The present invention is directed to
solid, sustained-release, oral
dosage form pharmaceutical compositions which contain therapeutic amount of a pharmaceutically acceptable salt of
fluvastatin; hydroxypropyl
methyl cellulose; and a non-ionic, hydrophilic
polymer selected from the group consisting of
hydroxyethyl cellulose having a number average molecular weight
ranging from 90,000 to 1,300,000,
hydroxypropyl cellulose having a number average molecular weight of 370,000 to 1,500,000, and poly(
ethylene oxide) having a number average molecular weight
ranging from 100,000 to 500,000 for the reduction of
plasma cholesterol levels.