22results about How to "Lasting effect" patented technology

The invention relates to the technical field of biological prevention and treatment, and discloses a composition for preventing and treating rice sheath blight disease, which is prepared from the following raw materials in parts by weight: 80 to 90 parts of validamycin, 30 to 45 parts of traditional Chinese medicine extract paste, 10 to 20 parts of traditional Chinese medicine raw medicine, 15 to 19 parts of white carbon black, 10 to 17 parts of copper sulfate, 12 to 16 parts of chitosan, 9 to 15 parts of gibberellin, 5 to 9 parts of tebuconazole, 1 to 5 parts of compound sodium nitrophenolate, 2 to 4 parts of emulsifier and 1 to 3 parts of synergist. Gleditsia sinensis, sanguisorba officinalis, flos rhododendri mollis and sapindus mukorossi peel in the traditional Chinese medicine raw medicines are used for synergistically killing bacteria, enhancing the immunity of plants and delaying the decomposition of validamycin, and meanwhile, extracts of honeysuckle, dandelion, croton and artemisia annua in the traditional Chinese medicine extract are complementary with validamycin in the aspects of sterilization, virus resistance and plant resistance improvement; therefore, the effect of validamycin is more durable, the duration of single application is longer, and the manpower and material resource cost is saved.

The invention discloses a dark-color isolated endophytic fungus strain and application thereof, the strain is a dark-color isolated endophytic fungus strain YMF1.068, the preservation name is dark-color isolated endophytic fungus (Paraphoma vinacea), the strain is preserved in China General Microbiological Culture Collection Center (CGMCC), the address of the preservation unit is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No.689. The preservation date is May 20, 2024; the preservation number is CGMCC (China General Microbiological Culture Collection Center) The strain can effectively prevent and treat root knot nematode disease, has high lethal activity, enhances plant resistance, is safe to human and livestock, and has no residue. The microbial agent prepared by utilizing the strain shows the control effect of 68% or above when being applied to tomatoes, cucumbers and tobaccos, the effect of the microbial agent is equivalent to that of a chemical pesticide, and the potential and market prospect of the microbial agent as a biological pesticide are shown.

The present invention provides a combination of a compound of formula (I) or a pharmaceutically acceptable salt thereof and an anti-cancer agent for the treatment of cancer wherein the compound of formula (I) is a bifunctional compound having G12D mutant KRAS inhibitory activity, and wherein the compound of formula (I) and the anti-cancer agent are as described in the specification.

The invention discloses a facial ligament lifting method, which comprises the following steps of S1, accurately marking a subcutaneous attachment end or a body surface projection area corresponding to a target facial ligament on the surface of facial skin on the basis of facial anatomical positioning and anatomical walking of the target facial ligament, so that the subcutaneous attachment end or the body surface projection area corresponding to the target facial ligament is accurately marked on the basis of facial anatomical positioning; acting force is accurately focused on the target ligament through a special instrument, and surrounding tissue is prevented from being damaged. The whole process is only operated on the skin surface, no incision or implantation is needed, surgical wounds and wire foreign matter risks are thoroughly avoided, the composite force can be effectively conducted to the deep ligament to enable the deep ligament to generate controllable folding deformation, stable fixation is achieved through a subsequent biological healing mechanism, ligament relaxation is fundamentally improved, the effect is more natural and lasting, and the application range is wide. Due to the fact that skin breaking is not needed and energy is controllable, the operation safety is greatly improved, and dynamically-adjusted mechanics and selectable hot-cold collaborative procedures aim at optimizing experience and ensuring the comfort degree of the process.

The invention relates to the field of medicines, in particular to application of tRF-5030c in preparation of a product for treating non-small cell lung cancer. The tRF-5030c provided by the invention is not a simple sequence design product, but is a direct experimental evidence based on the interaction of the tRF-5030c and the double-target protein. Cooperative regulation and control of two key mechanisms are achieved through the single molecular entity, and the problems of low synergistic efficiency and toxicity superposition caused by pharmacokinetic differences, structural isomerism and action target cell heterogeneity of multiple drugs are fundamentally solved. It is ensured that dual inhibition of PARP1 mediated DNA repair and EGFR driven survival signals is highly consistent in time and space.

The invention belongs to the technical field of air purification materials, and discloses an antibacterial formaldehyde removal catalyst as well as a preparation method and application thereof. The antibacterial formaldehyde removal catalyst comprises a perylene quaternary ammonium salt-graphene composite antibacterial agent, a catalytic active component, an inorganic biochar binder and a pore forming agent, manganese dioxide granulation is achieved by constructing a porous framework, the activity of manganese dioxide is reserved, graphene inhibits agglomeration through a flexible sheet layer and establishes a conductive path, and the common core lies in that through structure fixation instead of dense wrapping, the smoothness of a reactant diffusion channel is maintained to the maximum extent while the particles are endowed with mechanical strength, and the mechanical performance of the particles is improved. Shielding and sintering of active sites in the granulation process are avoided, so that the catalytic activity of manganese dioxide is efficiently reserved; the catalyst has a dual-function integrated effect, and also has efficient room-temperature catalytic formaldehyde removal capability and broad-spectrum antibacterial capability, so that the structure of an air purification system is simplified.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

The invention relates to the technical field of silicon dioxide materials, in particular to anti-aging quantum dot silicon dioxide and a preparation method and application thereof. The preparation method comprises the steps that silicon dioxide or silicic acid and a carbon source are subjected to first-stage calcination in a vacuum furnace, the first-stage calcination temperature is 300-750 DEG C, the first-stage calcination time is 10 min to 8 h, then air is introduced for second-stage calcination, the second-stage calcination temperature is 300-750 DEG C, and the second-stage calcination time is 10 min to 8 h. According to the anti-aging quantum dot silicon dioxide and the preparation method thereof, the anti-ultraviolet and anti-aging properties of the material are compounded and enhanced by utilizing the quantum dot effect and the oxygen vacancy effect, and the anti-aging quantum dot silicon dioxide is added into a matrix or sprayed on the surface of the matrix, so that the ultraviolet can be effectively prevented, and the aging of the material is prevented.

The invention discloses compound lactic acid bacteria, a metagen and a preparation method and application of the compound lactic acid bacteria and the metagen. Through composite compatibility of the probiotics separated from the yak yoghurt in the Qinghai-Tibet Plateau, a synergistic effect of various strains is exerted, negative effects caused by treatment by using a medicine means are avoided, side effects are avoided, and the problems of single effective microbial community, low regulation capability and the like in the prior art are solved. By adding the selective auxiliary materials, the survival rate of the compound probiotics after freeze-drying treatment is improved, the probiotics can more effectively resist the adverse environment of the gastrointestinal tract, the problems that in the prior art, the probiotics are prone to being damaged by gastric acid, the survival rate is reduced in the storage process, and a large amount of probiotics are inactivated before entering the intestinal tract are solved, the planting rate of the probiotics is increased, and the survival rate of the probiotics is increased. The effect is more durable and more stable. Through synergistic compatibility of the composite probiotics and functional prebiotics from characteristic plant resources from the Tibet Plateau, the intestinal flora balance adjusting capacity is improved, and the beneficial effects of effectively improving symptoms such as constipation and obesity are further achieved.

The application discloses a dark septate endophytic fungus strain and application thereof, and the strain is a dark septate endophytic fungus strain YMF1.068, the preservation name is Paraphoma vinacea, and the strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) and has a preservation unit address of No. 3, Xibin West Road, Chaoyang District, Beijing, a preservation date of May 20, 2024, and a preservation number of CGMCC No. 41305. The strain can effectively prevent and control root-knot nematode disease, has high lethal activity, enhances plant resistance, and is safe to humans and animals and free of residues. The application of a microbial agent prepared by using the strain on tomatoes, cucumbers and tobacco shows a control effect of more than 68%, which is equivalent to the effect of chemical pesticides, and the microbial agent shows potential and market prospects as a biological pesticide.

This application relates to the field of daily chemical technology, specifically disclosing a herbal compound nasal congestion-relieving essential oil composition and its processing method. The composition is prepared from a compound nasal congestion-relieving base oil obtained by mixed extraction of Magnolia biondii, Xanthium sibiricum, and Angelica dahurica, menthol rosmarinic acid ester, a homologous regulator of esterase activity, natural borneol extracted from natural plants, and medium-chain triglycerides. The homologous regulator of esterase activity is selected from oleanolic acid or crataegolic acid. The preparation method is as follows: first, the compound nasal congestion-relieving base oil is prepared by supercritical extraction; then, menthol rosmarinic acid ester is obtained through enzymatic synthesis; subsequently, the base oil undergoes micro-trace enzyme anchoring modification; finally, the components are mixed through a gradient phase fusion process and bottled to obtain the finished product. This composition can be used to relieve nasal congestion symptoms caused by acute rhinitis and allergic rhinitis, and has the advantages of stable nasal congestion-relieving effect, long duration of action, and low mucosal irritation. The preparation method is green and environmentally friendly, the product has high purity, and good batch-to-batch consistency.

The invention discloses a moisturizing and soothing hand cream containing jasmine extract. The hand cream of the scheme comprises extracts of pure natural plants, especially the jasmine extract is included in the functional component. The hand cream compounded with multiple components has the characteristics of safety, mildness and non-irritation. Compared with the existing hand cream, the hand cream of the scheme not only has the effect of moisturizing and hydrating, but also the chrysanthemum extract and the tea polypeptide extract in the raw material components can effectively improve the dry and cracked fine lines on the hands and achieve long-term repair; the thyme extract increases the expression of basal layer water channel protein APQ3, unclogs the skin water channel, and moisturizes the nails; the jasmine extract in the functional component can eliminate superoxide free radicals, and has the effects of beautifying the skin, anti-oxidation and anti-aging; and at the same time, it has strong permeability and helps other functional components to be absorbed by the skin; the amaranth extract in the functional component has a hemostatic effect, has a good promoting effect on the healing of the cut wound surface, and can prevent and treat chapped skin to a certain extent.

The present invention relates to the field of medical technology, and specifically to a ketohexokinase inhibitor compound, a pharmaceutically acceptable salt, an ester or a stereoisomer thereof, a pharmaceutical composition and a preparation containing the compound, a pharmaceutically acceptable salt, an ester or a stereoisomer thereof, a method for preparing the compound, a pharmaceutically acceptable salt, an ester or a stereoisomer thereof, and use of the compound, a pharmaceutically acceptable salt, an ester or a stereoisomer thereof in preparing a drug for treating and / or preventing diseases mediated by KHK and related diseases.

The invention relates to the field of dairy cow nipple medicated bath liquid, in particular to non-iodine preparation dairy cow nipple medicated bath liquid and a preparation method thereof, and the non-iodine preparation dairy cow nipple medicated bath liquid comprises the following medicines: purified water, biguanide fungicide, a skin care agent, a thickening agent, alcohols, a film-forming agent, a pH regulator, pigment and a nonionic surfactant. The problems that a traditional iodine-containing medicated bath liquid is unstable under illumination and high temperature and has a short bactericidal effect are solved, and the dairy cow nipple medicated bath liquid adopts the biguanide bactericide for sterilization, is efficient, broad-spectrum, lasting in effect, safe, free of side effects, not prone to drug resistance generation, appropriate in viscosity and free of dripping within 30 s, forms a protective film on dairy cow nipples within 10 min, and has a good application prospect. The invasion of microorganisms is effectively prevented; the waste amount of the medicated bath liquid is reduced, and the use cost of the medicated bath liquid is reduced.

The present disclosure belongs to the technical field of medicines, and specifically relates to a polycyclic DNA-PK kinase inhibitor compound as shown in formula (I), a pharmaceutically acceptable salt thereof or an isomer thereof, a pharmaceutical composition and formulation comprising the compound, the pharmaceutically acceptable salt thereof or the isomer thereof, a method for preparing the compound, the pharmaceutically acceptable salt thereof or the isomer thereof, and a use of the compound, the pharmaceutically acceptable salt thereof or the isomer thereof.

The invention discloses a lipid-lowering and plaque-removing composition and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. The lipid-lowering and plaque-removing composition comprises: salvia miltiorrhiza, hawthorn, chuanxiong, notoginseng, kudzu root, chrysanthemum, astragalus, radish seed, fructus aurantii and leech. Salvia miltiorrhiza can invigorate blood circulation and dredge menstruation, and is the main medicine; hawthorn, chuanxiong and notoginseng can regulate qi and invigorate blood circulation, eliminate accumulation and relieve fullness, and are collectively the ministerial medicines; kudzu root, chrysanthemum and astragalus can invigorate the spleen and replenish qi, and are sweet and cold and nourishing, and can prevent qi and blood circulation, eliminate accumulation and eliminate phlegm, and damage the body, and can achieve one elimination and one supplement, and balance yin and yang, and are used as the assistant medicine; leech is used to strengthen the effect of invigorating blood circulation and unblocking collaterals, and is used as the guiding medicine. The main, ministerial, assistant and guiding medicines in the prescription can play the effects of eliminating phlegm and eliminating accumulation, invigorating the spleen and regulating qi, and invigorating blood circulation and unblocking collaterals. The symptoms and the root cause are treated at the same time, and the biphasic regulation is achieved to achieve the effect of treating dyslipidemia. By optimizing the preparation process, the therapeutic effect can be further improved.

The invention belongs to the technical field of medicines, and particularly relates to a silybum marianum composition for improving liver function and a preparation method thereof, the composition comprises quick-release cholagogic micro powder and slow-release liver-nourishing particles in a mass ratio of 1: (2-4); the quick-release cholagogic micro powder is prepared from curcumin, fructus aurantii immaturus flavone, a tanshinone extract and PVP K30 through ball-milling solid dispersion; the slow-release liver-nourishing particle is of a core-shell structure, a freeze-drying core of the slow-release liver-nourishing particle contains silymarin and schizandrin extract, and a glycyrrhetinic acid-phospholipid / chitosan oligosaccharide targeted coating and a medicinal acrylic resin coating are sequentially arranged on an outer layer of the slow-release liver-nourishing particle. According to the composition, through sequential synergy of'first defibering and then repairing 'and a liver targeting effect, the content of silymarin in liver tissue is remarkably increased, the silymarin is retained for a long time, and liver function impairment such as non-alcoholic fatty liver disease is effectively improved.

This invention belongs to the field of oral solid dosage form technology and relates to a loratadine sustained-release capsule and its preparation method. This application provides a loratadine-containing sustained-release capsule, wherein loratadine is melt-mixed with citric acid and salicylic acid to prepare a drug-containing core, and the core is coated with a sustained-release layer, an immediate-release layer, and a protective layer. This not only effectively solves the problem of slow dissolution of loratadine in the presence of insufficient gastric acid, but also ensures uniform drug release, achieving long-lasting effects and increased efficacy.

This invention discloses a highly bioavailable ticagrelor solid dispersion, its formulation, preparation method, and application. The solid dispersion is prepared by hot melt extrusion of ticagrelor and a specific ternary carrier system, wherein the ternary carrier system is from Soluplus. ® The formulation consists of copovidone and hydroxypropyl methylcellulose. This solid dispersion is further combined with disintegrants, fillers, and lubricants to form a pharmaceutical composition. This invention utilizes the synergistic effect of a ternary carrier and hot-melt extrusion technology to ensure ticagrelor exists stably in an amorphous form, significantly improving drug dissolution and oral bioavailability. Experiments show that the formulation exhibits a dissolution rate ≥85% in pH 6.8 phosphate buffer after 30 min, and a relative bioavailability in beagle dogs reaching 150%–250% of commercially available tablets. It also demonstrates excellent stability, with no crystallization observed in a 6-month accelerated assay, indicating significant clinical value and market potential.

The invention provides a multi-effect plant antibacterial and antiviral preparation, which belongs to the technical field of antiviral drug preparation technology. The components of the multi-effect plant antibacterial and antiviral preparation include 0.5-1.8% of emblica extract, 0.5-1.2% of lysozyme, 0.2-0.8% of honeysuckle extract, 0.3-0.8% of scutellaria extract, 0.2-1.2% of egg yolk immunoglobulin, 0.2-0.8% of vitamin C, 3.0-6.0% of xylitol, 1.0-5.0% of glycerol, 0.3-1.0% of poloxamer, and the balance is deionized water. The invention can provide a safe, efficient, good-tasting plant antibacterial and antiviral oral antibacterial liquid which is effective against bacteria and viruses, and is a product which can be used for daily oral health care and auxiliary treatment of oral and upper respiratory tract infections.

The invention provides a fungus and actinomycete complex microbial inoculant for preventing and treating root rot. The complex microbial inoculant contains spiropolyspora rosea with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.42332 and streptomyces taenanensis with the preservation number of CGMCC No.36965. The invention further provides a preparation method of the fungus and actinomycete complex microbial inoculant. The invention also provides an application of the fungus and actinomycete complex microbial inoculant. The complex microbial inoculant provided by the invention contains fermentation products of spiropolyspora roseus HLY-1 and streptomyces talanigerum NYC 1-5, the two fermentation products have no inhibition effect, and a synergistic effect can be generated by mixed application of the two fermentation products.

The present invention provides a combination of a compound of formula (I) or a pharmaceutically acceptable salt thereof and an anti-cancer agent for use in the treatment of cancer, wherein the compound of formula (I) and the anti-cancer agent are as described in the specification.