The invention discloses a blueberry lees nutritional mask and a preparation method thereof. The blueberry lees nutritional mask is mainly prepared through the steps that: blueberry lees are subjected to treatment steps such as juice removing and impurity removing, and is mixed with a film-forming substance, a moisturizing agent, a preservative, an antioxidant, pearl powder, aromatic substance, and vitamin, such that the mask is obtained. The mask is composed of the components of, by weight: 45 parts of a mask base liquid, 50-60 parts of pretreated blueberry lees, 2-3 parts of the moisturizing agent, 0.2-0.5 parts of the preservative, 0.1-0.2 parts of the antioxidant, 4-8 parts of the pearl powder, 0.02-0.04 parts of natural aromatic oil, and 3-6 parts of Vitamin E. According to the invention, lees produced during blueberry wine brewing are reasonably utilized, such that natural active components and nutritional health-care functional factors in the lees are utilized to a maximal extent. Therefore, application value and economic value of the lees are greatly improved. The product provided by the invention has nourishing, whitening, anti-oxidizing, anti-aging, antibacterial, anti-inflammatory, spot-removing, and other functions. With the mask, requirements of nourishing, health-care, and beautifying can be satisfied.