The invention discloses a biological
hybrid nano preparation based on
cholesterol regulation and control as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: preparing a gold
nanoparticle solution, mixing the gold
nanoparticle solution with a
photosynthetic bacterium solution to obtain a PSB-coated GNP complex, mixing the PSB-coated GNP complex with a
proteus mirabilis bacterium solution to obtain a PM-PSB-coated GNP core solution, modifying the PM-PSB-coated GNP core solution with a
coating solution, and carrying out
spray drying to obtain the biological
hybrid nano preparation EC-PM-PSB-coated GNP. The preparation process is simple and controllable, complex and precise equipment is not needed, the
oral administration mode is convenient, the
patient compliance is high, compared with traditional chemical drugs and injection preparations, the toxic and side effects of the
whole body and the environmental
pollution risk are greatly reduced, meanwhile, the treatment procedures and the
medication cost are reduced, efficient, safe and precise
colorectal cancer treatment is achieved, and the clinical application prospect is wide. The clinical application requirements are met.