The invention relates to a full-automatic bag making and filling and sealing machine of a bag tail filling non-PVC (polyvinyl chloride) membrane transfusion soft bag, which belongs to the technical field of pharmacy packing machine. The full-automatic bag making and filling and sealing machine comprises a machine body which consists of a frame component (3), wherein a distribution box (1) is arranged at one side of the machine body, and a bag making machine and a filling and sealing machine are arranged on the upper part of the machine body. The machine is characterized in that a bag body transfer mechanism (12) is arranged between the bag making machine and the filling and sealing machine, a connector supply mechanism (17) and a preheating mechanism (6) are arranged at one side of the bag making machine, the bag making machine is provided with a made bag annular conveying component (8), the made bag annular conveying component is provided with a connector fixture, the filling and sealing machine is provided with an annular conveying belt, and the annular conveying belt is provided with a bag fixture (19). According to the invention, full-automatic production of the tail filling non-PVC membrane transfusion soft bag is realized through improving the bag, the working principle is simple, the structure is reliable, the operation is stable, the failure rate is low, the occupied space is small, and according to the characteristics of the soft bag, the production cost can be obviously reduced. The action of the machine is fast, and the production efficiency is high.