Applications of small molecular compound Salubrinal in drugs for treating or preventing osteoporosis and osteopenia diseases

A small molecule compound, osteoporosis technology, applied in bone diseases, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as lack

Inactive Publication Date: 2020-08-25
张平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently a lack of effective multi-target therapeutic drugs that both stimulate bone formation and inhibit bone resorption.

Method used

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  • Applications of small molecular compound Salubrinal in drugs for treating or preventing osteoporosis and osteopenia diseases
  • Applications of small molecular compound Salubrinal in drugs for treating or preventing osteoporosis and osteopenia diseases
  • Applications of small molecular compound Salubrinal in drugs for treating or preventing osteoporosis and osteopenia diseases

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Embodiment Construction

[0045] The invention will be further described below in conjunction with specific embodiments.

[0046] The symbols used in this specification, the drawings of the specification and the claims are explained as follows:

[0047]

[0048]

[0049] 1 Example of Salubrinal regulating the effect of endoplasmic reticulum stress on improving bone loss

[0050] 1.1 Experimental part

[0051] First, 54 C57BL / 6 (~16 weeks old, 20 g) female mice were used to evaluate the role of ER stress in the development and development of weightlessness-induced osteoporosis. These mice were divided into 9 groups: age-matched control group (AC) and 8 rat tail suspension groups (HU, grouped by suspension time: 3h, 6h, 12h, 1d, 2d, 3d, 7d and 14d; each group The average number of experimental animals is n=6). Samples were collected at different time points for histology and bone marrow cell experiments to detect the effects of rat tail suspension on osteoblast differentiation and osteoclast dev...

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Abstract

The invention discloses applications of a small molecular compound Salubrinal in drugs for treating or preventing osteoporosis and osteopenia diseases. Through the utilization of a mouse model of postmenopausal osteoporosis caused by OVX ovariectomy, a mouse model of disuse osteoporosis caused by tail suspension, in vivo and in vitro analysis of primary bone marrow-derived cells and the indicationof cell line-based experimental results, Salubrinal administration can effectively relieve OVX related symptoms, stimulate the differentiation of osteoblasts and inhibit the development of osteoclasts. Through the indication of precise molecular mechanism of the Salubrinal, the Salubrinal can be applied to drugs for treating or preventing osteopenia diseases caused by postmenopausal osteoporosis,disuse osteoporosis and other factors.

Description

technical field [0001] The invention belongs to the field of biotechnology, and specifically relates to the application of the small molecular compound Salubrinal in the treatment or prevention of osteoporosis and osteopenia disease drugs. Background technique [0002] The endoplasmic reticulum (ER) is an important organelle responsible for protein synthesis, folding, assembly and modification, lipid synthesis and cell membrane structure synthesis in eukaryotic cells, and plays a significant role in regulating cell stress and apoptosis. Therefore, the endoplasmic reticulum plays an important role in maintaining cellular homeostasis. A variety of physiological or pathological conditions, such as inhibition of protein glycosylation, loss of calcium ions, failure of proteins to form normal disulfide bonds, expression of mutant proteins, and changes in redox state, can cause unfolded or misfolded proteins The accumulation of plasma reticulum damages the normal physiological fun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4706A61P19/10A61P19/08
CPCA61K31/4706A61P19/08A61P19/10
Inventor 张平
Owner 张平
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