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Quercetin sustained release tablet and preparing method thereof

A technology of quercetin and sustained-release tablets, which can be applied in pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, and can solve problems such as no reports of quercetin sustained-release preparations, and achieve stable curative effect and convenient administration , low-cost effect

Inactive Publication Date: 2012-12-19
YANCHENG TEACHERS UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] There is no relevant report about quercetin sustained-release preparations

Method used

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  • Quercetin sustained release tablet and preparing method thereof
  • Quercetin sustained release tablet and preparing method thereof
  • Quercetin sustained release tablet and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] prescription

[0053] prescription composition

1000 pieces

Quercetin

216g

Hydroxypropyl methylcellulose K4M

10g

starch

115g

Croscarmellose sodium

14g

Magnesium stearate

5g

pure water

Appropriate amount

[0054] craft

[0055] (1) Pulverize the quercetin, sieve through an 80-mesh sieve, and set aside.

[0056] (2) Weigh the recipe quantities of quercetin, hydroxypropyl methylcellulose K4M, and starch and mix them evenly, add an appropriate amount of pure water as a wetting agent to make soft materials, pass the soft materials through a 20-mesh sieve to make wet granules, and bake at 60°C Dry, granulate with an 18-mesh sieve, add croscarmellose sodium and magnesium stearate in recipe quantities, and mix well.

[0057] (3) Tablet.

Embodiment 2

[0059] prescription

[0060] prescription composition

1000 pieces

[0061] Quercetin

216g

Hydroxypropyl methylcellulose K15M

5g

starch

120g

low substituted hydroxypropyl cellulose

14g

Talc powder

5g

pure water

Appropriate amount

[0062] craft

[0063] (1) Sieve the quercetin through an 80-mesh sieve and set aside.

[0064] (2) Weigh the recipe quantities of quercetin, hydroxypropyl methylcellulose K15M, and starch and mix them evenly, add an appropriate amount of pure water as a wetting agent to make soft materials, pass the soft materials through a 20-mesh sieve to make wet granules, and bake at 60°C Dry, granulate with an 18-mesh sieve, add low-substituted hydroxypropyl cellulose and talc powder in the recipe quantity, and mix well.

[0065] (3) Tablet.

Embodiment 3

[0067] prescription

[0068] prescription composition

1000 pieces

Quercetin

270g

Hydroxypropyl methylcellulose K4M

10g

starch

60g

Croscarmellose sodium

15g

Magnesium stearate

5g

pure water

Appropriate amount

[0069] craft

[0070] (1) Sieve the quercetin through an 80-mesh sieve and set aside.

[0071] (2) Weigh the recipe quantities of quercetin, hydroxypropyl methylcellulose K4M, and starch and mix them evenly, add an appropriate amount of pure water as a wetting agent to make soft materials, pass the soft materials through a 20-mesh sieve to make wet granules, and bake at 60°C Dry, granulate with an 18-mesh sieve, add croscarmellose sodium and magnesium stearate in recipe quantities, and mix well.

[0072] (3) Tablet.

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PUM

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Abstract

The invention discloses a quercetin sustained release tablet which is prepared from quercetin, a sustained release material and other auxiliary materials. The invention also discloses a preparing method of the quercetin sustained release tablet. With the sustained release tablet, the administration times and amount are reduced, stable and lasting release of the medicine is achieved, and the safety and effectiveness of the medicine are improved.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a pharmaceutical sustained-release solid preparation, in particular to a sustained-release tablet of quercetin and a preparation method thereof. Background technique [0002] Quercetin is a phyto-derived flavonoid found in fruits, vegetables and grains and other plants. It can be used as food, medicine, and health care products. Reduce capillary fragility, lower blood lipids, dilate coronary arteries, and increase coronary blood flow. In addition, quercetin has anti-inflammatory, antioxidant, expectorant, cough, diarrhea, and asthma effects. [0003] Quercetin is also known as 3,3',4',5,7-pentahydroxyflavone, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzo Pyran-4-one, quercetin, and quercetin are flavonoids. It is yellow crystal at normal temperature and pressure, soluble in hot ethanol, cold ethanol, soluble in methanol, acetone, ethyl acetate, glacial acetic ac...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/28A61K31/352A61K47/42A61K47/38A61P9/12A61P9/10A61P11/00A61P11/06A61P9/14A61P35/00
Inventor 喻樊
Owner YANCHENG TEACHERS UNIV
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