72 results about "Constipation" patented technology

The invention belongs to the field of pet food processing, and relates to a functional pet food for regulating intestinal health and a preparation method thereof. The functional pet food can increase MTL content in dog serum in a physiological range, reduce DAO activity and D-lactic acid and LPS content in dog serum, improve intestinal mucosa barrier function, and significantly improve dog intestinal health. The functional pet food can shorten gastrointestinal transmission time and effectively improve constipation. The functional pet food disclosed by the invention has a good effect in the aspects of treating diarrhea and constipation, and has a two-way regulation effect in regulating intestinal flora imbalance. The components of the raw materials have a synergistic effect, the nutrition is balanced, the preparation method is simple, the palatability is optimally designed, and the metabolic characteristic is free of burden, so that pets can safely take the feed for a long time, a convenient and efficient preventive health management scheme is provided for family pet raising, and the feed has a relatively good commercial application prospect.

The invention belongs to the technical field of microorganisms, and relates to a bifidobacterium breve strain capable of relieving constipation, the strain is bifidobacterium breve Bb-PG-14, the classification name of the strain is Bifidobacterium breve, the preservation number is CGMCC No.31861, the preservation time is September 4, 2024, the preservation unit is China General Microbiological Culture Collection Center, the preservation number is CGMCC No.31861, the preservation number is CGMCC No.31861, the preservation number is CGMCC No.31861, the preservation number is CGMCC No.31861, the preservation number is CGMCC No.31861, and the preservation number is CGMCC No.31861. The address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The strain is separated and purified from excrement of healthy babies, has relatively strong acid resistance, alkali resistance, cholate resistance and artificial simulated gastrointestinal fluid tolerance, and has the characteristics of probiotics.

The invention discloses a traditional Chinese medicine navel pill for treating constipation, diarrhea and chronic enteritis and a preparation method of the traditional Chinese medicine navel pill, and belongs to the technical field of traditional Chinese medicine. The preparation method comprises the following steps: weighing the raw materials, mixing, crushing and sieving to obtain mixed medicine powder, adding honey into the mixed medicine powder, stirring and kneading until the mixture is sticky, and preparing pills. The navel pill is applied to the navel, two-way conditioning of constipation and diarrhea is achieved through the synergistic effect of traditional Chinese medicine, chronic enteritis can be treated in a targeted mode, intestinal mucosa is effectively repaired, the intestinal inflammation state is improved, the navel pill has the advantages of being safe and convenient to apply, high in bioavailability, mild and free of side effects, stimulation of oral medicine to gastrointestinal tracts is avoided, and the curative effect is good. The food is suitable for digestion function conditioning of different people.

The present application relates to the technical field of health care products, in particular to a pelvic floor muscle repairing composition containing supermolecular tightening Dropsordry and a preparation method thereof, which comprises the following components in mass fraction: 10-14 parts of protein composition, 20-24 parts of chitosan modified Dropsordry, 5-7 parts of freeze-dried powder of Lactobacillus bulgaricus, 10-12 parts of hyaluronic acid, 6-8 parts of glycine and 15-17 parts of proline; each part of the protein composition comprises 20-30 parts of myosin, 30-34 parts of actin, 5-10 parts of hydrolyzed collagen and 240-280 parts of deionized water. The pelvic floor muscle repairing composition can reduce drug toxicity, reduce the amount of drug administration, continuously supplement the required elements of the body during treatment, and quickly relieve the constipation problem caused by the functional damage of the pelvic floor muscle.

The application provides bifidobacterium longum MG-G763 for improving constipation, and belongs to the technical field of microorganisms. The bifidobacterium longum MG-G763 provided by the application can effectively relieve constipation by integrating multiple effects such as nerve regulation, immune regulation, barrier repair and flora regulation, and systematically restoring intestinal function homeostasis. The bifidobacterium longum MG-G763 can significantly improve the defecation particle number and defecation weight of constipated mice, shorten the time for defecating the first black stool, improve the small intestinal transport rate of the mice, effectively improve and relieve the defecation condition of the constipated mice, and significantly increase the amount of intestinal beneficial bacteria and reduce the amount of harmful bacteria, thereby promoting intestinal health.

This invention discloses a guanylate cyclase-C (GC-C) activating peptide and its applications, belonging to the field of bioactive peptide technology. The amino acid sequence of the GC-C activating peptide is PFPGPIPN. The GC-C activating peptide of this invention can significantly activate GC-C activity, increasing intracellular cGMP levels. Furthermore, the GC-C activating peptide of this invention can alleviate constipation and abdominal pain symptoms in mice, thereby effectively preventing or improving irritable bowel syndrome (IBS). Therefore, the GC-C activating peptide provided by this invention has advantages such as high activity, safety and non-toxicity, and good water solubility. It can be used as a candidate molecule for alternative or adjuvant drugs in the clinical treatment of IBS, and also as a health product or food to improve constipation or abdominal pain.

The invention belongs to the technical field of medicinal and edible products, and particularly relates to a composition for improving constipation and diarrhea as well as a preparation method and application thereof. The composition for improving constipation and diarrhea provided by the invention comprises the following raw materials in parts by weight: Chinese yam, resistant dextrin, ginseng, radix ophiopogonis, poria cocos, dogwood, semen coicis, aronia melanocarpa freeze-dried powder, mulberry, radix polygonati officinalis, lycium ruthenicum freeze-dried powder, fructo-oligosaccharide and crystalline fructose. Experiments prove that through synergistic cooperation of the raw materials, the composition can effectively improve the diarrhea index of diarrhea rats, improve the intestinal barrier function, increase the villus length of small intestine tissues, reduce the depth of crypts, increase the water content of excrement of constipation mice and promote intestinal peristalsis, and has the effect of bidirectionally regulating diarrhea and constipation; the intestinal barrier function can be favorably repaired.

The application provides a probiotic preparation and application thereof. The probiotic preparation comprises active ingredients and adjuvants, wherein the active ingredients comprise oxygen scavenging bacteria, organic acid producing bacteria and space-occupying bacteria; the oxygen scavenging bacteria are Weizmannia bacteria, the organic acid producing bacteria are lactobacillus or lactobacillus plantarum, and the space-occupying bacteria are bifidobacterium; the water activity of the probiotic preparation is less than or equal to 0.3, preferably 0.04-0.3, further preferably 0.04-0.2, and more preferably 0.04-0.15. The probiotic preparation has high live bacteria stability when stored at room temperature. Moreover, the probiotic preparation can effectively improve functional gastrointestinal diseases and has bidirectional regulation function, and is suitable for different intestinal motility disorders, such as diarrhea and constipation.

The invention relates to the technical field of compositions, and particularly discloses a composition for bidirectionally regulating diarrhea and constipation and promoting Akk proliferation and application. The composition for bidirectionally regulating diarrhea and constipation and promoting Akk proliferation, provided by the invention, comprises bifidobacterium longum subsp. Infantis i18 and casei paracasei N1115. In the composition provided by the invention, all the components have a synergistic effect, so that diarrhea and constipation can be safely, effectively and bidirectionally regulated and improved, the intestinal microecological steady state can be further maintained by promoting Akk proliferation, and the composition has a wide application prospect.

The invention belongs to the technical field of medicines, and particularly relates to application of harpagide in preparation of a medicine for treating constipation. The technical problem to be solved by the invention is to provide a safer, milder and new effective choice for treating and relieving constipation. The technical scheme for solving the technical problem is to provide application of harpagide in preparation of drugs or health care products for treating or relieving constipation. The harpagide achieves or even exceeds the treatment effect of the fluid-increasing decoction compound. Meanwhile, in the small pigs, the constipation symptom of the small pigs in the gestation period is also obviously relieved. When the harpagide is used as a medicine for treating constipation, a safer, more efficient and standardized treatment effect can be achieved, a safer and milder treatment choice is provided for patients with constipation, and the harpagide has a very good application prospect.

The application belongs to the technical field of microorganisms, and provides application of Propionibacterium freudenreichii subsp. shermanii in preparation of products for improving constipation and depression, wherein the Propionibacterium freudenreichii subsp. shermanii NHNK-616 is preserved in the China Center for Type Culture Collection on July 1, 2024, and the preservation number is CCTCC NO: M 20241429. The inventors find that NHNK-616 has the functions of promoting 5-HT secretion, up-regulating intestinal aquaporin and brain-derived neurotrophic factor genes, metabolically producing gamma-aminobutyric acid, inhibiting growth of Candida albicans, inhibiting hypha formation of Candida albicans, combining with hypha of Candida albicans, and up-regulating expression of intestinal defensin and mucin genes, and therefore can be used for preparing products for improving constipation and depression.

The invention discloses a traditional Chinese medicine composition for treating constipation as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The composition comprises the following components in parts by weight: 45 to 85 parts of Chinese pulsatilla root, 45 to 85 parts of oldenlandia diffusa, 45 to 85 parts of sculellaria barbata, 80 to 140 parts of Chinese actinidia root, 45 to 85 parts of trogopterus dung, 80 to 140 parts of coix seed, 80 to 140 parts of poria cocos, 80 to 140 parts of rhizoma pinellinae praeparata, 45 to 85 parts of pericarpium citri reticulatae, 60 to 100 parts of bighead atractylodes rhizome, 45 to 85 parts of endothelium corneum gigeriae galli, 60 to 100 parts of white hyacinth bean, 60 to 100 parts of dried ginger and 45 to 85 parts of liquorice. The traditional Chinese medicine composition has a good treatment effect on constipation caused by gastrointestinal tumors, is mild in medicine property, and is specially developed for patients with constipation caused by tumors.

Provided herein are formulations for use in enteral tube feeding, that contain one or more whole food-based ingredients, mineral nutrients, small molecules, and / or large molecules, the combination of which is effective to bind bile acids when administered to a subject in need thereof. The combination of crafted ingredients for tube feeding reduce symptoms of gastroesophageal reflux, vomiting, abdominal pain, irregular stooling (diarrhea or constipation) and to reduce organ damage including pneumonia, pharyngitis, aspiration, esophagitis, gastritis and enteritis.

Disclosed are the use of methods for reducing one or more gastrointestinal side effects in a subject receiving glucagon-like peptide-1 (GLP-1) receptor agonist (RA) therapy. The methods include administering to a subject receiving GLP-1 RA therapy an amount of homotaurine-like gastrointestinal distress-relieving (HTL-GIDR) composition effective to reduce gastrointestinal side effects of GLP-1 RA therapy, e.g., nausea, vomiting, and constipation. Generally, the HTL-GIDR composition can be homotaurine or a homotaurine analog such as acamprosate calcium and valiltramiprosate (ALZ-801), or a combination thereof. Furthermore, the HTL-GIDR composition may facilitate tolerance during the GLP-1 RA dose escalation phases and enable administration of higher GLP-1 RA doses, thereby enhancing therapeutic outcomes in conditions including diabetes, obesity, and neurodegenerative diseases.

The present invention relates to the field of probiotics, in particular to an Akkermansia muciniphila MG784 for alleviating constipation, promoting defecation, improving intestinal barrier function and intestinal immunity, and its uses. The Akkermansia muciniphila MG784 provided by the present invention has the deposition number DSM 35549. The Akkermansia muciniphila MG784 provided by the present invention can increase the levels of motilin (MTL), gastrin (GAS), and acetylcholine in the gastrointestinal tract, promote intestinal peristalsis, improve the small intestine propulsion rate, and ameliorate defecation time and fecal output. Furthermore, Akkermansia muciniphila MG784 can also alleviate colonic mucosal inflammation, improve the thickness of the digestive tract muscular layer, modulate the structure of the intestinal microbiota, significantly increase the abundance of beneficial bacteria, and decrease the abundance of harmful bacteria.

The invention discloses an agaro-oligosaccharide oral solution with a constipation relieving function, and belongs to the technical field of food biology. The invention provides a preparation method of agarotriose. Main components which mainly exert anti-inflammatory activity are analyzed through clinical evaluation. According to the invention, agarotriose is extracted by adopting an enzymolysis method to treat LOP-induced constipation mice, and the influence of main components on model mice is investigated from the aspects of excrement water content, small intestine propulsion rate, first-grain black excrement discharge time, colon pathological structure and the like. Experimental results show that compared with an LOP group, the agarotriose high-dose group can significantly improve constipation symptoms, relieve inflammatory response and promote colonic mucosa repair, so that agarotriose can be used as a good functional food for relieving constipation.

The invention discloses a medicinal moxa composition for preventing and treating constipation and benign prostatic hyperplasia. The medicinal moxa composition comprises Chinese angelica, ligusticum wallichii, donkey-hide gelatin, cassia twig, white peony root, safflower, motherwort and moxa. Active volatile components contained in the medicinal moxa composition act on a plurality of key targets related to constipation and benign prostatic hyperplasia, participate in multi-channel regulation and control to synergistically play a treatment role, and directly regulate qi and blood circulation of related acupuncture points of the Ren channel through multiple ways of skin penetration, acupuncture point stimulation, infrared radiation and the like in moxibustion, so that the treatment effect is improved, and the treatment effect is improved. The pathological states of blood deficiency and downward flow of damp-heat are improved, and a new external treatment thought is provided for preventing and treating constipation and prostatic hyperplasia codiseases. A theoretical basis is provided for verifying related targets and pathways of the medicinal folium artemisiae argyi composition for preventing and treating the constipation and the prostatic hyperplasia co-disease, and a theoretical basis and a new practice direction are provided for healthy health-care research on the constipation and the prostatic hyperplasia co-disease.

The utility model discloses an enemator suitable for small-amount non-retention enema of various solutions, and relates to the field of medical instruments. In order to solve the problem that the treatment effect is reduced due to the fact that solutions are mixed in a container in the prior art, the utility model designs an enemator suitable for small-amount non-retention enema of various solutions, and the enemator is structurally characterized by comprising an enema tube with three cavities, a plurality of solutions are injected separately; one end of the connector is connected with the end of the enema tube, the other end of the connector is connected with the injector, and the connector is provided with channels matched with the three cavities respectively. Different solutions are injected into the rectum through different cavities by using an injector, so that the solutions are prevented from being mixed, excrement can be sufficiently softened by the solutions, damage to the anus or the rectum can be reduced by using other solutions or lubricants, meanwhile, the comfort level of a patient is increased, the compliance of the patient is improved, and therefore the purposes of promoting defecation and reducing the pain of the patient are achieved. The constipation is relieved.

The invention relates to the technical field of functional foods, and particularly discloses a tea leaf theanine-containing composition for improving intestinal health and a preparation method of the tea leaf theanine-containing composition. The composition consists of tea theanine rhzomorph, a pectin zinc complex, a gamma-aminobutyric acid rice germ fermented product, resistant dextrin, xylooligosaccharide, coconut water powder and natural mixed berry powder. Through unique processes such as biological fermentation and molecular complexation, active ingredients such as theanine, probiotics, zinc and gamma-aminobutyric acid in tea leaves are organically combined, and a multi-target systematic solution capable of acting on brain-intestinal axis communication, intestinal flora balance and physical barrier repair at the same time is constructed; the stability, intestinal targeting and bioavailability of active ingredients are remarkably improved, and the compound has excellent effects in preparation of food and health food for regulating intestinal flora, relieving constipation, enhancing intestinal barrier and reducing intestinal inflammation.

The invention relates to a constipation-preventing waterproof and oil-proof portable automatic-heating laparoscopic enema and electromagnetic stimulator, which comprises a grip and an expansion component mounted at the top, a mounting cavity is formed in the grip, a driving motor is arranged in the mounting cavity, a hollow shaft is connected to the tail end of an output shaft of the driving motor, and the hollow shaft is connected to the tail end of the output shaft of the driving motor. According to the dilatation device, the dilatation assembly is arranged, a driving motor of the dilatation assembly drives the hollow shaft to rotate, and the rotating disc connected with the tail end of the hollow shaft synchronously starts to rotate, so that the position of a strip-shaped sliding groove in the surface of the rotating disc is driven to change; then a limiting sliding block sliding on the surface of a strip-shaped sliding groove is driven to move outwards, so that a connecting support is pushed to synchronously move outwards, the connecting support slides on a connecting base, the connecting base and an expansion plate are pushed to start to rotate around a rotating center, the expansion plate is driven to start to rotate and expand, and the anus of a user is expanded through the expansion plate; medical staff can conveniently treat the anus of the patient.

The invention belongs to the technical field of medicine preparation, discloses a preparation method of a composite microbial preparation, focuses on a specific co-disease group of'depression-constipation-sleep disorder 'for the first time, provides a single-preparation comprehensive solution for comprehensively adjusting'intestine-brain axis' through multi-strain synergy, and fills the market blank. Constipation indexes are as follows: the intestinal tract propulsion rate of mice is increased by 50%, and the discharge time of first black feces is shortened by 30%. The depression index is as follows: in a forced swimming experiment, the immobile time is reduced by 40%, and the sweet water preference is obviously increased. Sleep indexes are as follows: the total sleep time is prolonged by 25%, and the sleep latency period is shortened by 20%. Biochemical indexes are as follows: the level of inflammatory factor IL-6 in serum is reduced by 60%, and the content of 5-HT and GABA in colon tissue is remarkably increased.

This invention relates to the field of microbial technology, specifically to Lactobacillus paracasei ZK-35 and its applications. The Lactobacillus paracasei ZK-35 of this invention is isolated from human oral rinsing fluid, exhibiting good compatibility with the human intestinal environment and high safety. It possesses excellent acid and bile salt resistance, and can alleviate the side effects of various antibiotics such as penicillins, cephalosporins, and quinolones. It can simultaneously regulate multiple intestinal flora, improve constipation and diarrhea, enhance intestinal barrier function, and promote nutrient absorption.

The application discloses a traditional Chinese medicine composition for treating infantile constipation and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The application aims to solve the technical problems of general treatment effect, poor treatment durability, easy recurrence after drug withdrawal and safety risk in treating infantile constipation. The application provides a traditional Chinese medicine composition for treating infantile constipation, which comprises the following raw materials according to weight parts: 1-12 parts of hemp seeds, 2-10 parts of radish seeds, 1-10 parts of immature bitter oranges, 2-10 parts of Chinese plantain, 3-11 parts of rehmannia, 1-7 parts of honeysuckle and 1-9 parts of magnolia officinalis. The traditional Chinese medicine composition can be used for treating water deficiency and dryness constipation, and can improve the symptoms of infantile constipation through the mechanism of promoting gastrointestinal peristalsis.

A spinal posterior postoperative deep infection drainage device comprises an integrated catheter with a closed front end and a connector part, and a drainage channel, a flushing channel and a bending control channel are arranged in the integrated catheter. Each channel is correspondingly provided with a drainage joint, a flushing joint and a bending control joint; a drainage hole and a flushing hole are respectively formed in the drainage channel and the flushing channel; a traction rope is arranged on the upper portion of the bending control channel in a penetrating mode and used for controlling bending of the end of the integrated catheter. Based on the arrangement of the bending control structure, a patient can get out of the bed to move during treatment, complications such as lower limb venous thrombosis, dropsy pneumonia, constipation and bedsore caused by long-term bed lying can be effectively prevented, the psychological stress of the patient can be relieved, the appetite of the patient is improved, the nutritional level of the patient is enhanced, and the rehabilitation speed is increased.

The invention relates to the technical field of medical instruments, in particular to a portable biofeedback instrument for constipation patients, which comprises a catheter and a host, the left end of the catheter is communicated with a rectum simulation air bag, the surface of the catheter is provided with an anal sphincter induction air bag, the right side of the top of the surface of the catheter is provided with a piezoelectric micropump I, and the left end of the catheter is provided with an anal sphincter induction air bag; one end of the first piezoelectric micropump is communicated with the guide pipe, the other end of the first piezoelectric micropump is communicated with a water tank, an inner pipe is arranged in an inner cavity of the guide pipe, and one end of the inner pipe penetrates to the outer side of the guide pipe and is communicated with a second piezoelectric micropump. The system has the advantages of high portability, intelligent analysis, personalized training, data synchronization and remote support; the host of the biofeedback instrument is in the size of a palm, accords with ergonomic holding, is internally provided with a rechargeable lithium battery, can be carried and used by a patient anytime and anywhere, does not need to go to a hospital and other professional places, greatly improves the flexibility and convenience of treatment, and saves the time and economic cost of the patient.

The invention discloses a paste dressing for invigorating spleen, replenishing qi and removing stagnation as well as a preparation method and application of the paste dressing. The active effective components of the paste dressing comprise the following components: lindera aggregata, radix angelicae, pepper, processed rhizoma typhonii, rhizoma zingiberis, ligusticum wallichii, elecampane and caulis spatholobi. The paste dressing disclosed by the invention has an excellent transdermal treatment effect through transdermal drug delivery, and has a good treatment effect on symptoms such as abdominal distension, abdominal distension of gastric mass diseases and constipation of patients with chronic gastritis in cooperation with a stone needle ironing therapy.

The application discloses strains for preventing and treating Parkinson's disease and compositions, applications and products thereof, and relates to the technical field of microorganisms.The application provides three strains of human milk origin, namely Lactobacillus helveticus LV-20, Lactobacillus plantarum LPP8 and Lactobacillus fermentum PL-15.The application also provides a composition capable of preventing and treating Parkinson's disease.The three strains can preferably prevent and treat Parkinson's disease.The composition can significantly improve motor dysfunction (such as static tremor, muscle rigidity, bradykinesia, posture balance and the like), reduce neuron damage, significantly reduce alpha-syn deposition, reverse sensory function degradation and cognitive impairment, relieve sleep disorders, inhibit neural inflammation and oxidative stress, reduce and repair intestinal barrier damage, relieve gastrointestinal dysfunction, improve constipation and regulate intestinal flora composition, and has a wide application prospect as a probiotic or synbiotic product for treating and preventing Parkinson's disease.

The present invention relates to methods of using compounds of Formula I,wherein R1a, R1b, R2, R3, R4, W, Y, and Z are as described herein, and pharmaceutically acceptable salts thereof. The compounds are potentiators of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). The invention also discloses pharmaceutical compositions comprising the compound, optionally in combination with additional therapeutic agents, and methods of potentiating, in mammals, including humans, CFTR by administration of the compounds. These compounds are useful for the treatment of cystic fibrosis (CF), asthma, bronchiectasis, chronic obstructive pulmonary disease (COPD), constipation, Diabetes mellitus, dry eye disease, pancreatitis, rhinosinusitis, Sjögren's Syndrome, and other CFTR associated disorders.