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Use of pepper amide compound in preparation of drug or healthcare product for reducing blood fat

A technology of piperonamide and compound is applied in the application field of piperonamide compound in the preparation of hypolipidemic drugs or health care products, and can solve problems such as literature reports that the application of piperonamide compound is not found.

Inactive Publication Date: 2005-07-06
INNER MONGOLIA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] No bibliographical reports on the application of piperonamide compounds in the preparation of blood lipid-lowering drugs and health products have been found so far

Method used

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  • Use of pepper amide compound in preparation of drug or healthcare product for reducing blood fat
  • Use of pepper amide compound in preparation of drug or healthcare product for reducing blood fat
  • Use of pepper amide compound in preparation of drug or healthcare product for reducing blood fat

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Experimental program
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Effect test

Embodiment Construction

[0078] The beneficial effect of the application of the piperonamide compounds of the present invention in blood lipid-lowering drugs or health products will be further illustrated by test examples below.

[0079] Antihyperlipidemic Efficacy Test and Data of Piperonamide Compounds

[0080] 1 Experimental animals and materials

[0081] Experimental animals: Secondary male Wistar rats, weighing 170±10g

[0082] (Provided by Animal Research Center of Inner Mongolia University).

[0083] experimental reagent :

[0084] Piperonamide compounds: piperine, n-butyl piperonamide, isobutyl piperonamide, pyrrole piperonamide are extracted and synthesized by our institute;

[0085] The total cholesterol kit was produced by Zhongsheng Beikong Biotechnology Co., Ltd.;

[0086] Production batch number: 180091, certificate number: Beijing T20010069

[0087] The triglyceride kit is produced by Zhongsheng Beikong Biotechnology Co., Ltd.;

[0088] Production batch number: 220411, certifi...

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Abstract

The invention relates to the use of pepper amide compound in preparation of drug or healthcare product for reducing blood fat with the general formula (I), wherein R, R1, R2 are defined in the specification, the piperamide compounds represented by formula (1) have the actions of substantially reducing cholesterin, triglyceride and increasing high density lipoprotein, fully activating lecithin cholesterol acyl transferase, forwarding extra-hepatic tissue cholesterol to liver, cleaning out plasma lipoproteins, plasma cholesterol and cholesterol esters, thus can be applied to the prevention and treatment of cardiovascular and cerebrovascular diseases, such as atherosclerotic, cerebrovascular, coronary artery and peribiliary vessel pathology and hyperlipemia.

Description

technical field [0001] The present invention relates to the application of piperonamide compounds, more precisely, the present invention relates to the application of piperonamide compounds in the preparation of blood lipid-lowering medicine or health food. Background technique [0002] Medical research shows that lipid metabolism is closely related to cardiovascular diseases, hyperlipidemia is one of the main causes of atherosclerosis, especially the increase of serum total cholesterol level is a risk indicator of atherosclerosis. Blood lipids are the general term for various lipids in serum. Blood lipids mainly include cholesterol, triglycerides, and phospholipids. In addition, there are a small amount of free fatty acids and very small amounts of other lipids, including fat-soluble vitamins and steroid hormones. Two-thirds of cholesterol exists in the form of cholesteryl esters, and the remaining one-third is free cholesterol. [0003] Cholesterol is not only an importan...

Claims

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Application Information

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IPC IPC(8): A61K31/357A61K31/4025A61K31/4525A61P3/06A61P9/00
Inventor 博日吉汗格日勒图那生桑金桩赵睿国高杰松林
Owner INNER MONGOLIA UNIVERSITY
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