihypertensive drug. A combination of an extract prepared by alcohol extraction and water extraction of the radix paeoniae alba and the caulis dendrobiiofficinalis powder has an outstanding curative effect on hypertension, and has an antihypertensive effect which can exceed a western medicine of irbesartan. Compared with conventional water extraction, the alcohol-water extraction method for the radix paeoniae alba has the advantages that component loss is reduced, the effectiveness is improved, complete utilization of oral radix paeoniae alba byhuman body is facilitated, and the curative effect is improved. Compared with most western antihypertensive drugs, the antihypertensive drug has a selective regulating effect on people with high blood pressure without influencing normal blood pressure: the antihypertensive drug can lower high blood pressure, but do not lower normal blood pressure or lower the high blood pressure below normal level.

Description

technical field [0001] The invention relates to medicine preparation technology, in particular to the application method of Radix Paeoniae Alba and Dendrobium officinale in the preparation of medicines for treating hypertension. Background technique [0002] Hypertension is a common high incidence clinically, which has serious harm to the heart, brain, kidney and other important organs. Western medicine treatment of hypertension still lacks the medicine for adjusting body constitution and can adjust blood pressure (depressor). The antihypertensive treatment of modern medicine is all symptomatic treatment. Currently commonly used antihypertensive drugs include calcium channel blockers (CCBs), angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), diuretics, and β-blockers. , still can not completely prevent the progression of hypertension and its secondary lesions. Most hypertensive patients need two or more antihypertensive drugs to rea...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P9/12A23L33/10
CPCA23V2002/00A23L33/10A23L33/105A23V2200/326A23V2300/14A23V2250/21
Inventor 吴人照吴悦陈宇
Owner HANGZHOU DANHE PHARM CO LTD
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