The invention discloses a
gene marker combination, a kit and a
system for
breast cancer molecular typing, and belongs to the field of precise medical
big data analysis. The
gene marker combination is composed of 17
gene markers, namely, CLDN19, DSG1, FABP7, FGFBP1, KLK7, KLK8, MAPK4, MAPT-AS1, MAPT-IT1, MIA, PTPRZ1, ROPN1, ROPN1B, SCN2B, SERPINA11, SOX11, and SRARP. The invention further discloses a preparation method of the gene marker combination. Based on the combination, a brand new
breast cancer GPS17
molecular typing system is constructed, the
breast cancer can be finely divided into eight molecular subtypes with remarkable expression difference, and at least four different molecular subgroups in the Luminal A subtype are systematically analyzed for the first time. Experiments show that the
molecular typing system is obviously superior to a traditional PAM50 molecular
typing system in balance accuracy,
macro F1
score and
macro AUC
score. The invention further provides a corresponding detection kit and an automatic
typing system integrated with a
machine learning model, and an auxiliary
diagnosis tool with excellent performance is provided for accurate diagnosis and treatment decision of breast
cancer.