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Gated amperometry

An amperometric, analyte technique used in the field of gated amperometry

Active Publication Date: 2008-10-29
ASCENSIA DIABETES CARE HLDG AG
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While each of these approaches weighs various advantages and disadvantages, no single approach is ideal

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Embodiment Construction

[083] Even with shorter analysis times, the gated amperometric pulse sequences of the present invention can still improve accuracy and / or precision compared to conventional methods. In one aspect, accuracy errors introduced by hematocrit effects and accuracy errors due to varying cap gap volumes can be reduced by the combination of a diffusion barrier layer and the pulse sequence of the present invention. In another aspect, errors otherwise caused by non-stationary sensor conditions and / or mediator backgrounds can be reduced. The gated pulse sequence of the present invention also enables determination of instantaneous current and profile curves for simulating steady state conditions. The instantaneous current curve can be used to provide multiple sets of calibration constants, non-fill detection, and the ability to determine the temperature of the sample rather than relying on the temperature from the measuring device.

[084] Figures 1A and 1B illustrate a sensor strip 100 tha...

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Abstract

A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated amperometric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and / or improve the accuracy and / or precision of the analysis. The disclosed gated amperometric pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, under-fill, temperature changes in the sample, and a single set of calibration constants.

Description

References to related applications The application requires the U.S. provisional application No.60 / 700,787 submitted on July 20th, 2005, titled "Gated Amperometry (gated current analysis method)" and submitted on May 08th, 2006, titled " Abnormal Output Detection system for a biosensor (abnormal output detection system for biosensors)" U.S. Provisional Application No. 60 / 746,771 priority, and the contents of these two provisional applications are incorporated herein by reference. Background technique [002] Quantitative determination of analytes in biological fluids is used in the diagnosis and treatment of physiological abnormalities. For example, measuring glucose levels in biological fluids such as blood is important for diabetics who must frequently check their blood sugar levels in order to adjust diet and / or medication. [003] Electrochemical systems have been used for this type of analysis. During analysis, the analyte undergoes a redox reaction with an enzyme or sim...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/49G01N33/487C12Q1/00A61B5/00
CPCG01N27/327G01N27/49G01N33/48707
Inventor 伍焕平克里斯廷·D·纳尔森格雷格·P·比尔
Owner ASCENSIA DIABETES CARE HLDG AG
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