4 results about "Amperometry" patented technology

Recently, aptamers have been considered in cancer diagnosis and treatment applications by binding to various bioreceptor molecules. Given that the p53 protein is responsible for approximately 50% of cancers, its identification is promising, but so far, no aptamer DNA sequence has been designed for the p53 protein and aptamer-based sensor. The purpose of this invention is to develop a nanoparticle-based aptamer sensor and use the p53 bioreceptor for cancer diagnosis with high sensitivity in the shortest time. In this regard, a DNA aptamer-based sensor was used on a glassy carbon electrode coated with gold nanoparticles / graphene oxide / conductive polymer . This sensor was created by the gold nanoparticles / aptamer-toluidine blue enhancer. The results obtained under optimal conditions of electrochemical investigation using amperometry indicated a detection limit of 0.29 picograms / mL in phosphate buffer and 0.341 picograms / mL in human blood plasma and a linear range of 1 to 300 picograms / mL for the sensor. This invention demonstrates the excellent and controllable performance of a modified carbon electrode to create a suitable sensor for detecting the cancer marker p53 protein.

The invention relates to the development of a fast, sensitive, and user-friendly electrochemical sensor suitable for point-of-care testing for lactate dehydrogenase (LDH) determination which includes a gold working electrode, a silver reference electrode, and a counter electrode. The electrode surface is modified with Polyaniline-b-Polyacrylic acid (PANI-b-PAA), a conductive polymer suitable for LDH determination.

A voice coil motor (VCM) in a hard disk drive having a VCM resistance is driven based on a value of the back electromotive force (BEMF) of the VCM reconstructed from a voltage drop indicative of the intensity of a current flowing towards the VCM detected by an amperometry resistance. The BEMF of the VCM is reconstructed as a function of the voltage drop via a first gain value, determined as the ratio of the VCM resistance to the amperometry resistance. A calibrated gain value, indicative of the ratio of the actual VCM resistance to the amperometry resistance is produced by applying a correction factor to the first gain value. The VCM is driven continuously based on a value of the BEMF of the VCM reconstructed by applying to the voltage drop the calibrated gain value.

There is disclosed a method and sensor for detecting a plurality of analytes in bodily fluid, the sensor comprising electrodes including a first working electrode, a second working electrode, a third working electrode, a counter electrode, and a reference electrode; wherein the first working electrode is configured to detect a first signal indicative of a first analyte concentration using potentiometry; wherein the second working electrode is configured to detect a second signal indicative of a second analyte concentration using amperometry; wherein the third working electrode is configured to detect a third signal indicative of a third analyte concentration using amperometry; wherein the first analyte, the second analyte, and third analyte are different analytes; wherein the first signal, the second signal, and the third signal are detected using the same reference electrode; wherein at least part of the detection of the first signal occurs simultaneously with the detection of the second signal; wherein the second signal and third signal are detected using the same counter electrode; wherein at least part of the detection of the second signal occurs simultaneously with the detection of the third signal; and wherein at least one of the second working electrode and third working electrode is continuously polarized by application of a polarization voltage during detection of the first signal, second signal and third signal.