170 results about "Constipation" patented technology

The invention discloses a constipation patient defaecation device and mobile terminal integrated system based on endoscope visualization and air bag assistance, and relates to the technical field of medical instruments, the constipation patient defaecation device comprises a display terminal, a connecting line, an operating handle and a comprehensive pipe, and the two ends of the operating handle are connected with the connecting line and the comprehensive pipe respectively. According to the non-invasive, high-safety and portable constipation patient defecation device, through the integrated design of endoscope real-time visual positioning, air bag auxiliary mechanical defecation and mobile terminal data interaction, the invasive operation pain is reduced, the defecation time is shortened, the complication risk is reduced, and the constipation patient defecation efficiency is improved. The pressure sensor monitors the internal pressure of the air bag in real time and feeds back the internal pressure to the dynamic pressure upper limit module and the mobile terminal in real time, and double protection of a hardware pressure release valve and software pressure limiting is triggered when the pressure exceeds the limit. The problems of high intestinal injury risk, low treatment efficiency, limited application scene and the like caused by operation blindness, function singleness or high invasiveness in the prior art are solved.

The invention provides a lactobacillus plantarum MG360 with the efficacy of improving constipation, the preservation number of the lactobacillus plantarum MG360 is CGMCC NO 32953, and the lactobacillus plantarum MG360 is preserved in China General Microbiological Culture Collection Center on February 14, 2025. Meanwhile, the invention further provides a compound probiotic composition of the plant lactobacillus MG360 and the lactobacillus rhamnosus Eupro, the compound probiotic composition can be used for fermenting the coix seed enzymatic hydrolysate, and a fermentation product of the compound probiotic composition is rich in ferulic acid, vanillic acid, short-chain fatty acid, glutamic acid and the like. The fermentation product can obviously shorten the first black excrement discharge time of constipation mice, obviously improve the small intestine propulsion rate and the excrement water content, obviously improve the level of motility hormone (MTL, Gas, AchE, SP and 5-HT) in serum of the constipation mice and obviously reduce the level of inhibitory hormone (SS and VIP), and it is indicated that the fermentation product can relieve constipation by adjusting the gastrointestinal hormone peptide level. The preparation method of the probiotic preparation containing the plant lactobacillus MG360 and the compound probiotic fermentation preparation of the compound probiotic composition is simple, large-scale production can be achieved, and good application prospects are achieved.

The invention belongs to the technical field of probiotics, and particularly relates to fermented lactobacillus mucus BM01 with an effect of relaxing bowel and application of the fermented lactobacillus mucus BM01. A new fermented lactobacillus mucus BM01 strain is separated from excrement of a healthy infant in Guangzhou city, Guangdong province, a zebra fish constipation model is constructed through loperamide hydrochloride, and research finds that the strain can remarkably promote intestinal tract movement, increase the content of in-vivo serotonin and inhibit the enzyme activity of dipeptidyl peptidase-4, so that the constipation of the zebra fish can be inhibited, the constipation of the zebra fish can be inhibited, and the constipation of the zebra fish can be inhibited. Therefore, the bowel relaxing effect is achieved. It is indicated that the BM01 strain can play the bowel relaxing effect through multiple mechanisms, has significant application value, can be used for research and development of drugs for treating constipation, irritable bowel syndrome and other intestinal diseases or development of health care products with the bowel relaxing effect, and can also be used as a feed additive to improve animal intestinal health and reduce disease risks. The culture benefit is improved.

The object of the present invention is to use the strain of bacteria named Lacticaseibacillus paracasei DG® CNCM I-1572 DSM 34154 for use in a method of treating dysbiosis, particularly in patients with IBS (Irritable Bowel Syndrome), preferably without constipation, who have high fecal levels of Collinsella aerofaciens.

The invention belongs to the technical field of biological medicine, and particularly relates to application of garlic polysaccharide in preparation of a product for repairing intestinal injury caused by constipation. An embodiment verifies that the garlic polysaccharide can effectively repair intestinal physical, chemical and immune barrier injuries caused by constipation, and by up-regulating expression of tight junction proteins (such as ZO-1 and Occludin) and reducing expression of Claudin-1, the garlic polysaccharide can enhance tight junction between intestinal epithelial cells and reduce intestinal permeability; besides, the garlic polysaccharide can promote secretion of intestinal mucoprotein and enhance the protection function of the intestinal mucous layer by up-regulating expression of MUC2 and MUC4 genes. The invention discloses a multi-aspect action mechanism of the garlic polysaccharide in repairing intestinal injury caused by constipation, and the garlic polysaccharide is expected to become a novel intestinal repairing agent for treating constipation and related complications thereof.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating constipation and a preparation method thereof. The traditional Chinese medicine composition for treating constipation comprises the following raw material components in parts by weight: 2-4 parts of fructus mali, 2-4 parts of desmodium caudatum, 1-3 parts of rhizoma atractylodis macrocephalae, 1-3 parts of poria cocos, 1-2 parts of malt and 1-2 parts of pericarpium citri reticulatae. The traditional Chinese medicine composition for treating constipation is developed and researched according to the traditional Chinese medicine theory, the usage and dosage of the prescription medicines are scientific and clear, the curative effect is guaranteed, clinical effectiveness is guaranteed, and the medicine taking compliance is improved. Experiments prove that the traditional Chinese medicine composition for treating constipation can improve the defecation quantity of mice with constipation, enhance the small intestine propulsion function of the mice, improve the water content of excrement and relieve intestinal injury caused by constipation, and has a treatment effect on the constipation of the mice.

The invention discloses a multi-layer multi-release metagen composition and application thereof in quickly promoting defecation, lubricating intestinal tracts, relieving intestinal problems such as flatulence, stomachache, diarrhea, constipation, irritable bowel syndrome and inflammatory bowel disease, maintaining intestinal flora balance, repairing intestinal tracts, repairing intestinal mucosa health, relieving dyspepsia and improving gastrointestinal functions.

The present disclosure provides solid forms of sodium chenodeoxycholate (NaCDC), as well as compositions thereof, and methods of use and preparation thereof. In some embodiments, the provided solid forms are useful for treating gastrointestinal disorders, such as constipation (e.g., IBS-C). In some embodiments, the provided solid forms are useful for preparing new formulations of NaCDC, such as formulations uniquely designed to address certain problems of prior formulations of CDCA or salts thereof.

The invention discloses a composition containing magnesium salt and probiotics and application of the composition. The invention belongs to the technical field of dietary nutrition supplements. Wherein the composition further comprises a metagen component and a polysaccharide component, and the composition can be used for relieving flatulence, stomachache, diarrhea, constipation, irritable bowel syndrome, inflammatory bowel disease and other intestinal tracts.

The invention belongs to the field of pet food processing, and relates to a functional pet food for regulating intestinal health and a preparation method thereof. The functional pet food can increase MTL content in dog serum in a physiological range, reduce DAO activity and D-lactic acid and LPS content in dog serum, improve intestinal mucosa barrier function, and significantly improve dog intestinal health. The functional pet food can shorten gastrointestinal transmission time and effectively improve constipation. The functional pet food disclosed by the invention has a good effect in the aspects of treating diarrhea and constipation, and has a two-way regulation effect in regulating intestinal flora imbalance. The components of the raw materials have a synergistic effect, the nutrition is balanced, the preparation method is simple, the palatability is optimally designed, and the metabolic characteristic is free of burden, so that pets can safely take the feed for a long time, a convenient and efficient preventive health management scheme is provided for family pet raising, and the feed has a relatively good commercial application prospect.

The invention discloses lactobacillus plantarum ZSHT-001 capable of relaxing bowels and application of the lactobacillus plantarum ZSHT-001, and belongs to the technical field of biology, and the lactobacillus plantarum ZSHT-001 is separated from pickled vegetables. The preservation number of the lactobacillus plantarum is GDMCC No: 66147. A fermentation product of the lactobacillus plantarum ZSHT-001 provided by the invention has excellent antibacterial performance, good acid resistance and cholate resistance and relatively high gastrointestinal tract peristalsis promoting capacity, has the potential of relieving constipation, and has important significance in developing medicines, health-care products and foods for preventing or treating constipation.

The invention discloses a composition containing magnesium salt and Ackerman bacteria and application of the composition. The invention belongs to the technical field of dietary nutrition supplements. Wherein the composition further comprises a plant extract and a polysaccharide component, and can be used for relieving flatulence, stomachache, diarrhea, constipation, irritable bowel syndrome, inflammatory bowel disease and other intestinal tracts; the composition can increase the defecation amount, increase the defecation volume, soften excrement, shorten the defecation time, repair the intestinal tract, lubricate the intestinal tract, repair the intestinal tract barrier, increase beneficial bacteria and regulate the intestinal flora balance, and has the effects of immunity, inflammation resistance and metabolism promotion.

The invention relates to the technical field of medical instruments, in particular to a constipation adjuvant therapy appliance and a using method thereof.The constipation adjuvant therapy appliance comprises an insertion tube, a vibration sleeve is arranged at the inner end of the insertion tube, and a vibration motor is arranged in the vibration sleeve; the outer end of the insertion pipe is connected with a medium pipeline used for inputting or outputting a medium into or out of a pipe cavity of the insertion pipe. A plurality of protruding blocks are arranged on the pipe wall of the outer side of the insertion pipe. Through mechanical pressure generated by expansion of the insertion tube and the adjusting cavity of the insertion tube and local stimulation of the outer side protruding block on the rectum wall, low-frequency vibration of the vibration motor in the vibration sleeve is combined, a rectum wall mechanical receptor and a nerve conduction path are cooperatively activated in a multi-mode mode, defecation reflex is triggered, and therefore targeted intervention on defecation reflex disorder of a constipation patient is achieved. The defect that a traditional therapy does not touch a neural mechanism is overcome, and a comprehensive solution from physiological reflex activation to mechanical power enhancement is provided for constipation treatment.

The invention discloses Kluyveromyces marxianus KUST3801 and application thereof in relieving constipation, and the preservation number of the Kluyveromyces marxianus KUST3801 is CGMCC (China General Microbiological Culture Collection Center) NO.32767. The Kluyveromyces marxianus strain is classified and named as Kluyveromyces marxianus, and the Kluyveromyces marxianus strain is named as Kluyveromyces marxianus. The sequence of the 16SrRNA is as shown in SEQ ID NO. 1; the composition is used for improving constipation symptoms. After the kluyveromyces marxianus KUST3801 is applied, the excrement water content and the small intestine propulsion rate of a mouse with ICR constipation induced by loperamide hydrochloride are remarkably improved, and the defecation frequency and the defecation number within the same time are remarkably increased; intestinal mucosa tissues of constipation mice can be protected, and intestinal mucosa injury is relieved; the concentration of SP and MTL is obviously improved, and the concentration of VIP is reduced; iL-6 concentration is reversed, and inflammatory response is relieved; the concentrations of acetic acid, butyric acid, isobutyric acid and isovaleric acid in the short-chain fatty acid are obviously higher than those of mice with constipation, and the composition has a relatively strong effect of relieving constipation symptoms.

The invention discloses a strain for preventing and treating Parkinson's disease as well as a composition, application and a product thereof, and relates to the technical field of microorganisms. The invention provides three strains from human milk, namely lactobacillus helveticus LV-20, plant lactobacillus LPP8 and lactobacillus fermentum PL-15, the invention further provides a composition capable of preventing and treating the Parkinson's disease, and the three strains can well prevent and treat the Parkinson's disease and can be used for preventing and treating the Parkinson's disease. The composition can significantly improve dyskinesia (such as static tremor, muscle stiffness, movement retardation, posture balance and the like), reduce neuron damage, significantly reduce alpha-syn deposition, reverse sensory function degradation and cognitive disorder, relieve sleep disorder, inhibit neuroinflammation and oxidative stress, reduce and repair intestinal barrier damage, relieve gastrointestinal dysfunction, and improve the curative effect. As probiotics or synbiotics, products for treating and preventing Parkinson's disease have a wide application prospect.

The present invention belongs to the field of biotechnology, and specifically relates to the use of nereids in the preparation of drugs for treating constipation. The present invention provides for the first time the use of nereid polypeptides in the preparation of products for improving intestinal function, products for improving immunity, and / or products for treating constipation. The present invention found that after nereids intervened in constipated mice, the mice gained weight, defecation time was shortened, feces moisture content increased, and stool shape was uniform, indicating that nereids have the effect of improving the intestinal function of constipated mice. In addition, after nereid intervention, the spleen and thymus indexes of mice showed significant increases, and the thymus index and spleen index were significantly improved. It can be considered that nereids can improve the body's immune capacity.

The invention belongs to the technical field of microorganisms, and relates to a bifidobacterium breve strain capable of relieving constipation, the strain is bifidobacterium breve Bb-PG-14, the classification name of the strain is Bifidobacterium breve, the preservation number is CGMCC No.31861, the preservation time is September 4, 2024, the preservation unit is China General Microbiological Culture Collection Center, the preservation number is CGMCC No.31861, the preservation number is CGMCC No.31861, the preservation number is CGMCC No.31861, the preservation number is CGMCC No.31861, the preservation number is CGMCC No.31861, and the preservation number is CGMCC No.31861. The address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The strain is separated and purified from excrement of healthy babies, has relatively strong acid resistance, alkali resistance, cholate resistance and artificial simulated gastrointestinal fluid tolerance, and has the characteristics of probiotics.

The invention discloses a traditional Chinese medicine navel pill for treating constipation, diarrhea and chronic enteritis and a preparation method of the traditional Chinese medicine navel pill, and belongs to the technical field of traditional Chinese medicine. The preparation method comprises the following steps: weighing the raw materials, mixing, crushing and sieving to obtain mixed medicine powder, adding honey into the mixed medicine powder, stirring and kneading until the mixture is sticky, and preparing pills. The navel pill is applied to the navel, two-way conditioning of constipation and diarrhea is achieved through the synergistic effect of traditional Chinese medicine, chronic enteritis can be treated in a targeted mode, intestinal mucosa is effectively repaired, the intestinal inflammation state is improved, the navel pill has the advantages of being safe and convenient to apply, high in bioavailability, mild and free of side effects, stimulation of oral medicine to gastrointestinal tracts is avoided, and the curative effect is good. The food is suitable for digestion function conditioning of different people.

The present application relates to the technical field of health care products, in particular to a pelvic floor muscle repairing composition containing supermolecular tightening Dropsordry and a preparation method thereof, which comprises the following components in mass fraction: 10-14 parts of protein composition, 20-24 parts of chitosan modified Dropsordry, 5-7 parts of freeze-dried powder of Lactobacillus bulgaricus, 10-12 parts of hyaluronic acid, 6-8 parts of glycine and 15-17 parts of proline; each part of the protein composition comprises 20-30 parts of myosin, 30-34 parts of actin, 5-10 parts of hydrolyzed collagen and 240-280 parts of deionized water. The pelvic floor muscle repairing composition can reduce drug toxicity, reduce the amount of drug administration, continuously supplement the required elements of the body during treatment, and quickly relieve the constipation problem caused by the functional damage of the pelvic floor muscle.

The application provides bifidobacterium longum MG-G763 for improving constipation, and belongs to the technical field of microorganisms. The bifidobacterium longum MG-G763 provided by the application can effectively relieve constipation by integrating multiple effects such as nerve regulation, immune regulation, barrier repair and flora regulation, and systematically restoring intestinal function homeostasis. The bifidobacterium longum MG-G763 can significantly improve the defecation particle number and defecation weight of constipated mice, shorten the time for defecating the first black stool, improve the small intestinal transport rate of the mice, effectively improve and relieve the defecation condition of the constipated mice, and significantly increase the amount of intestinal beneficial bacteria and reduce the amount of harmful bacteria, thereby promoting intestinal health.

This invention discloses a guanylate cyclase-C (GC-C) activating peptide and its applications, belonging to the field of bioactive peptide technology. The amino acid sequence of the GC-C activating peptide is PFPGPIPN. The GC-C activating peptide of this invention can significantly activate GC-C activity, increasing intracellular cGMP levels. Furthermore, the GC-C activating peptide of this invention can alleviate constipation and abdominal pain symptoms in mice, thereby effectively preventing or improving irritable bowel syndrome (IBS). Therefore, the GC-C activating peptide provided by this invention has advantages such as high activity, safety and non-toxicity, and good water solubility. It can be used as a candidate molecule for alternative or adjuvant drugs in the clinical treatment of IBS, and also as a health product or food to improve constipation or abdominal pain.

The invention relates to the technical field of microorganisms, in particular to lactobacillus paracasei ZK-35 and application thereof. The lactobacillus paracasei ZK-35 is separated from a human oral cavity flushing fluid, has good compatibility with the human intestinal environment, high safety and excellent acid and cholate resistance, has an effect of relieving side effects of various antibiotics such as penicillin, cephalosporin and quinolones, can regulate various intestinal florae at the same time, improves constipation and diarrhea, and has a good application prospect in the field of oral cavity flushing fluid, oral cavity flushing fluid, oral cavity flushing fluid, oral cavity flushing fluid, oral cavity flushing fluid, oral cavity flushing fluid, oral cavity flushing fluid, oral cavity flushing fluid and oral cavity flushing fluid. The intestinal barrier function is enhanced, and nutrient absorption is promoted.

The invention belongs to the technical field of medicinal and edible products, and particularly relates to a composition for improving constipation and diarrhea as well as a preparation method and application thereof. The composition for improving constipation and diarrhea provided by the invention comprises the following raw materials in parts by weight: Chinese yam, resistant dextrin, ginseng, radix ophiopogonis, poria cocos, dogwood, semen coicis, aronia melanocarpa freeze-dried powder, mulberry, radix polygonati officinalis, lycium ruthenicum freeze-dried powder, fructo-oligosaccharide and crystalline fructose. Experiments prove that through synergistic cooperation of the raw materials, the composition can effectively improve the diarrhea index of diarrhea rats, improve the intestinal barrier function, increase the villus length of small intestine tissues, reduce the depth of crypts, increase the water content of excrement of constipation mice and promote intestinal peristalsis, and has the effect of bidirectionally regulating diarrhea and constipation; the intestinal barrier function can be favorably repaired.

According to the application plaster formula for treating abdominal distension and constipation and the application method thereof, the effective components of the medicine are absorbed by stimulating acupuncture points, so that the effect of preventing and treating abdominal distension and constipation is achieved. The traditional Chinese medicines are ground into powder, the powder is blended into paste with normal saline, the paste is applied to an adhesive plaster, and the paste is applied to the acupoints of the abdomen (Shenque and Tianshu), the back (large intestine shu and small intestine shu) and the legs (Zusanli and upper giant deficiency), the Tianshu is the acupoint of the large intestine in the abdomen, the large intestine shu and the small intestine shu are the large intestine, and the back shu-acupoint of the small intestine in the back. Zusanli and upper giant deficiency are stomach meridian and large intestine meridian at the lower he acupoints of the legs. The compatibility of the acupuncture points embodies the compatibility use of the Yu-Mu matched acupuncture point and the Xiahe acupuncture point. The effect is better than that of purely applying to the Shenque acupoint. The traditional Chinese medicine composition conforms to the traditional Chinese medicine composition principle and the acupoint compatibility principle, the effect is better than that of single medicine and single acupoint application, and application transdermal absorption is easier to accept by people compared with oral medicine.

The utility model belongs to the technical field of medical enema devices, and particularly relates to an enema device capable of preventing enema liquid from leaking, which comprises an enema tube, a silica gel air bag is arranged on the upper side of the outer side of the enema tube, a liquid outlet hole is arranged on the lateral side of the enema tube, the enema tube is communicated with the inner side of the silica gel air bag through the liquid outlet hole, and a socket is arranged at the upper end of the enema tube. The lower end of the enema tube is aligned to the anus of a patient and is slowly inserted until the silica gel air bag is immersed into the inner side of the anus, then the container bottle is squeezed, enema liquid in the container bottle enters the intestinal tract along the enema tube, and blockage is caused by intestinal constipation and pressure generated when the container bottle is manually squeezed. When enema liquid passes through the enema tube, the enema liquid enters the silica gel air bag through the liquid outlet hole, the silica gel air bag expands, the silica gel air bag is attached to the inner side of the anus after expansion, the enema liquid is blocked, and the enema liquid is prevented from flowing out of the anus.

The application provides a probiotic preparation and application thereof. The probiotic preparation comprises active ingredients and adjuvants, wherein the active ingredients comprise oxygen scavenging bacteria, organic acid producing bacteria and space-occupying bacteria; the oxygen scavenging bacteria are Weizmannia bacteria, the organic acid producing bacteria are lactobacillus or lactobacillus plantarum, and the space-occupying bacteria are bifidobacterium; the water activity of the probiotic preparation is less than or equal to 0.3, preferably 0.04-0.3, further preferably 0.04-0.2, and more preferably 0.04-0.15. The probiotic preparation has high live bacteria stability when stored at room temperature. Moreover, the probiotic preparation can effectively improve functional gastrointestinal diseases and has bidirectional regulation function, and is suitable for different intestinal motility disorders, such as diarrhea and constipation.

The invention relates to the technical field of compositions, and particularly discloses a composition for bidirectionally regulating diarrhea and constipation and promoting Akk proliferation and application. The composition for bidirectionally regulating diarrhea and constipation and promoting Akk proliferation, provided by the invention, comprises bifidobacterium longum subsp. Infantis i18 and casei paracasei N1115. In the composition provided by the invention, all the components have a synergistic effect, so that diarrhea and constipation can be safely, effectively and bidirectionally regulated and improved, the intestinal microecological steady state can be further maintained by promoting Akk proliferation, and the composition has a wide application prospect.

The invention provides a strain capable of resisting radiation damage as well as a product and application thereof, and relates to the technical field of probiotics capable of resisting radiation damage. The probiotic strains are separated from healthy breast milk and comprise lactobacillus gasseri LG02, lactococcus lactis LL6 and bifidobacterium adolescentis BA18, and the three probiotic strains can improve the survival rate after ionizing radiation; the LG02 or LL6 strain relieves damage of ionizing radiation to tissue structures of the heart, the liver, the spleen, the lung, the kidney, the stomach, the small intestine, the colon and the femur, the physiological function of an organism is maintained, and recovery of the tissue structures is accelerated; the LG02 or LL6 strain accelerates the body repair after radiotherapy, reduces the side reactions of diarrhea, stomachache, constipation and cough, and reduces the incidence rate of hematochezia and radiation pneumonitis; the LG02 or LL6 strain increases or recovers the number of leukocytes, and improves the hematopoietic ability and immunity of the organism; the LG02 or LL6 strain has the effects of inhibiting harmful bacteria, improving the anti-infection and anti-inflammation capability of the body and improving the resistance; the LG02 or LL6 strain can improve the oxidation resistance of the body and enhance the aging resistance of the body.

The invention belongs to the technical field of medicines, and particularly relates to application of harpagide in preparation of a medicine for treating constipation. The technical problem to be solved by the invention is to provide a safer, milder and new effective choice for treating and relieving constipation. The technical scheme for solving the technical problem is to provide application of harpagide in preparation of drugs or health care products for treating or relieving constipation. The harpagide achieves or even exceeds the treatment effect of the fluid-increasing decoction compound. Meanwhile, in the small pigs, the constipation symptom of the small pigs in the gestation period is also obviously relieved. When the harpagide is used as a medicine for treating constipation, a safer, more efficient and standardized treatment effect can be achieved, a safer and milder treatment choice is provided for patients with constipation, and the harpagide has a very good application prospect.