Microneedle transdermal drug delivery paste for treating rheumatoid arthritis and preparation method of microneedle transdermal drug delivery paste

A rheumatoid, transdermal drug delivery technology, applied in the direction of microneedles, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve problems such as unacceptable by patients, reduce the efficacy of drugs, and toxic and side effects of patients, so as to avoid side effects, Avoid irritation, high drug delivery effect

Active Publication Date: 2019-03-29
BENGBU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, oral administration: the selectivity of the drug is poor, which can easily lead to different degrees of gastrointestinal reactions and kidney side effects in patients, and there is a first-pass elimination effect through liver metabolism, which will reduce the efficacy of the drug; intravenous injection: the curative effect is exerted through the systemic circulation, although the drug High bioavailability, but due to poor

Method used

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  • Microneedle transdermal drug delivery paste for treating rheumatoid arthritis and preparation method of microneedle transdermal drug delivery paste
  • Microneedle transdermal drug delivery paste for treating rheumatoid arthritis and preparation method of microneedle transdermal drug delivery paste
  • Microneedle transdermal drug delivery paste for treating rheumatoid arthritis and preparation method of microneedle transdermal drug delivery paste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A microneedle transdermal drug delivery patch for treating rheumatoid arthritis with a cuboid shape of 1 cm × 1 cm × 0.2 cm in the base layer and a conical microneedle was prepared, the number of microneedles was 100, the length of the microneedles was 800 microns and Regular arrangement of needle intervals:

[0047] (1) Mold preparation: CNC micro-milling technology is used to prepare the male mold, and then the male mold is used to replicate the female mold; the male mold is made of brass; the material of the female mold is polydimethylsiloxane (PDMS). There are interconnected microneedle chambers and base chambers in the female mold. The base chamber is a cuboid cavity with a length and width of 1 cm and a height of 0.2 cm. The 100 microneedle cavities are all conical cavities. The diameter of the bottom of the cavity is 100 microns, and the height is 800 microns, and each microneedle cavity is perpendicular to the base cavity and arranged evenly with each other;

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Embodiment 2

[0056] A microneedle transdermal drug delivery patch for treating rheumatoid arthritis with a cuboid shape of 1 cm × 1 cm × 0.2 cm in the base layer and a conical microneedle was prepared, the number of microneedles was 100, the length of the microneedles was 800 microns and Regular arrangement of needle intervals:

[0057] (1) Mold preparation: CNC micro-milling technology is used to prepare the male mold, and then the male mold is used to replicate the female mold; the male mold is made of aluminum; the female mold is made of polydimethylsiloxane (PDMS). There are interconnected microneedle chambers and base chambers in the female mold. The base chamber is a cuboid cavity with a length and width of 1 cm and a height of 0.2 cm. The 100 microneedle cavities are all conical cavities. The diameter of the bottom of the cavity is 100 microns, and the height is 800 microns, and each microneedle cavity is perpendicular to the base cavity and arranged evenly with each other;

[0058...

Embodiment 3

[0063] Prepare a microneedle transdermal patch for the treatment of rheumatoid arthritis with a diameter of 1 cm, a height of 0.2 cm, and a microneedle transdermal patch for the treatment of rheumatoid arthritis with microneedles in the shape of a flat cylinder with a diameter of 1 cm and a height of 0.2 cm. The number of microneedles is 80, and the length of the microneedles is 1000 microns and regular arrangement of microneedles:

[0064] (1) The male mold is prepared by CNC micro-milling technology, and then the female mold is copied by the male mold; the male mold is made of aluminum alloy; the material of the female mold is polydimethylsiloxane (PDMS). There are interconnected microneedle chambers and base chambers in the female mold. The base chamber is a flat cylindrical cavity with a bottom diameter of 1 cm and a height of 0.2 cm. The 80 microneedle cavities are all quadrangular pyramidal cavities. The bottom side length of the shaped cavity is 100 microns, and the hei...

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Abstract

The invention discloses a microneedle transdermal drug delivery paste for treating rheumatoid arthritis. The microneedle transdermal drug delivery paste comprises a base layer, and a plurality of microneedles, wherein the microneedles are vertically fixed on the surface of the base layer and are arranged at intervals mutually; the microneedles are provided with active medicine components. In treatment, the microneedles puncture through skin cuticle and enter epidermis, and then medicines stored in the microneedles can be released into tissue fluids, so that the purpose of treatment is achieved, defects that a conventional transdermal drug delivery preparation has difficulties in breaking through natural barriers of cuticle and is low in biological utilization rate can be overcome, and thetransdermal drug delivery rate of medicines can be greatly increased. The dissoluble microneedle paste comprises one or more active medicinal components for treating rheumatoid arthritis, and meanwhile a synergetic effect can be taken into play; due to puncture functions of the microneedles, auxiliary treatment can also be achieved. The invention further provides a preparation method of the microneedle transdermal drug delivery paste. By adopting the preparation method, medicines of different types of dissolubility can be carried by one same dissoluble microneedle paste, and multiple medicinescan be also carried to achieve synergetic drug delivery treatment.

Description

technical field [0001] The invention relates to a microneedle transdermal drug delivery patch for treating rheumatoid arthritis and a preparation method thereof. Background technique [0002] Rheumatoid arthritis is a common autoimmune disease that can cause joint swelling, pain, deformity, and varying degrees of disability, greatly affecting the quality of life of patients. Rheumatoid arthritis is a synovial inflammatory response, including increased blood vessel distribution and permeability, the most important of which is the increase of antigen-driven CD4+ cells, which produce different cytokines through cell-to-cell contact, such as INF -γ and TNF-α, etc., and then activate monocytes, macrophages and synovial fibroblasts to produce excessive inflammatory cytokines IL-1, IL-6 and TNF-α. These cytokines are involved in the activation of endothelial cells, the activation of osteoclasts and the destruction of cartilage, etc., leading to the continuous occurrence of inflamm...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K45/00A61K47/32A61K47/34A61K47/36A61M37/00A61P19/02A61P29/00
CPCA61K45/00A61K47/32A61K47/34A61K47/36A61M37/0015A61P19/02A61P29/00A61K9/0021A61K9/703A61M2037/0053
Inventor 王清清刘浩陈明龙韦颖梅赵伟曼董智勇
Owner BENGBU MEDICAL COLLEGE
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