Anti-infection and high-strength medical absorbable suture and preparation method thereof

An anti-infection, suture technology, applied in the field of medical materials, can solve the problems of not promoting wound healing, straight pull strength, knot strength, elongation at break and anti-infection, etc., and achieve good healing effect and good clinical Application value, good biocompatibility

Inactive Publication Date: 2016-09-28
林春梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the commonly used absorbable sutures have outstanding absorbability, but their direct tensile strength, knot strength, elongation at break and infection resistance are not good, and they do not have the function of promoting wound healing. somewhat limited the use of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] An anti-infection high-strength absorbable medical suture thread, the raw materials comprise by weight: 40 parts of polycaprolactone, 15 parts of polyglycolic acid, 10 parts of beta-chitosan, 4 parts of phenylalanine, and 2 parts of silkworm chrysalis shell powder parts, 3 parts of propolis, 3 parts of carbomer, 2 parts of polyethylene oxide, 1 part of polyvinylpyrrolidone, 3 parts of polyvinyl alcohol, 7 parts of plant extract containing Centella asiatica, 2 parts of polyhexamethylene biguanide, 5 parts of sorbitol, 2 parts of Tween 60.

[0022] The Centella asiatica-containing plant extract includes Centella asiatica, Corydalis chinensis and D. chinensis extracts in a weight ratio of 3:1:2.

[0023] The centella asiatica-containing plant extract is an ethanol or methanol extract, and the specific extraction steps are: drying the centella asiatica-containing plant and pulverizing it respectively, adding 20 times the weight of a 75% mass concentration ethanol or methano...

Embodiment 2

[0029] An anti-infective high-strength absorbable medical suture, the raw materials comprise by weight: 44 parts of polycaprolactone, 20 parts of polyglycolic acid, 14 parts of beta-chitosan, 6 parts of phenylalanine, and 4 parts of silkworm chrysalis shell powder parts, 5 parts of propolis, 4.5 parts of carbomer, 3.5 parts of polyethylene oxide, 3 parts of polyvinylpyrrolidone, 4.5 parts of polyvinyl alcohol, 9 parts of plant extract containing Centella asiatica, 4 parts of polyhexamethylene biguanide, 8 parts of sorbitol, 3.5 parts of Tween 60.

[0030] The Centella asiatica-containing plant extract includes Centella asiatica, Corydalis chinensis and D. chinensis extracts in a weight ratio of 4:1:3.

[0031] The centella asiatica-containing plant extract is an ethanol or methanol extract, and the specific extraction steps are as follows: drying the centella asiatica-containing plant and pulverizing it respectively, adding 35 times the weight of an 85% mass concentration etha...

Embodiment 3

[0037] An anti-infection high-strength absorbable medical suture thread, the raw materials comprise by weight: 48 parts of polycaprolactone, 24 parts of polyglycolic acid, 18 parts of beta-chitosan, 8 parts of phenylalanine, and 6 parts of silkworm chrysalis shell powder parts, 7 parts of propolis, 6 parts of carbomer, 5 parts of polyethylene oxide, 5 parts of polyvinylpyrrolidone, 3-6 parts of polyvinyl alcohol, 11 parts of plant extract containing Centella asiatica, 6 parts of polyhexamethylene biguanide parts, 12 parts of sorbitol, 5 parts of Tween 60.

[0038] The Centella asiatica-containing plant extract includes Centella asiatica, Corydalis chinensis and D. chinensis extracts in a weight ratio of 4:3:1.

[0039] The centella asiatica-containing plant extract is an ethanol or methanol extract, and the specific extraction steps are as follows: drying the centella asiatica-containing plant and pulverizing it respectively, adding 50 times the weight of a 95% mass concentrat...

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PUM

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Abstract

The invention discloses an anti-infection high-strength absorbable medical suture and a preparation method thereof. The raw materials of the medical suture include: polycaprolactone, polyglycolic acid, β-chitosan, phenylalanine, silkworm chrysalis shell powder , Propolis, Carbomer, Polyoxyethylene, Polyvinylpyrrolidone, Polyvinyl Alcohol, Plant Extract Containing Centella Asiatica, Polyhexamethylene Biguanide, Sorbitol, Tween 60. The absorbable medical suture prepared by the invention has a good healing effect on wounds, and the straight pull strength, knot strength and elongation at break are all significantly improved, and the healing rate is as high as over 98%, without complications and infection. In addition, the prepared absorbable medical suture has good absorption performance, good biocompatibility, and good clinical application value, which is worthy of popularization and application.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to an anti-infection high-strength absorbable medical suture thread and a preparation method thereof. Background technique [0002] Medical sutures are special threads used for wound closure, tissue ligation and tissue fixation. At present, medical sutures can be divided into non-absorbable sutures and absorbable sutures according to different biodegradability. Absorbable sutures can be self-degraded into soluble products in body tissues, and disappear from the implantation site within 2-6 months, making them a medical material with great development potential, which has attracted much attention and research. The ideal absorbable suture should be stable in the body, have little tissue reaction, not easily loosen after knotting, and the suture itself will not fray or split. Absorbable sutures are non-toxic, have good compatibility with human tissue and blood, and are degradable. F...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10A61L17/08A61L17/00
CPCA61L17/105A61L17/005A61L17/08A61L17/10
Inventor 林春梅
Owner 林春梅
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