2823 results about "Cutis" patented technology

The invention provides a radiotherapy patient skin injury real-time detection record management system based on image processing, and belongs to the technical field of radiotherapy patient skin injury real-time detection. Comprising a multispectral image acquisition module for imaging the skin of a patient at the same visual angle by adopting different spectrums to obtain three spectral images including near-infrared imaging, infrared imaging and ultraviolet imaging; a first identification module is used for fusing three spectral images to obtain an image data set, and a second identification module is used for constructing an epidermis injury coefficient # imgabs0 #, a dermis injury coefficient # imgabs1 # and a subcutaneous injury coefficient # imgabs2 # of the ith patient and evaluating the epidermis injury coefficient # imgabs0 #, the dermis injury coefficient # imgabs1 # and the subcutaneous injury coefficient # imgabs2 # respectively. A skin injury evaluation model is constructed, the comprehensive injury area ratio is calculated, the classification of injury levels is realized, data support is provided for a personalized treatment scheme, and a powerful auxiliary diagnosis tool is provided for a medical institution.

The invention discloses a working method of skin thermal therapy equipment which is convenient to use and can realize intelligent startup work and an itching relieving instrument. According to the technical scheme, the working method of the skin thermal therapy equipment comprises the following steps that a, whether a designated area makes contact with the skin of a user or not is detected, and if yes, the step b is executed; and b, detecting the skin contact time and the skin temperature of the contacted part, and if the detected temperature is within a preset range and the continuous contact time reaches the set time, starting the skin thermal therapy equipment to operate.

Wearable modular mask systems for combination face and skincare diagnostics and therapeutics. Systems include devices that can be attached to wearable masks for diagnosis and treatment of skin conditions, diseases, and disorders, as well as for cosmetic improvements to the skin of the face and scalp.

The present disclosure provides a target region positioning method, an electronic device and a computer readable storage medium, the target region positioning method comprising: acquiring, by a camera, a target image comprising a skin surface region corresponding to a reaction bone; wherein the reaction bone is a bone having a target feature; identifying the skin surface region from the target image; determining first device coordinate information of a center position of the skin surface region in a device coordinate system; determining second device coordinate information of a center position of a target region comprising a lesion in the device coordinate system according to the first device coordinate information and predetermined first position relationship information; wherein the first position relationship information is position relationship information between the center position of the skin surface region and the center position of the target region.

The invention belongs to the technical field of biological simulation, and discloses an anus cleaning effect evaluation method and system.The method comprises the steps that an execution assembly is controlled to wipe an anus anatomical structure with a to-be-detected sample according to a target wiping strategy, and a multi-mode sensing assembly is controlled to collect target parameters on the anus anatomical structure; obtaining target monitoring data; according to the residual dirt amount in the target monitoring data, a cleaning efficiency score is obtained through calculation, a target mechanical simulation model is called, according to the humidity permeation gradient value and the pressure value in the target monitoring data and the to-be-detected sample, a skin stimulation risk score is obtained through calculation, and the skin stimulation risk score and the cleaning efficiency score form a cleaning effect evaluation report. Simulation and prediction of the anus cleaning process are achieved, the simulation test effect and accuracy are greatly improved, and a cleaning effect evaluation report is given to illustrate the safety of the to-be-tested sample.

The invention relates to organoid culture. The invention provides a human epidermal organoid differential medium, a method for constructing an epidermal model and application of the human epidermal organoid differential medium, the human epidermal organoid differential medium comprises a basic medium component and an additive, and the additive comprises lipid. According to the method, the organoid is directly used for constructing the epidermal model, so that the problem of few cell sources is solved; a lipid component is added into the epidermal organ differentiation culture medium, so that the epidermal organ can enhance the barrier function of the cuticle, further differentiation of the epidermal organ can be effectively promoted by utilizing the epidermal organ differentiation culture medium, and a human epidermal model with a basal layer, a spinous layer, a granular layer and a cuticle which are completely morphologically differentiated is obtained. And the operation is simple, large-batch production is easy to realize, and a reliable tool is provided for in-vitro observation, interference of skin disease generation, injury repair and other life activities.

Systems for producing a cosmetic effect in skin tissue of a patient are provided. The systems include a treatment module and an actuation assembly. The treatment module includes at least one coring element configured to remove a portion of skin tissue when the coring element is inserted into and withdrawn from the skin tissue. The actuation assembly is operably attached to the treatment module and can translate and / or actuate the treatment module in one or more directions relative to a surface of the skin tissue. The system can perform a microcoring procedure that provides a cosmetic effect to the patient. Methods of performing a microcoring procedure are also provided.

Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning and / or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

Disclosed herein is a catheter, which in some embodiments includes a distal section configured to enter a skin insertion site. The distal section can include a tapered junction having one or more dilation structures configured to dilate the skin insertion site. The distal section can further include a distal portion extending from a distal end of the tapered junction, the distal portion having a diameter smaller than a proximal portion of the catheter. In combination, the tapered junction, the one or more dilation structures, and the specific actions of the user urging the catheter into the insertion site can result in an improved fit of the catheter in the insertion site.

The invention relates to an external composition for hair growth regulation and a preparation method thereof, and belongs to the technical field of cosmetics and medicines. The composition disclosed by the invention comprises nano mesoporous carbon for enhancing permeation, various surface functional modifications on the nano mesoporous carbon, minoxidil, protein fragments, polypeptides, oligopeptides, amino acids, dutasteride, bimatoprost, traditional Chinese medicine extracts, vitamins, caffeine, nucleosides, growth factors and various auxiliary functional components. Wherein the pore diameter of mesopores of the nano mesoporous carbon for enhancing permeation is 2-30 nm, the total pore volume of the mesopores is 1.5-3.5 cm < 3 > / g, and the particle size of the nano mesoporous carbon is 50-200 nm. The prepared nano mesoporous carbon is granular, controllable in size, stable in structure, free of irritation to skin, capable of keeping inert to various active ingredients in the composition, capable of enhancing absorption and permeation of other ingredients on the skin, wide in application range, capable of compounding various types of active ingredients and high in biological safety.

The invention relates to application of a platelet reaction protein 4 in preparation of an alopecia medicine, and belongs to the field of medical biology. The invention aims to solve the technical problems of limited curative effect, obvious side effect and narrow application range of the existing alopecia treatment medicine. The invention provides an application of a platelet reaction protein 4 (THBS4) in preparation of an alopecia medicinal preparation, which can promote hair follicles to be converted from a resting period to a growing period by regulating and controlling a mechanical microenvironment around the hair follicles, enhancing the interaction between fibroblasts and hair follicle stem cells and activating regeneration signal channels in hair papilla and hair bud areas. The traditional Chinese medicine composition breaks through the limitation that existing treatment only aims at specific alopecia types, and can be widely applied to various alopecia diseases such as androgenetic alopecia, pressure alopecia and alopecia after chemotherapy. And compared with the traditional medicine, the traditional Chinese medicine composition has the advantages of quick response, no skin irritation reaction and improved hair follicle regeneration efficiency, and provides a brand new solution for safe and efficient treatment of alopecia.

The invention discloses a novel application of bifidobacterium longum subsp. Infantis CCFM1269 in relieving atopic dermatitis, and belongs to the technical field of microorganisms. The bifidobacterium longum subsp. Infantis CCFM1269 provided by the invention can relieve atopic dermatitis, and is specifically reflected in that (1) ear swelling and back skin thickening of mice are relieved, dermatological symptoms are relieved, and mast cell infiltration is reduced; (2) reducing the total IgE level of serum; (3) the Treg level of mesenteric lymph nodes and the ILA content of serum are improved; (4) IL-4 and TSLP levels in skin tissues are reduced, IL-10 is improved, and Th1 / Th2 immune balance is recovered; (5) improving AHR and CYP1A1 in the skin tissue; and (4) high yield of ILA.

The invention discloses a barrier repair composition applicable to dry sensitive skin and application thereof. The composition comprises a golden camellia extract, a loquat leaf extract, an alfalfa extract and hydrolyzed royal jelly protein. According to the barrier repairing composition applicable to the dry sensitive skin, disclosed by the invention, through reasonable matching and synergistic interaction of all the components, a better skin barrier repairing effect can be achieved, so that the problems of dry and tight skin, desquamation, erythema, itching, dull luster, redness, burning heat sensation, pricking pain and the like of the dry sensitive skin are fundamentally solved.

Electric shaver (1) having a main body (3) and a shaving unit (5) coupled to the main body. The shaving unit has three hair-cutting units (9a, 9b, 9c) each having an external cutting member (11) with a skin-contact surface (13) with hair-entry openings (15) and an internal cutting member (17) which is rotatable relative to the external cutting member. The hair-cutting units each have at least one geometric parameter (w) that influences a hair-cutting process of each individual hair-cutting unit. The shaving unit can be positioned relative to the main body in at least two different angular positions about a central axis (37) of the shaving unit. A value of the geometric parameter of at least one of the hair-cutting units is different from the values of the geometric parameter of the other hair-cutting units.

Provided are a use of epicatechin or a legume extract containing epicatechin for preparing a composition for tranquilizing skin, and a skin itch treatment method comprising a step of applying a cosmetic composition to the skin of an individual causing itch, the cosmetic composition being the composition for tranquilizing skin.

The invention discloses a skin LC-OCT image segmentation method based on improved GAN and multi-feature fusion. The skin LC-OCT image segmentation method comprises the following steps: collecting a skin B-scan sample by adopting LC-OCT equipment and storing the skin B-scan sample as an image; the method comprises the following steps: constructing a generator fusing reflection filling, multi-scale coding-decoding, self-attention and residual blocks, cooperating with a multi-scale fusion discriminator and a weight sharing twin network, and realizing high-fidelity denoising and enhancement through joint optimization of perception loss, multi-scale SSIM loss and Wasserstein adversarial loss; preprocessing and positioning a skin area based on a threshold value or morphology and normalizing the skin area; gradient is extracted from the de-noised image, and dynamic path search is carried out in combination with a gradient difference minimum criterion and a random forest; and after adaptive sampling and spline fitting are carried out on the path, candidates are generated through a random forest, and fracture or dislocation of a focus area is corrected. Therefore, accurate segmentation of the LC-OCT image of the skin layer can be realized in a high-noise environment, a high-quality enhanced data set can be constructed, and a reliable basis is provided for early diagnosis of skin diseases.

The invention discloses an epidermal skin model and a construction method and application thereof. The construction method comprises the following steps: performing gas-liquid culture on a transwell membrane on a 3D epidermal organ prepared from epidermal stem cells to prepare an epidermal skin model. The epidermis skin model prepared by the construction method can be rapidly amplified to realize large-scale modeling application in a short time, and the epidermis skin model is complete in differentiation, high in integrity, good in barrier function and beneficial to epidermis-related safety detection or efficacy detection of drugs or cosmetics.

The invention discloses a laser depilation dynamic parameter adjustment method based on skin typing recognition, and relates to the technical field of laser depilation, and the method comprises the steps: constructing a three-dimensional skin model of a depilation region through multi-dimensional data cross validation; detecting local pigmentation caused by friction in each area; detecting the blood flow signal intensity of capillary vessels around the hair follicles, judging the period of the hair and generating a hair follicle activity thermodynamic diagram in real time; a three-dimensional energy focus is formed through double-beam crossing; skin curved surface data are obtained through a pressure sensor, liquid crystal molecules in a light valve are driven to be arranged, and light spots are adjusted to be in the shape attached to an unhairing area; the basal metabolic rate of the patient is measured through a noninvasive bioelectrical impedance analysis technology, and the energy density is adjusted based on the basal metabolic rate; and establishing a digital twinborn model, and integrating depilation data, skin state and hormone level information. A three-dimensional energy focus is formed through double-beam crossing, energy is accurately focused on the root of the hair follicle, and epidermis damage is avoided.

The invention relates to the technical field of intelligent medical assistance, in particular to a skin disease treatment electrode positioning system based on potential distribution. The system comprises a potential gradient severe region identification module, a lesion minimum surrounding region identification module, a similar potential region grouping module, an optimal electrode position prediction module, an electric field distribution calculation module, a sweat gland dense region identification module, an optimal electrode placement point screening module, an enhanced feature generation module and a final electrode position determination module. By fusing multi-source information such as skin surface potential distribution, lesion geometric characteristics, tissue conductivity, historical treatment data and the like, systematic optimization is performed on electrode positioning in skin disease treatment, the effectiveness of electrode stimulation is maximized on the premise of ensuring the treatment safety, and the treatment efficiency is improved. An accurate electrode placement scheme is provided for treatment of different types of skin diseases, and the method is suitable for accurate determination of the electrode placement position in electrical stimulation treatment.

In a hair-cutting unit for a rotary electric shaver, which is of the type comprising an external cutting member (10), an internal cutting member and a supporting member (30), an exposure distance over which a skin-contacting surface of a shaving track of the external cutting member (10) protrudes relative to an upper surface of the supporting member (30) is adjustable. To this end, an adjustment system is provided, which comprises, among other things, at least one adjustment set of a guiding channel and a following element (42) engaging the guiding channel, and also an initial position setting system configured to enable synchronization of the exposure distance setting between a number of the hair-cutting units, during which an initial position of the following element (42) in the guiding channel defined by a stop arrangement of the guiding channel is realized and maintained.

The invention discloses matrine-oleanolic acid ionic liquid and a preparation method and application thereof.The preparation method comprises the steps that matrine and oleanolic acid are dissolved in an organic solvent, heating and stirring are conducted, then rotary evaporation is conducted, and the matrine-oleanolic acid ionic liquid is obtained; wherein the mass ratio of the sum of the matrine and the oleanolic acid to the organic solvent is 1: (5-30), and the molar ratio of the matrine to the oleanolic acid is (3-10): 1. The ionic liquid disclosed by the invention not only can effectively improve the water solubility of oleanolic acid, but also can effectively inhibit the activity of 5 alpha-reductase and prevent the 5 alpha-reductase from catalyzing testosterone to be converted into DHT, so that the problems of rapid entry into a retrogression period, miniaturization, hair loss and the like caused by the fact that DHT acts on hair follicles after being combined with an androgen receptor are prevented. Meanwhile, expression of IL-1beta and TNF-alpha inflammatory factors in skin hair follicles can be inhibited, and the purposes of preventing alopecia and promoting hair growth are achieved. The effects of controlling oil, resisting inflammation, relieving, removing dandruff, relieving itching and the like are also achieved.

The invention relates to recombinant humanized collagen as well as a preparation method and application thereof, and belongs to the technical field of genetic engineering. The amino acid sequence of the recombinant humanized collagen is as shown in SEQ ID NO. 1, and the nucleotide sequence of the recombinant humanized collagen is as shown in SEQ ID NO. 2. According to the present invention, the effective sequence of the human VII type collagen is selected to construct and express the recombinant humanized collagen HF3, and the recombinant humanized collagen HF3 has characteristics of no cytotoxicity and good safety, and can effectively improve the skin epidermis and dermis structure and provide the anti-oxidation effect when the recombinant humanized collagen HF3 is applied to the skin care product so as to achieve the effects of skin repairing, skin whitening, skin whitening, skin whitening and skin care. Therefore, the traditional Chinese medicine composition has a good application prospect.

The invention discloses a bionic skin structure capable of generating a natural deformation effect. The bionic skin structure comprises bionic skin, a groove is formed in the back surface of the bionic skin; and / or a hard material is arranged on the back surface of the bionic skin or inside the bionic skin, and the hardness of the hard material is higher than that of the bionic skin; and / or a soft material is arranged on the back surface of the bionic skin or inside the bionic skin, and the hardness of the soft material is lower than that of the bionic skin; and / or the back surface of the bionic skin or the interior of the bionic skin is provided with a reinforcing material, and the reinforcing material is used for improving the tear resistance of the bionic skin; and / or the back surface of the bionic skin is provided with connecting points, and the connecting points are used for connecting attachment points on bones or bionic muscles. According to the scheme, the bionic skin can effectively and controllably generate the effects of specific wrinkles, traction and the like, the deformation effect is natural, simulated and more vivid, and therefore the man-machine interaction effect can be further improved.

The invention relates to a skin wound repairing material and a preparation method thereof, and belongs to the technical field of biological medicines. The repair material disclosed by the invention contains palmitoyl tripeptide-1, methacrylated collagen, cuttlebone extract, recombinant human epidermal growth factor lipidosome, polydopamine nanoparticles, hyaluronic acid, sodium alginate modified silk fibroin and the like in a specific proportion. Wherein the cuttlebone extract is a product which is obtained by carrying out common enzymolysis on cuttlebone through chitinase and nattokinase and then carrying out step-by-step enzymolysis on the cuttlebone through gelatinase and lumbrukinase and is less than 5kDa. The components are prepared into an efficient product by adopting a special method, the stability of the components is improved, the problem that the activity is difficult to maintain is solved, and the skin wound repairing effect is good through reasonable compatibility.

The application provides a tyrosinase-based transdermal delivery system for treating vitiligo, which is a core-shell structure, the core is tyrosinase, and the shell is a polymer shell layer. The application coats a polymer protective layer on the surface of the tyrosinase through in-situ polymerization reaction on the double bond of the tyrosinase, can effectively protect the activity of the tyrosinase and promote the transdermal delivery of the tyrosinase, and can control the targeted delivery of the tyrosinase nanogel to melanocytes in the deep part of the skin and hair follicle by adjusting the polymerization conditions of the polymer shell, so as to promote the in-situ synthesis of melanin. The transdermal delivery system of the application can also load active small molecules with anti-inflammatory function in the center of the tyrosinase, and the small molecules are released after being targeted and delivered to the inflammation area of vitiligo along with the tyrosinase nanogel, so as to relieve inflammation and protect melanocytes from damage.

The invention discloses a hair cutting assembly, which comprises a rigid stationary knife and a base, the stationary knife is fixed on the base, a plurality of side stationary knife teeth are arranged on a stationary knife body, the top surfaces of the stationary knife body and the side stationary knife teeth are used as skin contact surfaces, the left side and the right side of each side stationary knife tooth are respectively provided with a first knife edge with an acute angle; a movable cutter capable of moving left and right is arranged below the fixed cutter, side movable cutter teeth located below the side fixed cutter teeth are arranged on the movable cutter, second cutting edges with acute angles are arranged on the left side and the right side of the side movable cutter teeth respectively, and a middle installation hole is formed in the position, located on the inner sides of the side fixed cutter teeth, of the middle of the fixed cutter body. A middle cutter net which is exposed upwards from the middle mounting hole is arranged between the base and the fixed cutter, and a middle cutter assembly is arranged below the middle cutter net. The hair cutting assembly has the advantages of being sharp in cutting, good in safety, small in size and comfortable in skin feeling.

The disclosure provides negative pressure wound dressings having an island and a suction drape over the island. The island has an absorbent layer and a skin contact layer, with the skin contact layer configured to extend outwardly past the absorbent layer to space out the step down of the drape over the island. The step down of the drape over the extension of the skin contact layer provides a short step down that has been observed to reduce damage to the skin at the juncture of the drape and the skin.

The invention discloses a local oxygen therapy, flushing and skin stretching device for chronic wound treatment, and relates to the technical field of medical apparatuses and instruments, the local oxygen therapy, flushing and skin stretching device comprises a stretching disc, and a cleaning device is arranged in the middle of the stretching disc; according to the device, breakthrough is achieved through the combination of the circular structure of the stretching disc and the circumferentially-distributed T-shaped sliding racks; the circular geometric structure of the stretching disc has stress symmetry, and stretching force can be evenly dispersed; the position of the T-shaped sliding rack installed in a circumferential sliding mode can be flexibly adjusted in the radial direction of the stretching disc, and six or more stretching points can be set at will according to the boundary of the wound surface in cooperation with the sliding block and the T-shaped hook frame which can slide. For example, for an irregular polygonal wound surface of a diabetic foot, a medical worker can mark six stress balance points on the T-shaped sliding rack and fix the hook, synchronous or independent adjustment of multiple distraction points is achieved through linkage of the rotating gear ring and the multiple sets of gears, and the situation that skin ischemia blister is caused by too large local stress or tissue stretching is affected by insufficient stress is avoided.

The invention aims at providing a breast surgery retractor capable of avoiding skin scald, and relates to the field of medical surgical instruments, the breast surgery retractor comprises a fixing device, the fixing device comprises a first sliding rail, a supporting rod, a limiting stopper and a pressing plate, and the fixing device is used for adjusting the position and angle of the surgery retractor, so that the surgery retractor is more practical; the auxiliary device comprises a second sliding block, a second sliding rail, a third sliding rail and a first auxiliary drag hook assembly and assists the heat dissipation plate in traction, and the operation difficulty is reduced; the isolation device comprises a second auxiliary drag hook assembly, a traction rod, a shifting block, a sleeve, a connecting rod and a diaphragm, the skin can be isolated through the diaphragm, and the skin is prevented from being scalded due to heat conduction of metal. The problem that a metal drag hook easily scalds the skin is solved.

The invention discloses a scar-removing microneedle body and a scar-removing microneedle composite patch, and belongs to the technical field of microneedle patches, the scar-removing microneedle composite patch comprises a patch layer and a microneedle layer, the patch layer comprises a silica gel layer and a substrate layer, and the substrate layer is arranged between the microneedle layer and the silica gel layer; the microneedle layer comprises a plurality of microneedle bodies, each microneedle body comprises an epidermal segment and a dermis segment, and the epidermal segment is composed of a matrix and a first scar removing component; the dermis segment is composed of a matrix and a second scar removing component; the scar-removing microneedle body is of a two-section structural design, two scar-removing components are combined, different scar-removing components of epidermal layer targeting and corium layer targeting are accurately provided to a target skin layer, individual scar-removing components can be concentrated on the target skin layer, and the scar-removing effect is improved. Meanwhile, side effects or interference possibly generated by scar removing components on different skin layers can be avoided, and the precise and efficient compound scar removing effect is achieved.