The invention discloses a knowledge fusion method based on D-S (Dempster-Shafer) evidence theory. The knowledge fusion method comprises the steps of S1, obtaining sample data in each field, S2, determining a discernment frame of scientific experiments, S3, determining the probability of each discernment element in each field, S4, calculating the BPA value of each discernment element in each field, S5, obtaining a similarity distance function between the BPA values of any one discernment element in any two fields through calculation, S6, calculating the similarity measure between the BPA values of any one discernment element in any two fields, S7, calculating the support degree of any one discernment element, S8, calculating the credibility of any one discernment element from all support degrees of the discernment element, and S9, obtaining the BPA value of every discernment element after fusion from the credibilities of all the discernment elements. The knowledge fusion method is applicable to fusion of multiple reasoning result knowledge having great varieties and indeterminacy and one-sidedness.