Percutaneous microneedle with spiral microchannel

Abstract

The invention provides a percutaneous microneedle with a spiral microchannel. The microneedle comprises a microneedle body and the spiral microchannel formed in the surface of the microneedle body. The percutaneous microneedle with the surface spiral microchannel has enough mechanical strength and is beneficial to improving the skin piercing behavior of the microneedle, the threaded groove can reduce the contact area between the microneedle and skin tissue and reduce the piercing resistance of the microneedle, meanwhile, the pull-out force of the needle head is increased, and the microneedle is effectively prevented from falling off; the spiral micro-channel on the surface of the micro-needle is helpful for improving the drug loading capacity and the drug delivery efficiency of the micro-needle, especially for one or more compositions such as micro-nano-scale solid or semi-solid drug particles, microspheres, microcapsules, gel and the like; the above two points can finally greatly improve the quality of the percutaneous microneedle and the curative effect of percutaneous delivery of the drug, and improve the bioavailability of the percutaneous delivery drug.

Description

technical field [0001] The invention relates to the technical field of percutaneous microneedles, in particular to a percutaneous microneedle with a spiral microchannel. Background technique [0002] Transdermal administration refers to the delivery of drugs through the skin to the dermis or the blood system, thereby exerting the effect of local or systemic skin treatment. In recent years, the transdermal drug delivery system has attracted widespread attention because of its huge advantages: compared with oral administration, the transdermal drug delivery system can avoid the damage of the liver and gastrointestinal tract to the drug, and at the same time reduce the drug’s effect on the gastrointestinal tract. The stimulating effect of the tract reduces the side effects of the drug. In addition, it can regulate drug release, enhance drug absorption, and ultimately improve bioavailability; compared with injection drug delivery, the transdermal drug delivery system can achiev...

AI Technical Summary

Problems solved by technology

For example, the tiny size of the microneedle makes it possible for the microneedle to break or buckle during use, and the fragments of the broken microneedle entering the blood circulation may cause adverse consequences such as embolism; if buckling occurs during the insertion of the microneedle, the microneedle will The skin cannot be effectively penetrated, and the expected effect cannot be achieved; the design of the microneedle involves various aspects such as strength, stiffness, drug delivery efficiency, pain and trauma, and will be affected by the shape, size, material of the microneedle, skin structure, and skin performance. Due to the coupling effects of many factors such as the penetration method and the penetration method, the relevant optimization design and analysis are extremely difficult; at the same time, due to the tiny size of the microneedles and the smooth surface of the needle body, the general coating methods such as dipping and spraying methods are easy to cause the coating solution to be affected. Due to the influence of surface tension and gravity, it is deposited on the substrate, resulting in uneven drug content on the microneedles, and the transdermal absorption of the drug deposited on the substrate is limited, which affects the efficacy of the drug.

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