114results about How to "Prevent and treat hyperlipidemia" patented technology

The invention discloses konjac jelly powder. The konjac jelly powder comprises the following components in part by weight: 30 to 40 parts of konjac powder, 10 to 25 parts of carrageenin, 0 to 10 parts of xanthan gum, 0 to 15 parts of locust bean gum, 0 to 20 parts of guar gum, 5 to 12.5 parts of sodium citrate, 8 to 15 parts of potassium chloride, 0 to 7 parts of xylitol and 2 to 5 parts of citric acid. A method for preparing jellies by using the konjac jelly powder comprises the following steps of: mixing the konjac jelly powder and white granulated sugar uniformly; pouring the mixed white granulated sugar and konjac jelly powder into a stirred cold water proportioning cylinder; continuously adding the white granulated sugar or syrup, opening steam and heating; and performing filtration, packing and sterilization to obtain konjac jelly finished products. The konjac jelly powder provided by the invention has low production cost, adjustable taste and high dietary fiber content; the prepared konjac jellies do not need to be treated by alkali; and the method for preparing the jellies by using the konjac jelly powder has simple making process and low making cost.

The invention relates to a sugar-free konjac soft sweet which comprises the following components in percentage by weight: 0.5-4% of konjac powder, 3-10% of gelatin, 15-25% of xylitol, 30-50% of isomalt, 3-8% of sorbitol, 2-5% of maltitol, 0.15-2% of acidity regulator, 0-0.5% of edible flavorant, 0-0.01% of edible colorant and 10-20% of water. The preparation method of the sugar-free konjac soft sweet comprises the following steps of: (1) preparing a glue solution; (2) preparing syrup; (3) preparing a mixed material solution; (4) forming the soft sweet; (5) setting and drying the soft sweet; and (6) obtaining the finished product. The sugar-free konjac soft sweet provided by the invention has high dietary fiber content, can provide abundant dietary fibers to human bodies, has low calories, can not decay teeth and is beneficial to body health. The invention also provides the preparation method of the sugar-free konjac soft sweet, which has a simple process and a low manufacturing cost.

The invention discloses a tartary buckwheat complex tea. The tartary buckwheat complex tea is obtained by using tartary buckwheat as main raw material, blending the tartary buckwheat with a finished product tea, and packaging the tea by using a visible nylon and degradable material packaging bag through ultrasonic sealing. The blending ratio of the complex tea is as follows: in each 100 g complex tea, the content of the tartary buckwheat is 50-70 g and the content of the finished product tea is 30-50 g by weight. The complex tea disclosed by the invention has both nutritional values of the tartary buckwheat and health care function of the tea; and fragrances of the tartary buckwheat and the tea are organically blended so that the taste, fragrance and nutritional value of the complex tea are all largely superior to those of the traditional tartary buckwheat tea, green tea or black tea; and mellow taste and attractive fragrance are obtained so that double requirements on taste and health are both satisfied.

The invention discloses a compound probiotic agent for improving immunity of dogs and reducing incidence of diarrhea as well as a preparation method and application thereof, and belongs to the field of the compound probiotic agent. The compound probiotic agent is prepared by mixing and compounding a lactobacillus plantarum KT-Lp9 microbial agent, a lactobacillus casei zhang microbial agent, a lactobacillus plantarum P-8 microbial agent, a bifidobacterium animalis subsp. lactis V9 microbial agent and a dilution carrier, wherein the quantity of viable bacteria of the four kinds of microbial agents is more than or equal to 2*10<11>CFU / g. The compound probiotic agent with different contents of viable bacteria only can be applied to 96 dogs at different ages for 60 days, so that the immunity of the test dogs can be improved, and the incidence of diarrhea and the sickness degree are reduced. Main representations are that the feed intake and growth rate of the dogs are increased, leukocyte counts, lymphocytes counts and neutrophil counts in blood are controlled, and the contents of four immunologic factors including immune globulin G, interleukin 6, interferon alpha and tumor necrosis factor alpha in the blood can be increased; and meanwhile, the content of secretory immunoglobulin A (SigA) in excrement is increased.

A tea oil for preventing hypertension, hyperlipomia, coronary heart disease and habitual constipation is prepared from useless tea leaves and tea seeds through baking, squeezing to obtain raw oil and cake, refining the raw oil, immersion extracting of cake to obtain oil, and refining. Its advantages are simple process, low cost and high productivity.

The invention relates to the use of pepper amide compound in preparation of drug or healthcare product for reducing blood fat with the general formula (I), wherein R, R1, R2 are defined in the specification, the piperamide compounds represented by formula (1) have the actions of substantially reducing cholesterin, triglyceride and increasing high density lipoprotein, fully activating lecithin cholesterol acyl transferase, forwarding extra-hepatic tissue cholesterol to liver, cleaning out plasma lipoproteins, plasma cholesterol and cholesterol esters, thus can be applied to the prevention and treatment of cardiovascular and cerebrovascular diseases, such as atherosclerotic, cerebrovascular, coronary artery and peribiliary vessel pathology and hyperlipemia.

The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I):wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lower haloalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted cycloalkenyl group; a substituted or unsubstituted cycloalkylalkyl group; a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, X1, X2, X3, and X4 may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group; a lower alkoxy group; a cyano group; a nitro group; an acyl group; or an aryl group, Y represents —CO— or —SO2—, and Z represents a hydrogen atom or a mercapto-protecting group, or a prodrug compound, a pharmaceutically acceptable salt, or hydrate or solvate thereof. The compounds represented by the formula (I) can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity and, therefore, is expected to be useful as a new type of a preventive or therapeutic agent for atherosclerosis or hyperlipidemia.

The invention relates to the purpose of microRNA or inhibitors thereof, and in particular to application of microRNA and inhibitors thereof to preparation of medicaments for regulating lipid metabolism or preparation of medicaments for preventing or treating diseases related to lipid metabolism. The microRNA includes one or more selected from miRNA-96, miRNA-185 and miRNA-223. The invention also relates to the application of the microRNA or inhibitors thereof for to regulation of expression level of lipid metabolism-related proteins. The invention also relates to a composition comprising the microRNA or inhibitors thereof. The microRNA or inhibitors thereof provided by the invention can be used as pharmaceutical compositions for application to prevention or treatment of hyperlipidemia, atherosclerosis and coronary heart diseases.

The invention discloses an extract of Ginkgo Biloba leaves-cyclodextrin derivative inclusion compound and a preparation method thereof, which is prepared from 10 to 24 percent of total flavonol glycoside, 2 to 6 percent of terpene lactone and 70 to 88 percent of cyclodextrin derivative and auxiliary materials, according to the weight percentage; the preparing method comprises the following steps: dissolving cyclodextrin derivative in water, adding extract of Ginkgo Biloba leaves; stirring for 6 to 8 hours; reducing the pressure and vacuum drying at the temperature of 55 to 65 DEG C; and obtaining the extract of Ginkgo Biloba leaves-cyclodextrin derivative inclusion compound in a solid grinding way. The invention adopts an inclusion technology to greatly enhance the dissolubility and the dissolution of the ginkgo leaves in the water, to enhance the absorption in human stomach and intestine, and to simultaneously greatly increase the stability of the principal components in the extract of Ginkgo Biloba leaves, the extract of Ginkgo Biloba leaves and terpene lactones after being processed by adopting the inclusion technology. The extract of Ginkgo Biloba leaves, after being processed by adopting the inclusion technology, is 1 to 2 times higher than the ordinary preparation in bioavailability, and can be used for preparing the drugs for improving the disease of cardio-cerebrovascular systems, and preventing and remedying coronary heart diseases.

The invention relates to the use of piperic acid ester compound in preparation of drug or healthcare product for reducing blood fat, wherein R1, R2, R3 are defined in the description, the piperic acid ester compounds represented by formula (1) have the actions of substantially reducing cholesterin, triglyceride and increasing high density lipoprotein, fully activating lecithin cholesterol acyl transferase, forwarding extra-hepatic tissue cholesterol to liver, cleaning out plasma lipoproteins, plasma cholesterol and cholesterol esters, thus can be applied to the prevention and treatment of cardiovascular and cerebrovascular diseases, cerebrovascular, coronary artery and peribiliary vessel pathology and hyperlipemia.

The invention provides a preparation method of a conjugate in the formula (I) and application thereof as medicine preventing or treating liver cirrhosis, adiposis hepatica, hyperlipidemia, hyperglycemia, obesity and hepatic fibrosis. Pharmacological experiments find that the conjugate has drug activity with various value. Specifically, the conjugate shows the functions of reducing blood sugar and low-density lipoprotein and improving the transaminase level in animal experiments. Besides, the invention further relates to a preparation, a preparation method and application of the conjugate.

The invention relates to a novel compound propolis preparation and a preparation method thereof. The compound propolis product is prepared form the following ingredients: supercritical propolis, supercritical perilla frutescens seed oil, supercritical glossy ganoderma spore oil and ethanol extracted supercritical propolis residue. A main technical method has the following steps: removing impurities from raw materials; pulverizing raw materials; carrying out CO2 supercritical extraction; preparing microcapsule emulsion; carrying out vacuum freeze drying; carrying out pulverization; stirring and mixing all ingredients; and carrying out sterilization, capsule filling and package. The product of the invention belongs to the health care food with higher nutritional value, and has various health care effects of blood pressure reduction, blood fat reduction, antioxidation, immunity improvement and the like.

The invention provides a meat substitute stuffing dessert and a preparation method thereof. The meat substitute stuffing dessert comprises main materials and auxiliary materials, wherein the main materials comprise edible mushrooms, textured soybean protein, soybean protein isolate, starch, konjaku flour, edible oil and edible salt. The preparation method comprises the following steps: washing the edible mushrooms, soaking and dicing into small blocks; then stirring and blending the components of the edible mushrooms, the textured soybean protein, the soybean protein isolate, the konjaku flour and the like in a chopping mode, then encrusting, steam cooking, quickly freezing and packaging to obtain the meat substitute stuffing dessert. The preparation method of traditional dessert is changed, and the vegetable diet food materials of the edible mushrooms, the konjaku flour and the like are added to the dessert, so that the nutritional value of the dessert is improved, and the vegetable diet characteristic of the meat substitute stuffing dessert can also be used for preventing and curing a plenty of modern diseases.

A Chinese medicine in the form of oral liquid or others for preventing diabetes and its complication, hyperlipemia, hypertension, retinosis and cardiovascular disease is prepared from 9 Chinese-medicinal materials including ginseng, wolfberry fruit, red sage root, pueraria root, etc. Its preparing process is also disclosed.

The invention discloses a citrus chachiensis hortorum polymethoxylated flavonoids effective part and application thereof for treating hyperlipidaemia. The effective part is prepared from the following steps: step S1, extracting: grinding the citrus chachiensis hortorum, extracting by use of an alcohol-water solution, concentrating; step S2, removing impurities; sampling the concentrated solution obtained in the step S1 on macroporous resin, eluting and removing impurities by use of an ethanol water solution with the volume percent concentration of 40-45%, wherein the model of the macroporous resin is D101 type; and step S3, eluting: eluting the macroporous resin by use of the ethanol water solution with the volume percent concentration of 90% or more, collecting eluent, concentrating to obtain the citrus chachiensis hortorum polymethoxylated flavonoids effective part. The citrus chachiensis hortorum polymethoxylated flavonoids effective part provided by the invention can effectively lower the blood lipid level of hyperlipidaemia model mice, and is non-toxic, safe and effective, and can be used for preventing or treating hyperlipidaemia.

An application of peperate compounds in preparing the medicines or health-care food for preventing and treating cardiovascular disease, cerebrovascular disease, hyperlipemia, etc is disclosed.

The invention discloses health tea capable of reducing high blood pressure, high blood sugar and high blood fat and relates to the technical field of traditional Chinese medicines. The health tea is prepared from the following raw materials in percentage by weight: 35-55% of momordica grosvenori flower, 10-30% of herba abri, 3-8% of gynostemma pentaphylla, 6-15% of prunella vulgaris, 3-8% of folium mori, 3-8% of parasitic loranthus, 3-8% of pueraria lobata, 1-4% of uncaria rhynchophylla, 1-4% of herba epimedii and 1-4% of stigma maydis. The health tea is remarkable in reducing and preventing high blood pressure, high blood sugar and high blood fat, free of toxic or side effect, convenient to dissolve, particularly suitable for being drunk daily, and used for treating and preventing high blood pressure, high blood sugar and high blood fat.

A medicine for supplementing Ca, Mg and VD to human body is proportionally prepared from Ca preparation, Mg preparation and VD.

The invention discloses a Chinese medicine used for the prevention and treatment of atherosclerosis and coronary heart disease, and a preparation method thereof. The Chinese medicine is prepared by bulk drugs with following weight percentages: 10 to 30 parts by weight of radix pseudoginseng, 10 to 30 parts by weight of ginkgo leaf, 10 to 30 parts by weight of radix salviae miltiorrhizae, 10 to 30 parts by weight of astragalus root, 10 to 30 parts by weight of radix puerariae, 10 to 20 parts by weight of semen cassiae, 10 to 20 parts by weight of radix paeoniae rubra, 10 to 20 parts by weight of rhizoma curcumae longae, 10 to 20 parts by weight of herba epimedii, 10 to 20 parts by weight of dwarf lilyturf root, 10 to 20 parts by weight of rehmanniae and 5 to 10 parts by weight of liquorice. With the effectiveness of activating blood circulation to dissipate blood stasis, benefiting vital energy to remove stagnation and promoting pulse to descend the turbid, the Chinese medicine of the invention can be used for preventing and treating atherosclerosis, hyperlipemia, coronary heart disease and angina, etc.

The invention discloses health-care fresh biscuit for preventing hyperlipidemia and a manufacturing method thereof. The biscuit comprises 55-75% of low-gluten flour, 1.5-3% of white rib extract, 0.5-2% of ipomoea pescaprae extract, 0.5-2% of article ficuscunia extract, 1.5-3% of moso bamboo shoot head extract, 2-5% of locust pollen, 5-7% of abelmoschus manihot seed oil, 1.5-3% of pectin, 5-7% of palatinitol, 1.5-3% of dried skim milk, 0.3-0.5% of bamboo salt, 5-8% of partridge egg and 0.7-1.5% of instant dry yeast by weight. The raw materials are processed reasonably to form biscuit, the prescription is reasonable, the synergistic effect of the raw materials is strong, the sensing quality of the biscuit is improved, the shelf life is improved, and the nutritive elements are better balanced and richer; the health-care fresh biscuit for preventing hyperlipidemia is featured with crisp, delicious and sweet mouth feel, low energy, high dietary fiber content and low fatness and capable of preventing hyperlipidemia, lowering lipid and protecting health by means of regular intake. The health-care fresh biscuit for preventing hyperlipidemia is especially suitable for the hypertension and hyperlipidemia patients and obesity.

The invention discloses a traditional Chinese medicine containing pseudo-ginseng powder and a preparation method thereof. The traditional Chinese medicine comprises, by mass, 60-100 parts of pseudo-ginseng powder, 20-30 parts of red sage root, 10-20 parts of licorice, 30-40 parts of radix rehmanniae, 15-25 parts of root of kudzu vine, 40-50 parts of radix astragali, 20-30 parts of bighead atractylodes rhizome, 60-80 parts of dextrin and 5-7 parts of powdered steatile. The traditional Chinese medicine utilizes pseudo-ginseng powder, red sage root and licorice as raw materials, does not contain hormones and antibiotics in Western medicines, and does not produce drug resistance. Natural plants adopted by the preparation method has no obvious toxic or side effects in research, have high safety, can be absorbed easily, can produce effects fast and are convenient for use. The traditional Chinese medicine can treat inner and outer hemorrhagic diseases such as a bleeding wound, blood stasis, gastrorrhagia and hematuria, has effects of expanding blood vessel, dissolving thrombus, improving microcirculation, preventing and treating cardiovascular and cerebrovascular diseases such as hyperlipidemia, cholesterol increasing, coronary heart disease, stenocardia and cerebral hemorrhage sequel, treating liver diseases such as fatty liver and liver fibrosis, and treating physical deficiency caused by hemorrhage, delivery and aeipathia, has a low cost and simple processes, and can be widely used.

The invention discloses a houttuynia cordata thunb beverage belonging to the food field. The production method thereof is as follows: (1) fresh houttuynia cordata thunb is juiced by being added with 2-3 times of water, and tea leaves are added with 2-3 times of water for soaking or the fresh houttuynia cordata thunb is crushed into 300 to 1000 items and then added with 4-5 times of water; (2) 10 to 20 percent of houttuynia cordata thunb juice, 10 to 20 percent of tea, 1 to 5 percent of citric acid, 5 to 9 percent of sugar and the balance of 50 to 60 percent of water are mixed, evenly stirred, filtered and then packed, thus obtaining the beverage. The beverage has better mouthfeel, can accelerate gastrointestinal absorption and effectively protect lung cells, prevent and cure hyperlipoidemia and cerebral apoplexy, and has the functions of cellular oxidation inhibiting and anti-aging and health care.

The invention discloses application of polyoxymethylflavone, a polyoxymethylflavone composition and a polyoxymethylflavone preparation for prevention or treatment of hyperlipidemia. The active ingredient of a drug for the prevention or treatment of the hyperlipidemia comprises polyoxymethylflavone, wherein the polyoxymethylflavone refers to 3,5,6,7,8,3',4'-heptamethoxyflavones, and the active ingredient further comprises pharmaceutically acceptable carriers or excipients so as to be prepared into a pharmaceutically acceptable dosage form. The high level of either of the total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-c) of plasma can cause the hyperlipidemia. The invention confirms that 3,5,6,7,8,3',4'-heptamethoxyflavones (HMF) can significantly reduce the levels of the TG, the TC and the LDL-c, significantly increase the level of HDL-C in the plasma, and prevent or treat the hyperlipidemia.

The invention relates to a preparation method and use of Xanthoceras sobifoba kernel oil extracted from supercritical fluid and a preparation of the Xanthoceras sobifoba kernel oil. The preparation method comprises the steps of grinding Xanthoceras sobifoba kernels, sieving by virtue of a 10-100-mesh sieve, and carrying out supercritical fluid extraction in an extraction kettle, so as to obtain the Xanthoceras sobifoba kernel oil and a kernel residue rich in proteins, wherein the kernel residue can be used for extracting total saponins and has an extremely high medical value. Compared with a traditional squeezing process, a CO2 supercritical fluid extraction method has the advantages that the process is simple, the production cycle is short, the extraction efficiency is high, and the serious damage of unsaturated fatty acid in grease and the denaturationof the proteins in medicine residues at the high temperature are avoided. Compared with a method for extracting by virtue of organic solvents such as petroleum ether, the CO2 supercritical fluid extraction method has the advantages that the residual solvent is avoided, operation condition are mild, and the production is safe, toxic free and environmentally friendly. The oil extraction rate of the Xanthoceras sobifoba kernels is not lower than 50%, and GC-MS detection shows that the content of unsaturated fatty acid reaches up to 75% or above. By adding medical auxiliary materials, the dose forms of soft capsules, micro-capsules, cyclodextrin coated preparations, dripping pills and the like can be prepared and can be used for developing health products for preventing and treating hypertension, hyperlipemia and diseases of cardiovascular systems.

The invention provides a method for preparing a nutrient supplement peony seed oil microcapsule. According to the method, peony seed oil, corn syrup and sodium caseinate serving as main raw materials of the additive are subjected to high-pressure homogenization and spray-drying to prepare powder, and the powder is screened and packaged to obtain peony seed oil microcapsule powder. The peony seed oil microcapsule prepared by the method is easily available in raw materials, is safe and non toxic, is simple in preparation process and low in cost, and is suitable for large-scale production. The peony seed oil microcapsule can be used as a nutrient supplement and widely added into milk powder for middle-aged and old people, protein powder and other solid beverage powders.

A pharmaceutical composition useful for the prevention and / or treatment of hyperlipidemia, which comprises combining an effective amount of a squalene synthase inhibitor and a HMG-CoA reductase inhibitor is provided. Furthermore, a method for preventing and / or treating hepatic toxicity caused by the administration of a HM6-C0A veductase inhibitor, which comprisis adminisvering an effective amount of a sgualence synthase inhibitor, is provided .

The invention relates to blood-fat-reducing nutritional healthcare rice and a preparation method of the blood-fat-reducing nutritional healthcare rice. The blood-fat-reducing nutritional healthcare rice comprises 2-3 parts by weight of black rice, 1-2.5 parts by weight of shelled buckwheat, 1.5-2 parts by weight of sliced yam, 1-2 parts by weight of sliced sweet potato, 1-2 parts by weight of avena sativa kernel, 1-2 parts by weight of small red bean, 1-2 parts by weight of medlar, 1-2 parts by weight of sliced carrot and 0.5-1 part by weight of dry red jujube slice. The preparation method is simple and only comprises the steps of adding raw materials according to a proportion, uniformly mixing and stewing. The blood-fat-reducing nutritional healthcare rice is reasonable in formula, scientific in nutritional structure and rich in various nutrients necessary for a human body, is stewed by using a purple casserole, is rich in fragrance and attractive in color, and has the effect of regulating blood fat. The blood-fat-reducing nutritional healthcare rice has edible and healthcare effects and is very suitable for patients with high blood fat.

A Chinese medicine for treating vascular dementia is prepared from ginseng, notoginseng and earthworm. Its preparing process is also disclosed.

The invention discloses an application of lactobacillus casei and ginkgo leaf extract in preparing medicines used for controlling hyperlipidemia. With a synergetic effect of lactobacillus casei and ginkgo leaf extract, obese mice body mass, TC, TG and MDA are substantially reduced. Degradation rates of TC and TG are respectively improved by 24.48% and 20.93%; mice weight is reduced by 13.22% than a high-fat group; and MDA content is reduced by 5.98%. In mice serum, HDL-C is substantially increased, wherein an increasing rate reaches 167.85%. GSH-PX in mice body is increased by 13.14%. Activities of enzymes such as CAT and SOD are respectively reduced by 49.02% and 3.13%. With the synergetic effect of lactobacillus casei and ginkgo leaf extract, functions of blood fat reducing, cholesterol metabolism promoting, and weight controlling are provided. Therefore, lactobacillus casei and ginkgo leaf extract can be used in preventing and treating hyperlipidemia.

A medication of possessing effect for reducing fat and treating fatty liver,which can make into capsules or other formulation with americanwater plantain and curcuma longa according to conventional chinese medicine processing method.This medicine possesses the effects of good reducing fat and treating fatty liver,virus side effect low and suitable for industrial large production.