Bionic microneedle patch for percutaneous drug delivery

Abstract

The invention is applicable to the technical field of percutaneous microneedle patches, and provides a bionic microneedle patch for percutaneous drug delivery. The bionic microneedle patch comprises asubstrate and a microneedle array distributed on the substrate; wherein the microneedle array is formed by arranging a plurality of individual microneedle bodies, a needle tip of any microneedle bodyis arranged facing away from the substrate, and a bionic structure is arranged outside the microneedle body in a matched mode. The novel microneedle patch with a special bionic structure is helpful for improving skin penetration behavior of the microneedle patch and reducing or eliminating a phenomenon of microneedle breakage, so that safety and percutaneous drug delivery efficiency of the microneedle patch can be improved. 3D printing technology based on photocuring polymerization reaction is used for preparing the microneedle patch, precise, automatic and intelligent preparation of a percutaneous microneedle patch with a special biomimetic structure can be realized, and quality and curative effect of the percutaneous microneedle patch are greatly improved.

Description

technical field [0001] The invention relates to the technical field of transdermal microneedle patches, in particular to a bionic microneedle patch for transdermal drug delivery. Background technique [0002] Safe, efficient, and controllable delivery of drugs into human tissue systems has always been an important issue of concern. At present, the most commonly used methods of drug delivery in medical procedures are oral administration and injection. In oral drug delivery technology, drugs need to pass through tissues and organs such as the gastrointestinal tract and liver. On the one hand, the inactivation of the gastrointestinal tract and the "first-pass effect" of the liver will cause some drugs to be metabolized and reduce their bioavailability; on the other hand, some Drugs can cause adverse irritation to the gastrointestinal tract, thereby limiting the scope of application of oral administration, especially not suitable for the delivery of multiple births and protein d...

AI Technical Summary

Problems solved by technology

Broken microneedle fragments entering the blood circulation may cause adverse consequences such as embolism; if buckling occurs during the microneedle insertion process, the microneedle will not be able to penetrate the skin effectively, and the expected effect will not be achieved

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