46 results about "In vitro analysis" patented technology

The bottom of the cuvette comprises a curved raceway placed so as to guide the oscillating movement of a ball inserted into the cuvette. In addition, the cuvette comprises means of attachment, in two perpendicular directions, to adjacent unit cuvettes. The cuvettes can thus be stored as plates in a feed magazine of an analytical device. The analytical device comprises several stations placed around a rotary ring. Only where it is desired to determine the clotting time of the blood contained in the cuvette a ball is introduced into the latter, at a ball distribution post. The cuvette equipped in this way is then brought to a station where the test is carried out. The major advantage of the invention is the polyvalence of the cuvette and of the analytical device.

An in vitro method of determining an analyte concentration of a sample includes placing the sample into a low-field, bench-top time-domain nuclear magnetic resonance (TD-NMR) spectrometer. The NMR spectrometer is tuned to measure a selected type of atom. A magnetic field is applied to the sample using a fixed, permanent magnet. At least one 90 degree radio-frequency pulse is applied to the sample. The radio-frequency pulse is generally perpendicular to the magnetic field. The 90 degree radio-frequency pulse is removed from the sample so as to produce a decaying NMR signal. The decaying NMR signal is measured at a plurality of times while applying a plurality of 180 degree refocusing radio-frequency pulses to the sample. The analyte concentration is calculated from the plurality of measurements associated with the decaying NMR signal and a selected model.

This invention relates generally to the analytical testing of tissue samples in vitro, and more particularly to aspects of genetic polymorphisms associated with the conversion from Mile Cognitive Impairment to dementia, e.g., Alzheimer's Disease (AD). The invention provides AD-associated mutations which are useful in the diagnosis, prognosis or therapeutic treatment of dementia, e.g., Alzheimer's Disease.

A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. An optical conduit, preferably an optical fiber has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.

Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and / or in vitro analyte sensors, e.g., continuous and / or automatic in vivo monitoring using analyte sensors and / or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

The device has a microinvasive or micro-sampling investigating system comprising a flexible metallic guide with an end containing a series of pits. The pits are directly coupled to a specific reactive group of a substrate, where the end is perforated. Another end of the metallic guide is used to maneuver the metallic guide and associated with an aspiration system. A removable protection system e.g. flexible catheter, is arranged at the former end of the metallic guide. An independent claim is also included for a method for detecting ex vivo of a substrate present in a tissue or organ.

The invention relates to a positioning base used for accommodating and positioning a detection card in an in vitro detection and analysis device. The positioning base includes a first positioning mechanism and a second positioning mechanism. An open positioning groove is opened on the upper surface of the positioning base. The positioning groove forms an opening on the side of the positioning base for inserting the detection card. The positioning groove includes an inner bottom surface and a pair of inner side surfaces. A first receiving groove is opened on the inner bottom surface to accommodate the first positioning mechanism. A second accommodating groove is opened on one of the inner surfaces for accommodating the second positioning mechanism. The first positioning mechanism and the second positioning mechanism are used to jointly position the inserted detection card. The invention also relates to a dark chamber using the positioning base and an in vitro detection and analysis device using the dark chamber.