Microneedle transdermal drug delivery paste for treating rheumatoid arthritis and preparation method of microneedle transdermal drug delivery paste

Abstract

The invention discloses a microneedle transdermal drug delivery paste for treating rheumatoid arthritis. The microneedle transdermal drug delivery paste comprises a base layer, and a plurality of microneedles, wherein the microneedles are vertically fixed on the surface of the base layer and are arranged at intervals mutually; the microneedles are provided with active medicine components. In treatment, the microneedles puncture through skin cuticle and enter epidermis, and then medicines stored in the microneedles can be released into tissue fluids, so that the purpose of treatment is achieved, defects that a conventional transdermal drug delivery preparation has difficulties in breaking through natural barriers of cuticle and is low in biological utilization rate can be overcome, and thetransdermal drug delivery rate of medicines can be greatly increased. The dissoluble microneedle paste comprises one or more active medicinal components for treating rheumatoid arthritis, and meanwhile a synergetic effect can be taken into play; due to puncture functions of the microneedles, auxiliary treatment can also be achieved. The invention further provides a preparation method of the microneedle transdermal drug delivery paste. By adopting the preparation method, medicines of different types of dissolubility can be carried by one same dissoluble microneedle paste, and multiple medicinescan be also carried to achieve synergetic drug delivery treatment.

Description

technical field [0001] The invention relates to a microneedle transdermal drug delivery patch for treating rheumatoid arthritis and a preparation method thereof. Background technique [0002] Rheumatoid arthritis is a common autoimmune disease that can cause joint swelling, pain, deformity, and varying degrees of disability, greatly affecting the quality of life of patients. Rheumatoid arthritis is a synovial inflammatory response, including increased blood vessel distribution and permeability, the most important of which is the increase of antigen-driven CD4+ cells, which produce different cytokines through cell-to-cell contact, such as INF -γ and TNF-α, etc., and then activate monocytes, macrophages and synovial fibroblasts to produce excessive inflammatory cytokines IL-1, IL-6 and TNF-α. These cytokines are involved in the activation of endothelial cells, the activation of osteoclasts and the destruction of cartilage, etc., leading to the continuous occurrence of inflamm...

AI Technical Summary

Problems solved by technology

For example, oral administration: the selectivity of the drug is poor, which can easily lead to different degrees of gastrointestinal reactions and kidney side effects in patients, and there is a first-pass elimination effect through liver metabolism, which will reduce the efficacy of the drug; intravenous injection: the curative effect is exerted through the systemic circulation, although the drug High bioavailability, but due to poor selectivity, it may act on multiple target organs or target cells, which may cause adverse reactions and poor patient tolerance

Intra-articular injection: Although this treatment method can directly inject drugs into the lesion, multi-site intra-articular injection is complicated to operate and poorly tolerated by patients. At the same time, it requires special personnel to operate, which is expensive and unacceptable to ordinary patients.

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