3,4-diarylmaleimide derivative and preparation method as well as application thereof

A technology of maleimide and derivatives, applied in the field of 3,4-diarylmaleimide derivatives and its preparation, can solve problems such as ineffective reversal of atherosclerosis and safety risks
CN104447489AActive Publication Date: 2015-03-25南京易腾药物研究院有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
南京易腾药物研究院有限公司
Publication Date
2015-03-25

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Abstract

The invention discloses a 3,4-diarylmaleimide derivative and a preparation method as well as application thereof. The general formula of the 3,4-diarylmaleimide derivative is shown in the specification. The 3,4-diarylmaleimide derivative can be applied to treating or preventing atherosclerosis or reducing plasma cholesterol level, has higher plasma cholesterol reduction activity and has broader market prospect.
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Description

technical field

[0001] The invention belongs to the technical field of chemical synthesis, and specifically relates to 3,4-diarylmaleimide derivatives and their preparation methods and applications. Background technique

[0002] Cardiovascular and cerebrovascular diseases are the number one killer that endangers human life and health today. Hyperlipidemia caused by blood lipid metabolism disorders is one of the important causes of cardiovascular and cerebrovascular diseases such as atherosclerosis, liver cirrhosis, and hypertension. Currently clinically used cholesterol-lowering drugs mainly include statins, fibrates, niacin derivatives and bile acid sequestrants, but the side effects of these drugs are also obvious, especially cerivastatin among statins Many clinical deaths were caused by side effects of rhabdomyolysis. (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)- 2-azetidinone (Ezetimibe, Ezetimibe, Zetia TM ) is a new type...

Claims

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