15 results about "Amperometry" patented technology

Provided are systems, cartridges, devices and methods for detecting a target analyte in a test sample. The system employs a multitude of magnetic sources for moving magnetic beads in a sequential movement through various portions of e.g. a cartridge or strip, such as from one or more hybridization portions, through one or more washing portions, and to a redox portion. The system employs an electrode set and a potentiostat for performing amperometry to obtain an electrochemical measurement based on conversion of a redox active molecule. Also provided are methods for detecting a target analyte using the systems, and cartridges and strips for use in the system or a device of the system.

A method and sensor for detecting a plurality of analytes in a bodily fluid, the sensor comprising electrodes including a first working electrode, a second working electrode, a third working electrode, a counter electrode, and a reference electrode; wherein the first working electrode is configured to detect a first signal indicative of a first analyte concentration using potentiometry; wherein the second working electrode is configured to detect a second signal indicative of a second analyte concentration using amperometry; wherein the third working electrode is configured to detect a third signal indicative of a third analyte concentration using amperometry; wherein the first analyte, the second analyte, and the third analyte are different analytes; wherein the first signal, the second signal and the third signal are detected by using the same reference electrode; wherein at least a portion of the detection of the first signal occurs concurrently with the detection of the second signal; wherein the second signal and the third signal are detected using the same pair of electrodes; wherein at least a portion of the detection of the second signal occurs concurrently with the detection of the third signal; and wherein at least one of the second working electrode and the third working electrode is continuously polarized by applying a polarization voltage during detection of the first signal, the second signal, and the third signal.

An implant device implantable within a body of a patient. The implant device includes a set of electrodes in an array spaced apart on the implant device, measurement circuitry configured to perform measurement modes on signals from the electrodes, a multiplexer that interconnects different pairs of electrodes in the array to the measurement circuitry, and a controller. The controller controls the multiplexer to selectively connect different pairs of electrodes in the array over time to perform the measurement modes that include at least two of: open circuit potential (OCP) measurement, amperometry measurement, and electrochemical impedance measurement.

The invention relates to immunological-based biosensor chip systems, devices, kits and diagnostic methods for detection, quantification and / or monitoring of at least one target compound, specifically, at least one small molecule compound, specifically, cyanotoxins in a sample. The present disclosure relates to a biosensor chip system usable for identifying and / or quantifying and / or monitoring at least one target in a sample. More specifically, the system comprises at least one of: at least one first and at least one second chip devices. It should be noted that the first chip device comprises a first plurality of electrodes connectable to at least one electronic device. It should be further noted that the first plurality of electrodes is configured for electrochemical impedance spectroscopy (EIS) analysis of the sample. The second chip device comprises a second plurality of electrodes connectable to at least one electronic device. The second plurality of electrodes is configured for electrochemical voltammetry or amperometry analysis of said sample.

The invention discloses wearable Parkinson's disease treatment monitoring equipment and a use method thereof. The wearable Parkinson's disease treatment monitoring equipment comprises a flexible patch, a flexible circuit board and a mobile intelligent terminal app, the flexible patch comprises a substrate layer, an electrode layer, a flow channel layer and a packaging layer, the electrode layer comprises electric stimulation induction double electrodes, levodopa, tryptophan and a pH sensing electrode, and a sweat stimulation area and a sensing area are separated under the assistance of the flow channel layer; the terminal and the clamping groove are used for connecting the patch and the flexible circuit board; the flexible circuit board excites the redox reaction of the electrode interface target through an ampere method and an open-circuit voltage method, acquires and reads an electric signal, and transmits data to a patient mobile intelligent terminal app through a Bluetooth module on the flexible circuit board. The device is attached to the body surface in the form of plaster, has high human body compliance, can realize real-time visualization of biochemical data of a patient, realizes a closed loop in the diagnosis and treatment process of Parkinson's disease, and promotes the modernization of medical treatment and care equipment.

A microfluidic electrochemical device has a microfluidic channel and an electrochemical cell having a pair of working electrodes separated by an inter-electrode distance in a flow direction of the fluid in the microfluidic channel, a counter-electrode and a reference electrode. The microfluidic electrochemical device has an electrochemical amperometry measurement system configured to bias the pair of working electrodes so that each electrode produces an amperometric signal by oxidation reaction or by reduction reaction with the electroreactive fluid or with a chemical species associated with a redox couple intended for the fluid. The microfluidic electrochemical device determines the volume flow rate of the fluid in the microfluidic channel, notably based on the inter-electrode distance and a time delay between the amperometric signals produced by the pair of working electrodes.

Recently, aptamers have been considered in cancer diagnosis and treatment applications by binding to various bioreceptor molecules. Given that the p53 protein is responsible for approximately 50% of cancers, its identification is promising, but so far, no aptamer DNA sequence has been designed for the p53 protein and aptamer-based sensor. The purpose of this invention is to develop a nanoparticle-based aptamer sensor and use the p53 bioreceptor for cancer diagnosis with high sensitivity in the shortest time. In this regard, a DNA aptamer-based sensor was used on a glassy carbon electrode coated with gold nanoparticles / graphene oxide / conductive polymer . This sensor was created by the gold nanoparticles / aptamer-toluidine blue enhancer. The results obtained under optimal conditions of electrochemical investigation using amperometry indicated a detection limit of 0.29 picograms / mL in phosphate buffer and 0.341 picograms / mL in human blood plasma and a linear range of 1 to 300 picograms / mL for the sensor. This invention demonstrates the excellent and controllable performance of a modified carbon electrode to create a suitable sensor for detecting the cancer marker p53 protein.

Provided herein are neuromodulation leads and systems including the leads that can be used to both detect chemical analytes in the brain and stimulate the brain. The neuromodulation leads described herein can detect chemical analytes by measuring an electrochemical signal, for example, in response to an applied energy waveform. The systems described herein can utilize a two-electrode and / or three-electrode sensing electrode arrangement to measure electrochemical signals. Moreover, various measuring modalities, such as impedance, amperometry, potentiometry, and / or cyclic voltammetry can be used to measure electrochemical signals. Based on the measured electrochemical signal, the concentration of the chemical analytes in the brain can be determined. The determination of the chemical analytes present in the tissue, including the concentration of the chemical analytes, can be used to inform stimulation parameters of the neuromodulation therapy, exogenous drug dosing, and / or diagnosis chronic diseases.

To provide an implant device that can be implanted in a patient's body.SOLUTION: The implant device includes a set of electrodes in an array spaced apart on the implant device, a measurement circuit configured to perform a measurement mode on signals from the electrodes, a multiplexer interconnecting different pairs of electrodes in the array to the measurement circuit, and a controller. The controller controls the multiplexer to selectively connect different electrode pairs in the array over time to perform a measurement mode, wherein the measurement mode includes at least two of an open circuit potential (OCP) measurement, an amperometry measurement, and an electrochemical impedance measurement.SELECTED DRAWING: Figure 1

The invention relates to the development of a fast, sensitive, and user-friendly electrochemical sensor suitable for point-of-care testing for lactate dehydrogenase (LDH) determination which includes a gold working electrode, a silver reference electrode, and a counter electrode. The electrode surface is modified with Polyaniline-b-Polyacrylic acid (PANI-b-PAA), a conductive polymer suitable for LDH determination.

The present invention relates to a new device for selective arsenic sensing using electrochemically reduced graphene oxide (ERGO) based reusable flexible electrode strip. Active electrode of the device was prepared by a very simple method in which the thin film of graphene oxide (GO) was reduced electrochemically at a low DC potential (0 to −1.5 V). The said device selectively detects As3+ in field water sample within a wide range of concentrations with a limit of detection of less than 25 ppb. More importantly, the selectivity of the electrode is independent of conductivity and TDS levels of measured field water samples which were collected from various parts of India. Selective detection of As3+ by ERGO was controlled by optimizing the surface electronic conductivity through structural modification of it during electroreduction process.

The invention discloses a method for determining nine breast milk oligosaccharides in infant formula milk powder, and belongs to the technical field of food detection. The method comprises the following steps: filling a sample into an extraction tank, carrying out ASE extraction, adding water into a collected liquid to dilute and fix the volume, purifying through a Captiva EMR-Lipid purification column, passing through a membrane, and diluting a filtrate to obtain a sample to be detected; and determining the sample to be detected by adopting an ion chromatography-pulse integral amperometry, and calculating the contents of the nine breast milk oligosaccharides in the sample to be detected according to the standard curve model. The method has the remarkable advantages of being high in automation degree, good in protein precipitation effect, free of derivatization and the like, and qualitative and quantitative detection of nine kinds of breast milk oligosaccharides is achieved at the same time.

A voice coil motor (VCM) in a hard disk drive having a VCM resistance is driven based on a value of the back electromotive force (BEMF) of the VCM reconstructed from a voltage drop indicative of the intensity of a current flowing towards the VCM detected by an amperometry resistance. The BEMF of the VCM is reconstructed as a function of the voltage drop via a first gain value, determined as the ratio of the VCM resistance to the amperometry resistance. A calibrated gain value, indicative of the ratio of the actual VCM resistance to the amperometry resistance is produced by applying a correction factor to the first gain value. The VCM is driven continuously based on a value of the BEMF of the VCM reconstructed by applying to the voltage drop the calibrated gain value.

A voice coil motor (VCM) in a hard disk drive having a VCM resistance is driven based on a value of the back electromotive force (BEMF) of the VCM reconstructed from a voltage drop indicative of the intensity of a current flowing towards the VCM detected by an amperometry resistance. The BEMF of the VCM is reconstructed as a function of the voltage drop via a first gain value, determined as the ratio of the VCM resistance to the amperometry resistance. A calibrated gain value, indicative of the ratio of the actual VCM resistance to the amperometry resistance is produced by applying a correction factor to the first gain value. The VCM is driven continuously based on a value of the BEMF of the VCM reconstructed by applying to the voltage drop the calibrated gain value.

There is disclosed a method and sensor for detecting a plurality of analytes in bodily fluid, the sensor comprising electrodes including a first working electrode, a second working electrode, a third working electrode, a counter electrode, and a reference electrode; wherein the first working electrode is configured to detect a first signal indicative of a first analyte concentration using potentiometry; wherein the second working electrode is configured to detect a second signal indicative of a second analyte concentration using amperometry; wherein the third working electrode is configured to detect a third signal indicative of a third analyte concentration using amperometry; wherein the first analyte, the second analyte, and third analyte are different analytes; wherein the first signal, the second signal, and the third signal are detected using the same reference electrode; wherein at least part of the detection of the first signal occurs simultaneously with the detection of the second signal; wherein the second signal and third signal are detected using the same counter electrode; wherein at least part of the detection of the second signal occurs simultaneously with the detection of the third signal; and wherein at least one of the second working electrode and third working electrode is continuously polarized by application of a polarization voltage during detection of the first signal, second signal and third signal.