Gated amperometry

Abstract

A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated amperometric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and / or improve the accuracy and / or precision of the analysis. The disclosed gated amperometric pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, under-fill, temperature changes in the sample, and a single set of calibration constants.

Description

References to related applications The application requires the U.S. provisional application No.60 / 700,787 submitted on July 20th, 2005, titled "Gated Amperometry (gated current analysis method)" and submitted on May 08th, 2006, titled " Abnormal Output Detection system for a biosensor (abnormal output detection system for biosensors)" U.S. Provisional Application No. 60 / 746,771 priority, and the contents of these two provisional applications are incorporated herein by reference. Background technique [002] Quantitative determination of analytes in biological fluids is used in the diagnosis and treatment of physiological abnormalities. For example, measuring glucose levels in biological fluids such as blood is important for diabetics who must frequently check their blood sugar levels in order to adjust diet and / or medication. [003] Electrochemical systems have been used for this type of analysis. During analysis, the analyte undergoes a redox reaction with an enzyme or sim...

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