1045results about How to "Lasting effect" patented technology

A chewing gum comprising at least one active pharmaceutical ingredient (API) with a core onto which is applied at least one inner polymer film coating and thereafter onto which is applied at least one outer hard coating. A preferred API is nicotine. Flavoring agents may be incorporated in the core, in the at least one inner polymer film coating and/or in the at least one outer hard coating. The gums formed exhibit a long lasting effect of flavoring agent(s) and result in the domination of flavoring agents in the coating(s) over flavoring agent(s) in the core, thereby (a) avoiding problems of chemical or pharmaceutical incompatibility between an API in the core and flavoring agent(s) in the coating(s) and (b) achieving an increased control of the release of the API and of non-active excipients.

The invention discloses a concrete surface hardener and a construction method thereof, wherein, the concrete surface hardener comprises the compositions by weight percent of 10-40 percent of inorganic silicate, 1-10 percent of alkali, 0.1-5 percent of catalyst, 0.1-2 percent of wetting dispersant, 1-5 percent of stabilizer and rest of water. The hardener prepared by the invention is characterized by easily-obtained material, simple production and convenient construction, unhealthy and environmentally harmful VOC avoidance, etc. In addition, the hardener can penetrate into the interior of the concrete to seal the capillary of the concrete, thus improving the surface density of the concrete, strengthening the impervious capability and strength of the concrete and prolonging the service life of the concrete. As the hardener does not comprise unhealthy and environmentally harmful substances, the increasingly improved requirements of the present environmental protection can be met, thus having extensive application prospect.

The invention relates to an edible composition, in particular an edible composition containing active bacterium and suitable for all people, and its preparing process which comprises, (1) bacterial strain screening, bacterium culturing, (3) viable bacteria powder preparation, (4) preparation of edible compositions.

The invention relates to a micro-ecological regulator, which belongs to the category of micro-ecological preparations. The product contains Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium adolesentis, lactobacillus acidophilus, fructo-oligosaccharides, galacto-oligosaccharides, vitamins and the like. A concrete production process comprises the following steps: 1. bacterial strains are respectively or jointly subjected to liquid deep high-density cultu, so as to obtain fermentation liquid; 2. after the fermentation liquid is centrifuged, bacterial sludge is collected, added to protective agents and made into freeze-dried powder; 3. the freeze-dried powder is added to microcapsule materials and made into microcapsules through air suspension treatment; and 4. the microcapsules are mixed with oligosaccharides, vitamins and the like and then are made into a synbiotics pharmaceutical composition. By directly replenishing human intestines with Bifidobacterium and lactobacillus acidophilus, and by simultaneously providing prebiotics for ensuring that beneficial bacteria after entering intestines can be activated rapidly and proliferate, the product adjusts and improves intestinal micro-ecosystem, so as to achieve the aims of regulating organism immunity, delaying senility, inhibiting tumors, regulating blood lipid and improving intestines and stomach. A preparation method of the product can solve the technical problem that the prior probiotics medicine is difficult to keep the stability of probiotics at normal temperature and unstable under acidic conditions, and provides a pharmaceutical composition which can be stably stored at normal temperature.

The invention belongs to the technical field of medicaments, and in particular relates to a hetero-aromatic ring shown by a general formula (I) as well as a derivative type tyrosine kinase inhibitor, a pharmaceutically acceptable salt or a stereoisomer thereof, wherein X, Z, W, R1, R2, R3, L1, L2, a, b, c, d, e, p, q, A and B are as defined in the specification. The invention also relates to preparation methods of these compounds, a pharmaceutical preparation containing these compounds, and important functions of these compounds in preparation of medicaments for treating B cell related leukemia (such as B cell chronic lymphocytic carcinoma and non-hodgkin lymphoma) and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus and the like).

The invention relates to a device for automatically realizing visual reuse of a Web system, which relates to the field of information technology, in particular to a Web front-end development technology. The device of the invention is composed of a bottom module set and an upper application set. The bottom module set consists of a component module, a page layout module, a style management module, aNodejs service module, a user-defined template analysis module and a system construction module. The upper application set consists of a page prototyping tool, an editable large-screen resource library, a page rapid production tool, a user-defined template development tool and an open source technology page development tool. The device of the invention adopts the mode of combining the server technology and the browser technology, so that the Web front-end code is developed by using a unified development pattern, when the system is developed, the most advanced Web front-end technology can be integrated. After the system is developed, the code that meets the production requirements can be generated by compiling tools, so that the Web development process becomes more pure, and the browser compatibility related problems need not to be considered too much in the development process,and the development efficiency and the development quality can be improved.

A cooling sensate compound having the general formula (I): wherein n is an integer from 2 to 6. The compound is effective in imparting a refreshing and cooling sensation of long duration. A cooling sensate composition having the general formula (I) is used in a variety of formulations to impart the refreshing and cooling sensation. These cooling sensates are useful in a variety of consumer products including mouth formulations, food products and toiletries.

The invention provides a toothbrush hair having an anti-bacterial and health-caring function and a preparation method thereof. The toothbrush hair includes the following raw materials, by weight, 75-90% of a polymer, 3-20% of a natural anti-bacterial agent, 1.8-3% of pomegranate seed oil, and 1.2-2% of a coupling agent. The natural anti-bacterial agent is prepared from following components comprising, by weight, 75-90% of loess powder, 4-10% of an extract of commelina communis, 3.5-9% of an extract of herba houttuyniae and 2.5-6% of an extract of caryopteris incana. By means of the technical scheme, the toothbrush hair is produced through various process methods. The toothbrush hair is wide in anti-bacterial spectrum, is high and durable in efficiency and is safe to use, has excellent light-prevention, wear-resistant and aging-resistant performance, has the health-caring effect of increasing fragrance and protecting teeth, is beneficial to environment cleaning and odor eliminating, has the effects of preventing and controlling decayed tooth and periodontal diseases, is good in anti-dirt property, rebound elasticity, flexibility and hydrophobicity, is free of deformation, is long in service life, is low in production cost and is easy to popularize.

The invention relates to health food for enhancing human immunity and increasing bone mineral density and a preparation method thereof; the health food of the invention comprises the following components: hyaluronic acid, glucosamine, collagen, kudzu root extracts, chondroitin sulfate, vitamins, calcium, etc; because of the embedding processing of hyaluronic acid, the defect of property change of hyaluronic acid due to moisture absorption and influence of environmental factors is overcome; the health food prepared by the organic combination of the embedded hyaluronic acid with glucosamine, collagen, plant extracts, vitamins, mineral matter and the like has functions and effects which can supplement each other, has the effects of lubricating joints, increasing bone mineral density, and enhancing bone strength during long-term administration, and also has the functions of delaying aging, removing freckles and beautifying faces, and the like; the health food of the invention can be prepared into powder, granules, tablets, capsules, is convenient for carrying and taking, has stable and lasting efficacy, has no side effects, and is an ideal health food of patients with hypoimmunity and osteoporosis.

The preparation method of ginkgo leaf slow-released tablet mainly for curing cerebrovascular disease includes the following steps: 1. preparing gingko leaf extract; and 2. preparing slow-released tablet: using gingko leaf extract 120 portions, hydroxypropyl methyl cellulose 80-100 portions, lactose 50-80 portions and starch 30-80 portions, mixing them uniformly, adding anhydrous ethanol 0.8-1.2 portions to make granulation, then adding magnesium stearate 2-5 portions, uniformly mixing them and tabletting to obtain said invented product.

The invention relates to the fields of sand-fixing agent preparation and environment protection. According to the invention, with vinylacetate (VAC) as a main monomer, methyl methacylate (MMA) as a hard monomer, butyl acrylate (BA) as a soft monomer, ammonium persulfate (APS) as an initiating agent, lauryl sodium sulfate and tween-60 as a complex emulsifying agent and water as a dispersion medium, a macromolecular environmentally-friendly sand-fixing dust suppressant, particularly a VAC/MMA/BA terpolymerization sand-fixing dust suppressant which is used for fixing sand, is prepared by emulsion polymerization without the use of any organic solvent.

The general multifunctional foam fire-extinguishing agent consists of plant protein 0.8-30 wt%, sugar 0.8-30 wt%, hydrocarbon surfactant 1-12 wt%, fluoric surfactant 0.1-5 wt% and additive 5-20 wt%, except water. The general multifunctional foam fire-extinguishing agent may be used to extinguish fire of alcohol and other polar chemical matter and/or light oil, heavy oil and other non-polar chemical matter. The general multifunctional foam fire-extinguishing agent contains no corrosive chemical matter, and has self-cleaning property, capacity of prolonging the service life of the fire-extinguishing equipment, no toxicity and no harm to human body and no environmental pollution.

The present invention belongs to the technical field of medicine, and particularly relates to a CDK kinase inhibitor represented by a general formula (I), a pharmaceutically acceptable salt of the CDK kinase inhibitor, an ester of the CDK kinase inhibitor, a solvate of the CDK kinase inhibitor and stereoisomers of the CDK kinase inhibitor, the pharmaceutically acceptable salt, the ester and the solvate, wherein R1, R2, R3, R4, R5 and n are defined in the specification. The present invention further relates to preparation methods of the compounds, pharmaceutical formulations containing the compounds, pharmaceutical compositions containing the compounds, and applications of the compound, the pharmaceutically acceptable salt, the ester, the solvate and the stereoisomers in preparation of treatment and/or preparation of CDK kinase-mediated cancer associated diseases. The formula (I) is defined in the specification.

An endermic liniment comprising a polyoxyethylene dicarboxylate represented by the following chemical formula (1). (In this formula, R1 and R2 are hydrogen or alkyl or branched alkyl groups having 1-4 carbon atoms, and m, n, X, and Y are integers 0-5 which are not all zero at the same time. R3 is a branched or linear chain alkylene group having 0-10 carbon atoms.) The endermic liniment of the present invention achieves superior tactile sensation during use, smoothness in particular, without a sticky sensation, while maintaining a lasting moisture retaining effect by means of blending in a humectant and a polyoxyethylene dicarboxylate.

The invention discloses an external Chinese medicine for treating bedsore. The external Chinese medicine is prepared from moschus, dragon bone, myrrh, minium, bee wax, dried alum, pseudo-ginseng root, dragon's blood, suberect spatholobus stem, szechuan lovage rhizome, red-rooted salvia root, common clubmoss herb, honeysuckle flower, safflower, weeping forsythia, dahurian angelica root, fried pangolin, fried spina gleditsiae, thunberg fritillary bulb, sinkiang arnebia root, pepper, liquoric root, crude fructus gardenia, amur corktree bark, astragalus, coptis root, baikal skullcap root, garden burnet root, frankincense, borneol, pearl powder, sesame oil, common bletilla tuber, Japanese ampelopsis root and white paeony root in a certain ratio. The external Chinese medicine for treating bedsore can play roles in diminishing inflammation and sterilizing, and can be used for prompting convergence of bedsore surfaces and rapid regression of redness and swelling till bedsore surfaces are fully cured.

The invention discloses an external medicine for treating the parasitic infection, fungal infection and bacterial infection of pets, which is prepared by processing radix stemonae, dittany bark, common cnidium fruits, belvedere fruits, red paeony roots, Japanese honeysuckle stems, lightyellow sophora roots, rhizoma coptidis, sulfur and mint. The external medicine can effectively and safely resist mites, lice, fleas, ticks and other parasites, and has the functions of resisting fungal infection and bacterial infection.

The invention relates to a compound shown as formula (I), a pharmaceutically acceptable salt, ester or stereoisomer thereof. R1, R2, R3, R4, m, n, W, A, Z, E, F, X and Y are defined as the specification. The invention also relates to a preparation method of the compounds, pharmaceutical preparations and application in drugs for treatment and/or prevention of FXR (farnesoid X receptor) mediated nonalcoholic fatty liver diseases, primary biliary cirrhosis, lipid metabolism disorders, diabetic complications, malignant tumors and other related diseases. (formula (I)).

The invention relates to a compound shown as formula (I), a pharmaceutically acceptable salt, ester or stereoisomer thereof. R1, R2, R3, R4, m, n, W, A, Z, E, F, X and Y are defined as the specification. The invention also relates to a preparation method of the compounds, pharmaceutical preparations and application in drugs for treatment and/or prevention of FXR (farnesoid X receptor) mediated nonalcoholic fatty liver diseases, primary biliary cirrhosis, lipid metabolism disorders, diabetic complications, malignant tumors and other related diseases. (formula (I)).

The present invention pertains to a filler composition comprising β-glucan moieties and optionally a cosmetically and/or pharmaceutically acceptable carrier. It further relates to a filler composition, wherein the β-glucan moieties are cross-linked. in one embodiment of the instant invention the filler composition is a dermal filler. In one further embodiment of the present invention the filler composition is for the treatment of wrinkles and/or folds. In another embodiment of the instant invention the filler composition is for use in the treatment of a medical condition. The filler composition provided in the present invention may further comprise one or more active pharmaceutical ingredients. Further, the present invention pertains to a process for preparing the filler composition as claimed herein.

A composition to be used as a topical treatment for carpet and textiles, and a process for producing the composition are provided. The composition has desirable antibacterial, antimicrobial, and antifungal properties, and is made up of an effective amount of an antimicrobial agent having a blend of substituted ammonium salts of alkylated phosphoric acids admixed with free alkylated phosphoric acid, an effective amount of a pesticide containing Permethrin, a sufficient amount of an emulsifier in the form of an ammonium nonylphenol ether sulfate, and, optionally, an effective amount of a fragrance additive, all mixed with water. The process involves premixing with water the emulsifier, the antimicrobial agent, and, where used, the fragrance additive, adding this premix to a larger quantity of water, agitating the composition, slowly adding the pesticide while agitating, and continuing the agitation for a predetermined period of time.