107 results about "Cholesterol absorption" patented technology

The invention relates to compositions containing cholesterol absorption inhibitors alone or in combination with other therapeutic agents for treating non-alcoholic fatty liver disease-associated disorders by administering a therapeutically effective amount of the compositions to a subject in need thereof.

This invention provides cholesterol absorption inhibitors of Formula I:

and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.

The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.

This invention provides cholesterol absorption inhibitors of Formula I:

and the pharmaceutically acceptable salts thereof, wherein R¹² is an alkyl, alkeny or alkynyl group mono- or poly-substituted with —OH, —COOH or a combination of—OH and —COOH, and R⁹ contains an alkyl, alkeny or alkynyl group substituted with a heterocyclic ring, amino or sulfonyl. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.

To provide a bacterium belonging to the genus Bifidobacterium which is excellent in a survival ability in the gastrointestinal tract, has an effect of inhibiting the cholesterol absorption in the intestinal tract, and is excellent in lipid metabolism ameliorating effects including decreasing the blood cholesterol level and the like, and shows a high survival rate after storage, and a cholesterol absorption inhibitor using the same. The invention provides a cholesterol absorption inhibitor containing, as an active ingredient, at least one microorganism selected from Bifidobacterium animalis subsp. animalis YIT 10394, Bifidobacterium animalis subsp. lactis JCM 1253, Bifidobacterium animalis subsp. lactis JCM 7117, and Bifidobacterium pseudolongum subsp. globosum.

The invention provides a composition and a method for lowering blood serum cholesterol levels or for preventing elevated blood serum cholesterol levels, as well as a suitable composition comprising (a) one or more phytosterols and/or phytostanols capable of reducing cholesterol absorption in the intestine and/or one or more soluble fibres capable of inhibiting ileal bile acid absorption, (b) a composition capable of inhibiting cholesterol biosynthesis, and (c) a composition capable of increasing cholesterol metabolism, wherein at least one of compositions (b) and (c) is preferably derived from plants.

The invention relates to Sedum aizoon L. tea, which is prepared by using the following raw materials in percentage by weight: 70 to 85 percent of Sedum aizoon L. leaves, 11 to 30 percent of aloe leaves, 3 to 15 percent of ginseng leaves and 3 to 15 percent of folium cortex eucommiae, optimally 76 percent of Sedum aizoon L. leaves, 18 percent of aloe leaves, 3 percent of ginseng leaves and 3 percent of folium cortex eucommiae. Sitosterol in the Sedum aizoon L. tea can prevent the cholesterol absorption of human bodies, reduce blood fat and prevent angiosclerosis; flavones in the Sedum aizoon L. tea can expand blood vessels, promote blood circulation and reduce myocardial oxygen consumption; and oleanolic acid in the Sedum aizoon L. tea can protect liver tissues and prevent liver fibrosis. The Sedum aizoon L. tea can be drunk for a long time for strengthening body, preventing arteriosclerosis and heart diseases, protecting the liver and delaying aging.

Embodiments of the present invention relate generally the use of certain compositions, e.g., compositions comprising a glutathione precursor and a selenium source, in the therapy of subjects suffering from diseases associated with hyperiipidemia and/or hypercholesterolemia. Related embodiments of the present invention relate to treatment and/or reducing the incidence of the side effects of statin therapy comprising administering to a subject in need, a composition comprising a glutathione precursor and a selenium source. Embodiments of the invention also relate to the use of the compositions in combination therapy with other agents such as statins, cholesterol absorption inhibitors, bile acid binding resins, or fibrates. In other embodiments, the invention relates to the use of such compositions comprising the glutathione precursor and the selenium source in the therapy of subjects suffering from erectile dysfunction and/or viral diseases such as Ebola virus disease (EVD) or Ebola hemorrhagic fever (EHF).

The invention discloses a Chinese medicine formula for treating hyperlipidemia, and relates to the technical field of traditional Chinese medicines. The Chinese medicine formula comprises the components: rhizoma alismatis, rhizoma polygonati, polygonum multiflorum, semen trigonellae, semen cassia, eucommia ulmoides, hawthorn, radix curcumae longae, lotus leaf, root of red-rooted salvia, black soya bean and Chinese-date. The Chinese medicine formula can be used as a Chinese medicine prescription, can be decocted to take orally, and can also be prepared into pills to take orally. The Chinese medicine formula disclosed by the invention is scientific and reasonable in combination, available in materials, simple in preparation method, short in course of treatment, and good in treatment effect; the Chinese medicine formula compounded by a plurality of medicines has the functions of promoting blood circulation to remove blood stasis, tonifying the liver and kidney, promoting blood circulation to remove meridian obstruction, reducing cholesterol absorption, and reducing blood fat, so as to achieve an effect of treating the hyperlipidemia. The effect of the Chinese medicine formula is significant in clinical application; the effective rate is 95.48%.

The present invention relates to a blood fat lowering mung bean cake. The preparation comprises: grinding mung bean into mung bean powder, spreading the mung bean powder, drying, crushing hawthorn, plantaginis semen shell, brown algae and salvia miltiorrhiza, placing the crushed materials into a leaching tank, carrying out dipping and boiling to obtain a leaching liquid, mixing the leaching liquid and the mung bean powder, adding lactase, carrying out constant temperature enzymolysis to obtain an enzymolysis product, adding Sa-son seed gum, uniformly stirring, dividing into small blocks, placing into a steaming drawer to steam, and carrying out cooling solidification. According to the present invention, with the blood fat lowering mung bean cake, the cholesterol absorption of the intestinal tract is inhibited, the enterocinesia is promoted, the fat oxidation decomposition is accelerated, and the cholesterol excretion rate is increased so as to reduce the cholesterol content in the blood; the preparation process is simple and easy to perform, and the obtained blood fat lowering mung bean cake has characteristics of delicate and fragrant taste, soft and smooth hand-feeling, no hard block and easy digestion and absorption, is suitable for people with pool stomach and pool spleen, is rich in polysaccharides, proteins, vitamins, mineral elements and cellulose, and further has high nutritional values and health functions.

We claim an isolated polypeptide having ability of binding with cholesterol. Said polypeptide is useful for investigating regulation of intestinal cholesterol absorption and cholesterol levels. Also, we claim a composition comprising said polypeptide bound to cholesterol or ezetimibe and a fusion protein comprising the polypeptide thereof.

The invention discloses a Jiangzhining granule. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 25 to 27.5 parts of hawthorn, 1 to 1.25 parts of radix polygonum multiflorum preparata, 1 to 1.25 parts of semen cassiae and 3.25 to 3.75 parts of lotus leaves. The prepared Jiangzhining granule has functions of expanding coronary vessels, increasing coronary flow, reducing cholesterol absorption, accelerating cholesterol excretion, inhibiting the rising of serum cholesterol and the formation of atherosclerotic plaques, reducing blood fat and cholesterol and the like.

The invention is directed in part to methods for treating and/or controlling hepatitis C in a patient. The methods are directed in part to combination therapies using a microsomal triglyceride transfer protein (MTP) inhibitor (for example, AEGR-733 and implitapide) and at least one other active agent.