98 results about "Absorbable suture" patented technology

A fastener preferably made from a shape memory alloy is provided which can access internal tissue or other synthetic material by catheter delivery through an endovascular pathway. After the fastener is deployed through layers of tissue or other material, it assumes a shape that automatically applies to the layers of tissue or other material an appropriate hemostatic compression which is relatively independent of tissue or material thickness. The fastener is a suitable replacement for conventional non bio-absorbable sutures and staples in certain clinical applications. The shape, method of deployment, and low force requirements make the disclosed apparatus suitable for endosurgical procedures where access to the wound site is limited. A method for deploying the fastener is also provided.

Film structures, packages, films and methods of making the same are provided wherein the film structures have a desiccant material incorporated into at least one layer of the film structures and further wherein the film structures can comprise a material for making a peelable seal when the film structures are heat sealed to other film structures. The film structures are utilized for a package to hold a product that may be sensitive to the presence of moisture. The product may preferably be pharmaceutical products, nutraceutical products, or devices such as absorbable sutures or medical stents, although any moisture-sensitive product is contemplated by the present invention.

Synthetic absorbable sutures are filled with a stabilizing agent, preferably a mixture of glycerol and calcium lactate, and inserted into a retainer having a narrow convoluted passageway. The retainer is inserted into an open foil pouch with a package stabilizing element such as a paper sheet filled with stabilizing agent. The package containing the suture, retainer and package stabilizing element is sterilized, aerated, equilibrated to a relatively high moisture level, and sealed. Long lengths of suture and doubled-over and tripled-over suture may be withdrawn from the retainer with low force without damaging the suture. Bends and kinks in the suture are prevented so as to provide a synthetic absorbable suture having highly desirable out of package hand and feel. The suture an removed from the package exhibits improved tissue drag characteristics.

A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.

A sac composed of woven bio-absorbable suture with an opening (2) for placement of bone graft or bone graft substitutes (5). The device is contoured and sized for positioning in various anatomic areas (FIGS. 3, 4, and 7) and may be coupled to an implantable electronic fusion stimulator device (6 and 7).

A degradable copolymer filament comprising an internal structure having the following separate phases: (a) a matrix phase comprised as a primary component of a polymer segment which exhibits a tensile Young's modulus of 2 GPa or less and a strength retention of 50% or more after two weeks in water at 37 DEG C., pH 7.3, and (b) a micro-dispersed phase comprised as a primary component of a polymer segment which exhibits a tensile strength of 200 MPa or more and a strength reduction greater than the matrix phase in water at 37 DEG C., pH 7.3. The weight ratio of each component in the matrix phase and dispersed phase is 50:50 to 95:5, respectively, and the dispersed phase a needle structure oriented by stretching in the fiber direction. A degradable monofilament having an excellent mechanical strength and flexibility, moderate hydrolyzability, high ligature stability and being suitable as a material of surgical absorbable suture can be obtained. A preparation process is also provided.

The invention relates to an absorbable suture nail for an anastomat. The absorbable suture nail comprises a suture nail body, a degradable biological ceramic thin film bottom layer and a degradable macromolecule surface layer, wherein the suture nail body is made of medical degradable magnesium alloy wire materials, the degradable biological ceramic thin film bottom layer is attached on the surface of the magnesium alloy wire materials, and the degradable macromolecule surface layer is used for sealing holes. By the aid of surface double-layer protection formed by the degradable ceramic coating layer and the macromolecule thin film and hole sealing effect of an organic coating layer to the surface of an inorganic ceramic coating layer, the absorbable suture nail for the anastomat can be improved effectively, degrading speed of the suture nail is controlled, and the suture nail can be degraded and absorbed completely in in-vivo environment. Meanwhile, at early stage of postoperation, the suture nail has indispensable acid-resisting or alkali-resisting corrosive performance so as to resist early corrosion damage in the strong acid environment of the stomach and is applicable to anastomosis and suture after various operations in vivo, particularly alimentary canal operation.

Film structures, packages, films and methods of making the same are provided wherein the film structures have a desiccant material incorporated into at least one layer of the film structures and further wherein the film structures can comprise a material for making a peelable seal when the film structures are heat sealed to other film structures. The film structures are utilized for a package to hold a product that may be sensitive to the presence of moisture. The product may preferably be pharmaceutical products, nutraceutical products, or devices such as absorbable sutures or medical stents, although any moisture-sensitive product is contemplated by the present invention.

This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.

The invention provides a sterilization process and equipment of absorbable sutures. The invention belongs to the technical field of sterilization and relates to an ethylene oxide sterilizer and process of absorbable sutures. According the invention, the problems that after being sterilized by the previous ethylene oxide sterilizers, the absorbable sutures have relatively high ethylene oxide residues and relative high humidity are solved, thus the requirements for asepsis, low ethylene oxide residues and low humidity of the sterilized sutures are met. The sterilization process is characterizedby comprising the following steps: firstly maintaining the temperature and humidity in a container; secondly introducing ethylene oxide into the container; and finally, vacuumizing the container. Theequipment for sterilization comprises a control cabinet with a programmable logic controller (PLC), a box body, a heating system, a vacuum system, a feeding system and a humidifying system, and the heating system, the vacuum system, the feeding system and the humidifying system are connected with the box body.

The invention belongs to the technical field of sterilization and relates to a pretreatment device and process of products before sterilization. By utilizing the invention, the problems that after being sterilized by the previous ethylene oxide sterilizers, the absorbable sutures have relatively high ethylene oxide residues and relatively high humidity are solved, thus the requirements for asepsis, low ethylene oxide residues and low humidity of the sterilized sutures are met. The sterilization process is characterized by comprising the following steps: firstly, maintaining the temperature ina container; secondly, introducing hot air and wet gas into the container; finally vacuumizing the container and repeating the above steps. The equipment for sterilization comprises a box body, a heating system, a humidifying system, a hot air supplying system, a vacuum system and a programmable logic controller (PLC), and the heating system, the humidifying system, the hot air supply system, thevacuum system and the PLC are connected with the box body.

This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.

The invention discloses an auxiliary implantable flexible microelectrode of a non-absorbable suture line and a production method thereof, wherein the electrode comprises a flexible microelectrode, a non-absorbable suture line and a medical suture needle, the flexible microelectrode and the non-absorbable suture line are spirally wounded together, the combination tail end of the non-absorbable suture line and the flexible microelectrode is fixed via polydimethysiloxane, and the medical suture needle is connected with the two ends of the non-absorbable suture line. The auxiliary implantable flexible microelectrode utilizes the characteristics that the suture line penetrates through the tissues easily and has the relatively fixed positions, so the flexible microelectrode and the suture line are produced together, and the flexible microelectrode is implanted when the suture line penetrates through the tissues. The auxiliary implantable flexible microelectrode has strong operability, the prepared suture line with the flexible microelectrode is only needed to be implanted and fixed in the targeted tissues through a surgical suture technology for use, so the accuracy of the implantation position of the microelectrode can be ensured for a long term.

The invention relates to a method for preparing the nerve fiber absorbable suture thread, wherein it comprises: washing the nerve fiber to remove the surface dirt, to be washed in the hank's; removing resin and water in the alcohols with different densities, to be dipped in the stomach prolease solution and the internal shear enzyme solution; then washing it in the 5% pawpaw prolease; the invention can naturally remove the tail nerve fiber, to form hundreds of integral fiber lines, to improve the produced number and improve the extract rate to 100%. The invention has smooth surface without burr, while it removes the harmful organism in the nerve fiber, to avoid the rejection between human body and suture thread.

The invention discloses an absorbable suture containing medium-chain PHA (Polyhydroxyalkanoate) (PHBV (Polyhydroxylbutyrate Valerate) or PHBHHx (poly (3-hydroxybutyrate-co-3-hydroxyhexanoate))). The invention specifically discloses a PHBHHx monofilament fiber, a PHBHHx / PLA (Poly Lactic Acid) monofilament fiber and a PHBV / PLA bunched fiber and preparation methods thereof. Blending with the PLA is performed, so that a spinning process is simple, complementary material performance is achieved, and the PHBHHx and the PHBV fibers are good in handfeel. Compared with the conventional material, the absorbable suture has the advantage of higher biocompatibility in the field of nerve and vascular repair due to the use of the PHA material. Moreover, the PHA is high in mechanical strength and slow in degradation speed, so that the PHA is excellent in application effect on the suture repair of cartilages and bone tissues. On the aspect of novel minimally invasive surgical repair, the PHBHHx and the PHBV contain nontoxic and non-irritant degradation products with high compatibility, so that surgical scars can be effectively reduced, and the absorbable suture has an application prospect in esthetic restoration.

A PGA / PLA copolymer suture fiber having a fiber tenacity of between approximately 7.2 to 8.0 grams per denier and a fiber elongation between approximately 22% and 35% is produced by a process that utilizes extruder apparatus having at least one heated zone that is maintained at a temperature of from about 20° C. below the copolymer melting point to about 5° C. above the copolymer melting point, a metering pump and a heated block that are maintained at a temperature of no more than about 40° C. above the copolymer melting point, a spinneret that is maintained at a temperature of from about 40° C. to about 60° C. above the copolymer melting point, and an elongated heated sleeve extending between six and twenty inches from the spinneret that is maintained at a temperature of at least about 60° C. above the copolymer melting point.

The invention provides a composite drug-loaded fiber for an absorbable surgical suture. The existing absorbable surgical suture has few varieties and has the defects that the natural absorbable surgical suture has low strength and has the risk of generating rejection reaction, and the in-vivo degradation time of the synthesized absorbable surgical suture is too long. In order to solve the problems, the invention provides the composite drug-loaded fiber for the absorbable surgical suture, so as to make up the defects of the existing suture, avoid the pain of a patient during postoperative suture removal and reduce the infection risk. The drug-loaded fiber is prepared by compounding a main material, a reinforcing material, a pore-foaming agent, a coating material and an anti-inflammatory, antibacterial and anticoagulant drug and combining the processes of spinning, coating and the like. The fiber provided by the invention has the beneficial effects that the surface structure is uniform and smooth; the diameter is adjustable and controllable; the fiber has a porous internal structure; the fiber has good mechanical strength, extensibility, toughness and tensile property; the fiber hasexcellent biocompatibility; the fiber has more ideal in-vivo degradation time; and the fiber has good drug slow release performance, and the effects of early anti-inflammatory, antibacterial or anticoagulant of wound suture are achieved.

The invention discloses polyhydroxyalkanoate fibers, a preparing method and application thereof. The polyhydroxyalkanoate fibers contain 0.05-2 wt% of carbon nano tubes, and polyhydroxyalkanoate is copolyester of 3-hydroxybutyric acid and 3-hydroxy caproic acid. The carbon nano tubes are added into polyhydroxyalkanoate PHBHHx, it is accidentally found that the crystallization velocity of polyhydroxyalkanoate is greatly increased by the carbon nano tubes, the crystallization time in the spinning and forming process is shortened, the spinning and forming efficiency is improved, and then production cost is reduced. The fibers are suitable for serving as absorbable suture lines.

The invention provides a gastrointestinal minimally-invasive anastomat and a gastrointestinal minimally-invasive anastomosing method, and relates to the anastomat field. The gastrointestinal minimally-invasive anastomat comprises a head ring and a bottom ring which are of the same structure and have the magnetism; each of the head ring and the bottom ring comprises at least two magnetic blocks which are connected in series and connected through an absorbable suture line; the head ring is connected with a tectorial membrane sleeve, the two ends of the tectoral membrane sleeve serve as an opening end and a tying end respectively, the opening end is connected with the axial end face, far away from the bottom ring, of the head ring, and the tying end of the tectorial membrane sleeve is provided with a tying piece; the magnetic blocks of the head ring are each connected with a head traction piece; the magnetic blocks of the bottom ring are each connected with a bottom traction piece. The gastrointestinal minimally-invasive anastomat can be applied to a surgery for cutting and anastomosing the gastrointestinal tract in a minimally-invasive mode and can be conveniently excreted out of a body.

The invention discloses an absorbable suture containing medium-chain PHA (Polyhydroxyalkanoate) (PHBV (Polyhydroxylbutyrate Valerate) or PHBHHx (poly (3-hydroxybutyrate-co-3-hydroxyhexanoate))). The invention specifically discloses a PHBHHx monofilament fiber, a PHBHHx / PLA (Poly Lactic Acid) monofilament fiber and a PHBV / PLA bunched fiber and preparation methods thereof. Blending with the PLA is performed, so that a spinning process is simple, complementary material performance is achieved, and the PHBHHx and the PHBV fibers are good in handfeel. Compared with the conventional material, the absorbable suture has the advantage of higher biocompatibility in the field of nerve and vascular repair due to the use of the PHA material. Moreover, the PHA is high in mechanical strength and slow in degradation speed, so that the PHA is excellent in application effect on the suture repair of cartilages and bone tissues. On the aspect of novel minimally invasive surgical repair, the PHBHHx and the PHBV contain nontoxic and non-irritant degradation products with high compatibility, so that surgical scars can be effectively reduced, and the absorbable suture has an application prospect in esthetic restoration.

The invention discloses an absorbable suture . The suture is prepared from a suture body which is obtained by the mutual winding weaving of multiple yarns processed, the number of yarn is 8-140, and the yarns are natural mulberry silks. The invention further provides a preparation method of the absorbable suture, the natural mulberry silks are taken as the raw material, the absorbable mulberry silk suture with high purity and strength is obtained, the suture can be used for the suturing of normal soft tissue surgical operation and the suturing of tissue operation with slower repairing and higher mechanical demands of meniscus, shoulder sleeve tissues, tendon ligament tissues and the like, and clinical demands are met.

The invention relates to an antimicrobial and absorbable suture line and a preparation method thereof. The suture line is made from glycolide, lactide, calcium stearate and chlorhexidine gluconate and has good tensile strength and antibacterial properties. The preparation method includes the following steps that firstly, the glycolide (GA) and the lactide (LA) are put in a reaction kettle in a certain proportion, a catalyst and an initiator are added, vacuumizing is performed, and ring opening polymerization is performed under a stirring condition to generate poly (l-lactide-co-glycolide) (PGLA); secondly, synthesized PGLA is spun on a small home-made spinning machine; thirdly, coating and drug carrying are conducted on PGLA silk threads with a calcium stearate coating solution and a chlorhexidine gluconate solution; finally, the PGLA silk threads are stranded and knitted to prepare the antimicrobial and absorbable suture line. The preparation method is simple and low in production cost, and mechanized large-scale production can be achieved. The prepared antimicrobial and absorbable suture line has good antibacterial properties and can meet the wound operation suture and antimicrobial demand.

The invention relates to a digital signal processor (DSP) based linear array charge coupled device (CCD) online detection system for absorbable suture line diameter. The DSP based linear array CCD online detection system for absorbable suture line diameter comprises structural members and a system circuit. The structural members include a light source support, a CCD support, guide wheels and a guide rail. The guide wheels and the guide rail are fixed to the surface of a platform of a wet spinning machine. A linear array CCD comprises a linear array CCD module and a casing; a plug rod B is arranged at the bottom of the casing and is in close fit with a central slot of a holder B. A telecentric lens is mounted at the front end of the linear array CCD and provided with a shading device. The shading device consists of a lens hood and a shade piece. The system circuit consists of an optical imaging module, a linear array CCD drive module, a high-speed analog / digital (A / D) data acquisition and DSP digital signal processing module. Compared with the conventional measurement method, the DSP based linear array CCD online detection method for the absorbable suture line diameter has the advantages that the line diameter can be detected in real time accurately during production and twisting of absorbable sutures, a DSP controller output end provides detection data for a spinneret mechanism and a tension control system to realize closed-loop control of spinneret pressure and stretch tension, thus the produced sutures have good uniformity.

The invention relates to a konjac glucomannan surgical suture and a preparation method thereof. The preparation method of the konjac glucomannan surgical suture comprises steps of preparing a blend, preparing spinning dope and preparing the absorbable suture. Compared with absorbable surgical sutures prepared with general methods, the nanoscale konjac glucomannan surgical suture prepared from konjac glucomannan as the main material and other auxiliary materials capable of completely absorbed by a body through sufficient use of the advantages of high antibacterial property and viscoelasticity and good biocompatibility of konjac glucomannan has the advantages of being higher in antibacterial property and flexibility, low in friction coefficient, convenient to knot and the like, indexes suchas absorbing time, flexibility, raw material cost, safety and the like of the konjac glucomannan surgical suture are better than other surgical sutures in the market, and the konjac glucomannan surgical suture has huge potential market value.

The invention discloses an anti-infection high-strength absorbable medical suture and a preparation method thereof. The raw materials of the medical suture include: polycaprolactone, polyglycolic acid, β-chitosan, phenylalanine, silkworm chrysalis shell powder , Propolis, Carbomer, Polyoxyethylene, Polyvinylpyrrolidone, Polyvinyl Alcohol, Plant Extract Containing Centella Asiatica, Polyhexamethylene Biguanide, Sorbitol, Tween 60. The absorbable medical suture prepared by the invention has a good healing effect on wounds, and the straight pull strength, knot strength and elongation at break are all significantly improved, and the healing rate is as high as over 98%, without complications and infection. In addition, the prepared absorbable medical suture has good absorption performance, good biocompatibility, and good clinical application value, which is worthy of popularization and application.

The invention discloses a high-strength absorbable suture and a preparation method thereof. The suture is composed of the following components in parts by mass: 39-51 parts of chitosan, 7-16 parts of zinc acetate, 2-11 parts of glutaraldehyde, 11-26 parts of polyhydroxybutyrate, 2-8 parts of Ca5(OH)(PO4)3, 13-24 parts of sulfonated castor oil, 9-17 parts of polyglycolide acid, and 1-8 parts of itaconic anhydride. According to the prepared suture disclosed by the invention, tensile strength can be improved, elongation is increased, moreover, complete absorption is realized and the suture can be widely applied to clinical treatment.

The invention discloses an absorbable suture containing medium-chain PHA (Polyhydroxyalkanoate) (PHBV (Polyhydroxylbutyrate Valerate) or PHBHHx (poly (3-hydroxybutyrate-co-3-hydroxyhexanoate))). The invention specifically discloses a PHBHHx monofilament fiber, a PHBHHx / PLA (Poly Lactic Acid) monofilament fiber and a PHBV / PLA bunched fiber and preparation methods thereof. Blending with the PLA is performed, so that a spinning process is simple, complementary material performance is achieved, and the PHBHHx and the PHBV fibers are good in handfeel. Compared with the conventional material, the absorbable suture has the advantage of higher biocompatibility in the field of nerve and vascular repair due to the use of the PHA material. Moreover, the PHA is high in mechanical strength and slow in degradation speed, so that the PHA is excellent in application effect on the suture repair of cartilages and bone tissues. On the aspect of novel minimally invasive surgical repair, the PHBHHx and the PHBV contain nontoxic and non-irritant degradation products with high compatibility, so that surgical scars can be effectively reduced, and the absorbable suture has an application prospect in esthetic restoration.

The invention belongs to the technical field of medical equipment, and particularly relates to an absorbable suture anchor and a preparation method thereof. The suture anchor comprises an anchor bodyand a suture. The material of the anchor is formed by compounding polylactic acid and inorganic calcium phosphate, wherein the polylactic acid is L-polylactic acid (PLLA) or L-racemic polylactic acid(PLDLLA) or a combination of the L-polylactic acid (PLLA) and the L-racemic polylactic acid (PLDLLA), and the inorganic calcium phosphate is hydroxyapatite (HA) or beta-tricalcium phosphate (TCP) ora combination of the HA and the TCP. The suture is formed by weaving absorbable monofilament materials, and the absorbable monofilament materials comprise one or more of polylactic acid-glycolic acid(PLGA), polycaprolactone (PCL), polydioxanone (PPDO), polyhydroxyalkanoate (PHA) and polyhydroxybutyric acid (PHB). The anchor disclosed by the invention is formed by compounding the polylactic acid and the calcium phosphate, and meanwhile, the absorbable suture is adopted, so that degradation and absorption are carried out while bones and soft tissues grow together, and perfect biological fusionis achieved.

The invention discloses an acupoint catgut embedding gun with two operation modes available. The acupoint catgut embedding gun comprises a puncturing needle, a catgut embedding gun body, a flat-head ejector pin, a firing pin, a firing pin motor, a gear position assembly, a spool, a spool box and an electric knife, wherein the puncturing needle is arranged at the central position of the catgut embedding gun body and extends out from the left end part of the catgut embedding gun body, a suture inlet through which an absorbable suture can be placed in is arranged at the end part, extending out ofthe catgut embedding gun body, of the puncturing needle, the flat-head ejector pin extends into the catgut embedding gun body from the right end part of the catgut embedding gun body, the flat-head ejector pin can extend into an inner cavity of the puncturing needle, the left end part of the firing pin attaches to the right end part of the puncturing needle, the firing pin is driven by the firingpin motor, the firing pin can push the puncturing needle to extend out from the left end part of the catgut embedding gun body, the gear position assembly and the spool box are arranged on the catgutembedding gun body, the spool is arranged in the spool box, the absorbable suture is arranged on the spool, and the electric knife is arranged in the catgut embedding gun body. According to the different work conditions, two work methods are available.