Gated amperometry

An amperometric, analyte technique used in the field of gated amperometry

Active Publication Date: 2014-02-05
ASCENSIA DIABETES CARE HLDG AG
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  • Abstract
  • Description
  • Claims
  • Application Information

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While each of these approaches weighs various advantages and disadvantages, no single approach is ideal

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Embodiment Construction

[0083] The present invention takes advantage of the discovery that a gated amperometric pulse sequence comprising multiple duty cycles can provide improved accuracy and precision for the analysis while reducing the time to completion of the analysis. Each duty cycle consists of one excitation which can be provided at a relatively constant voltage. Each duty cycle also includes a relaxation which can be provided by an open circuit. The pulse sequence of the present invention does not necessarily require additional delays and pulses, such as an "incubation" delay to provide reagent rehydration, a "burn-off" pulse to refresh the electrodes, and a "burn-off" pulse to refresh the mediator. The time required for the above-mentioned analysis can be shortened by reducing the analysis time by recovering the pulse of the mediator in the oxidized state.

[0084]Even with shorter analysis times, the gated amperometric pulse sequence of the present invention can still improve accuracy and...

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Abstract

A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated amperometric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and / or improve the accuracy and / or precision of the analysis. The disclosed gated amperometric pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, under-fill, temperature changes in the sample, and a single set of calibration constants.

Description

[0001] This application is a divisional application of the patent application No. 200680026346.2 with the filing date of July 19, 2006 and the title of the invention being "gated current analysis method". [0002] References to related applications [0003] This application claims U.S. Provisional Application No. 60 / 700,787, filed July 20, 2005, entitled "Gated Amperometry" and filed May 08, 2006, entitled "Abnormal Output Detection system for a biosensor (abnormal output detection system for biosensors)" U.S. Provisional Application No. 60 / 746,771, the contents of which are incorporated herein by reference. Background technique [0004] Quantitative determination of analytes in biological fluids for diagnosis and treatment of physiological abnormalities. For example, measuring glucose levels in biological fluids such as blood is important for diabetics who must frequently check their blood sugar levels in order to adjust diet and / or medication. [0005] Electrochemical syst...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/49G01N27/327G01N33/487C12Q1/00
CPCA61B5/14546C12Q1/006A61B2562/0295G01N27/3273A61B5/14532G01N27/26C12Q1/26A61B5/1486A61B5/00C12Q1/00G01N27/49G01N33/487
Inventor 伍焕平克里斯廷·D·纳尔森格雷格·P·比尔
Owner ASCENSIA DIABETES CARE HLDG AG
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