Antimicrobial and absorbable suture line and preparation method thereof

The technology of suture and silk thread is applied in the field of antibacterial and absorbable suture and its preparation.

Inactive Publication Date: 2017-05-10
WUHAN YIJIABAO BIOMATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, injection or oral antibiotic drugs are often used clinically,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0027] 1 Put GA and LA into the reactor according to the ratio of 90:10, add the catalyst stannous octoate (0.5% of the monomer mass) and the initiator 1,4-butanediol (0.1% of the monomer mass), Vacuumize to 10 Pa, heat to 200°C with stirring, react for 5 hours, maintain vacuum and cool to room temperature after the reaction, dissolve the product with a small amount of dichloromethane, and then use glacial ether 10 times the volume of the solution Sedimentation, suction filtration, and drying in a vacuum oven at room temperature for 72 hours is the synthesized polylactide (PGLA).

[0028] 2 The PGLA synthesized above was spun on a self-made micro-spinning machine, the spinning temperature was 255°C, and the spinning speed was adjusted to 100 m / min.

[0029] 3 The specific steps of coating are as follows: (1) Disperse calcium stearate of the same quality as PGLA with absolute ethanol, add it to PGLA dissolved in tetrahydrofuran, and ultrasonically oscillate for 2 h until the ca...

Embodiment example 2

[0033] 1 Put GA and LA into the reactor according to the ratio of 90:10, add the catalyst stannous octoate (0.5% of the monomer mass) and the initiator 1,4-butanediol (0.1% of the monomer mass), Vacuumize to 10 Pa, heat to 200°C with stirring, react for 5 hours, maintain vacuum and cool to room temperature after the reaction, dissolve the product with a small amount of dichloromethane, and then use glacial ether 10 times the volume of the solution Sedimentation, suction filtration, and drying in a vacuum oven at room temperature for 72 hours is the synthesized polylactide (PGLA).

[0034] 2 The PGLA synthesized above was spun on a self-made micro-spinning machine, the spinning temperature was 255°C, and the spinning speed was adjusted to 200 m / min.

[0035] 3 The specific steps of coating are as follows: (1) Disperse calcium stearate of the same quality as PGLA with absolute ethanol, add it to PGLA dissolved in tetrahydrofuran, and ultrasonically oscillate for 2 h until the ca...

Embodiment example 3

[0039]1 Put GA and LA into the reactor according to the ratio of 90:10, add the catalyst stannous octoate (0.5% of the monomer mass) and the initiator 1,4-butanediol (0.1% of the monomer mass), Vacuumize to 10 Pa, heat to 200°C with stirring, react for 5 hours, maintain vacuum and cool to room temperature after the reaction, dissolve the product with a small amount of dichloromethane, and then use glacial ether 10 times the volume of the solution Sedimentation, suction filtration, and drying in a vacuum oven at room temperature for 72 hours is the synthesized polylactide (PGLA).

[0040] 2 The PGLA synthesized above was spun on a self-made micro-spinning machine, the spinning temperature was 255°C, and the spinning speed was adjusted to 100 m / min.

[0041] 3 The specific steps of coating are as follows: (1) Disperse calcium stearate with 1 / 2 of the mass of PGLA with absolute ethanol, add it into PGLA dissolved in tetrahydrofuran, and oscillate ultrasonically for 2 hours until ...

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PUM

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Abstract

The invention relates to an antimicrobial and absorbable suture line and a preparation method thereof. The suture line is made from glycolide, lactide, calcium stearate and chlorhexidine gluconate and has good tensile strength and antibacterial properties. The preparation method includes the following steps that firstly, the glycolide (GA) and the lactide (LA) are put in a reaction kettle in a certain proportion, a catalyst and an initiator are added, vacuumizing is performed, and ring opening polymerization is performed under a stirring condition to generate poly (l-lactide-co-glycolide) (PGLA); secondly, synthesized PGLA is spun on a small home-made spinning machine; thirdly, coating and drug carrying are conducted on PGLA silk threads with a calcium stearate coating solution and a chlorhexidine gluconate solution; finally, the PGLA silk threads are stranded and knitted to prepare the antimicrobial and absorbable suture line. The preparation method is simple and low in production cost, and mechanized large-scale production can be achieved. The prepared antimicrobial and absorbable suture line has good antibacterial properties and can meet the wound operation suture and antimicrobial demand.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to an antibacterial absorbable suture and a preparation method thereof. Background technique [0002] Polyglycolide (PGLA) is a polyester biodegradable polymer material obtained by ring-opening polymerization of glycolide (GA) and lactide (LA) in a certain ratio. When it is used as a suture, it not only has the advantages of high tensile strength, good flexibility, and easy knotting, but also has good biocompatibility and biodegradability, no carcinogenicity and mutation reactions, and the degradation product is CO 2 and H 2 O, can be degraded and absorbed by the human body and has no adverse reaction to the human body. There is no need to remove stitches after surgery, and no scars will be left. [0003] As an important part of suture, coating has an important impact on the performance of suture, not only can improve the surface properties of suture, but also affect its degra...

Claims

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Application Information

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IPC IPC(8): A61L17/10A61L17/14A61L17/00C08G63/08D01F6/62
CPCA61L17/105A61L17/005A61L17/145A61L2300/202A61L2300/404C08G63/08D01F6/625
Inventor 柯林松唐小雄雷勇
Owner WUHAN YIJIABAO BIOMATERIAL CO LTD
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