The invention belongs to the technical field of daily chemical products, and in particular discloses anti-inflammatory and itching-relieving body wash and a preparation method of the anti-inflammatoryand itching-relieving body wash. The anti-inflammatory and itching-relieving body wash is prepared from the following ingredients in percentage by weight: 10-40 % of an amino acid surfactant, 5-15 %of an auxiliary surfactant, 0-4 % of a thickening agent, 0-5 % of an emollient, 0.1-5 % of a pericarpium citri reticulatae extract, 2-10 % of polyhydric alcohols, 0.02-0.5 % of a preservative, and thebalance of water, wherein the weight percentage of flavone in the pericarpium citri reticulatae extract is 70-95 %. According to the anti-inflammatory and itching-relieving body wash and the preparation method of the anti-inflammatory and itching-relieving body wash, the amino acid surfactant is adopted, so that the anti-inflammatory and itching-relieving body wash is mild and friendly to the skin, the bubbles are stable, the decontamination effect is good, meanwhile, the natural barrier of the skin can be maintained, and the problem that the skin is dry, rough and itchy after a skin-cleaningproduct is used is solved. Meanwhile, the pericarpium citri reticulatae extract is adopted as the functional component, therefore, the anti-inflammatory and itching-relieving body wash has the advantage of being easy to absorb while having the efficacies of resisting inflammation, resisting allergy and reliving itching, and also has the function of nourishing and soothing the skin. For the obtained body wash, the production process is simple and suitable for the mass production, and the market prospect is broad.