The invention relates to a composition comprising vitamins and mineral substances. The composition comprises the vitamins and the mineral substances, wherein the vitamins include vitamin A, vitamin C, vitamin D3, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, nicotinic acid amide and pantothenic acid, and the mineral substances include calcium, iron, zinc, and selenium. According to the composition, the amounts of the vitamins and the mineral substances are reasonably proportioned strictly according to the needing amounts of a human body; the mineral substance iron is supplied by ferrous fumarate, so that the destroy on the active substances, such as vitamins, by the addition of the inorganic iron can be effectively prevented; the mineral substance selenium is provided by selenium enriched beer yeast, the toxic and side effects of chemical selenium (such as sodium selenite) on the human body and intestines and stomach stimulation are eliminated, and therefore the selenium can be absorbed and utilized by the human body more efficiently and safely.