12 results about "Dermal matrix" patented technology

A universal biological prosthesis of acellular dermal matrix (ADM) intended for use in body reconstruction processes and method of manufacture. A universal biological prosthesis of acellular dermal matrix (ADM) intended for use in body reconstruction processes, comprising: a first layer of ADM of biological origin arranged inferiorly to delimit a cavity with a lower edge; a filling material disposed in the cavity surrounded by the first layer of ADM consisting of a ground ADM having the consistency of a fibrous paste; and a second layer of ADM of biological origin arranged on the upper part covering the filling material and whose upper edge rests peripherally on the lower edge of the first layer of ADM, thus defining a rim;where the first layer of ADM and the second layer of ADM are joined by an eyebrow overlap along the upper edge of the first layer of ADM with the lower edge of the peripheral rim using a biocompatible adhesive, or by absorbable suture; where the first layer of ADM, the second layer of ADM and the ADM filling material are not immunogenic; and where the ADM comprises collagen fibers, fibronectin, elastin, laminin, glycosaminoglycans and hyaluronic acid. Method for its manufacture.

This invention discloses a method for culturing skin organoids for large-scale production and the skin organoids used for large-scale production, belonging to the fields of tissue engineering and biomanufacturing technology. The method involves laying a dermal matrix layer composed of orthogonal double-network hydrogels embedding fibroblasts in a bioreactor containing multiple independently operable culture modules. After inoculating keratinocytes, negative pressure is used to drive a uniform descent of the culture medium level to achieve gas-liquid interface culture. The first network of the orthogonal double-network hydrogel is formed by photocrosslinking of methacrylamide recombinant collagen, and the second network is formed by Michael addition of thiolated polysaccharides and multi-arm polyethylene glycol maleimide. During the culture process, the barrier maturity is assessed in real time by online monitoring of transepithelial resistance, and the negative pressure is controlled accordingly. A single batch can produce 3000 cm³ of skin organoids. 2 The above-mentioned qualified skin organoids have a transepithelial resistance coefficient of variation of less than 10%.

The present invention relates to a dispersion comprising acellular dermal matrix microparticles, a filler comprising the same, and uses thereof. More specifically, the present invention relates to a filler comprising a dispersion containing acellular dermal matrix microparticles obtained by supercritical fluid extraction and high pressure dispersion operations, and a method for preparing the same. The acellular dermal filler according to the present invention has excellent biological stability and biocompatibility, and extracellular matrix components such as collagen and elastin are significantly preserved therein. In addition, the filling agent also shows excellent biochemical stability, the pH value or the collagen content and the elastin content are kept unchanged in the storage process, and the filling agent also shows physical stability and can continuously maintain injectability. Therefore, the acellular dermal filler can be effectively used as an injectable filler for repair or volume expansion of soft tissue and reduction of wrinkles in the field of plastic and regenerative medicine.

The utility model discloses a water bath device for dermal matrix processing, and belongs to the field of water bath devices. The water bath device for leather matrix processing comprises a discharging assembly, a cleaning assembly is arranged on the discharging assembly, the discharging assembly comprises a discharging box used for storing water and containing leather, a plurality of sets of partition plates are fixedly installed on a roller, and the multiple sets of partition plates form cavities on the outer side of the roller. According to the water bath device for leather matrix processing, water can be stored in the discharging box, so that leather can be wetted and cleaned, meanwhile, the driving assembly and the cleaning assembly are used in cooperation, the roller can rotate, and therefore the leather can be cleaned, and the leather can be cleaned. According to the cleaning device for the leather, the cleaning efficiency of the leather can be further improved, and after the leather is cleaned, water on the leather can be thrown out through the cleaning assembly, so that the effect of removing dampness is achieved.

The invention relates to the technical field of skin care products, and particularly discloses an anti-aging polypeptide composition as well as a preparation method and application thereof. According to the anti-aging polypeptide composition disclosed by the invention, through a multi-target-point and multi-layer synergistic effect, efficient wrinkle smoothing, tightening and anti-aging are realized. The anti-aging polypeptide composition can act on a neuromuscular joint and a dermal matrix at the same time, and has double effects of immediate improvement and long-term repair. According to the anti-aging polypeptide composition, the active ingredients and the penetration enhancer are synergistic, and compared with exogenous supplement collagen, the anti-aging polypeptide composition can be effectively absorbed in a transdermal mode, enhance the regeneration capacity of autologous collagen, better regulate extracellular matrixes and improve the anti-aging effect of the composition, and the anti-aging polypeptide composition has the advantages that by endogenous stimulation of regeneration of structural protein such as skin collagen, the anti-aging effect of the anti-aging polypeptide composition is improved, and the anti-aging effect of the anti-aging polypeptide composition is improved. The problem of skin laxity and aging caused by loss of structural proteins such as skin collagen is thoroughly solved, and the efficient wrinkle smoothing and anti-aging effects are achieved.

The invention provides a moldable and self-adhesive cartilage repair material and a preparation method thereof, and the preparation method comprises the following steps: (1) uniformly mixing decellularized cartilage particles obtained by treating fresh articular cartilage tissue, a decellularized fibrous dermal matrix obtained by treating fresh skin tissue, mussel protein and purified water to obtain composite slurry; the composite slurry is prepared from the following components in percentage by mass: 1 to 30 weight percent of decellularized cartilage particles, 55 to 73 weight percent of decellularized fibrous dermal matrix, 2 to 5 weight percent of mussel protein and 5 to 21 weight percent of purified water; and (2) carrying out freeze-drying treatment on the composite slurry to obtain the moldable and self-adhesive cartilage repair material. The cartilage repair material provided by the invention retains main components of cartilage, has plasticity and self-adhesion performance, and can effectively simulate a cartilage regeneration repair microenvironment.

To provide a composition comprising a fibrous acellular dermal matrix having enhanced physical properties, which is easily applicable even to a bent wound site, and a method for producing the same.SOLUTION: A composition comprising 48 to 95.5 wt.% of a fibrous acellular dermal matrix and 0.5 to 52 wt.% of water, wherein a biocompatible polymer is not added, an average tensile strength value of 0.2 N / mm2 or more is satisfied, and the composition is a sheet type.SELECTED DRAWING: Figure 1

The present disclosure relates to a method of obtaining a decellularized dermal matrix from a skin graft of a rabbit, hare or beaver, the method comprising the steps of: degreasing the skin graft using a hydrocarbon solvent, perchloroethylene, a modified alcohol or supercritical carbon dioxide, or a combination thereof; liming the degreased graft by immersing the graft in a solution comprising calcium hydroxide, sodium hydroxide, hydrogen peroxide, or a mixture thereof; fleshing the skin graft; optionally, de-ashing the skin graft; incubating the skin graft in an ethylenediamine tetraacetic acid solution; the skin graft is treated with the detergent solution for 30 minutes to 3 hours to obtain a decellularized dermal matrix. The present disclosure also relates to a decellularized dermal matrix obtained by said method; a composition comprising the decellularized dermal matrix for use in a medicament or veterinary medicament; and a dermal-epidermal skin substitute scaffold comprising the disclosed decellularized dermal matrix.

The present invention relates to a dispersion comprising acellular dermal matrix microparticles, a membrane comprising the same, and uses thereof. More specifically, the present invention relates to a membrane comprising a dispersion containing acellular dermal matrix microparticles obtained by supercritical fluid extraction and high pressure dispersion operations, and a method for preparing the same. The acellular dermal membrane according to the present invention exhibits excellent biological stability and biocompatibility, and shows significantly better preservation of extracellular matrix components such as collagen. In addition, the material has excellent mechanical properties, so that the material is easily applied to transplantation operation and suture, and has a porous structure, so that body fluid flow is facilitated, and tissue regeneration can be supported. Thus, the acellular dermal membrane can be applied as wound dressing, adhesion barrier and implantable biomaterials such as drug delivery grafts and artificial skin in the field of regenerative medicine.

The present invention relates to a biomatrix and a manufacturing method therefor, the biomatrix comprising, as active ingredients, a fibrous acellular dermal matrix and a biocompatible material and having a layered cross-section and thus having enhanced physical properties.

This invention relates to an anti-aging composition of donkey-hide gelatin powder, its preparation method, and its application. The anti-aging composition of donkey-hide gelatin powder comprises, by mass percentage: 1-4% donkey-hide gelatin powder, 0.1-1% antioxidant and anti-inflammatory short peptides, 0.01-0.5% rare ginsenoside CK, 500-5000 ppm expression line relaxing short peptides, 1-3% solubilizer, and the balance water. By specifically setting the component content and the preparation method, a multi-level, multi-target three-dimensional anti-aging network is constructed, covering multiple key aging pathways such as nerve conduction, dermal matrix, cell metabolism, and moisturizing barrier. Furthermore, donkey oil is added to the anti-wrinkle cream used in its application, highlighting the role of donkey-hide gelatin in anti-aging in conjunction with the donkey-hide gelatin powder. The cream, serum, lotion, and lip balm formulas provided by this invention are stable, biocompatible, and possess good anti-aging and antioxidant effects, providing a safe and effective solution for addressing skin aging problems.