The invention discloses an application of a
bifidobacterium longum microbial inoculum in preparation of a
medicine for preventing and treating Parkinson's
disease, which proves that
selenium-rich
bifidobacterium longum and
bifidobacterium longum can be used for preventing and treating a Parkinson's
disease model for the first time, and the application of the
selenium-rich
bifidobacterium longum microbial inoculum in 1-methyl-4-phenyl-1, 2, 3, 4-tetramethyl-1, 2, 3, 4-tetramethyl-1, 2, 3, 4- An acute Parkinson's
disease model constructed by 2, 3, 6-tetrahydropyridine (
MPTP) and a chronic Parkinson's disease model constructed by
rotenone verify that the
selenium-rich
bifidobacterium longum and the
bifidobacterium longum can improve central symptoms and
peripheral symptoms of the Parkinson's disease. The invention proves that selenium-rich bifidobacterium longum and bifidobacterium longum can comprehensively prevent and treat Parkinson's disease from
peripheral and central symptoms for the first time, including acute Parkinson's disease mouse models and chronic Parkinson's disease mouse models. The selenium-rich bifidobacterium longum microbial inoculum has the effects of both medicines and
nutrition functions, is high in safety, is proved to be in an actual non-toxic level by an acute oral
toxicity test of rats, and can be taken for a long time for prevention or treatment.