50 results about "Cholesterol lowering" patented technology

The invention belongs to the field of microorganisms, and provides lactobacillus paracasei Jlus660321 with a function of assisting in reducing blood fat and cholesterol and application of the lactobacillus paracasei Jlus660321, and the preservation number of the lactobacillus paracasei Jlus660321 is CGMCC No. 33962. The lactobacillus paracasei Jlus 660321 has the functions of assisting in lowering blood fat and lowering cholesterol, shows excellent cholesterol lowering performance in a cholesterol degradation experiment, and can degrade 61.60% of cholesterol in the experiment. A hemolysis experiment result is gamma-hemolysis, namely, hemolysis is avoided, and toxic and side effects are small. Rat in-vivo experiments show that the lactobacillus paracasei Jlus 660321 can effectively slow down the increase of body weight, liver weight, liver index, low-density lipoprotein content and triglyceride content caused by high-fat diet, and further show that the lactobacillus paracasei Jlus 660321 has the function of assisting in reducing blood fat and cholesterol; the compound can be used for preparing medicines, nourishment or health care products for assisting in reducing blood fat and / or reducing cholesterol.

Disclosed herein are pharmaceutical compositions to treat or prevent obesity, excess or overweight conditions, and metabolic syndrome comprising an effective amount of one or more mTOR inhibitors and optionally an effective amount of one or more thyroid hormones and / or an effective amount of one or more cholesterol-lowering agents. Further disclosed herein are methods of treating or preventing obesity, excess or overweight conditions, and metabolic syndrome comprising administering an effective amount of a pharmaceutical composition comprising one or more mTOR inhibitors and optionally an effective amount of one or more thyroid hormones and / or an effective amount of one or more cholesterol-lowering agents.

The present disclosure relates to a stable pharmaceutical composition comprising a fixed dose combination of olbistetrapib and ezetimibe or a salt, solvate, or derivative of olbistetrapib and ezetimibe. The disclosure further describes the use of ezetimibe and Eubiquitrapib, for example in such fixed dose combinations, for the preparation of an agent for the treatment of a subject in need of lowering LDL-cholesterol or a subject suffering from hyperlipidemia or mixed dyslipidemia, and methods of treatment for the subject.

The invention belongs to the technical field of medicines and health-care products, and discloses an earthworm protein peptide polypeptide tablet with functions of dissolving thrombus and protecting blood vessels. Comprising the following components in parts by mass: 20 to 50 parts of earthworm protein peptide, 30 to 40 parts of sorbitol, 2 to 5 parts of lactose, 2 to 10 parts of freeze-dried natto powder, 2 to 10 parts of rice bran fatty alkanol, 1 to 5 parts of dunaliella salina powder, 1 to 5 parts of bovine myocardial peptide powder, 0.01 to 0.05 part of collagen peptide, 0.01 to 0.05 part of soybean peptide powder, 0.01 to 0.05 part of vitamin B6, 0.04 to 0.12 part of a compound nutrition enhancer, 1 to 5 parts of fructo-oligosaccharide, 0.01 to 0.05 part of magnesium stearate and 0.04 to 0.012 part of a compound coating agent. The earthworm protein peptide polypeptide tablet has the effects of thrombolysis and blood fat reduction, can assist in preventing thrombosis, regulating blood fat metabolism and assisting in reducing cholesterol, and has an antioxidant function.

The invention discloses a Weissella virida 38-3 strain and an application thereof. Relates to the technical field of microorganisms. The invention provides a strain and application thereof. The strain is safe in separation source, high in growth speed and excellent in fermentation performance; the strain has the advantages of good biological safety, no hemolytic activity and no generation of bioamine, is sensitive to antibiotics such as ampicillin, erythromycin, kanamycin, streptomycin, tetracycline, vancomycin, chloramphenicol, gentamicin, clindamycin, ciprofloxacin, cefixime and the like, has good probiotic performance, has good gastric juice and intestinal juice tolerance and strong cell surface adhesion, and can be used for preparing antibiotics. Good pathogenic bacterium inhibiting and cholesterol lowering capabilities are realized. The strain disclosed by the invention can be used as a probiotic to prepare a food leavening agent, multifunctional medicines, functional foods or health-care foods, and has wide market prospects and application values.

The invention relates to the technical field of biological medicine, in particular to application of cyclic dipeptide to improvement or treatment of dyslipidemia related diseases. According to the present invention, the research results show that the cyclo (glycerol-casein) dipeptide has good safety and cholesterol lowering activity, and can reduce mouse serum total cholesterol, low density lipoprotein cholesterol, increase serum high density lipoprotein cholesterol, reduce the content of liver total cholesterol, reduce liver fat accumulation, and slow down the weight increase of mice. The cyclic (glycerol-casein) dipeptide can realize the effect of lowering cholesterol by regulating intestinal flora. The cyclic (glycerol-tyrosine) dipeptide is derived from probiotics, food and medicines, belongs to food-borne cyclic dipeptide, and is high in safety and small in toxic and side effects. The cyclo (glycerol-casein) dipeptide is expected to be developed into a class of innovative medicines and health-care foods with the effect of reducing cholesterol, and has a very good application prospect. The invention also provides the cyclic (sweet-tyrosine) dipeptide and a health food and a pharmaceutical composition containing the cyclic (sweet-tyrosine) dipeptide.

The invention relates to the technical field of microorganisms, and discloses an application of a secondary metabolite of phytobacterium plantarum YN-06 in lowering cholesterol, the phytobacterium plantarum YN-06 is preserved in China Center for Type Culture Collection, the preservation address is Wuhan University, Wuhan, China, the preservation time is March 13, 2025, the preservation number is CCTCC NO: M 2025471, and the classification name is Lactobacillus plantarum YN-06. According to the application of the secondary metabolite of the phytobacterium plantarum YN-06 in lowering cholesterol, the YN-06 has a remarkable cholesterol degradation effect, can produce various beneficial metabolites such as L-beta-homoserine and 5-amino valeraldehyde, can be used for developing fermented dairy products and other functional foods with a cholesterol lowering function, and has a wide application prospect. And new strategies and products are provided for preventing and improving hypercholesteremia and related cardiovascular diseases.

The invention provides a preparation method of an apple water kefir beverage and application of the apple water kefir beverage in lowering cholesterol. The method comprises the following steps: preparing apple juice, activating water kefir grains, inoculating the activated water kefir grains into the apple juice, and fermenting to prepare the apple water kefir beverage. The volatile component change in the fermentation process is analyzed through GC-MS and GC-IMS systems, it is proved that the unique bouquet characteristic and flavor coordination of the apple water kefir beverage are improved through water kefir grain fermentation, and meanwhile the organic acid composition is optimized. A mouse model verifies that the apple water kefir beverage has the effect of reducing cholesterol, can reduce liver lipid droplets, total cholesterol, low-density lipoprotein and triglyceride levels, and also can regulate intestinal microbial communities (increase firmicobacteria, bacteroides and faecalis bacteria). The apple water kefir beverage disclosed by the invention has wide market potential and provides a scientific basis for the development of functional beverages.

The present application provides a kind of compound with indazole group, THR beta receptor agonist and use, compound with indazole group or its pharmaceutically acceptable salt.The present application develops a kind of THR beta selective agonist with better specificity and drugability, the present agonist is better selective agonist THR beta and avoids the activation of THR alpha, separates the harmful influence of thyroid hormone excess from potential beneficial effects such as lowering cholesterol and blood lipids, provides a kind of new type of treatment drug with broad prospects for treating a series of major metabolic diseases in urgent need of solution.

The invention provides a dairy product and a preparation method thereof, and the dairy product contains 4-6% of protein based on the total weight of the dairy product. Based on 100 parts by weight of protein, the dairy product contains 2.5-34g of sterol ester; the dairy product also contains 1.25 to 6.0 g of phospholipid, 0.75 to 3.0 g of stearoyl lactate, preferably 1.25 to 2.5 g of stearic acid sodium lactate, and 2.5 to 3.0 g of mono / diglycerol fatty acid ester based on 100 parts by weight of protein. The dairy product disclosed by the invention is simple in formula composition, does not contain colloid, is clean in label, and can be stored at normal temperature for more than 6 months; meanwhile, the health effects of lowering cholesterol and the like are achieved.

The invention belongs to the technical field of microorganisms, and discloses a new application of ackermania martensii and a new strain Amass-2. The strain is safe, has no toxic factors, and has the functions of reducing cholesterol, inhibiting fat synthesis and reducing body weight.

The invention belongs to the technical field of edible oil, and particularly relates to edible oil with a blood fat reducing effect and a preparation method of the edible oil. Comprising the following raw materials in parts by weight: 1 to 10 parts of base oil, 90 to 100 parts of 1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride, 0.3 to 0.5 part of an emulsifier, 0.05 to 0.09 part of an antioxidant and 0.02 to 0.05 part of a stabilizer. The base oil is composed of the sunflower seed oil and the tea seed oil, and the base oil and the 1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride are matched for use, so that the oil has a good blood fat reducing effect, and can effectively reduce cholesterol, maintain cardiovascular health and prevent arteriosclerosis. The antioxidant is composed of the vitamin E, the alpha-mangostin and the oryzanol, all the components have a synergistic effect and jointly improve the oxidation stability of the edible oil, and meanwhile, the antioxidant is matched with the stabilizer, so that the storage life of the edible oil can be effectively prolonged, and the storage stability is improved.

According to the functional healthy plant blend oil and the application thereof disclosed by the invention, various edible oils are reasonably selected and matched, so that intake of different fatty acids can be met, the nutritional value is high, and the health-care effect of the functional healthy plant blend oil can be improved; the product has prevention and auxiliary improvement effects on part of diseases including high cholesterol, obesity, cancer, haemorrhoids, constipation, rheumatic arthritis and the like, for example, rich unsaturated fatty acid can achieve the effect of reducing cholesterol, and vitamin E contained in the product also has the effects of resisting oxidation and the like, so that damage of free radicals to cells can be reduced.

The invention relates to the technical field of feeds, and particularly discloses a wormwood compound feed capable of reducing cholesterol and resisting viruses as well as a preparation method and application of the wormwood compound feed. The wormwood compound feed comprises the following raw materials: wormwood dry powder, mulberry leaf powder, moringa oleifera leaf powder, a houttuynia cordata extract and a fermentation carrier, the fermentation carrier comprises at least one of lactobacillus fermented soybean meal and lactobacillus fermented corn flour. The invention successfully develops the wormwood compound feed capable of reducing cholesterol and resisting viruses through scientific proportioning and an innovative process. The feed can significantly reduce cholesterol, and has high practical application value and market prospect. Compared with the traditional feed, the feed disclosed by the invention has obvious advantages in the aspects of functionality, safety, bioavailability, economic benefit and the like.

The invention provides a compound with a heterocyclic structure, a THRbeta receptor agonist and application, and the compound with the heterocyclic structure or pharmaceutically acceptable salt thereof. The invention develops a THRbeta selective agonist with better specificity and druggability, the THRbeta selective agonist can better selectively agonize THRbeta so as to avoid activation of THRalpha, and the harmful effect of excessive thyroid hormone is separated from the potential beneficial effects of lowering cholesterol and blood fat and the like; the invention provides a novel therapeutic drug with a wide prospect for treating a series of serious metabolic diseases to be solved urgently.

The present disclosure provides a cholesterol liquid crystal display device and a driving method thereof. The cholesterol liquid crystal display device comprises a cholesterol liquid crystal display panel, a time sequence control module and a driving module. The time sequence control module is used for outputting an enable signal and a latch signal. The driving module is used for receiving the enable signal and the latch signal and outputting a driving voltage to the cholesterol liquid crystal display panel. The enable signal is used for controlling the driving module to stop outputting the driving voltage, and the latch signal is used for controlling the driving module to enable the driving voltage to be discharged to zero volt. Therefore, the power consumption of the cholesterol liquid crystal display device is reduced.

This invention belongs to the field of traditional Chinese medicine technology. More specifically, it relates to the application of a processed product of Citrus reticulata peel or Citrus reticulata peel embryo (with bitterness removed) in the preparation of products for lowering lipids and preventing and treating hyperlipidemia. Compared with the original product, the processed product of Citrus reticulata peel or Citrus reticulata peel embryo provided by this invention significantly reduces bitterness while significantly enhancing its effects in lowering cholesterol and triglycerides and regulating blood lipids. This processed product helps maintain normal levels of serum cholesterol, triglycerides, and low-density lipoprotein, and can significantly improve liver damage caused by hyperlipidemia, thus having important application value in lowering lipids and protecting the liver.

The present invention provides a novel preparation which has an excellent lipolysis-promoting effect, an excellent visceral fat and body fat loss effect, an excellent weight loss effect, and an excellent BMI improvement effect. Another purpose of the present invention is to provide a novel preparation which has an excellent insulin resistance amelioration effect, an excellent cholesterol level reduction effect, and the like.　The present invention is an internal composition which contains glyasperin B and which is used for at least one of lipolysis, fat burning, fat consumption support, BMI improvement, BMI reduction support, abdominal fat loss, visceral fat loss, body fat loss, waist circumference reduction, insulin resistance amelioration, and LDL cholesterol level reduction. The internal composition according to the present invention is preferably used by adults who have a BMI of at least 23 kg / m2 but less than 30 kg / m2 and adults who have a visceral fat area of at least 100 cm2.

The present invention relates to a composite probiotic agent for reducing cholesterol and a preparation method thereof. The composite probiotic agent capable of reducing cholesterol comprises at least two of Lactobacillus johnsonii CICC 6084, Bifidobacterium animalis CICC 6250 and Lactobacillus reuteri CICC 6132. The three probiotics are subjected to high-density anaerobic fermentation, freeze drying and other steps to obtain probiotic freeze-dried bacterial powder. Any two of the three probiotic freeze-dried bacterial powders have significant synergistic effects in reducing serum cholesterol in vitro or in vivo compared with a single bacterial agent. The composite bacterial agent composed of the three probiotic freeze-dried bacterial powders also has significant synergistic effects compared with any two of them. The obtained composite probiotic agent is applied to the preparation of cholesterol-reducing agents, which has great application prospects.

The invention belongs to the technical field of microorganisms, and particularly relates to multifunctional Ackermania muci-3 and application thereof. The preservation number of the ackermania muci-3 is CCTCC (China Center For Type Culture Collection) NO: M 2024048, and the ackermania muci-3 has multiple functions of reducing cholesterol, inhibiting fat synthesis, controlling body weight, resisting tumors and the like.

The invention provides application of bacillus natto in fermentation of agrocybe cylindracea and co-production of polypeptide and vitamin K2 and a method, and belongs to the technical field of microbial fermention.The bacillus natto is used for fermentation of agrocybe cylindracea to obtain polypeptide and vitamin K2; the bacillus natto is preserved in Guangdong Microbial Culture Collection Center on October 21, 2020, and the preservation number of the bacillus natto is GDMCC No: 61234. The agrocybe cylindracea polypeptide and the vitamin K2 can be co-produced, compared with a traditional enzyme method for preparing the agrocybe cylindracea peptide, the method has the advantages of being high in conversion rate, simple in process, green, economical and the like, the fermented agrocybe cylindracea peptide has multiple functions of lowering cholesterol and blood sugar and resisting oxidation, and the method has very high application value and economic value.

To provide a material (agent) and so on for liver function improvement and / or cholesterol reduction for use in human beings, etc.SOLUTION: There are provided: (1) an agent for liver function improvement containing cynaropicrin; (2) an agent for cholesterol reduction containing cynaropicrin; (3) an oral composition containing the agent according to (1) or (2); and so on.SELECTED DRAWING: None

The present invention relates to a composition for alleviating, preventing, or treating a kidney disease or a vascular disease accompanied by hypoxia, the composition comprising a Panax ginseng extract fermented with a Lactobacillus plantarum strain. When the Lactobacillus palantarum strain is treated with cells, hypoxia-suppressing and cholesterol accumulation-lowering effects are exhibited. Therefore, the composition can be effectively used in a composition for alleviating, preventing, or treating a kidney disease or a vascular disease accompanied by hypoxia.

The present invention describes a cholesterol synthesis inhibitor alone or in association with at least another anticancer agent for use in the treatment of cancers characterized by aberrant expression of hERG1. Further the present invention describes also a kit for a simultaneous, separate or sequential use in the treatment of cancers characterized by aberrant expression of hERG1, said kit comprising a cholesterol lowering agent and at least an anticancer agent, preferably a cholesterol synthesis inhibitor, an anti-hERG1 / β1 integrin complex bispecific antibody and / or chemotherapy agent.

The application provides a preparation method and application of a double-network emulsion gel with anti-freezing property, and belongs to the technical field of food processing. The application takes hydrophilic polysaccharide, plant protein, phytosterol, vegetable fat and water as main raw materials, and adopts a reverse solvent method to prepare an aqueous phase containing plant protein and polysaccharide, so as to form a first layer network structure by using the plant protein and the polysaccharide; then the oil solution of the phytosterol is mixed with the aqueous phase, and a second layer network structure is formed by using the plant protein and the phytosterol in the oil-water mixture; finally, high-speed homogenization is performed to make the double-network structure more compact, and self-assembly is formed during the cooling process to form an emulsion gel; the obtained emulsion gel can resist repeated freezing and thawing, has the health and nutritional characteristics of low saturated fat and reduced cholesterol, and can be widely used to replace animal fat or fat tissue partially or entirely.

The invention relates to the field of microorganisms, in particular to lactococcus, a microbial agent and application of the lactococcus and the microbial agent in lowering cholesterol. The invention provides lactococcus. The lactococcus is selected from at least one of lactococcus with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No. 32756, lactococcus with the preservation number of CGMCC No. 32757 and lactococcus with the preservation number of CGMCC No. 32758. The lactococcus separated from yak ghee provided by the invention has good cholesterol lowering capacity and excellent acid resistance, cholate resistance and high temperature resistance, and provides a reference basis for application and development of the lactococcus in fermented food and development of probiotic functional milk products.

The invention belongs to the technical field of microorganisms, and discloses ackermania martensii Amass-1 with the preservation number of CCTCC (China Center For Type Culture Collection) NO: M20241157 and application of the ackermania martensii Amass-1. The strain is safe, has no toxic factors, and has the functions of reducing cholesterol, inhibiting fat synthesis, reducing body weight and improving diarrhea.

The invention discloses a low-sugar badam milk beverage. The low-sugar badam milk beverage comprises the following raw materials: badam and xylitol. The preparation method of the low-sugar Badam milk beverage comprises the following steps: raw material pretreatment, peeling, primary pulping, secondary pulping, slurry mixing, filling and sterilization. The invention belongs to the technical field of plant milk processing, and particularly provides a Badam milk which selects xylitol as a sweetening agent, is suitable for people with controlled sugar to drink, is smooth and light in taste, is rich in nutritional ingredients such as plant protein, unsaturated fatty acid, vitamin E and dietary fiber, is beneficial to promoting reduction of cholesterol, and is suitable for being drunk by people with controlled sugar. The invention relates to a low-sugar almond milk beverage capable of protecting cardiovascular health, maintaining blood sugar stability and regulating intestinal functions and a preparation method thereof.

The invention discloses lactobacillus mucus fermentation HF04 with cholesterol lowering capacity and application of the lactobacillus mucus fermentation HF04. The lactobacillus mucus fermentation HF04 is lactobacillus mucus fermentation HF04 and is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC NO.25482. The invention further discloses a preparation method of the lactobacillus mucus fermentation HF04. Probiotic strains with cholesterol removing capacity are screened out according to in-vitro experiments, and strains with good tolerance are obtained through simulated gastric juice and simulated intestinal juice tolerance experiments of the strains. Experiments prove that the lactobacillus mucilaginosus HF04 disclosed by the invention has acid-resistant and cholate-resistant capabilities, and in-vitro and in-vivo experiments show that the lactobacillus mucilaginosus HF04 has cholesterol removal capability; animal experiments show that the strain has the function of remarkably reducing cholesterol, can reduce the level of total cholesterol, triglyceride and low-density lipoprotein cholesterol in serum, and meanwhile, can remarkably reduce the level of liver lipid and relieve liver injury caused by long-term high-fat diet of mice.

The invention relates to the technical field of biology, in particular to a hydrolysis method and application of oligopeptide. According to the method, the oligopeptide with the effect of reducing cholesterol is obtained through enzymolysis separation from the waste soybean meal for the first time, the attributes of the soybean meal are fully considered in the preparation method, the oligopeptide is prepared by adopting a two-time composite enzymolysis process and combining an ultrasonic-assisted means, and compared with an existing single enzymolysis process, the oligopeptide has the advantages that the content of cholesterol in the oligopeptide is reduced; the method has outstanding dominant positions, can be used for effectively obtaining the oligopeptide with excellent cholesterol lowering activity, has a blood fat lowering effect, and has a relatively great application prospect and market.