11results about How to "Lasting effect" patented technology

The invention discloses a facial ligament lifting method, which comprises the following steps of S1, accurately marking a subcutaneous attachment end or a body surface projection area corresponding to a target facial ligament on the surface of facial skin on the basis of facial anatomical positioning and anatomical walking of the target facial ligament, so that the subcutaneous attachment end or the body surface projection area corresponding to the target facial ligament is accurately marked on the basis of facial anatomical positioning; acting force is accurately focused on the target ligament through a special instrument, and surrounding tissue is prevented from being damaged. The whole process is only operated on the skin surface, no incision or implantation is needed, surgical wounds and wire foreign matter risks are thoroughly avoided, the composite force can be effectively conducted to the deep ligament to enable the deep ligament to generate controllable folding deformation, stable fixation is achieved through a subsequent biological healing mechanism, ligament relaxation is fundamentally improved, the effect is more natural and lasting, and the application range is wide. Due to the fact that skin breaking is not needed and energy is controllable, the operation safety is greatly improved, and dynamically-adjusted mechanics and selectable hot-cold collaborative procedures aim at optimizing experience and ensuring the comfort degree of the process.

The invention relates to the field of medicines, in particular to application of tRF-5030c in preparation of a product for treating non-small cell lung cancer. The tRF-5030c provided by the invention is not a simple sequence design product, but is a direct experimental evidence based on the interaction of the tRF-5030c and the double-target protein. Cooperative regulation and control of two key mechanisms are achieved through the single molecular entity, and the problems of low synergistic efficiency and toxicity superposition caused by pharmacokinetic differences, structural isomerism and action target cell heterogeneity of multiple drugs are fundamentally solved. It is ensured that dual inhibition of PARP1 mediated DNA repair and EGFR driven survival signals is highly consistent in time and space.

The invention belongs to the technical field of air purification materials, and discloses an antibacterial formaldehyde removal catalyst as well as a preparation method and application thereof. The antibacterial formaldehyde removal catalyst comprises a perylene quaternary ammonium salt-graphene composite antibacterial agent, a catalytic active component, an inorganic biochar binder and a pore forming agent, manganese dioxide granulation is achieved by constructing a porous framework, the activity of manganese dioxide is reserved, graphene inhibits agglomeration through a flexible sheet layer and establishes a conductive path, and the common core lies in that through structure fixation instead of dense wrapping, the smoothness of a reactant diffusion channel is maintained to the maximum extent while the particles are endowed with mechanical strength, and the mechanical performance of the particles is improved. Shielding and sintering of active sites in the granulation process are avoided, so that the catalytic activity of manganese dioxide is efficiently reserved; the catalyst has a dual-function integrated effect, and also has efficient room-temperature catalytic formaldehyde removal capability and broad-spectrum antibacterial capability, so that the structure of an air purification system is simplified.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

The invention discloses compound lactic acid bacteria, a metagen and a preparation method and application of the compound lactic acid bacteria and the metagen. Through composite compatibility of the probiotics separated from the yak yoghurt in the Qinghai-Tibet Plateau, a synergistic effect of various strains is exerted, negative effects caused by treatment by using a medicine means are avoided, side effects are avoided, and the problems of single effective microbial community, low regulation capability and the like in the prior art are solved. By adding the selective auxiliary materials, the survival rate of the compound probiotics after freeze-drying treatment is improved, the probiotics can more effectively resist the adverse environment of the gastrointestinal tract, the problems that in the prior art, the probiotics are prone to being damaged by gastric acid, the survival rate is reduced in the storage process, and a large amount of probiotics are inactivated before entering the intestinal tract are solved, the planting rate of the probiotics is increased, and the survival rate of the probiotics is increased. The effect is more durable and more stable. Through synergistic compatibility of the composite probiotics and functional prebiotics from characteristic plant resources from the Tibet Plateau, the intestinal flora balance adjusting capacity is improved, and the beneficial effects of effectively improving symptoms such as constipation and obesity are further achieved.

The application discloses a dark septate endophytic fungus strain and application thereof, and the strain is a dark septate endophytic fungus strain YMF1.068, the preservation name is Paraphoma vinacea, and the strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) and has a preservation unit address of No. 3, Xibin West Road, Chaoyang District, Beijing, a preservation date of May 20, 2024, and a preservation number of CGMCC No. 41305. The strain can effectively prevent and control root-knot nematode disease, has high lethal activity, enhances plant resistance, and is safe to humans and animals and free of residues. The application of a microbial agent prepared by using the strain on tomatoes, cucumbers and tobacco shows a control effect of more than 68%, which is equivalent to the effect of chemical pesticides, and the microbial agent shows potential and market prospects as a biological pesticide.

This application relates to the field of daily chemical technology, specifically disclosing a herbal compound nasal congestion-relieving essential oil composition and its processing method. The composition is prepared from a compound nasal congestion-relieving base oil obtained by mixed extraction of Magnolia biondii, Xanthium sibiricum, and Angelica dahurica, menthol rosmarinic acid ester, a homologous regulator of esterase activity, natural borneol extracted from natural plants, and medium-chain triglycerides. The homologous regulator of esterase activity is selected from oleanolic acid or crataegolic acid. The preparation method is as follows: first, the compound nasal congestion-relieving base oil is prepared by supercritical extraction; then, menthol rosmarinic acid ester is obtained through enzymatic synthesis; subsequently, the base oil undergoes micro-trace enzyme anchoring modification; finally, the components are mixed through a gradient phase fusion process and bottled to obtain the finished product. This composition can be used to relieve nasal congestion symptoms caused by acute rhinitis and allergic rhinitis, and has the advantages of stable nasal congestion-relieving effect, long duration of action, and low mucosal irritation. The preparation method is green and environmentally friendly, the product has high purity, and good batch-to-batch consistency.

The invention belongs to the technical field of medicines, and particularly relates to a silybum marianum composition for improving liver function and a preparation method thereof, the composition comprises quick-release cholagogic micro powder and slow-release liver-nourishing particles in a mass ratio of 1: (2-4); the quick-release cholagogic micro powder is prepared from curcumin, fructus aurantii immaturus flavone, a tanshinone extract and PVP K30 through ball-milling solid dispersion; the slow-release liver-nourishing particle is of a core-shell structure, a freeze-drying core of the slow-release liver-nourishing particle contains silymarin and schizandrin extract, and a glycyrrhetinic acid-phospholipid / chitosan oligosaccharide targeted coating and a medicinal acrylic resin coating are sequentially arranged on an outer layer of the slow-release liver-nourishing particle. According to the composition, through sequential synergy of'first defibering and then repairing 'and a liver targeting effect, the content of silymarin in liver tissue is remarkably increased, the silymarin is retained for a long time, and liver function impairment such as non-alcoholic fatty liver disease is effectively improved.

This invention belongs to the field of oral solid dosage form technology and relates to a loratadine sustained-release capsule and its preparation method. This application provides a loratadine-containing sustained-release capsule, wherein loratadine is melt-mixed with citric acid and salicylic acid to prepare a drug-containing core, and the core is coated with a sustained-release layer, an immediate-release layer, and a protective layer. This not only effectively solves the problem of slow dissolution of loratadine in the presence of insufficient gastric acid, but also ensures uniform drug release, achieving long-lasting effects and increased efficacy.

This invention discloses a highly bioavailable ticagrelor solid dispersion, its formulation, preparation method, and application. The solid dispersion is prepared by hot melt extrusion of ticagrelor and a specific ternary carrier system, wherein the ternary carrier system is from Soluplus. ® The formulation consists of copovidone and hydroxypropyl methylcellulose. This solid dispersion is further combined with disintegrants, fillers, and lubricants to form a pharmaceutical composition. This invention utilizes the synergistic effect of a ternary carrier and hot-melt extrusion technology to ensure ticagrelor exists stably in an amorphous form, significantly improving drug dissolution and oral bioavailability. Experiments show that the formulation exhibits a dissolution rate ≥85% in pH 6.8 phosphate buffer after 30 min, and a relative bioavailability in beagle dogs reaching 150%–250% of commercially available tablets. It also demonstrates excellent stability, with no crystallization observed in a 6-month accelerated assay, indicating significant clinical value and market potential.

The invention provides a fungus and actinomycete complex microbial inoculant for preventing and treating root rot. The complex microbial inoculant contains spiropolyspora rosea with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.42332 and streptomyces taenanensis with the preservation number of CGMCC No.36965. The invention further provides a preparation method of the fungus and actinomycete complex microbial inoculant. The invention also provides an application of the fungus and actinomycete complex microbial inoculant. The complex microbial inoculant provided by the invention contains fermentation products of spiropolyspora roseus HLY-1 and streptomyces talanigerum NYC 1-5, the two fermentation products have no inhibition effect, and a synergistic effect can be generated by mixed application of the two fermentation products.