12 results about "Cholesterol lowering" patented technology

The invention provides a preparation method of an apple water kefir beverage and application of the apple water kefir beverage in lowering cholesterol. The method comprises the following steps: preparing apple juice, activating water kefir grains, inoculating the activated water kefir grains into the apple juice, and fermenting to prepare the apple water kefir beverage. The volatile component change in the fermentation process is analyzed through GC-MS and GC-IMS systems, it is proved that the unique bouquet characteristic and flavor coordination of the apple water kefir beverage are improved through water kefir grain fermentation, and meanwhile the organic acid composition is optimized. A mouse model verifies that the apple water kefir beverage has the effect of reducing cholesterol, can reduce liver lipid droplets, total cholesterol, low-density lipoprotein and triglyceride levels, and also can regulate intestinal microbial communities (increase firmicobacteria, bacteroides and faecalis bacteria). The apple water kefir beverage disclosed by the invention has wide market potential and provides a scientific basis for the development of functional beverages.

The present application provides a kind of compound with indazole group, THR beta receptor agonist and use, compound with indazole group or its pharmaceutically acceptable salt.The present application develops a kind of THR beta selective agonist with better specificity and drugability, the present agonist is better selective agonist THR beta and avoids the activation of THR alpha, separates the harmful influence of thyroid hormone excess from potential beneficial effects such as lowering cholesterol and blood lipids, provides a kind of new type of treatment drug with broad prospects for treating a series of major metabolic diseases in urgent need of solution.

The invention belongs to the technical field of microorganisms, and discloses a new application of ackermania martensii and a new strain Amass-2. The strain is safe, has no toxic factors, and has the functions of reducing cholesterol, inhibiting fat synthesis and reducing body weight.

This invention belongs to the field of traditional Chinese medicine technology. More specifically, it relates to the application of a processed product of Citrus reticulata peel or Citrus reticulata peel embryo (with bitterness removed) in the preparation of products for lowering lipids and preventing and treating hyperlipidemia. Compared with the original product, the processed product of Citrus reticulata peel or Citrus reticulata peel embryo provided by this invention significantly reduces bitterness while significantly enhancing its effects in lowering cholesterol and triglycerides and regulating blood lipids. This processed product helps maintain normal levels of serum cholesterol, triglycerides, and low-density lipoprotein, and can significantly improve liver damage caused by hyperlipidemia, thus having important application value in lowering lipids and protecting the liver.

The present invention relates to a composition for alleviating, preventing, or treating a kidney disease or a vascular disease accompanied by hypoxia, the composition comprising a Panax ginseng extract fermented with a Lactobacillus plantarum strain. When the Lactobacillus palantarum strain is treated with cells, hypoxia-suppressing and cholesterol accumulation-lowering effects are exhibited. Therefore, the composition can be effectively used in a composition for alleviating, preventing, or treating a kidney disease or a vascular disease accompanied by hypoxia.

The application provides a preparation method and application of a double-network emulsion gel with anti-freezing property, and belongs to the technical field of food processing. The application takes hydrophilic polysaccharide, plant protein, phytosterol, vegetable fat and water as main raw materials, and adopts a reverse solvent method to prepare an aqueous phase containing plant protein and polysaccharide, so as to form a first layer network structure by using the plant protein and the polysaccharide; then the oil solution of the phytosterol is mixed with the aqueous phase, and a second layer network structure is formed by using the plant protein and the phytosterol in the oil-water mixture; finally, high-speed homogenization is performed to make the double-network structure more compact, and self-assembly is formed during the cooling process to form an emulsion gel; the obtained emulsion gel can resist repeated freezing and thawing, has the health and nutritional characteristics of low saturated fat and reduced cholesterol, and can be widely used to replace animal fat or fat tissue partially or entirely.

The invention belongs to the technical field of microorganisms, and discloses ackermania martensii Amass-1 with the preservation number of CCTCC (China Center For Type Culture Collection) NO: M20241157 and application of the ackermania martensii Amass-1. The strain is safe, has no toxic factors, and has the functions of reducing cholesterol, inhibiting fat synthesis, reducing body weight and improving diarrhea.

To provide a dextran having a water-soluble dietary fiber content of a predetermined level or higher.SOLUTION: The present invention provides a branched dextran derived from a lactic acid bacterium belonging to Leuconostoc citreum in which the glycosidic bonds of the branched dextran comprise 50% to less than 99% of α-1, 6 bonds, 1% to less than 40% of α-1,2 bonds, and 0.1 to less than 20% of α-1,3 bonds, the value obtained by dividing the weight average molecular weight of the branched dextran by the number average molecular weight of the branched dextran is 100 to less than 1500, and the branched dextran contains 80% by mass or more of water-soluble dietary fiber.SELECTED DRAWING: None

The present disclosure relates to combinations of obicetrapib and ezetimibe, or their salts, solvates or derivatives thereof. The disclosure further describes the use of ezetimibe and obicetrapib, e.g. in the form of a fixed dose combination product, for preparation of medicaments and method of treatment of subjects requiring reduction in LDL-cholesterol or those suffering from hyperlipidemia or mixed dyslipidemia.

The invention provides a phytosterol-gallic acid derivative with cholesterol lowering and antioxidant activity and a preparation method thereof, and belongs to the technical field of functional food raw material synthesis. A step-by-step construction strategy is adopted, firstly, C-3 site of phytosterol is subjected to succinic acid esterification, then, a flexible bridging unit is further constructed through an ethylene glycol chain segment, finally, gallic acid is introduced into the tail end, and finally, the phytosterol-gallic acid derivative which is also called phytosterol-succinic acid-ethylene glycol-gallic acid is obtained. The designed structure of the derivative avoids the loss of phenolic hydroxyl groups caused by direct esterification, and ensures that trihydroxy groups of gallic acid are kept complete; the adjustability of molecular conformation is effectively improved by introducing an ethylene glycol flexible chain, so that a polyphenol terminal group is easier to expose on an interface, the antioxidant function of the polyphenol terminal group is favorably exerted, meanwhile, the insertion and adaptability of molecules in a biological membrane are improved, and a structural basis is provided for improving the cholesterol lowering potential of sterol.

The invention discloses a preparation method of a low-GI whole grain base material rich in dietary fibers. The method comprises the following steps: step 1, extracting low-GI grain starch; and step 2, enzyme modification of the whole grain base material. According to the invention, 14 whole grain raw materials are screened, and low-GI whole grains are preferably selected and compounded, so that the selection of low-GI food industry raw materials is enriched, and the raw materials are different from single grains in the current market and are multi-grain compound base materials. The whole-grain base material not only meets the low GI requirement, but also is rich in dietary fibers and flavonoid substances, so that the whole-grain base material has the effects of enhancing satiety, promoting intestinal tract movement, regulating gastrointestinal functions, reducing cholesterol and glucose levels, improving vascular elasticity and promoting insulin secretion, and can better meet various requirements in the field of functional foods.

3 β-hydroxy-5-cholestenoic acid 3-sulfate (CA3S), a sulfated derivative of 3β-hydroxy-5-cholestenoic acid (CA), is provided. Both CA and CA3S have potent cholesterol and triglyceride lowering and anti-inflammatory activities. Methods of using CA and CA3S to lower lipids and prevent or treat inflammation-associated diseases are also provided.